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LATS2

  • LATS2

    • Protein-coding gene in the species Homo sapiens

    Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene. This gene encodes a serine/threonine protein kinase belonging

    LATS2

    LATS2

    LATS2

  • Nocodazole

    • Microtubule depolymerizing drug

    microtubules-independent mechanisms. Nocodazole stimulates the expression of LATS2 which potently inhibits the Wnt signaling pathway by abrogating the interaction

    Nocodazole

    Nocodazole

    Nocodazole

  • Cyclin-dependent kinase 4

    • Human protein

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • (Pyruvate, phosphate dikinase) kinase

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    (Pyruvate, phosphate dikinase) kinase

    (Pyruvate,_phosphate_dikinase)_kinase

  • Protein kinase domain

    • Protein domain

    IRAK4 ; ITK ; JAK1 ; JAK2 ; JAK3 ; KALRN ; KDR ; KIT ; KSR1 ; KSR2 ; LATS1 ; LATS2 ; LCK ; LIMK1 ; LIMK2 ; LMTK2 ; LMTK3 ; LRRK1 ; LRRK2 ; LTK ; LYN ; MAK ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • Angiomotin

    • Protein-coding gene in the species Homo sapiens

    TAZ (transcriptional co-activator with PDZ-binding motif), and activating LATS2 through a novel conserved domain. The activity of YAP and TAZ can be restricted

    Angiomotin

    Angiomotin

    Angiomotin

  • CHEK2

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    CHEK2

    CHEK2

    CHEK2

  • MAPKAPK2

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAPKAPK2

    MAPKAPK2

    MAPKAPK2

  • Myosin light-chain kinase

    • Class of kinase enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • MAP2K4

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAP2K4

    MAP2K4

    MAP2K4

  • NDR kinase

    • Ndr1 (or STK38), Ndr2 (or STK38L), Lats1 (large tumor suppressor-1) and Lats2. In animals these kinases have reported roles in the regulation of diverse

    NDR kinase

    NDR_kinase

  • SPEG

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    SPEG

    SPEG

    SPEG

  • Cyclin-dependent kinase 1

    • Mammalian protein found in Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • Cyclin-dependent kinase 9

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Cyclin-dependent kinase 9

    Cyclin-dependent kinase 9

    Cyclin-dependent_kinase_9

  • PRKCG

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PRKCG

    PRKCG

    PRKCG

  • NUAK2

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    NUAK2

    NUAK2

    NUAK2

  • Titin

    • Largest known protein in human muscles

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Titin

    Titin

    Titin

  • Cyclin-dependent kinase 7

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Cyclin-dependent kinase 7

    Cyclin-dependent kinase 7

    Cyclin-dependent_kinase_7

  • PHKA2

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PHKA2

    PHKA2

    PHKA2

  • STK3

    • Protein-coding gene in the species Homo sapiens

    domain, MST2 phosphorylates LATS1/LATS2 with the help of SAV1, MOB1A/MOB1B, and Merlin (protein). In turn, LATS1/LATS2 phosphorylates and inhibits YAP1

    STK3

    STK3

    STK3

  • PCTK1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PCTK1

    PCTK1

    PCTK1

  • LATS1

    • Protein-coding gene in the species Homo sapiens

    Y, Miyoshi Y, Takahata C, et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically

    LATS1

    LATS1

    LATS1

  • FOXP3

    • Immune response protein

    MYC oncogenes and induces expression of tumour suppressor genes P21 and LATS2 in breast and prostate cancer cells. Second, over-expression of FOXP3 in

    FOXP3

    FOXP3

    FOXP3

  • CDC2L1

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    CDC2L1

    CDC2L1

    CDC2L1

  • Contact inhibition

    • Two related phenomena in cell biology

    STK3 genes, respectively, in mammals) activates a secondary kinase (Lats1/Lats2), which phosphorylates YAP, a transcriptional activator of growth genes

    Contact inhibition

    Contact_inhibition

  • Mitogen-activated protein kinase

    • P38 mitogen-activated protein kinases

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • C-Jun N-terminal kinases

    • Chemical compounds

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • ACVR2B

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    ACVR2B

    ACVR2B

    ACVR2B

  • MTOR

    • Mammalian protein found in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MTOR

    MTOR

    MTOR

  • AMP-activated protein kinase

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • List of human protein-coding genes 4

    • HGNC:18874; O43561 8571 LAT2 HGNC:12749; Q9GZY6 8572 LATS1 HGNC:6514; O95835 8573 LATS2 HGNC:6515; Q9NRM7 8574 LAX1 HGNC:26005; Q8IWV1 8575 LAYN HGNC:29471; Q6UX15

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • VRK2

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    VRK2

    VRK2

    VRK2

  • MTORC1

    • Protein complex

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MTORC1

    MTORC1

    MTORC1

  • P70-S6 Kinase 1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    P70-S6 Kinase 1

    P70-S6 Kinase 1

    P70-S6_Kinase_1

  • ACVR1

    • Protein-coding gene

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    ACVR1

    ACVR1

    ACVR1

  • PLK1

    • Mammalian protein found in Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PLK1

    PLK1

    PLK1

  • Protein kinase A

    • Family of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • Cyclin-dependent kinase

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • PLK2

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PLK2

    PLK2

    PLK2

  • IKBKG

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    IKBKG

    IKBKG

    IKBKG

  • Protein kinase C

    • Family of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Protein kinase C

    Protein_kinase_C

  • Phosphoinositide-dependent kinase-1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent_kinase-1

  • Ca2+/calmodulin-dependent protein kinase II

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent_protein_kinase_II

  • Extracellular signal-regulated kinases

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • Wee1

    • Nuclear protein

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Wee1

    Wee1

    Wee1

  • WWTR1

    • Protein-coding gene in the species Homo sapiens

    through phosphorylation by kinases in the Hippo pathway, namely LATS1 and LATS2. This recruits the binding of the regulatory protein, 14-3-3, which prevents

    WWTR1

    WWTR1

    WWTR1

  • Phototropin

    • Class of photoreceptor proteins in plants

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Phototropin

    Phototropin

  • IkappaB kinase

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    IkappaB kinase

    IkappaB_kinase

  • Protein kinase B

    • Set of three serine threonine-specific protein kinases

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • MAP kinase kinase kinase kinase

    • Family of proteins

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAP kinase kinase kinase kinase

    MAP_kinase_kinase_kinase_kinase

  • MTORC2

    • Protein complex

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MTORC2

    MTORC2

  • P38 mitogen-activated protein kinases

    • Protein family

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • Mitogen-activated protein kinase kinase

    • Kinase enzyme

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • Serine/threonine-specific protein kinase

    • Class of protein kinase enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • GSK-3

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    GSK-3

    GSK-3

    GSK-3

  • WW domain

    • Protein domain

    dystrophin-like protein; vertebrate YAP protein, substrate of LATS1 and LATS2 serine-threonine kinases of the Hippo tumor suppressor pathway; Mus musculus

    WW domain

    WW domain

    WW_domain

  • BRAF (gene)

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    BRAF (gene)

    BRAF (gene)

    BRAF_(gene)

  • CHEK1

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    CHEK1

    CHEK1

    CHEK1

  • MTOR inhibitors

    • Class of pharmaceutical drugs

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MTOR inhibitors

    MTOR inhibitors

    MTOR_inhibitors

  • IKBKE

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    IKBKE

    IKBKE

    IKBKE

  • GRK5

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    GRK5

    GRK5

    GRK5

  • Acetate kinase

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Acetate kinase

    Acetate kinase

    Acetate_kinase

  • Protein kinase C zeta type

    • Mammalian protein found in Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Protein kinase C zeta type

    Protein kinase C zeta type

    Protein_kinase_C_zeta_type

  • VRK1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    VRK1

    VRK1

    VRK1

  • RPS6KA1

    • Enzyme

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    RPS6KA1

    RPS6KA1

    RPS6KA1

  • MIPOL1

    • Protein-coding gene in the species Homo sapiens

    proteins, verified via two-hybrid screening. A few notable examples include: LATS2: Negatively regulates YAP1 in the Hippo signaling pathway that plays a pivotal

    MIPOL1

    MIPOL1

    MIPOL1

  • Protein kinase R

    • Human protein and coding gene

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Protein kinase R

    Protein kinase R

    Protein_kinase_R

  • CAMK

    • Enzyme type

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    CAMK

    CAMK

  • Phosphatidylinositol 3-kinase-related kinase

    • Protein family

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Phosphatidylinositol 3-kinase-related kinase

    Phosphatidylinositol_3-kinase-related_kinase

  • Hippo signaling pathway

    • Signaling pathway that controls organ size

    protein, facilitating Warts phosphorylation by Hippo Warts (Wts) LATS1, LATS2 Nuclear DBF-2-related kinase that phosphorylates and inactivates Yki Mob

    Hippo signaling pathway

    Hippo signaling pathway

    Hippo_signaling_pathway

  • CDKL5

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    CDKL5

    CDKL5

    CDKL5

  • NUAK1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    NUAK1

    NUAK1

    NUAK1

  • PIK3R4

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PIK3R4

    PIK3R4

    PIK3R4

  • ACVR1C

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    ACVR1C

    ACVR1C

    ACVR1C

  • SMG1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    SMG1

    SMG1

    SMG1

  • RAF kinase

    • 11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    RAF kinase

    RAF kinase

    RAF_kinase

  • NLK

    • Mammalian protein found in Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    NLK

    NLK

    NLK

  • PRKACB

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PRKACB

    PRKACB

    PRKACB

  • IRAK4

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    IRAK4

    IRAK4

    IRAK4

  • Aurora inhibitor

    • Putative drug class for treating cancer

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Aurora inhibitor

    Aurora inhibitor

    Aurora_inhibitor

  • MAPK11

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAPK11

    MAPK11

    MAPK11

  • WNK3

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    WNK3

    WNK3

    WNK3

  • MAP3K11

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAP3K11

    MAP3K11

    MAP3K11

  • ACVRL1

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    ACVRL1

    ACVRL1

    ACVRL1

  • MKNK2

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MKNK2

    MKNK2

    MKNK2

  • Casein kinase 1, alpha 1

    • Enzyme found in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Casein kinase 1, alpha 1

    Casein kinase 1, alpha 1

    Casein_kinase_1,_alpha_1

  • CHUK

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    CHUK

    CHUK

    CHUK

  • GAK (protein)

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    GAK (protein)

    GAK (protein)

    GAK_(protein)

  • Pyruvate dehydrogenase kinase

    • Class of enzymes

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Pyruvate dehydrogenase kinase

    Pyruvate dehydrogenase kinase

    Pyruvate_dehydrogenase_kinase

  • Ribosomal s6 kinase

    • Family of protein kinases

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Ribosomal s6 kinase

    Ribosomal s6 kinase

    Ribosomal_s6_kinase

  • Aurora kinase A

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Aurora kinase A

    Aurora kinase A

    Aurora_kinase_A

  • ATM serine/threonine kinase

    • Mammalian protein found in Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    ATM serine/threonine kinase

    ATM serine/threonine kinase

    ATM_serine/threonine_kinase

  • MAPKAPK3

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAPKAPK3

    MAPKAPK3

    MAPKAPK3

  • MAPK14

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAPK14

    MAPK14

    MAPK14

  • PKMYT1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    PKMYT1

    PKMYT1

    PKMYT1

  • MAP2K6

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MAP2K6

    MAP2K6

    MAP2K6

  • FASTK

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    FASTK

    FASTK

    FASTK

  • IRAK2

    • Protein-coding gene in humans

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    IRAK2

    IRAK2

    IRAK2

  • MASTL

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    MASTL

    MASTL

    MASTL

  • Protein kinase D1

    • Protein-coding gene in the species Homo sapiens

    11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2

    Protein kinase D1

    Protein kinase D1

    Protein_kinase_D1

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