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Modified forms of synthetic insulin
An insulin analogue (also called an insulin analog) is a type of medical insulin that has been modified to alter its pharmacokinetic properties while
Insulin_analogue
Use of insulin protein and analogs as medical treatment
insulin is identical to the naturally occurring molecule whereas insulin analogues have slightly different molecules that allow for modified time of
Insulin_(medication)
Intermediate acting insulin formulation
NPH insulin to other insulin analogues (insulin detemir, insulin glargine, insulin degludec) in both children and adults with Type 1 diabetes. Insulin detemir
NPH_insulin
Ultralong-acting basal insulin analogue
Insulin icodec, sold under the brand name Awiqli, is an ultralong-acting basal insulin analogue used in the treatment of diabetes. It is administered
Insulin_icodec
Drugs that lower blood glucose levels to treat diabetes
using these insulin analogues between adults and children. Most oral anti-diabetic agents are contraindicated in pregnancy, in which case insulin is preferred
Diabetes_medication
Long-acting insulin
Insulin glargine sold, among others, under the brand name Lantus (manufactured and marketed by Sanofi) is a long-acting modified form of medical insulin
Insulin_glargine
Rapid-acting insuline analog
approved for use in the United States in 1996. It is a manufactured analogue of human insulin where two amino acids have swapped positions. In 2023, it was
Insulin_lispro
Ultralong-acting basal insulin analogue
Insulin degludec (INN/USAN) is an ultralong-acting basal insulin analogue that was developed by Novo Nordisk under the brand name Tresiba. It is administered
Insulin_degludec
Rapid-acting man-made insulin
Insulin aspart, sold under the brand name Novolog, among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. It is
Insulin_aspart
of insulin may offer any of the following preparation methods: vials, pens, cartridges, IV bags or inhalers. All insulin analogues and non-analogue insulins
List of commercially available insulins
List_of_commercially_available_insulins
Peptide hormone
human insulin under the brand name Humulin. The vast majority of insulin used worldwide is biosynthetic recombinant human insulin or its analogues. Recently
Insulin
Chemical compound
established. GLP-1 receptors improve insulin sensitivity and increase satiety. Retatrutide has shown to increase insulin secretion. Furthermore, agonism of
Retatrutide
Medication
Insulin efsitora alfa, sold under the brand name Onswik, is an antidiabetic medication used for the treatment of type 2 diabetes. It is a long-acting
Insulin_efsitora_alfa
Gastrointestinal peptide hormone involved in glucose homeostasis
sugar levels in a glucose-dependent manner by enhancing the secretion of insulin. Beside the insulinotropic effects, GLP-1 has been associated with numerous
Glucagon-like_peptide-1
Pharmaceutical drug classification
version. A10AB01 Insulin (human) A10AB02 Insulin (beef) A10AB03 Insulin (pork) A10AB04 Insulin lispro A10AB05 Insulin aspart A10AB06 Insulin glulisine A10AB30
ATC_code_A10
Long-acting man-made insulin
review also compared the effects of insulin detemir to NPH insulin and other insulin analogues (insulin glargine, insulin degludec) in both children and adults
Insulin_detemir
Combination drug
Insulin icodec/semaglutide is an experimental fixed-dose combination of insulin icodec and semaglutide in development for type 2 diabetes by Novo Nordisk
Insulin_icodec/semaglutide
Medication used to treat diabetes
It works by decreasing glucose production in the liver, increasing the insulin sensitivity of body tissues, and increasing GDF15 secretion, which reduces
Metformin
Anti-diabetic and anti-obesity medication
of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes
Semaglutide
Experimental insulin analogue
to Se-Ins) is an experimental insulin analogue first described in 2017. It is a modified form of bovine pancreatic insulin in which the interchain disulfide
Selenoinsulin
Pharmaceutical drug
Insulin degludec/liraglutide, sold under the brand name Xultophy, is a fixed-dose combination medication for the treatment of adults with type 2 diabetes
Insulin_degludec/liraglutide
Combination medication
Insulin degludec/insulin aspart, sold under the brand name Ryzodeg, is a fixed-dose combination medication for the treatment of diabetes mellitus. It contains
Insulin degludec/insulin aspart
Insulin_degludec/insulin_aspart
Class of organic compounds used in medicine and agriculture
are medically used in the management of type 2 diabetes by stimulating insulin secretion. Sulfonylureas are the most widely used herbicide. Many sulfonylureas
Sulfonylurea
Anti-diabetic and anti-obesity medication
insulin resistance, with a reduction of around 8% from baseline, measured using HOMA2-IR (computed with fasting insulin). Fasting levels of insulin-like
Tirzepatide
Rapid-acting insulin analogue
Insulin glulisine, sold under the brand name Apidra among others, is a rapid-acting modified form of medical insulin used for the treatment of diabetes
Insulin_glulisine
Medication
receptor agonist) also known as incretin mimetics. It works by increasing insulin release from the pancreas and decreases excessive glucagon release. Exenatide
Exenatide
Anti-obesity medication
Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine Insulin lispro Short-acting Regular insulin# Long-acting Insulin detemir# Insulin
Orforglipron
Chemical compound
in conjunction with insulin therapy.[citation needed] Mainly used in Type II diabetes, metformin is considered to increase insulin sensitivity in vivo
Biguanide
Combination drug
Insulin glargine/lixisenatide, sold under the brand name Soliqua among others, is a fixed-dose combination medication that combines insulin glargine and
Insulin_glargine/lixisenatide
Pharmaceutical compound
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Brenipatide
Chemical compound
sulfonylurea family of medications. It works mostly by increasing the release of insulin. Gliclazide was patented in 1966 and approved for medical use in 1972.
Gliclazide
Diabetes medication
aiding the pancreas to release the correct amount of insulin when blood sugar levels are high. Insulin helps to move sugar from the blood onto other body
Dulaglutide
Genetically engineered variety of rose
Frogs Bacteria and viruses Ice-minus bacteria Hepatitis B vaccine Insulin analogue Oncolytic virus Processes Inserting DNA Agrobacteria Biolistics Electroporation
Blue_rose
Chemical compound
treat type 2 diabetes. It may be used with metformin, a sulfonylurea, or insulin. Use is recommended together with exercise and diet. It is not recommended
Pioglitazone
Chemical compound
and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the
Vildagliptin
Diabetes medication
be assessed. Dapagliflozin can cause low blood sugar when combined with insulin. To lessen the risk of developing ketoacidosis after surgery, the US FDA
Dapagliflozin
Short-acting insulin formulation
Regular insulin, also known as neutral insulin and soluble insulin, is a type of short-acting medical insulin. It is used to treat type 1 diabetes, type
Regular_insulin
Class of drugs used to treat diabetes
incretin effect of GIP and GLP-1 accounts for around 50–70% of post-meal insulin secretion. This effect is substantially reduced in people with type 2 diabetes
GLP1_poly-agonist_peptides
Chemical compound
fasting plasma glucose and HBA1c in diabetes patients. Saroglitazar is an insulin sensitizer. It is a first in class drug which acts as a dual PPAR agonist
Saroglitazar
Chemical compound
It works by stimulating the pancreas to release insulin and increases tissue sensitivity to insulin. Glipizide was approved for medical use in the United
Glipizide
Chemical compound
hypoglycemia associated with insulin and earlier oral antidiabetic drugs. It was further believed that reducing insulin resistance would potentially reduce
Troglitazone
Medical condition
N, Gonzalez-Padilla DA (January 2016). "Subcutaneous rapid-acting insulin analogues for diabetic ketoacidosis". The Cochrane Database of Systematic Reviews
Diabetic_ketoacidosis
Powdered insulin delivered with an inhaler
Inhalable insulin is a powdered form of insulin, delivered with an inhaler into the lungs where it is absorbed. In general, inhaled insulins have been
Inhalable_insulin
Diabetes medication
weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately
Empagliflozin
Class of medication
gliflozins cause less stimulation of endogenous insulin secretion or lower dose of exogenous insulin that results in diabetic ketoacidosis. They can specifically
SGLT2_inhibitor
Diabetes drug
2 diabetes. In the European Union, its use is limited to complementing insulin therapy. As of 2017 it is unclear if they affect a person's risk of death
Lixisenatide
Diabetes medication
Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β cells of the pancreas along with insulin after a meal
Pramlintide
Diabetes medication
peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas. In the United
Sitagliptin
Pharmaceutical compound
Insulin tregopil is a fast-acting insulin analog which, unlike other forms of insulin, is delivered by mouth. It is developed by Biocon for diabetes.
Insulin_tregopil
Chemical substance
fusion of insulin granula in the cell membrane, and therefore increased secretion of (pro) insulin. Blicklé JF (April 2006). "Meglitinide analogues: a review
Meglitinide
Formulary by the World Health Organization
Medroxyprogesterone acetate Insulin (analogue, long-acting) Insulin (analogue, rapid-acting) Insulin (human, intermediate-acting) Insulin (human, short-acting)
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Peptide drug
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Survodutide
Combination drug
Pramlintide/insulin A21G (development name ADO09) is a combination of the amylin analogue pramlintide and an insulin analog. It is being developed by Adocia
Pramlintide/insulin_A21G
Class of chemical compounds
protein, this causes upregulation of genes (for a full list see PPARγ): Insulin resistance is decreased Adipocyte differentiation is modified VEGF-induced
Thiazolidinedione
Historical formulation of insulin as medication
favor with doctors in the mid-2000s, when insulin analogues such as glargine began to be approved. Insulin analogues made by recombinant DNA production methods
Lente_insulin
American biotechnology company
Frogs Bacteria and viruses Ice-minus bacteria Hepatitis B vaccine Insulin analogue Oncolytic virus Processes Inserting DNA Agrobacteria Biolistics Electroporation
AquaBounty_Technologies
Anti-diabetic medication
receptor agonist) also known as incretin mimetics. It works by increasing insulin release from the pancreas and decreases excessive glucagon release. Common
Liraglutide
Chemical compound
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Lotiglipron
Medication
diabetes; its mode of action is to increase insulin secretion by the pancreas. However it requires adequate insulin synthesis as prerequisite to treat appropriately
Glimepiride
Chemical compound
sulfonylureas class of medications and works by increasing the release of insulin from the pancreas. Glibenclamide was discovered in 1969 and approved for
Glibenclamide
Oral anti-diabetic drugs
Helen (2017). "Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind
Alpha-glucosidase_inhibitor
Chemical compound
dipeptidyl peptidase-4 inhibitor that works by increasing the production of insulin and decreasing the production of glucagon by the pancreas. It is generally
Linagliptin
Chemical compound
USA'S Food & Drug Administration not approving sotagliflozin along with insulin for the emergency treatment of hyperglycemia. Similar concerns led to the
Sotagliflozin
Chemical compound
delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose uptake into cells, and inhibits synthesis of glucose
Buformin
Experimental drug
ORMD-0801 is an experimental insulin analog that is taken by mouth, rather than injected. It is developed by Oramed Pharmaceuticals to treat diabetes
ORMD-0801
Antidiabetic medication
low blood sugar levels when used in combination with insulin or medications that increase insulin in the body, and serious urinary tract infections. The
Bexagliflozin
Chemical compound
hepatic gluconeogenesis, increase muscle glucose uptake, and restore normal insulin secretion. It is the first approved drug of this class of anti-diabetic
Imeglimin
Excess growth of certain parts of the body
treatment can cause diabetes because somatostatin and its analogues can inhibit the release of insulin.[citation needed] With an aggressive adenoma that is
Acromegaly
Cellular therapy medication
secretion of insulin by the infused allogeneic islet beta cells. In some people with type 1 diabetes, these infused cells can produce enough insulin, so the
Donislecel
Enzyme blocker and diabetes treatment drug
(GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels
Dipeptidyl peptidase-4 inhibitor
Dipeptidyl_peptidase-4_inhibitor
Chemical compound
class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the
Rosiglitazone
Chemical compound
in combination with metformin and pioglitazone, or in combination with insulin, from initial HbA1c levels of 7.8% to 8.1%. When added to metformin, canagliflozin
Canagliflozin
Pharmaceutical drug
blood sugar levels) when the medicine is taken with a sulphonylurea or insulin, infections of the urinary tract and genitals, and increased urination
Empagliflozin/metformin
Alpha-glucosidase inhibitor
mellitus. Postprandial hyperglycemia (PPHG) is primarily due to first phase insulin secretion. Alpha glucosidase inhibitors delay glucose absorption at the
Voglibose
Pharmaceutical drug
tolerated) or in combination with other antidiabetic drugs, including insulins. According to a 2015 analysis, albiglutide is less effective than other
Albiglutide
Medical simulation computer program
lispro (Humalog)-like rapidly acting insulin analogues, and the glargine (Lantus) very long-acting insulin analogue, into the freeware diabetes simulator
AIDA interactive educational freeware diabetes simulator
AIDA_interactive_educational_freeware_diabetes_simulator
Drug storage and delivery device
Bloudek, L; Sarnes, E (July 2018). "Costs associated with long-acting insulin analogues in patients with diabetes". The American Journal of Managed Care.
Injector_pen
Chemical compound
by people without any toxic effects. Combining ertugliflozin with insulin or insulin secretagogues (such as sulfonylureas) may result in an increased risk
Ertugliflozin
Medication
control in otherwise healthy cats with diabetes not previously treated with insulin. "Notice: Multiple additions to the Prescription Drug List (PDL) [2024-10-18]"
Velagliflozin
Pharmaceutical drug
agonist; and as add-on to insulin as an adjunct to diet and exercise to improve glycemic control in people when stable dosage of insulin and metformin alone
Sitagliptin/metformin
Type of insulin
Deepak; Weiss, Michael A (2022-04-01). "New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals". The Journal of Clinical
NNC2215
Combination drug
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Glibenclamide/metformin
Combination drug
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Empagliflozin/linagliptin/metformin
Empagliflozin/linagliptin/metformin
Chemical compound
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Danuglipron
Long-acting form of insulin
Ultralente insulin was a long-acting form of insulin. It has an onset of 4 to 6 hours, a peak of 14 to 24 hours, and a duration of 28 to 36 hours. Due
Ultralente_insulin
Two drugs combined to treat diabetes
Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine Insulin lispro Short-acting Regular insulin# Long-acting Insulin detemir# Insulin
Dapagliflozin/metformin
GLP1 poly-agonist drug
Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine Insulin lispro Short-acting Regular insulin# Long-acting Insulin detemir# Insulin
Mazdutide
Drug used for the treatment of symptoms of metabolic syndrome
thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen)
PPAR_agonist
Pharmaceutical drug
triple combination therapy with insulin as an adjunct to diet and exercise to improve glycaemic control in patients when insulin at a stable dose and metformin
Vildagliptin/metformin
Chemical compound
responsible for the beneficial actions of saxagliptin, including increasing insulin production in response to meals and decreasing the rate of gluconeogenesis
Saxagliptin
Chemical compound
resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs. Nateglinide is contraindicated
Nateglinide
Anti-diabetic drug
Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine Insulin lispro Short-acting Regular insulin# Long-acting Insulin detemir# Insulin
Alogliptin
Chemical compound
Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine Insulin lispro Short-acting Regular insulin# Long-acting Insulin detemir# Insulin
Epalrestat
Genetic technique that uses homologous recombination to change an endogenous gene
Frogs Bacteria and viruses Ice-minus bacteria Hepatitis B vaccine Insulin analogue Oncolytic virus Processes Inserting DNA Agrobacteria Biolistics Electroporation
Gene_targeting
Chemical compound
by prolonging the activity of incretins (GLP-1 and GIP), which enhances insulin secretion and suppresses glucagon release in a glucose-dependent manner
Trelagliptin
Pharmaceutical compound
medication, insulins and insulin analogues, and other drugs used in diabetes (A10) Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine
Conveglipron
Formulary
listings in this section. Insulin (analogue, long-acting) Insulin (analogue, rapid-acting) Insulin (human, intermediate-acting) Insulin (human, short-acting)
WHO Model List of Essential Medicines for Children
WHO_Model_List_of_Essential_Medicines_for_Children
Chemical compound
if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. It is not routinely used due to a higher incidence of
Tolbutamide
Chemical compound
Insulins and insulin analogues Fast-acting Insulin aspart Insulin glulisine Insulin lispro Short-acting Regular insulin# Long-acting Insulin detemir# Insulin
Remogliflozin_etabonate
clinically meaningful development. However, by 1996, the advent of insulin analogues which had vastly improved absorption, distribution, metabolism, and
History_of_diabetes
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INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
INSULIN ANALOGUE
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