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Chemical compound
Biguanide (/baɪˈɡwɒnaɪd/) is the organic compound with the formula HN(C(NH)NH2)2. It is a colorless solid that dissolves in water to give a highly basic
Biguanide
Chemical compound
Polyaminopropyl biguanide (PAPB) is a polymer containing biguanide group connected with a three methylene (propyl) linker. The polymer is a propyl analogue
Polyaminopropyl_biguanide
Pharmaceutical compound
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide
Polyhexanide
Medication used to treat diabetes
doses or prescribed to people with severe kidney problems. Metformin is a biguanide anti-hyperglycemic agent. It works by decreasing glucose production in
Metformin
Chemical compound
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed
Buformin
Antimicrobial agent that inactivates or destroys microbes
their metabolism.[citation needed] Thymol Pine oil The biguanide polymer polyaminopropyl biguanide is specifically bactericidal at very low concentrations
Disinfectant
Species of flowering plant in the pea family
traditional medicine over centuries, G. officinalis is at the foundation of the biguanide class of antidiabetic drugs, which also included phenformin and buformin
Galega_officinalis
Chemical compound
Alexidine is an antimicrobial of the biguanide class. More specifically, it is a bisbiguanide. Barrios, Rocío; Ferrer-Luque, Carmen María; Arias-Moliz
Alexidine
Combination drug
diabetes. It contains glibenclamide, a sulfonylurea, and metformin, a biguanide. "TGA eBS - Product and Consumer Medicine Information Licence". Archived
Glibenclamide/metformin
Chemical compound
first after the discovery of insulin. Later development of nontoxic, safe biguanides led to the long-used first-line diabetes control medicine metformin, introduced
Guanidine
Disinfectant and antiseptic
Slee AM, Kamay BA (December 1977). "Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque activity". Antimicrobial Agents
Chlorhexidine
Inflammation of the pancreas
While some association exists between the occurrence of pancreatitis and biguanide agents such as metformin, as well as with dipeptidyl peptidase 4 inhibitors
Pancreatitis
Series of interconnected biochemical reactions
PMID 24283301. S2CID 23259898. Sirtori CR, Pasik C (1994). "Re-evaluation of a biguanide, metformin: mechanism of action and tolerability". Pharmacological Research
Cori_cycle
antiseptics chlorhexidine and alexidine. They are named for having two biguanide moieties, which themselves are named for having two guanide parts. Bisbiguanide
Bisbiguanide
Drugs that lower blood glucose levels to treat diabetes
sensitizers address the core problem in type 2 diabetes – insulin resistance. Biguanides reduce hepatic glucose output and increase uptake of glucose by the periphery
Diabetes_medication
Decrease in blood sugar
medications used to treat diabetes such as insulin, sulfonylureas, and biguanides. Risk is greater in people with diabetes who have eaten less than usual
Hypoglycemia
Medical treatment approach
polyhexamethylene biguanide solution, Ringer's solution or saline in 112 venous leg ulcer patients. The study group received the polyhexamethylene biguanide solution
Wound_bed_preparation
Pharmaceutical drug
contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide). The combination was approved for medical use in the United States in
Sitagliptin/metformin
Chemical compound
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s
Phenformin
Quaternary ammonium surfactant and antiseptic agent
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Cetrimonium_bromide
Antimicrobial substance or compound
inflammation of the gums (gingivitis). Polyhexanide (polyhexamethylene biguanide, PHMB) is an antimicrobial compound suitable for clinical use in critically
Antiseptic
Material used in surgery
electrospun bicomponent nanofibrous mesh incorporating poly(hexamethylene biguanide) and 5-chloro-8-quinolinol. The SEM micrograph presents the bactericidal
Surgical_mesh
Medication used to treat malaria and babesiosis
artemether# halofantrine Antifolates DHFR inhibitors pyrimethamine cycloguanil biguanides chlorproguanil proguanil# Sulfonamides sulfadoxine sulfalene Co-formulation
Quinine
Antiseptic solution
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Povidone-iodine
Combination drug
diabetes. It contains pioglitazone, a thiazolidinedione, and metformin, a biguanide. Pioglitazone is a member of the thiazolidinedione class, it decreases
Pioglitazone/metformin
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Silver_nitrate
Anti-diabetic and anti-obesity medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Tirzepatide
Gastrointestinal peptide hormone involved in glucose homeostasis
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Glucagon-like_peptide-1
Diabetes medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Empagliflozin
Pharmaceutical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Brenipatide
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Hydrogen_peroxide
Chemical compound responsible for rotten fish odor
(nitrogen mustard) Related compounds Unsymmetrical dimethylhydrazine Biguanide Dithiobiuret Trimethylphosphine Trimethylarsine Trimethylstibine Trimethylbismuth
Trimethylamine
Anti-static agent, surfactant and antimicrobial
Benzalkonium chloride – Surfactant and antiseptic agent Polyaminopropyl biguanide, an alternative preservative for contact lens solutions Ethylenediaminetetraacetic
Stearalkonium_chloride
Organomercury antiseptic and antifungal agent
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Thiomersal
fluid Nitromersol Ozone Peracetic acid Phenols Pine oil Polyaminopropyl biguanide Potassium hypochlorite Potassium permanganate Povidone-iodine Pseudomonas
List_of_cleaning_products
Simplest secondary alcohol
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Isopropyl_alcohol
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Retatrutide
Organomercuric antiseptic for external use on minor cuts
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Merbromin
Ultralong-acting basal insulin analogue
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Insulin_icodec
Chemical compound
P280, P284, P302+P350, P310 Related compounds Related compounds Biuret Biguanide Thiourea Except where otherwise noted, data are given for materials in
Dithiobiuret
Peptide drug
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Survodutide
Antifungal and antiparasitaric chemical compound
voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide". Journal of Clinical Microbiology. 41 (8). American Society for Microbiology:
Amphotericin_B
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Lotiglipron
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Sotagliflozin
Withdrawn diabetes drug
PMID 16505498. Roger P, Auclair J, Drain P (1999). "Addition of benfluorex to biguanide improves glycemic control in obese non-insulin-dependent diabetes: a double-blind
Benfluorex
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Potassium_permanganate
Diabetes medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Dapagliflozin
Antidiabetic medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Bexagliflozin
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Danuglipron
Chemical compound
phosphorylation inhibitor and AMP-activated protein kinase activating biguanide. Certain types of cancer cells requires oxidative phosphorylation to survive
HL156A
Chemical compound (CH2)3(CHO)2
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Glutaraldehyde
Surfactant
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Octenidine_dihydrochloride
Anti-diabetic and anti-obesity medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Semaglutide
Chemical compound
(nitrogen mustard) Related compounds Unsymmetrical dimethylhydrazine Biguanide Dithiobiuret Agmatine Except where otherwise noted, data are given for
Triethylamine
Surfactant and antiseptic agent
chloride – Anti-static agent, surfactant and antimicrobial Polyaminopropyl biguanide – an alternative preservative for contact lens solutions Ethylenediaminetetraacetic
Benzalkonium_chloride
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Hexachlorophene
Skin sore sustained by a vasculatory disease
is beneficial or whether wound cleaning solutions (polyhexamethylene biguanide, aqueous oxygen peroxide, etc.) are better than sterile water or saline
Venous_ulcer
Chemical compound
(nitrogen mustard) Related compounds Unsymmetrical dimethylhydrazine Biguanide Dithiobiuret Agmatine Except where otherwise noted, data are given for
Tris(2-aminoethyl)amine
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Glipizide
Series of events that restore integrity to damaged tissue after an injury
promoting healing or whether wound cleaning solutions (polyhexamethylene biguanide, aqueous hydrogen peroxide, etc.) are better than sterile water or saline
Wound_healing
Rapid-acting insuline analog
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Insulin_lispro
Long-acting insulin
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Insulin_glargine
Eye infection caused by a protist
One class of medications used in treatment is the biguanides, which include polyhexamethylene biguanide (PHMB) 0.02% to 0.06% drops, and chlorhexidine 0
Acanthamoeba_keratitis
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Phenol
Anti-obesity medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Orforglipron
of the first of the sulfonylureas in 1942 Reintroduction of the use of biguanides for type 2 diabetes in the late 1950s. The initial phenformin was withdrawn
History_of_diabetes
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Didecyldimethylammonium chloride
Didecyldimethylammonium_chloride
Medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Dapagliflozin/sitagliptin
Medication
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Clioquinol
Anti-diabetic medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Liraglutide
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Cetylpyridinium_chloride
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Sodium_hypochlorite
Modified forms of synthetic insulin
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Insulin_analogue
Chemical compound
(nitrogen mustard) Related compounds Unsymmetrical dimethylhydrazine Biguanide Dithiobiuret Agmatine Except where otherwise noted, data are given for
Triisopropylamine
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Canagliflozin
Indian academic
designed molecules (anti-diabetic belonging to class PPAR-γ agonist and biguanides), drug delivery using dendrimers. Fellowship of Alexander von Humboldt
Prasad_V._Bharatam
Agents used in the treatment of malaria
only used in concert with a sulfonamide Proguanil (chloroguanide) is a biguanide; a synthetic derivative of pyrimidine. It was developed in 1945 by a British
Antimalarial_medication
Dopamine agonist medication
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Bromocriptine
Type of biological molecule
excess) The following compounds are known to be pseudo-uncouplers: Azide Biguanides Bupivacaine Calcimycin (A23187) Dodecyltriphenylphosphonium (C12TPP) Lasalocid
Uncoupler
Chemical compound
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Glibenclamide
Toxic mercury compound known as 'corrosive sublimate'
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Mercury(II)_chloride
Anti-diabetic drug
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Alogliptin
Over-the-counter UTI drug
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Methenamine/sodium_salicylate
Combination drug
trials: †Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists
Insulin_glargine/lixisenatide
Pharmaceutical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Boric_acid_(vaginal)
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Potassium_hypochlorite
American biochemist (1895–1987)
chemistry from the University of Breslau in 1923 where he discovered that the biguanided metformin lowers the blood glucose concentration in rabbits. He continued
Karl_Slotta
Failure to ovulate during a menstrual cycle
sequelae of PCOS and if present, contribute to anovulation. Metformin, a biguanide, is a common insulin sensitizer often given to treat women with PCOS.
Anovulation
Indian federal government rules
4-oxazolidinediones, ureides), hypoglycemic drugs (e.g. sulfonylureas, biguanides), antihistamines, etc. The drug label must display the text "Caution:
Drugs and Cosmetics Rules, 1945
Drugs_and_Cosmetics_Rules,_1945
Medication for urinary tract infections
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Urinary_anti-infective_agent
Combination drug
Empagliflozin SGLT2 inhibitor Linagliptin DPP-4 inhibitor Metformin Anti-diabetic biguanide Clinical data Trade names Trijardy XR AHFS/Drugs.com Professional Drug
Empagliflozin/linagliptin/metformin
Empagliflozin/linagliptin/metformin
Medication
Exenatide is used to treat type 2 diabetes as an add-on to metformin, a biguanide, or a combination of metformin and a sulfonylurea, or thiazolidinediones
Exenatide
Indian inorganic chemist and historian of chemistry
designed several organic reagents including rubeanic acid, bismuthiol-I and biguanide for detecting and estimating metal ions with volumetric, gravimetric and
Priyadaranjan_Ray
Relationship between metabolism and specific types of cancer
altering one-carbon metabolism. Serine/glycine depletion delays growth in biguanide-treated cases. Fructose restriction limits glycolysis in Apc models. Amino
Tumor-informed_metabolism
Management of diabetes
blood sugar levels. Metformin is an example of a class of medicine called biguanides. The medication works by reducing the new creation of glucose from the
Diabetes_management
Common type of liver cancer
found to confer the highest magnitude of HCC risk, whereas treatment with biguanides or thiazolidinediones was associated with a 70% HCC risk reduction among
Hepatocellular_carcinoma
Pharmaceutical drug classification
ATC code P01 Antiprotozoals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed
ATC_code_P01
Topics referred to by the same term
PAPB may refer to: Polyaminopropyl biguanide, a preservative used in cleaning solutions for contact lenses St. George Airport (Alaska) (ICAO location
PAPB
Professor of pathology in New Zealand
Variation in the Metabolism and Pharmacokinetics of the Antimalarial Biguanides at the University of Liverpool. Helsby carried out postdoctoral research
Nuala_Helsby
Chemical compound
(D08) Acridine derivatives Ethacridine lactate 9-Aminoacridine Euflavine Biguanides and amidines Dibrompropamidine Chlorhexidine# Propamidine Hexamidine Polihexanide
Halazone
travel, tourism, insurance
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