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HDAC3

  • HDAC3
  • Protein-coding gene in humans

    Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice. Histones are alkaline positively charged proteins that package and

    HDAC3

    HDAC3

    HDAC3

  • Histone acetylation and deacetylation
  • Biological processes used in gene regulation

    as regulatory cross-talk between factors. HDAC3 has been found to be most closely related to HDAC8. HDAC3 contains a non-conserved region in the C-terminal

    Histone acetylation and deacetylation

    Histone acetylation and deacetylation

    Histone_acetylation_and_deacetylation

  • Sodium butyrate
  • Chemical compound

    class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin

    Sodium butyrate

    Sodium butyrate

    Sodium_butyrate

  • Reward system
  • Group of neural structures responsible for motivation and desire

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Reward system

    Reward system

    Reward_system

  • Substance dependence
  • Need for a drug, whose discontinuation results in withdrawal symptoms

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Substance dependence

    Substance_dependence

  • Epigenetics in learning and memory
  • Heritable characteristics affecting learning

    major target of SAHA HDAC3 is also a negative regulator of long term potentiation formation. McQuown et al. have shown that: KOs of HDAC3 in dorsal hippocampus

    Epigenetics in learning and memory

    Epigenetics_in_learning_and_memory

  • Histone deacetylase
  • Class of enzymes important in regulating DNA transcription

    subunit is controlled by acetylation via PCAF and by deacetylation via HDAC3 and HDAC6. These are just some examples of constantly emerging non-histone

    Histone deacetylase

    Histone deacetylase

    Histone_deacetylase

  • 3,3'-Diindolylmethane
  • Chemical compound

    a histone deacetylase inhibitor, specifically against HDAC1, HDAC2, and HDAC3. DIM is a metabolite of indole-3-carbinol. DIM was found to be a mild cannabinoid

    3,3'-Diindolylmethane

    3,3'-Diindolylmethane

    3,3'-Diindolylmethane

  • Caffeine dependence
  • Medical condition

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Caffeine dependence

    Caffeine dependence

    Caffeine_dependence

  • Toxoplasma gondii
  • Species of protozoan parasite

     gondii. Farhat and colleagues showed that chromatin modifiers MORC and HDAC3 play critical roles in silencing sexual development-specific genes. In MORC-depleted

    Toxoplasma gondii

    Toxoplasma gondii

    Toxoplasma_gondii

  • Butyric acid
  • Chemical compound (CH3CH2CH2COOH)

    agonist of HCA2. It is also an HDAC inhibitor (specifically, HDAC1, HDAC2, HDAC3, and HDAC8), a drug that inhibits the function of histone deacetylase enzymes

    Butyric acid

    Butyric acid

    Butyric_acid

  • Addiction
  • Disorder resulting in compulsive behaviors

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Addiction

    Addiction

    Addiction

  • Motivational salience
  • Cognitive process

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Motivational salience

    Motivational_salience

  • Β-Hydroxybutyric acid
  • Chemical compound

    inhibitor. Through inhibition of the HDAC class I isoenzymes HDAC2 and HDAC3, β-hydroxybutyric acid has been found to increase brain-derived neurotrophic

    Β-Hydroxybutyric acid

    Β-Hydroxybutyric acid

    Β-Hydroxybutyric_acid

  • Entinostat
  • Chemical compound

    for treatment of various cancers. Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. Syndax pharmaceuticals currently

    Entinostat

    Entinostat

    Entinostat

  • Tucidinostat
  • Chemical compound

    known as HBI-8000. It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10. Tucidinostat is approved by the Chinese FDA

    Tucidinostat

    Tucidinostat

    Tucidinostat

  • Substance use disorder
  • Continual use of drugs despite negative consequences

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Substance use disorder

    Substance use disorder

    Substance_use_disorder

  • Sexual addiction
  • Proposed compulsive sexual disorder

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Sexual addiction

    Sexual_addiction

  • Cannabis use disorder
  • Continued use of cannabis despite clinically significant impairment

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Cannabis use disorder

    Cannabis use disorder

    Cannabis_use_disorder

  • NF-κB
  • Family of transcription factor protein complexes

    310, by favoring the recruitment of HDAC3 to p65. In fact IFRD1 forms trimolecular complexes with p65 and HDAC3. The NAD+-dependent protein deacetylase

    NF-κB

    NF-κB

    NF-κB

  • Peroxisome proliferator-activated receptor gamma
  • Nuclear receptor protein found in humans

    interact with: Tetrahydrocannabivarin Cannabidiol Anandamide CD36 EDF1 EP300 HDAC3 NCOA4 NR0B2 PPARGC1A RB1. miR3666 PPAR-gamma agonists have been used in

    Peroxisome proliferator-activated receptor gamma

    Peroxisome proliferator-activated receptor gamma

    Peroxisome_proliferator-activated_receptor_gamma

  • TBL1X
  • Protein-coding gene in the species Homo sapiens

    chromosome TBL1Y gene. TBL1X has been shown to interact with: GPS2, and HDAC3, NCOA1, and NCOA2. GRCh38: Ensembl release 89: ENSG00000101849 – Ensembl

    TBL1X

    TBL1X

    TBL1X

  • Behavioral addiction
  • Compulsion to engage in a non-substance related behavior

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Behavioral addiction

    Behavioral_addiction

  • Nuclear receptor co-repressor 1
  • Protein found in humans

    Androgen receptor, CHD1, Calcitriol receptor GPS2, Glucocorticoid receptor, HDAC3, HDAC4, HDAC7A, HDAC9, HEY2, Histone deacetylase 5, MAP3K7IP2, MECP2, Peroxisome

    Nuclear receptor co-repressor 1

    Nuclear receptor co-repressor 1

    Nuclear_receptor_co-repressor_1

  • Histone deacetylase 5
  • Enzyme found in humans

    transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with

    Histone deacetylase 5

    Histone deacetylase 5

    Histone_deacetylase_5

  • Amphetamine dependence
  • Medical condition

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    Amphetamine dependence

    Amphetamine dependence

    Amphetamine_dependence

  • Zabadinostat
  • Chemical compound

    concentrations (IC50) of 62 nM, 570 nM and 550 nM, against HDAC1, HDAC2 and HDAC3, respectively. It shows no activity against HDAC class II. The ortho-aminoanilide

    Zabadinostat

    Zabadinostat

    Zabadinostat

  • Lipoic acid
  • Chemical compound

    citric acid cycle. The GCS regulates glycine concentrations. HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are targets of the reduced form (open dithiol)

    Lipoic acid

    Lipoic acid

    Lipoic_acid

  • CBFA2T3
  • Protein found in humans

    in the Golgi apparatus. CBFA2T3 has been shown to interact with: HDAC1, HDAC3, LDB1, PRKAR2A, RUNX1T1 and TAL1, and TCF3. GRCh38: Ensembl release 89:

    CBFA2T3

    CBFA2T3

    CBFA2T3

  • FOSB
  • Protein

    drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors has been conducted

    FOSB

    FOSB

    FOSB

  • Rev-ErbA alpha
  • Protein-coding gene in the species Homo sapiens

    interaction with the class I histone deactylase 3 (HDAC3) - NCoR complex. The catalytic activity of HDAC3 is activated only when it complexes with NCoR or

    Rev-ErbA alpha

    Rev-ErbA alpha

    Rev-ErbA_alpha

  • TBL1XR1
  • WD40-repeat-containing protein

    PMID 11063877. Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the

    TBL1XR1

    TBL1XR1

    TBL1XR1

  • Retinoblastoma protein
  • Mammalian protein found in humans

    repressors proteins. pRb interacts with the histone deacetylases HDAC1 and HDAC3. pRb binds to HDAC1 in its pocket domain in a region that is independent

    Retinoblastoma protein

    Retinoblastoma protein

    Retinoblastoma_protein

  • Nuclear receptor co-repressor 2
  • Protein found in humans

    co-repressor 2 has been shown to interact with: AR BCL6 C-Fos C-jun HDAC1 HDAC3 HDAC4 HDAC5 HDAC10 MeCP2 NR4A1 POU2F1 PPARD PGR PML RBPJ RELA RUNX1T1 RARA

    Nuclear receptor co-repressor 2

    Nuclear receptor co-repressor 2

    Nuclear_receptor_co-repressor_2

  • HDAC4
  • Protein found in humans

    and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation

    HDAC4

    HDAC4

    HDAC4

  • Lysine malonylation
  • Post-translational modification

    intermediate Enzymatic deacylation: Enzymes (Eraser) Nucleus: HDAC1, HDAC2, HDAC3, Sirtuin 1, Sirtuin 2 Cytoplasm: Sirtuin 1, Sirtuin 2 Mitochondria: Sirtuin

    Lysine malonylation

    Lysine malonylation

    Lysine_malonylation

  • THAP7
  • Protein-coding gene in the species Homo sapiens

    histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor". J. Biol. Chem. 280 (8): 7346–58

    THAP7

    THAP7

    THAP7

  • Peroxisome proliferator-activated receptor delta
  • Nuclear receptor protein found in humans

    Peroxisome proliferator-activated receptor delta has been shown to interact with HDAC3 and NCOR2. GRCh38: Ensembl release 89: ENSG00000112033 – Ensembl, May 2017

    Peroxisome proliferator-activated receptor delta

    Peroxisome proliferator-activated receptor delta

    Peroxisome_proliferator-activated_receptor_delta

  • Rhabdomyosarcoma
  • Cancer originating in precursors to muscle cells

    alveolar rhabdomyosarcoma (aRMS) by specifically blocking the activity of HDAC3, thereby preventing epigenetic suppression of a microRNA that inhibits PAX3:FOXO1

    Rhabdomyosarcoma

    Rhabdomyosarcoma

    Rhabdomyosarcoma

  • IFRD1
  • Protein-coding gene in the species Homo sapiens

    subunit, by favoring the recruitment of HDAC3 to p65. In fact, IFRD1 forms trimolecular complexes with p65 and HDAC3. Thus, IFRD1 can induce muscle regeneration

    IFRD1

    IFRD1

    IFRD1

  • Mocetinostat
  • Chemical compound

    works by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11. "Pharmion Corporation (PHRM) Release: Clinical Data On Oncology

    Mocetinostat

    Mocetinostat

    Mocetinostat

  • NRIP1
  • Protein-coding gene in the species Homo sapiens

    deacetylation Histone deacetylase 5 (HDAC5) Chromatin compaction HDAC1, HDAC2, HDAC3 Histone deacetylation RELA (NF‑κB subunit) Coactivation of proinflammatory

    NRIP1

    NRIP1

    NRIP1

  • Mitchell Guttman
  • Molecular biologist

    identify its target sites on the X chromosome, interact with the SHARP/SMRT/HDAC3 complex to exclude RNA Polymerase II and silence transcription, and remodel

    Mitchell Guttman

    Mitchell_Guttman

  • Brown adipose tissue
  • Type of adipose tissue

    its longevity promoting benefits. Under basal environmental temperatures, HDAC3 primes expression of UCP1 and the brown fat thermogenic program to ensure

    Brown adipose tissue

    Brown adipose tissue

    Brown_adipose_tissue

  • RUNX2
  • Protein-coding gene in humans

    cell cycle. RUNX2 has been shown to interact with: AR ER-α C-Fos, C-jun, HDAC3, MYST4, SMAD1 SMAD3, and STUB1. and SMOC1. miR-133 and CyclinD1/CDK4 directly

    RUNX2

    RUNX2

    RUNX2

  • HDAC7
  • deacetylase activity and therefore requires association with the class I HDAC, HDAC3 in order to suppress gene expression. It has been demonstrated through crystal

    HDAC7

    HDAC7

    HDAC7

  • HDAC1
  • Protein-coding gene in the species Homo sapiens

    associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4

    HDAC1

    HDAC1

    HDAC1

  • H3K9ac
  • Histone acetylation on tail of histone H3

    Shengfu; Zeng, Yong; Lu, Qing R.; Huo, Yanying; Shi, Yujun; Bu, Hong (2019). "HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition"

    H3K9ac

    H3K9ac

  • Treatment and management of addiction
  • drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors has been conducted

    Treatment and management of addiction

    Treatment_and_management_of_addiction

  • GTF2I
  • Protein-coding gene in humans

    disorders. GTF2I has been shown to interact with: Bruton's tyrosine kinase, HDAC3, Histone deacetylase 2, MAPK3, Myc, PRKG1, Serum response factor and USF1

    GTF2I

    GTF2I

    GTF2I

  • T-complex 1
  • Protein-coding gene in the species Homo sapiens

    have been characterized. TCP1 has been shown to interact with PPP4C and HDAC3. TRiC directly interacts with lectin type oxidized LDL receptor-1 (LOX-1)

    T-complex 1

    T-complex 1

    T-complex_1

  • XBP1
  • Protein-coding gene in the species Homo sapiens

    XBP1 protects endothelial cells from oxidative stress by interacting with HDAC3. This protein has also been identified as a cellular transcription factor

    XBP1

    XBP1

    XBP1

  • HDAC9
  • Protein-coding gene in the species Homo sapiens

    motor innervation. HDAC9 has been shown to interact with: IKK1, IKK2, CBX5, HDAC3, BTG2, Myocyte-specific enhancer factor 2A Nuclear receptor co-repressor

    HDAC9

    HDAC9

    HDAC9

  • YY1
  • Transcriptional repressor protein

    affected individuals. YY1 has been shown to interact with: ATF6, EP300 FKBP3 HDAC3 Histone deacetylase 2 Myc NOTCH1 RYBP and SAP30 Serine—tRNA ligase GRCh38:

    YY1

    YY1

    YY1

  • CDKN2A
  • Protein-coding gene in humans

    Lieberman DA, Dashwood RH (2015-01-01). "Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon"

    CDKN2A

    CDKN2A

    CDKN2A

  • Histone deacetylase 2
  • Protein-coding gene in the species Homo sapiens

    associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4

    Histone deacetylase 2

    Histone deacetylase 2

    Histone_deacetylase_2

  • RELA
  • Protein-coding gene in the species Homo sapiens

    in vitro. RELA is also under the control of deacetylation via HDAC, and HDAC3 is the mediator of this process both in vivo and in vitro. Methylation of

    RELA

    RELA

    RELA

  • HIST2H4A
  • Protein-coding gene in the species Homo sapiens

    and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047

    HIST2H4A

    HIST2H4A

    HIST2H4A

  • Polycomb-group proteins
  • Family of proteins that play a role in chromatin remodeling

    Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3". Nature. 521 (7551): 232–6. Bibcode:2015Natur.521..232M. doi:10.1038/nature14443

    Polycomb-group proteins

    Polycomb-group_proteins

  • Jun dimerization protein 2
  • Protein-coding gene in the species Homo sapiens

    (INHAT). JDP2 recruits histone deacetylases HDAC1 and HDAC2, HDAC6 and HDAC3. JDP2 has INHAT activity and inhibits histone methylation in vitro. Gene

    Jun dimerization protein 2

    Jun dimerization protein 2

    Jun_dimerization_protein_2

  • RBBP4
  • Protein-coding gene in the species Homo sapiens

    has been shown to interact with: BRCA1, CREBBP, GATAD2B, HDAC1, HDAC2, HDAC3, MTA2, RB, SAP30, and SIN3A. GRCh38: Ensembl release 89: ENSG00000162521

    RBBP4

    RBBP4

    RBBP4

  • Promyelocytic leukemia protein
  • Protein found in humans

    CREB-binding protein, Cyclin T1, Death associated protein 6, GATA2, HDAC1, HDAC3, HHEX, MAPK11, MYB, Mdm2, Nerve Growth factor IB, Nuclear receptor co-repressor

    Promyelocytic leukemia protein

    Promyelocytic leukemia protein

    Promyelocytic_leukemia_protein

  • SUV39H1
  • Protein-coding gene in humans

    RNA. SUV39H1 has been shown to interact with: CBX1, CBX5, DNMT3A, HDAC1, HDAC3, HDAC9, Histone deacetylase 2, MBD1, RUNX1, Retinoblastoma protein, and

    SUV39H1

    SUV39H1

    SUV39H1

  • PPP4R1
  • Protein-coding gene in the species Homo sapiens

    Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase

    PPP4R1

    PPP4R1

    PPP4R1

  • GPS2 (gene)
  • Protein-coding gene in the species Homo sapiens

    signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was

    GPS2 (gene)

    GPS2 (gene)

    GPS2_(gene)

  • Dineo Khabele
  • American obstetrician and researcher

    Yuan, Jia-ling; Bonine-Summers, Alyssa R.; Wells, Christina E. (2010). "Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability"

    Dineo Khabele

    Dineo_Khabele

  • ZBTB33
  • Protein-coding gene in the species Homo sapiens

    Caribbeans, Trinidad & Tobago, e.t.c. ZBTB33 has been shown to interact with HDAC3, Nuclear receptor co-repressor 1 and CTNND1. GRCh38: Ensembl release 89:

    ZBTB33

    ZBTB33

    ZBTB33

  • Epigenetics of depression
  • Field of study

    general acetylation across histones H2B and H3. Another study found that HDAC3 was decreased in individuals resilient to depression. In the hippocampus

    Epigenetics of depression

    Epigenetics_of_depression

  • HIST1H4A
  • Protein-coding gene in the species Homo sapiens

    and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047

    HIST1H4A

    HIST1H4A

    HIST1H4A

  • Transactivation domain
  • Transcription factor scaffold domain

    Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

    Transactivation domain

    Transactivation_domain

  • Rev-ErbA beta
  • Protein-coding gene in the species Homo sapiens

    Rev-Erb proteins also requires interaction of class I histone deacetylase 3 (HDAC3) with NCoR, which results in gene repression via histone deacetylation.

    Rev-ErbA beta

    Rev-ErbA beta

    Rev-ErbA_beta

  • List of human protein-coding genes 4
  • HGNC:16977; Q9UBK5 6962 HDAC1 HGNC:4852; Q13547 6963 HDAC2 HGNC:4853; Q92769 6964 HDAC3 HGNC:4854; O15379 6965 HDAC4 HGNC:14063; P56524 6966 HDAC5 HGNC:14068; Q9UQL6

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • PCAF
  • Protein-coding gene in humans

    acetyltransferase activity. PCAF interacts with and is deacetylated by HDAC3, leading to a reduction in PCAF acetyltransferase activity and cytoplasmic

    PCAF

    PCAF

    PCAF

  • BUB1B
  • Protein-coding gene in the species Homo sapiens

    with: AP2B1 BRCA2 BUB3 CDC20 MAD2L1 CBP SIRT2 PLK1 PP2A-B56 HDAC1 HDAC2 / HDAC3 SNCG GRCh38: Ensembl release 89: ENSG00000156970 – Ensembl, May 2017 GRCm38:

    BUB1B

    BUB1B

    BUB1B

  • CNOT2
  • Protein-coding gene in humans

    Zwartjes CG, van Schaik FM, Timmers HT (2006). "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human

    CNOT2

    CNOT2

    CNOT2

  • MAP3K7IP2
  • Protein-coding gene in the species Homo sapiens

    human congenital heart defects. MAP3K7IP2 has been shown to interact with: HDAC3, TAB1, MAP3K7IP3, MAP3K7, NFKB1, NUMBL, Nuclear receptor co-repressor 1

    MAP3K7IP2

    MAP3K7IP2

    MAP3K7IP2

  • Epigenetics of anxiety and stress–related disorders
  • Field of study

    inhibitors. The three classes of HDACs are class I, consisting of HDAC1, HDAC2, HDAC3, HDAC8, class II, consisting of HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10

    Epigenetics of anxiety and stress–related disorders

    Epigenetics_of_anxiety_and_stress–related_disorders

  • Epigenetic regulation of neurogenesis
  • 2020 showed that HDAC3 maintains adult hippocampal neural stem cells by balancing quiescence and activation, and by deleting HDAC3, neurogenesis is disrupted

    Epigenetic regulation of neurogenesis

    Epigenetic regulation of neurogenesis

    Epigenetic_regulation_of_neurogenesis

  • HIST1H4F
  • Protein-coding gene in the species Homo sapiens

    and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047

    HIST1H4F

    HIST1H4F

    HIST1H4F

  • HIST2H3C
  • Human protein-coding gene

    and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–1346. doi:10.1093/emboj/cdg120. PMC 151047

    HIST2H3C

    HIST2H3C

    HIST2H3C

  • PPP4C
  • Protein-coding gene in humans

    Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase

    PPP4C

    PPP4C

    PPP4C

  • Cyclin D1
  • Protein found in humans

    has been shown to interact with: NR3C4, BRCA1, CCNDBP1, CDK4, CDK6, ESR1, HDAC3, HDACs, NEUROD1, NCOA1, NRF1, p300, PACSIN2, PCNA, PPARG, RAD51, RB1, TAF1

    Cyclin D1

    Cyclin D1

    Cyclin_D1

  • BCL9L
  • Protein-coding gene in the species Homo sapiens

    Bièche I, Lidereau R, Lallemand F (2015). "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2

    BCL9L

    BCL9L

    BCL9L

  • E2F1
  • Protein-coding gene in the species Homo sapiens

    Nicolas E, Ait-Si-Ali S, Trouche D (August 2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein". Nucleic Acids Res. 29 (15):

    E2F1

    E2F1

    E2F1

  • EHMT2
  • Protein-coding gene in the species Homo sapiens

    c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood

    EHMT2

    EHMT2

    EHMT2

  • Deficiency of RbAp48 protein and memory loss
  • Nicolas, E.; Ait-Si-Ali, S; Trouche, D (2001). "The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein". Nucleic Acids Research. 29

    Deficiency of RbAp48 protein and memory loss

    Deficiency of RbAp48 protein and memory loss

    Deficiency_of_RbAp48_protein_and_memory_loss

  • GATA2
  • Protein found in humans

    MPL, GPR56). In a wide range of tissues, GATA2 similarly interacts with HDAC3, LMO2, POU1F1, POU5F1, PML SPI1, and ZBTB16. GATA2 binds to a specific nucleic

    GATA2

    GATA2

    GATA2

  • Ubiquitin C
  • Mammalian protein found in humans

    has been shown to interact with: BIRC2, BSG, CDC2, CFAP298, E2F1, EGFR, HDAC3, HIF1A, IRAK1, KIAA0753. MARK4, MDM2, NDUFA3, NFE2L2, NOTCH1, NUAK1, OPRK1

    Ubiquitin C

    Ubiquitin C

    Ubiquitin_C

  • MAPK11
  • Protein-coding gene in the species Homo sapiens

    to be a substrate of this kinase. MAPK11 has been shown to interact with HDAC3 and Promyelocytic leukemia protein. p38 mitogen-activated protein kinases

    MAPK11

    MAPK11

    MAPK11

  • HIST2H2AC
  • Protein-coding gene in the species Homo sapiens

    and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047

    HIST2H2AC

    HIST2H2AC

    HIST2H2AC

  • SIN3A
  • Protein-coding gene in the species Homo sapiens

    PMID 10220385. Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the

    SIN3A

    SIN3A

    SIN3A

  • Testicular receptor 2
  • Human protein-coding gene

    been shown to interact with: Androgen receptor, Estrogen receptor alpha, HDAC3, and HDAC4. Testicular receptor GRCh38: Ensembl release 89: ENSG00000120798

    Testicular receptor 2

    Testicular receptor 2

    Testicular_receptor_2

  • FBXL3
  • Protein-coding gene in the species Homo sapiens

    the repression of Bmal1 transcription by inactivating the REV-ERBα and HDAC3 repressor complex. The FBXL3 protein has also been found to cooperatively

    FBXL3

    FBXL3

    FBXL3

  • CORO2A
  • Protein-coding gene in the species Homo sapiens

    and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–46. doi:10.1093/emboj/cdg120

    CORO2A

    CORO2A

    CORO2A

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Online names & meanings

  • HERODIAS
  • Female

    Greek

    HERODIAS

    (Ἡρωδιάς) Feminine form of Greek Herodes ("hero"), HERODIAS means "heroic." In the bible, this is the name of the daughter of Aristoboulos and granddaughter of Herod the Great.

  • Anviga
  • Girl/Female

    Indian

    Anviga

    Powerful and Complete

  • TORGER
  • Male

    Swedish

    TORGER

    Swedish and Norwegian form of Old Norse Þorgeirr, TORGER means "Thor's spear." 

  • Yakob
  • Biblical

    Yakob

    Yacob, Yacoub - Jacob

  • SHUMAN
  • Female

    Native American

    SHUMAN

    Native American Hopi name SHUMAN means "rattlesnake handler."

  • Hansi
  • Girl/Female

    Indian

    Hansi

    Innocent, Swan, Soul, Pure

  • PRUDENCIO
  • Male

    Spanish

    PRUDENCIO

    Spanish form of Latin Prudentius, PRUDENCIO means "cautious."

  • Abeed
  • Boy/Male

    Indian

    Abeed

    Servant of God

  • Krishnachand
  • Boy/Male

    Hindu, Indian

    Krishnachand

    Lord Krishna

  • Nevan
  • Boy/Male

    Bengali, Christian, French, Hindu, Indian, Marathi, Tamil

    Nevan

    Little Saint; Little Holy One; From the New Town

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