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Similar DNA, RNA or protein sequences within genomes or among species
biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences), or within
Conserved_sequence
DNA sequence
A conserved non-coding sequence (CNS) is a DNA sequence of noncoding DNA that is evolutionarily conserved. Sequence conservation is a useful marker of
Conserved_non-coding_sequence
Topics referred to by the same term
fruits or vegetables Conserve (NGO), an Indian environmental organization Conserve (publisher), a Dutch publisher Conserved sequence, a protein or nucleic
Conserve
Process in bioinformatics that identifies equivalent sites within molecular sequences
sequence can be interpreted as a rough measure of how conserved a particular region or sequence motif is among lineages. The absence of substitutions
Sequence_alignment
Most common variant of a genetic sequence across samples
conservation of these sites. The conserved sequence motifs are called consensus sequences and they show which residues are conserved and which residues are variable
Consensus_sequence
Class of enzymes
relatively less affected. The heme in cytochrome P450 binds to a conserved sequence: FxxGxRxCxG, where "x" denotes some variant amino acid. The cysteine
Cytochrome_P450
Ribosomal binding site in prokaryotic messenger RNA
this sequence between such distantly related eukaryotes implied that this nucleotide tract played an important role in the cell. Since this conserved sequence
Shine–Dalgarno_sequence
Gene found in humans
that the HOTAIR conserved sequences predate whole genome duplication events at the root of vertebrate. While the conserved sequence paralogous with HOXD
HOTAIR
Topics referred to by the same term
(disambiguation) Conserve (disambiguation) Conserved quantity, in mathematics, a function of dependent variables that remains constant Conserved sequence, similar
Conservation
Bioinformatic graphic
sequences, or DNA sequences that have common conserved binding sites, are aligned so that the most conserved parts create good alignments. A sequence
Sequence_logo
Shared ancestry between DNA, RNA or protein sequences
used to mean "sequence similarity", that is the percentage of identical residues (percent identity), or the percentage of residues conserved with similar
Sequence_homology
Involution (shrinking) of the thymus after the neonatal period
regulated, with the nucleic material responsible forming an example of a conserved sequence — one maintained through natural selection (though the pressures shaping
Thymic_involution
Grouping of proteins
more evolutionarily conserved than sequence, such that proteins with highly similar structures can have entirely different sequences. Over very long evolutionary
Protein_superfamily
Branch of bioinformatics
several reasons: Identifying conserved sequence: Visualization helps researchers identify conserved regions across sequences, which are indicative of functional
Biological_data_visualization
Species of virus
that are highly conserved in Matonaviruses: a stem-and-loop structure at the 5' end of the genome, a 51-nucleotide conserved sequence near the 5' end
Rubella_virus
Biological database
The Conserved Domain Database (CDD) is a database of well-annotated multiple sequence alignment models and derived database search models, for ancient
Conserved_Domain_Database
Nucleotide or amino-acid sequence pattern
Nucleic acid sequence Protein primary structure Protein I-sites Sequence logo Sequence mining Structural motif Short linear motif Conserved sequence Protein
Sequence_motif
Protein domain
heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety
KH_domain
Openings in nuclear envelope of eukaryotic cells
protein molecules, from an evolutionarily conserved set of 35 distinct nucleoporins. The conserved sequences that code for nucleoporins regulate molecular
Nuclear_pore_complex
differences (polymorphisms) between related genes in a sequence alignment (are not conserved). Segregating sites include conservative, semi-conservative
Segregating_site
Family of zinc-dependent metalloendopeptidases
is bound by three histidine residues found in the conserved sequence HExxHxxGxxH. Hence, this sequence is a zinc-binding motif. The gelatinases, such as
Matrix_metalloproteinase
An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of
Immunoreceptor tyrosine-based activation motif
Immunoreceptor_tyrosine-based_activation_motif
Sequences of noncoding DNA
Recombination signal sequences are conserved sequences of noncoding DNA that are recognized by the RAG1/RAG2 enzyme complex during V(D)J recombination
Recombination signal sequences
Recombination_signal_sequences
Class of enzymes
synthetase, each composed of ten enzymes: Class I has two highly conserved sequence motifs. It aminoacylates at the 2'-OH of a terminal adenosine nucleotide
Aminoacyl_tRNA_synthetase
Class of small RNA molecules
less-well-conserved copy of the C and D motifs (referred to as C' and D') located in the central portion of the snoRNA molecule. A conserved region of
Small_nucleolar_RNA
Shared protein sequence feature
Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic
Conserved_signature_indels
RNA family
replication mechanism. The hammerhead sequence is sufficient for self-cleavage and acts by forming a conserved three-dimensional tertiary structure. In
Hammerhead_ribozyme
Protein-coding gene in the species Homo sapiens
extracellular environment. Biochemical studies have shown that a conserved sequence motif D-Y-L-S-F at the C-terminus, as well as the overall length of
PEN-2
American computational biologist (born 1972)
statistical methods and software tools for identifying evolutionarily conserved sequences. Siepel is currently Chair of the Simons Center for Quantitative
Adam_C._Siepel
ATP-binding protein sequence motifs
The Walker A and Walker B motifs are protein sequence motifs, known to have highly conserved three-dimensional structures. These were first reported in
Walker_motifs
Protein family
appears to be associated with binding the incoming amino acid. The conserved sequence motifs found in the four Mur enzymes also map to other members of
Muramyl_ligase
Type of toxic lectin
that is contained in a highly conserved sequence of 12 nucleotides universally found in eukaryotic ribosomes. The sequence, 5'-AGUACGAGAGGA-3', termed the
Ricin
completely unrelated structure, in terms of different conserved sequence features and a different conserved secondary structure. malK-I motifs are found in
MalK_RNA_motifs
RNA family
end where 85% of the positions are conserved. Moreover, several secondary structural elements are also conserved including stem loops I, II, III, IV
U2_spliceosomal_RNA
members of the PfkB/RK family are identified by the presence of three conserved sequence motifs and the enzymatic activity of this family of protein generally
Ribokinase
Enzyme involved in the production of energy by cells
fingerprint, GxxGDLA (residues 38–44 on human G6PD), and a partially conserved sequence EKPxG near the substrate binding site (residues 170–174 on human G6PD)
Glucose-6-phosphate dehydrogenase
Glucose-6-phosphate_dehydrogenase
one new strand. See also dispersive replication. conserved sequence A nucleic acid or protein sequence that is highly similar or identical across many
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
RNA family
motif exhibits little conserved sequence in comparison to many known RNAs, although its secondary structure is well conserved. It is generally located
OsmY_RNA_motif
Family of transcription factors involved in anatomical development
19 subdivisions based on conserved sequence similarity. The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acids
FOX_proteins
Small protein domain found in some kinases and GTPases
of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in
SH3_domain
Succession of nucleotides in a nucleic acid
sequence can be interpreted as a rough measure of how conserved a particular region or sequence motif is among lineages. The absence of substitutions
Nucleic_acid_sequence
Nucleic acid motif in molecular biology
coding for Methionine. upper-case letters indicate highly conserved bases, i.e. the 'AUGG' sequence is constant or rarely, if ever, changes. 'R' indicates
Kozak_consensus_sequence
Group of evolutionarily-related proteins
loops, giving rise to blocks of conserved sequence when the sequences of a protein family are compared (see multiple sequence alignment). These blocks are
Protein_family
Congenital Conjugation tube Consanguineous Consanguinity Consensus sequence Conserved sequence Constant region Constitutive gene Contig Contig map Contig maps
Index_of_genetics_articles
RNA family
Z168/Z174 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the
Small_nucleolar_RNA_Z168/Z174
gene-expression regulatory sequences (promoter and poly-A addition site sequences) also could have originated from stop codons. A conserved sequence, AATAAA, exists
Split_gene_theory
Protein domain
all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of
CBS_domain
Non-coding region of the mitochondrial DNA
mitochondrial DNA and include elements like conserved sequence blocks (CSBs) and termination-associated sequences (TAS). The control region also has secondary
MtDNA_control_region
transform) is a program used to create multiple sequence alignments of amino acid or nucleotide sequences. Published in 2002, the first version used an
MAFFT
Study of patterns and natural variation in life
molecular level, comparative studies often focus on identifying conserved sequences which characterise the functional elements of genes or proteins,
Comparative_biology
transcripts are first cleaved 10–30 nucleotides downstream of a highly conserved AAUAAA sequence, then the poly(A) tail is generated from the chaining of multiple
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Complete set of nucleic acid sequences for humans
70–90 million years ago. So computer comparisons of gene sequences that identify conserved sequences will be an indication of their importance in functions
Human_genome
Class of enzymes
are conserved as well as the amino acids. Therefore, the active sites amongst most prokaryotic isocitrate dehydrogenase enzymes should be conserved as
Isocitrate_dehydrogenase
Genes coding for ribosomal RNA
remote species as human and frog comparison of sequences at ITS tracts is not appropriate. Conserved sequences at coding regions of rDNA allow comparisons
Ribosomal_DNA
Protein fold
structurally conserved Rossmann fold motif. In 1989, Israel Hanukoglu from the Weizmann Institute of Science discovered that the consensus sequence for NADP+
Rossmann_fold
American geneticist
between chromosomes. She also studies ultra-conserved elements (UCEs), proposing that these highly conserved sequences play a role in maintaining genome integrity
Ting_Wu
Organelle in eukaryotic cells responsible for respiration
(OriH) localized on the L strand, three conserved sequence boxes (CSBs 1–3), and a termination-associated sequence (TAS). The origin of replication for the
Mitochondria
Any cause that reduces reproductive success in a proportion of a population
to describe the mechanism of natural selection Conserved sequence – Similar DNA, RNA or protein sequences within genomes or among species "Natural selection"
Evolutionary_pressure
Portion of gene's sequence which codes for protein
concept of interspecies constraint in conserved sequences. Researchers termed these highly constrained sequences constrained coding regions (CCRs), and
Coding_region
Mirorder of mammals
ML, Li ML, Ayoola AO, Murphy RW, Wu DD, Shao Y (November 2019). "Conserved sequences identify the closest living relatives of primates". Zoological Research
Primatomorpha
RNA component
between hypervariable regions, with more conserved regions correlating to higher-level taxonomy and less conserved regions to lower levels, such as genus
16S_ribosomal_RNA
An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains
Immunoreceptor tyrosine-based inhibitory motif
Immunoreceptor_tyrosine-based_inhibitory_motif
Protein family
is present in certain bacteria as well as in plants. Three highly conserved sequence regions are found in all known beta-amylases. The first of these regions
Glycoside_hydrolase_family_14
Protein family
The MADS box is a conserved sequence motif. The genes which contain this motif are called the MADS-box gene family. The MADS box encodes the DNA-binding
MADS-box
Enzyme in glycolysis
members of the PfkB/RK family are identified by the presence of three conserved sequence motifs. The structures of several PfK family of proteins have been
Phosphofructokinase
Matrix representing the frequency of evolution of a protein or nucleotide sequence
computed by looking at "blocks" of conserved sequences found in multiple protein alignments. These conserved sequences are assumed to be of functional importance
Substitution_matrix
Gene involved in controlling expression of other genes
requires statistical rates of conserved and non-conserved sequences. Using the information provided by multiple sequence alignments and statistical rates
Regulator_gene
Hierarchical outline list of articles related to genetics
haploid haploinsufficiency hematopoietic stem cell heterozygous highly conserved sequence holoprosencephaly homologous recombination homozygous human artificial
Outline_of_genetics
Method of protein structure prediction using other known proteins
protein structures are more conserved than protein sequences amongst homologues, but sequences falling below a 20% sequence identity can have very different
Homology_modeling
Distinct pattern of nucleotides in molecular biology
by a conserved linker sequence is a sequence of 21 amino acids vital in the specific DNA to CCAAT box binding. The A1 and A2 domains are conserved towards
CAAT_box
Protein family
translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs". Protein Sci. 4 (8): 1608–1617. doi:10.1002/pro.5560040819
EIF-W2_protein_domain
Mutation that removes a part of a DNA sequence
deletion came from. Recent work suggests that some deletions of highly conserved sequences (CONDELs) may be responsible for the evolutionary differences present
Deletion_(genetics)
ODB (Operon DataBase) is a database of conserved operons in sequenced genomes. Operon Okuda, Shujiro; Yoshizawa Akiyasu C (Jan 2011). "ODB: a database
Operon_database
Volatile chemical compounds perceived by the sense of smell
there are no known structures for any olfactory receptor. There is a conserved sequence in roughly three quarters of all ORs. This is a tripodal metal-ion
Odor
Bocaparvoviruses known to infect humans
The coat proteins have a conserved, eight stranded beta barrel motif that forms the core of the capsid. There is also a conserved alpha helix. The HBoV capsid
Human_bocavirus
Protein domain
domain was discovered in 1999 and named after a conserved sequence motif found in its protein sequence. Roth and colleagues showed that the yeast Akr1p
DHHC_domain
Medical condition
they contain the same genes in the same order and orientation. This conserved sequence has been exploited to learn more about SMS and PTLS. Through genetic
Potocki–Lupski_syndrome
Recognizable amino acid sequence
14p. A few peroxisomal matrix proteins have a different, and less conserved sequence, at their amino termini. This PTS2 signal is recognized by the PTS2
Peroxisomal_targeting_signal
Protein found in humans
identified in syncytin-1 at residues 117-144. The amino acid sequence at this region is well conserved amongst RDR interference group members. The motif SDGGGX2DX2R
Syncytin-1
Type of enzyme
Their conserved structural motifs are: LAGLIDADG: Every polypeptide has 1 or 2 LAGLIDADG motifs. The sequence LAGLIDADG is a conserved sequence of amino
Homing_endonuclease
RNA family
snoRNA TBR12 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the
Small_nucleolar_RNA_TBR12
Alignment of more than two molecular sequences
conserved domains. When looking at multiple sequence alignments, it is useful to consider different aspects of the sequences when comparing sequences
Multiple_sequence_alignment
Type of keratin found in hair and nails
cell types. Examination of keratin gene promoter regions reveals conserved sequence motifs that might govern these cell-specific traits. Moreover, through
Hair_keratin
Technique used in genetics
preferences of transcription factors are well-conserved between diverse species. Important non-coding DNA sequences that are essential for regulating gene expression
Phylogenetic_footprinting
Group of extracellular ribonucleases secreted by fungi
single phosphodiester bond of the rRNA that is found in a universally conserved sequence. This cleavage leads to cell death by apoptosis. However, since they
Fungal_ribotoxin
One of the five main histone proteins
(H3T), Histone H3.5, Histone H3.X and Histone H3.Y but have highly conserved sequences differing only by a few amino acids. Histone H3.3 has been found
Histone_H3
amino acid sequence located at its C-terminus that fits a common class I motif, usually ending in threonine–glutamate–valine. This conserved structure
Tax1
Protein family
yeast and will facilitate replication from those sites. A highly conserved sequence of 11bp (known as the A element) is thought to be essential for origin
Origin_recognition_complex
Type of vector space in math
energy—measured by the Hamiltonian—there are no other functionally independent conserved quantities on the phase space. More explicitly, suppose that the energy
Hilbert_space
RNA family
be regulated by the sucA RNA motif and the sucC RNA motif, but the conserved sequence and structure features of these motifs suggest they are not structurally
Rothia-sucC_RNA_motif
RNA sequence directing the translation of UGA codons as selenocysteines
elongation. In most cases the "kink-turn" part bound to SBP2 has a very conserved sequence "AUGA", but "GGGA" has also been found. 60S ribosomal protein L30
SECIS_element
Family of DNA sequences found in prokaryotic organisms
repeats. The PAM sequence appears to be important during spacer insertion in type I-E systems. That sequence contains a strongly conserved final nucleotide
CRISPR
exhibits 20.7% sequence identity and 32% sequence similarity to the human gene. This pattern implies that while C15orf62 is relatively well-conserved within the
C15orf62
Class of enzymes
Cheng X (November 1995). "Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism
DNA_adenine_methylase
DNA replication in prokaryotes
out of which three boxes R1, R2 and R4 (which have a highly conserved 9 bp consensus sequence 5' - TTATC/ACACA ) are high affinity DnaA boxes. They bind
Prokaryotic_DNA_replication
Branching diagram of evolutionary relationships between organisms
nearest neighbors on the tree before hybridisation takes place, and conserved sequences. Also, there are problems in basing an analysis on a single type
Phylogenetic_tree
RNA family
MBII-202 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the
Small_nucleolar_RNA_MBII-202
RNA family
snoRNA TBR4 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the
Small_nucleolar_RNA_TBR4
Protein-coding gene in the species Homo sapiens
conserved across all of the strict orthologs of the human uncharacterized protein FAM120AOS isoform 1. The amino acid G95 was found to be conserved across
FAM120AOS
Protein family
ASD2 is the most highly conserved sequence element shared by Shrm1, Shrm2, Shrm3, and Shrm4. It possesses a well conserved series of leucine residues
Shroom_protein_family
CONSERVED SEQUENCE
CONSERVED SEQUENCE
Boy/Male
Indian
One who conversed with Allah
Girl/Female
Tamil
Conceived in the mind
Girl/Female
Hindu
Someone who is concerned about the welfare (Hita) of others, Indian
Girl/Female
Tamil
Someone who is concerned about the welfare (Hita) of others, Indian
Girl/Female
Biblical
A bog, converted.
Girl/Female
Biblical
A bog, converted.
Girl/Female
Tamil
Conceived in the mind
Girl/Female
Hindu
Conceived in the mind
Girl/Female
Indian, Punjabi, Sikh
Conceived; Formed; Created
Girl/Female
Hindu
Conceived in the mind
Boy/Male
Hindu, Indian, Marathi
Agreed; Consented
Girl/Female
Biblical
Things to be especially observed.
Girl/Female
Latin
Dove. Famous bearer: 6th century Irish abbot and missionary St Columba converted the inhabitants...
Girl/Female
Tamil
Someone who is concerned about the welfare (Hita) of others, Indian
Boy/Male
Muslim
One who conversed with Allah
Biblical
things to be especially observed
Biblical
Hezir, a bog; converted
Boy/Male
Arabic, Muslim
One who Conversed with Allah; An Epithet of Prophet Moses
Boy/Male
Tamil
Agreed, Consented
Girl/Female
Hindu
Someone who is concerned about the welfare (Hita) of others, Indian
CONSERVED SEQUENCE
CONSERVED SEQUENCE
Boy/Male
French, Hindu, Indian
Power Holder
Boy/Male
Arabic, Urdu
Servant of a Creator
Girl/Female
Hindu, Indian
Early Morning Raga Sung in Rainy Season
Boy/Male
Indian
Patron, Superior, Guardian
Girl/Female
Hindu
To be pleased
Girl/Female
Arabic, Muslim
Paradise; Heaven; Eternal
Girl/Female
Muslim/Islamic
Star
Girl/Female
French English
Warlike.
Girl/Female
African, Australian, Nigerian
Grace of God; God's Favor; Divine Grace
Girl/Female
American, Australian, British, Christian, English, French, German, Irish, Italian, Jamaican, Latin, Portuguese, Romanian, Spanish, Swedish, Swiss
Lame; Persevering; Limping; Disabled
CONSERVED SEQUENCE
CONSERVED SEQUENCE
CONSERVED SEQUENCE
CONSERVED SEQUENCE
CONSERVED SEQUENCE
v. t.
To prepare with sugar, etc., for the purpose of preservation, as fruits, etc.; to make a conserve of.
p. pr. & vb. n.
of Conserve
a.
Tending to conserve; preservative.
imp. & p. p.
of Converge
n.
A conserve made of grapes.
n.
Anything fancifully conceived.
v. t.
Disturbed; troubled; solicitous; as, to be much concerned for the safety of a friend.
a.
Anxious; solicitous; concerned.
imp. & p. p.
of Converse
n.
A medicinal confection made of freshly gathered vegetable substances mixed with finely powdered refined sugar. See Confection.
v. t.
To keep in a safe or sound state; to save; to preserve; to protect.
imp. & p. p.
of Construe
n.
Anything which is conserved; especially, a sweetmeat prepared with sugar; a confection.
imp. & p. p.
of Convert
imp. & p. p.
of Conserve
n.
One who conserves.
a.
Mutually contrived or planned; agreed on; as, concerted schemes, signals.
a.
Concerned; occupied.
n.
A conservatory.
a.
Converted into glass.