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Irreversible reaction step at the branch points of biochemical pathways
In biochemistry, the committed step (also known as the first committed step) is an effectively irreversible, enzyme-catalyzed reaction that occurs at a
Committed_step
Chemical compound
olpyruvyltransferase, also known as MurA. This enzyme catalyzes the committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate
Fosfomycin
Coenzyme, notable for its synthesis and oxidation role
by the enzyme pantothenate kinase (PanK; CoaA; CoaX). This is the committed step in CoA biosynthesis and requires ATP. A cysteine is added to 4′-phosphopantothenate
Coenzyme_A
Class of enzymes
by many activators and inhibitors. PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose
Phosphofructokinase_1
Chemical reactions and pathways involving lysis of purine nucleotides
not the committed step to purine synthesis because PRPP is also used in pyrimidine synthesis and salvage pathways. The first committed step is the reaction
Purine_metabolism
Slowest step in a series of biochemical reactions
Branched pathways Metabolic control analysis Biochemical systems theory Committed step Nelson, David L.; Cox, Michael M. (2005). Lehninger Principles of Biochemistry
Rate-limiting step (biochemistry)
Rate-limiting_step_(biochemistry)
Class of enzymes
The reaction catalyzed by DGAT is considered the terminal and only committed step in the acyl-CoA-dependent triglyceride synthesis, universally important
Diglyceride_acyltransferase
The following is an episode list for the American television sitcom Step by Step. The series originally ran for six seasons on ABC from September 20, 1991
List_of_Step_by_Step_episodes
Chemical compound
synthase to form δ-aminolevulinic acid (dALA). This process is the committed step in the biosynthesis of porphobilinogen and thus hemoglobin. Succinyl
Succinyl-CoA
Enzyme
which is also the committed step in the formation of creatine. L-arginine + glycine ornithine + glycocyamine The second step of the process
Arginine:glycine amidinotransferase
Arginine:glycine_amidinotransferase
Chemical compound
biosynthesis of carotenoids. The synthesis of phytoene is the first committed step in the synthesis of carotenoids in plants. Phytoene is produced from
Phytoene
Protein family
molecules of farnesyl diphosphate (FPP) into squalene. It is the first committed step in the cholesterol biosynthetic pathway. The reaction carried out by
Squalene/phytoene synthase family
Squalene/phytoene_synthase_family
Class of enzymes
trans-cinnamate + NH3 Phenylalanine ammonia lyase (PAL) is the first and committed step in the phenyl propanoid pathway and is therefore involved in the biosynthesis
Phenylalanine_ammonia-lyase
Family where one parent has children that are not genetically related to the other parent
child from another relationship. The earliest recorded use of the prefix step-, in the form steop-, is from an 8th-century glossary of Latin-Old English
Stepfamily
Phosphatidylcholine biosynthetic process
cells phosphorylate choline by the enzyme choline kinase, the first committed step of CDP-choline pathway. Choline kinase (CK) is a cytosolic protein that
CDP-choline_pathway
Class of enzymes
1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme that catalyzes the first committed step in peptidoglycan biosynthesis of bacteria: phosphoenolpyruvate +
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UDP-N-acetylglucosamine_1-carboxyvinyltransferase
Process of fatty acid breakdown
mitochondria in eukaryotes to generate acetyl-CoA. The acetyl-CoA product of this step of fatty acid metabolism enters the citric acid cycle, generating NADH and
Beta_oxidation
Species of evergreen shrub
Dephosphorylation of xanthosine-5'-monophosphate into xanthosine is the committed step for the xanthosines entering the beginning of the most common pathway
Camellia_sinensis
Class of enzymes
both the urea cycle and polyamine synthesis, and this reaction is the committed step in that latter polyamine pathway. In the urea cycle, ornithine is instead
Ornithine_decarboxylase
Type of chemical compound
and protozoa, as well as the α-proteobacteria group of bacteria, the committed step for porphyrin biosynthesis is the formation of δ-aminolevulinic acid
Porphyrin
Chemical compound
also uses two molecules of ATP in its initial stages as a committed and irreversible step. For this reason glycolysis is not reversible and has a net
1,3-Bisphosphoglyceric_acid
2014 American film
Step Up: All In is a 2014 American dance film directed by Trish Sie and written by John Swetnam. The film is the sequel to Step Up Revolution (2012) and
Step_Up:_All_In
Class of enzymes
second ATP to give carbamoyl phosphate plus ADP. It represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes
Carbamoyl phosphate synthetase
Carbamoyl_phosphate_synthetase
Biological molecules constituting nucleic acids
glycine (N&C), aspartate (N), folic acid (C1), or CO2. This is the committed step in purine synthesis. The reaction occurs with the inversion of configuration
Nucleotide
Class of enzymes
squalene, with the consumption of NADPH. Catalysis by SQS is the first committed step in sterol synthesis, since the squalene produced is converted exclusively
Farnesyl-diphosphate farnesyltransferase
Farnesyl-diphosphate_farnesyltransferase
Carboxylic acid
carboxylated by acetyl-CoA carboxylase into malonyl-CoA, the first committed step in the synthesis of fatty acids. Malonyl-CoA is then involved in a repeating
Fatty_acid
Carotenoid pigment
tail-to-tail configuration to give the 40-carbon phytoene, the first committed step in carotenoid biosynthesis. Through several desaturation steps, phytoene
Lycopene
Species of virus
peptidoglycan by binding to MurA, which catalyzes the first enzymatically committed step in cell wall biosynthesis. RNA from Bacteriophage Qβ was used by Sol
Bacteriophage_Qbeta
American astronaut (1930–2012)
Module Columbia. When Armstrong first stepped onto the lunar surface, he famously said: "That's one small step for [a] man, one giant leap for mankind
Neil_Armstrong
Chemical compound
characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis". Plant Journal. 40 (2):
4-Hydroxyphenylacetaldehyde
Protein-coding gene in the species Homo sapiens
coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject
PANK2
Series of interconnected biochemical reactions
carboxylated by acetyl-CoA carboxylase into malonyl CoA, the first committed step in the synthesis of fatty acids, or it can be combined with acetoacetyl-CoA
Glycolysis
Set of biological processes
carboxylated by acetyl-CoA carboxylase into malonyl-CoA, the first committed step in the synthesis of fatty acids. Acetyl-CoA is formed into malonyl-CoA
Fatty_acid_metabolism
Class of chemical compounds
G, Breitel D, Grossman N, et al. (2016). "Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain
Betalain
Class of chemical compounds
a phosphocholine from phosphatidylcholine to a ceramide. The first committed step of sphingomyelin synthesis involves the condensation of L-serine and
Sphingomyelin
1939–1945 global conflict
mass rape. Soviet soldiers also committed mass rapes in occupied territories, especially Germany. War crimes were committed by the Western Allied powers
World_War_II
"Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew". J. Biol. Chem. 270 (15): 8686–90
Taxadiene_synthase
Protein-coding gene in the species Homo sapiens
expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces
DPAGT1
Class of enzymes
bifunctional enzyme with GTP cyclohydrolase II that catalyses the first committed step in the biosynthesis of riboflavin. No sequences with significant homology
3,4-dihydroxy-2-butanone-4-phosphate synthase
3,4-dihydroxy-2-butanone-4-phosphate_synthase
Metabolic enzyme PHGDH
transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the committed step in the phosphorylated pathway of L-serine biosynthesis. It is also essential
Phosphoglycerate dehydrogenase
Phosphoglycerate_dehydrogenase
of other substituted cinnamoyl-CoA's as well. Catalyzing the first committed step in monolignol biosynthesis, this enzyme plays a critical role in lignin
Cinnamoyl-CoA_reductase
Large biological molecule that acts as a catalyst
first enzymes of the pathway (usually the first irreversible step, called committed step), thus regulating the amount of end product made by the pathways
Enzyme
Konig WA, Bouwmeester HJ (1998). "(+)-Germacrene A Biosynthesis : The Committed Step in the Biosynthesis of Bitter Sesquiterpene Lactones in Chicory". Plant
Germacrene-A_synthase
Chemical compound
Sarrion-Perdigones A, Weithorn E, Pliner M, et al. (2016). "Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain
L-DOPA
Token used in addiction programs
5 in) in diameter. In other twelve-step programs it is to mark time abstaining from whatever the recipient has committed to renounce. There is no official
Sobriety_coin
ring opening of guanosine triphosphate (GTP). This reaction is the committed step in the biosynthesis of multiple coenzymes (such as riboflavin and folate)
GTP_cyclohydrolase
Class of enzymes
Glyceollin synthase is an enzyme that catalyzes the last committed step in glyceollin biosynthesis. It has been classified as a cytochrome dependent monooxygenase
Glyceollin_synthase
gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides". J. Biol. Chem. 286 (9):
Delta6-protoilludene_synthase
Protein family
2015). "The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit
Pii nitrogen regulatory proteins
Pii_nitrogen_regulatory_proteins
Protein family
cofactor, NAD+. The reaction this enzyme catalyses represents the first committed step in the production of all inositol-containing compounds, including phospholipids
Inositol-3-phosphate_synthase
delay learning to drive. Ty talks to Cassandra, she realizes she wants a committed relationship with Caleb. Georgie decides to face her fears and has Tim
List_of_Heartland_episodes
Protein-coding gene in the species Homo sapiens
coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject
PANK1
Class of enzymes
3-α(S)-strictosidine Since the condensation of tryptamine and secologanin is the first committed step in alkaloid synthesis, strictosidine synthase plays a fundamental role
Strictosidine_synthase
Enzyme
decarboxylation of a C4 molecule, creating a C3 molecule. As the first committed step in gluconeogenesis, PEPCK decarboxylates and phosphorylates oxaloacetate
Phosphoenolpyruvate carboxykinase
Phosphoenolpyruvate_carboxykinase
Class of enzyme
barrel topology. The conversion of chorismate to prephenate is the first committed step in the pathway to the production of the aromatic amino acids: tyrosine
Chorismate_mutase
Type of plant tissue culture
Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway". Journal of Biotechnology. 176:
Hairy_root_culture
Businessman and public official (born 1971)
presidential election. Musk also promised to step down as CEO after a Twitter poll, and five months later, Musk stepped down as CEO and transitioned his role
Elon_Musk
Chemical reaction
of the Henry reaction are reversible. This is due to the lack of a committed step in the reaction to form product. It is for this reason that research
Henry_reaction
American basketball player (born 1989)
offensive moves; two of the most prominent among them being his Euro step and his step-back jumper. Since his trade to the Houston Rockets in the 2012–13
James_Harden
Chemical compound
carboxylation by acetyl-CoA carboxylase into malonyl CoA, the first committed step in the synthesis of fatty acids. This conversion occurs primarily in
Acetyl-CoA
Prime Minister of the United Kingdom since 2024
as we have so often in our past, the challenges of an insecure world. Committed to a calm and patient rebuilding. So with respect and humility, I invite
Keir_Starmer
Approach to finding numerical solutions of ordinary differential equations
truncation error is the cumulative effect of the local truncation errors committed in each step. The number of steps is easily determined to be t i − t 0 h {\textstyle
Euler_method
RNA family
carbamoyl phosphate synthase, which is an enzyme that catalyzes the first committed step in pyrimidine and arginine biosynthesis. CarA ncRNA has been found in
CarA_ncRNA_motif
American anthology series (1959–1961)
Alcoa Presents: One Step Beyond (also known as One Step Beyond) is an American anthology series created by Merwin Gerard. The original series was broadcast
Alcoa Presents One Step Beyond
Alcoa_Presents_One_Step_Beyond
synthetase) apart from the promoter and operator region. The first committed step of purine biosynthesis starts from 5-phosphoribosyl 1 pyrophosphate
Gua_Operon
Protein-coding gene in the species Homo sapiens
coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject
PANK4
Chemical compound
Bouwmeester HJ (August 1998). "(+)-Germacrene A Biosynthesis : The Committed Step in the Biosynthesis of Bitter Sesquiterpene Lactones in Chicory". Plant
Absinthin
salvage — AIR synthetase is a component of the de novo pathway. The first committed step of the de novo pathway begins with phosphoribosyl pyrophosphate (PRPP)
AIR_synthetase_(FGAM_cyclase)
Rare autosomal recessive human diseases
transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the committed step in the phosphorylated pathway of L-serine biosynthesis. It is also essential
D-glycerate dehydrogenase deficiency
D-glycerate_dehydrogenase_deficiency
Chemical compound
4′-phosphopantothenate by the enzyme pantothenate kinase. This is the committed step in CoA biosynthesis and requires ATP. A cysteine is added to 4′-phosphopantothenate
Pantothenic_acid
United States federal statute
powder cocaine convictions—retroactively. Under the First Step Act, prisoners who committed offenses "covered" by the Fair Sentencing Act are permitted
First_Step_Act
Ongoing conflict since 2014
independent states. While Russian troops surrounded Ukraine, its proxies stepped up attacks on Ukrainian forces in the Donbas. On 24 February 2022, Putin
Russo-Ukrainian_war
Enzyme
It is a zinc-dependent metalloamidase that catalyses the second and committed step in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharide (the
UDP-3-O-N-acetylglucosamine deacetylase
UDP-3-O-N-acetylglucosamine_deacetylase
American businessman (born 1964)
committed to doing our part and filling this capital need by coming together in a new coalition. We will form a network of private capital committed to
Jeff_Bezos
Email service provided by Google
Gmail supports two-step verification, an optional additional measure for users to protect their accounts when logging in. Once 2-Step Verification (2SV)
Gmail
Set of biochemical processes
AK-III catalyzes the phosphorylation of aspartic acid that is the committed step in this biosynthetic pathway. Aspartate kinase becomes downregulated
Amino_acid_synthesis
4-dideoxy-d-arabino-heptulosonic acid 7-phosphate has been proposed to be the first committed step in the aminoshikimate pathway. Guo and Frost demonstrated that the unusual
Aminoshikimate_pathway
Class of enzymes
via an increased rate of messenger RNA degradation. CHS, as the first committed step in the flavonoid pathway, facilitate production of flavanoids, isoflavonoid-type
Chalcone_synthase
Protein-coding gene in the species Homo sapiens
encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian
PI4KA
humanity and the crime of genocide, which Israeli security forces have committed or been accused of committing since the founding of Israel in 1948. These
Israeli_war_crimes
South African and American actress (born 1975)
14-month contract she signed with Raymond Weil in 2005. The contract committed her to wear Raymond Weil watches during public events, especially when
Charlize_Theron
Prime Minister of Israel (1996–1999; 2009–2021; 2022–present)
step in the right direction. The acceptance of a Palestinian state was present there". Obama's press secretary said the speech was an "important step
Benjamin_Netanyahu
General election held in Wales on 7 May 2026
manifesto at an event in Swansea. Alongside their existing pledges the party committed to a freeze on the Welsh rates of income tax, pressing medical need being
2026_Senedd_election
Legality of sexual relationships between family members
and their natural or adoptive child, a step-parent and their step-child, whether the step-child's parent and step-parent are married under the Marriage
Legality_of_incest
1937–1938 mass murder in China
capturing Shanghai in November. As the Japanese marched on Nanjing, they committed violent atrocities in a terror campaign, including killing contests and
Nanjing_Massacre
Class of enzymes
Irino F, Yoneyama N, Fujimura T, Ashihara H (July 2003). "The first committed step reaction of caffeine biosynthesis: 7-methylxanthosine synthase is closely
7-methylxanthosine_synthase
General election held in Scotland on 7 May 2026
to step down at next Holyrood election". The National. Retrieved 26 February 2025. PA Media (26 February 2025). "Tory MSP Edward Mountain to step down
2026 Scottish Parliament election
2026_Scottish_Parliament_election
Canadian singer (born 1994)
support for Budnick's Anti-Recidivism Coalition. During the visit, Bieber committed to provide buses to transport relatives of the inmates who have been unable
Justin_Bieber
Family of transferases enzymes
2014). "Structure and Mechanism of Soybean ATP Sulfurylase and the Committed Step in Plant Sulfur Assimilation". Journal of Biological Chemistry. 289
Sulfate_adenylyltransferase
Parent of one's parents
25% genetic overlap. A step-grandparent can be the step-parent of the parent or the step-parent's parent or the step-parent's step-parent (though technically
Grandparent
Chemical reactions and pathways
capsulatus. Anaerobic pathway in which cobalt insertion is the first committed step towards cobalamin synthesis; found in Salmonella typhimurium, Bacillus
Cobalamin_biosynthesis
Enzyme
and CTP. CTP (cytidine triphosphate) synthetase catalyzes the last committed step in pyrimidine nucleotide biosynthesis: ATP + UTP + glutamine → ADP +
CTP_synthetase
Descendant of an ancestor's sibling
pair of full siblings. Step-cousins are either stepchildren of an individual's aunt or uncle, nieces and nephews of one's step-parent, or the children
Cousin
American basketball player (born 1990)
Phoenix Suns, Green played one minute, made one defensive rebound, and committed one foul. Green gradually received more playing time in subsequent games
Draymond_Green
American actor (born 1982)
Awards for Shadowhunters. Shum has appeared in the films Step Up 2: The Streets (2008), Step Up 3D (2010), White Frog (2012), Revenge of the Green Dragons
Harry_Shum_Jr.
Recessive genetic condition
two FPP leads to the formation of squalene; this represents the first committed step towards cholesterol biosynthesis. Squalene leads to the creation of
Smith–Lemli–Opitz_syndrome
American-Canadian comedian and actor
up and are the oldest of five children, with two full siblings, and two step siblings. Michaelis attended the University of Toronto Scarborough for two
Vic_Michaelis
English serial killer (1941–1995)
1 January 1995) was an English serial killer and child molester, who committed at least twelve murders between 1967 and 1987 in Gloucestershire, England—the
Fred_West
American actress (born 1982)
in Todd Haynes' legal drama Dark Waters, about environmental poisoning committed by the chemical company DuPont. Writing for Variety, Owen Gleiberman termed
Anne_Hathaway
Japanese samurai class woman
and once again attacked Osaka Castle. Yodo-dono and her son, Hideyori, committed suicide as Osaka Castle burned, ending the Toyotomi legacy. No eyewitness
Yodo-dono
COMMITTED STEP
COMMITTED STEP
Female
English
Feminine form of English Stephen, STEPHENIE means "crown."Â
Surname or Lastname
English
English : nickname from Middle English step ‘step’ + toe ‘toe’, perhaps for someone who treads lightly.
Girl/Female
French Latin
From the Latin Lucretia. Famous bearer: Lucrece, a Roman matron who committed suicide as a public...
Female
English
Feminine form of Latin Stephanus, STEPHANIA means "crown."Â
Female
English
Feminine form of English Stephen, STEPHANIE means "crown."Â
Boy/Male
German, Greek, Russian
Crowned with Laurels; Form of Stephen; Crowned
Female
English
Celtic legend name of a tragic heroine who committed suicide after the murder of her lover. She is sometimes referred to as Deirdre of the Sorrows. The name is of uncertain derivation. Some sources give the DEIRDRE means "young girl."
Surname or Lastname
English
English : patronymic from the personal name Stephen (see Steven).
Male
Greek
(ΚαπανεÏÏ‚) Greek name KAPANEUS means "arrogant." In mythology, this is the name of one of the Seven Against Thebes. He is said to have had a body of immense size and strength, but he was notoriously arrogant and was eventually struck and killed by a thunderbolt sent by Zeus. His wife Euadne committed suicide by throwing herself on his funeral pyre.Â
Female
English
Modern variant spelling of English Stephanie, STEPHANI means "crown."
Male
Greek
(ΣτÎφανος) Greek name derived from the word stephanos, STEPHANOS means "crown." In the bible, this is the name of one of the seven deacons of the church at Jerusalem who was stoned to death by the Jews.Â
Boy/Male
Greek English
Crown; wreath. In the bible Stephen was the first Christian martyr. Surname.
Female
Greek
(Ἀκελδαμά) Greek form of Aramaic ħqêl dmâ, AKELDAMA means "field of blood." In the bible, this is the name of the place where Judas Iscariot committed suicide.Â
Boy/Male
English American Greek
Crown; wreath. From biblical Stephen, the first Christian martyr.
Girl/Female
Hebrew
Wild goat. In the Old Testament, Jael committed murder by driving a tent peg through a male...
Male
German
German form of Latin Stephanus, STEPHAN means "crown."
Surname or Lastname
English
English : variant spelling of Stephens.Reduced form of German Stephanhans, from a compound of the personal names Stephan (see Steven) + Hans.
Surname or Lastname
English (mainly Sussex)
English (mainly Sussex) : habitational name from Stepney in London, named probably with an unattested Old English personal name, Stybba (genitive Stybban) + h̄þ ‘hythe’, ‘landing place’.
Boy/Male
Shakespearean American Greek English Biblical
King Richard The Second' Sir Stephen Scroop.
Female
English
Modern variant spelling of English Stephanie, STEPHANY means "crown."
COMMITTED STEP
COMMITTED STEP
Boy/Male
Hindu
With wide shoulders
Boy/Male
English Scandinavian American
The mythological Scandinavian Wayland was a blacksmith with supernatural powers. Modern singer...
Girl/Female
Gujarati, Hindu, Indian, Modern
A Beautiful Angle
Boy/Male
Hindu, Indian, Marathi, Sanskrit
Lovable; Charming
Girl/Female
Assamese, Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya
Firmly Fixed
Boy/Male
Hindu, Indian, Sanskrit
The Triumphant Gopala
Boy/Male
Arabic, Muslim
Unique
Girl/Female
Arabic, Swahili
Star; Woman; Life; Lively (Women); Beautiful
Boy/Male
Tamil
Enjoying, Associate with the Goddess Lakshmi
Boy/Male
Indian, Sanskrit
Thinker; Wise
COMMITTED STEP
COMMITTED STEP
COMMITTED STEP
COMMITTED STEP
COMMITTED STEP
n.
One to whom the keeping of sequestered property is committed.
a.
Capable of being committed; liable to be committed.
a.
A person who has committed a felony.
imp. & p. p.
of Comment
a.
Capable of being committed.
n.
A member of a committee.
n.
The act of committing, or the state of being committed; commitment.
imp. & p. p.
of Commix
a.
Delivered; committed in trust.
imp. & p. p.
of Comminute
a.
Capable of being omitted; that may be omitted.
imp. & p. p.
of Immit
n.
One or more persons elected or appointed, to whom any matter or business is referred, either by a legislative body, or by a court, or by any collective body of men acting together.
imp. & p. p.
of Commit
v. t.
One to whom the charge of the person or estate of another, as of a lunatic, is committed by suitable authority; a guardian.
n.
An under committee; a part or division of a committee.
n.
A fornicator.
n.
One who commits; one who does or perpetrates.
imp. & p. p.
of Commute