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STRICTOSIDINE SYNTHASE

Strictosidine synthase

Class of enzymes

Strictosidine synthase (EC 4.3.3.2) is an enzyme in alkaloid biosynthesis that catalyses the condensation of tryptamine with secologanin to form strictosidine

Strictosidine synthase

Strictosidine_synthase

Strictosidine

Chemical compound

tryptamine with secologanin, catalyzed by the enzyme strictosidine synthase. Thousands of strictosidine derivatives are sometimes referred to by the broad

Strictosidine

Quinine

Medication used to treat malaria and babesiosis

enzyme strictosidine synthase catalyzes a stereoselective Pictet–Spengler reaction between tryptamine and secologanin to yield strictosidine. Suitable

Quinine

Strychnine

Poisonous substance used as pesticide

enzyme, strictosidine synthase, catalyzes the condensation of tryptamine and secologanin, followed by a Pictet-Spengler reaction to form strictosidine. Many

Strychnine

Pictet–Spengler reaction

Chemical reaction including condensation

Natural Pictet–Spengler reaction typically employ an enzyme, such as strictosidine synthase. Pictet–Spengler products can be isolated from many products initially

Pictet–Spengler reaction

Pictet–Spengler_reaction

Camptothecin

Chemical compound

MVA or MEP pathway are converted to strictosidine through a condensation reaction catalyzed by strictosidine synthase. Although it is not fully resolved

Camptothecin

Ajmalicine

Chemical compound

tryptophan. Strictosidine synthase (STR) then catalyzes the formation of strictosidine from the intermediates of the previous pathways. Strictosidine is the

Ajmalicine

Ajmaline

Chemical compound

tryptamine. Strictosidine synthase (STR), uses a Pictet–Spengler reaction to form strictosidine from tryptamine and secologanin. Strictosidine is oxidized

Ajmaline

List of EC numbers (EC 4)

glycerol-phosphate synthase EC 4.3.3.1: 3-ketovalidoxylamine C-N-lyase EC 4.3.3.2: strictosidine synthase EC 4.3.3.3: deacetylisoipecoside synthase EC 4.3.3.4:

List of EC numbers (EC 4)

List_of_EC_numbers_(EC_4)

Dimerization of catharanthine and vindoline

Chemical process

vinblastine and vincristine. The precursor of catharanthine and vindoline is strictosidine, the common precursor of all indole alkaloids. The localization of catharanthine

Dimerization of catharanthine and vindoline

Dimerization_of_catharanthine_and_vindoline

Toxiferine

One of the most toxic plant alkaloids

strictosidine. Strictosidine in turn is derived from the alkaloid tryptamine and the terpene secologanin through the action of strictosidine synthase

Toxiferine

Indoloquinolizidine alkaloids

Chemical group of natural compounds

pathway where a family of dihydrogeissoschizine synthases (DCS1–4) selectively reduces the strictosidine aglycone into either (20R)-demethylcorynantheidine

Indoloquinolizidine alkaloids

Indoloquinolizidine_alkaloids

Iridoid

Class of chemical compounds

iridoid secologanin can react with tryptamine to form the indole alkaloid strictosidine, the precursor of many biologically active compounds such as strychnine

Iridoid

7-Fluorotryptamine

Pharmaceutical compound

Treimer JF, Zenk MH (November 1979). "Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation". European Journal

7-Fluorotryptamine

Ashok Jain (biotechnologist)

screened a cDNA library of Arabidopsis thaliana for genes encoding Strictosidine synthase (AtSS) and isolated, sequenced, and annotated three distinct genes

Ashok Jain (biotechnologist)

Ashok_Jain_(biotechnologist)

Voacangine

Chemical compound

biosynthesized from the late stage intermediate stemmadenine acetate, a strictosidine-derived biosynthetic intermediate for a wide number of plant natural

Voacangine

Ibogaine

Psychoactive substance found in plants in the family Apocynaceae

is reacted with tryptamine to make strictosidine. A glycosidic bond cleavage of strictosidine by strictosidine β-deglucosidase (SGD) produces a lactol

Ibogaine

Natural product

Chemical compound or substance produced by a living organism, found in nature

condensation of an aldehyde with an amine, as seen in the biosynthesis of strictosidine, a precursor to numerous monoterpene indole alkaloids. Oxidoreductases

Natural product

Natural_product

List of EC numbers (EC 3)

4-β-galactosidase EC 3.2.1.104: steryl-β-glucosidase EC 3.2.1.105: 3α(S)-strictosidine β-glucosidase EC 3.2.1.106: mannosyl-oligosaccharide glucosidase EC

List of EC numbers (EC 3)

List_of_EC_numbers_(EC_3)