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Susceptibility of cells to radiation
Radiosensitivity is the relative susceptibility of cells, tissues, organs or organisms to the harmful effect of ionizing radiation. Cells are least sensitive
Radiosensitivity
Greek physicist, radiobiologist, and cytogeneticist
(PCC) assay and a standardized G2-assay for predicting individual radiosensitivity. He was an emeritus Director of Research at the Institute of Nuclear
Gabriel_Pantelias
Genomics-informed framework to personalize radiotherapy dose
physical radiation dose by combining a tumor's gene-expression–derived radiosensitivity with a radiobiological dose–effect model (e.g. the linear–quadratic
Genomic adjusted radiation dose
Genomic_adjusted_radiation_dose
Therapy using ionizing radiation, usually to treat cancer
response of a cancer to radiation is described by its radiosensitivity. Highly radiosensitive cancer cells are rapidly killed by modest doses of radiation
Radiation_therapy
Aggressive type of brain cancer
Gupta B, Larner J, Rich JN, Park DM (October 2010). "Improving the radiosensitivity of radioresistant and hypoxic glioblastoma". Future Oncology. 6 (10):
Glioblastoma
Group of diseases involving cell growth
Crowther D, McMorran S, Youngmin S, Wacogne I, Pleat J, et al. "tumour radiosensitivity – General Practice Notebook". Archived from the original on 24 September
Cancer
1945 attacks in Japan during WWII
data collected suggests a threshold fetal dose for SMR at the most radiosensitive period of cognitive development, when there is the largest number of
Atomic bombings of Hiroshima and Nagasaki
Atomic_bombings_of_Hiroshima_and_Nagasaki
Phenomenon in biochemistry
biochemistry, the oxygen effect refers to a tendency for increased radiosensitivity of free living cells and organisms in the presence of oxygen than in
Oxygen_effect
Rare neurodegenerative disease
Gatti RA (June 2002). "Early diagnosis of ataxia–telangiectasia using radiosensitivity testing". The Journal of Pediatrics. 140 (6): 724–31. doi:10.1067/mpd
Ataxia–telangiectasia
Principal curcuminoid of turmeric
to death. In 2016, laboratory research established and compared the radiosensitivity of three organic food colorants including curcumin, carmine, and annatto
Curcumin
Indian agronomist (1925–2023)
and rice, in areas such as cytogenetics, ionizing radiation, and radiosensitivity. He was a president of the Pugwash Conferences and the International
M._S._Swaminathan
Medical condition
RIDDLE syndrome is a rare genetic syndrome. The name is an acronym for Radiosensitivity, ImmunoDeficiency Dysmorphic features and Learning difficulties. The
RIDDLE_syndrome
Medical treatment at raised ambient pressure
Churchill-Davidson, in the UK, used hyperbaric oxygen to enhance the radiosensitivity of tumours, while Ite Boerema [nl], at the University of Amsterdam
Hyperbaric_medicine
Medical specialty for imaging procedures
harmful effects from ionizing radiation Radiologists Without Borders Radiosensitivity: measure of the susceptibility of organic tissues to the harmful effects
Radiology
Salt of oxamic acid
"Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells". Oncology Reports. 30 (6): 2983–2991
Oxamate
Type of nerve damage
to the magnitude of ionizing radiation and the peripheral nerves' radiosensitivity and may be further aggravated if combined with chemotherapy consisting
Radiation-induced lumbar plexopathy
Radiation-induced_lumbar_plexopathy
Mammalian protein found in Homo sapiens
Jiao Y, Wang HC, Fan SJ (December 2007). "Growth suppression and radiosensitivity increase by HMGB1 in breast cancer". Acta Pharmacologica Sinica. 28
HMGB1
Cancer arising from the cervix
be maintained if the patient desires. Because cervical cancers are radiosensitive, radiation may be used in all stages where surgical options do not exist
Cervical_cancer
Chemical compound
cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle. In animal cloning procedures, demecolcine makes
Demecolcine
Mammalian protein found in humans
Li J, Gui R, Nie X, Huang R (May 2019). "CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p".
P53
Radiation testing site in Wisconsin, US
cambial growth, and dosimetry. Woody plant species were measured for radiosensitivity, based on the interphase chromosome volume. In total, 193 plant species
Enterprise_Radiation_Forest
Events leading to cell division
of the cycle. M and S do not vary much. In general, cells are most radiosensitive in late M and G2 phases and most resistant in late S phase. For cells
Cell_cycle
X-ray fluoroscope machines installed in shoe stores 1920s-1970s
who were chronically exposed, and to children, who are about twice as radiosensitive as adults. Monitoring of American salespersons found dose rates at pelvis
Shoe-fitting_fluoroscope
provided: the tumour targeted falls in the range suitable for radiation, no radiosensitive organs are involved, and it can be meta-sized. It can be done either
Cancer_in_cats
Quantitative measurement of the relative safety of a drug
cells are in G1 and S phase. Irradiation at G2 phase showed increased radiosensitivity and thus G1 arrest has been a focus for therapeutic treatment. Irradiation
Therapeutic_index
dose (GARD), which uses tumor gene-expression signatures to estimate radiosensitivity. The term radiogenomics was coined in 2002 by Andreassen et al. (2002)
Radiogenomics
Electron microscopy technique
electron microscope column. Most biological specimens are extremely radiosensitive, so they must be imaged with low-dose techniques (usefully, the low
Cryogenic_electron_microscopy
Protein-coding gene in the species Homo sapiens
HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression". J. Cell. Physiol.
Selenophosphate_synthetase_1
Telomere-restoring protein active in the most rapidly dividing cells
Chen M, Xing LN (2012). "siRNA-mediated inhibition of hTERC enhances radiosensitivity of cervical cancer". Asian Pacific Journal of Cancer Prevention. 13
Telomerase
Protein-coding gene in the species Homo sapiens
CM, de Groot R, Zdzienicka MZ, van Gent DC, van Dongen JJ (2003). "Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation
Artemis_(protein)
Protein-coding gene in humans
survival in radiotherapy treatments, while silencing its gene increases radiosensitivity. As a result, GJA1 may serve as a target for improving the success
GJA1
disrupt the cell cycle, increasing radiosensitivity at specific phases. Taxanes: Arrest cells in the radiosensitive G2/M phase. Antimetabolites: Interfere
Radiosensitizer
Medical condition
PJ, Arlett CF, Scott D (1996). "Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients.". Genetic predisposition to cancer
Thymic_hypoplasia
Enzymes that catalyze acyl group transfer from acetyl-CoA to histones
increases the sensitivity of cells to radiation damage. Increases in radiosensitivity may increase the effectiveness of radiotherapy. Histone-modifying enzymes
Histone_acetyltransferase
Cancer caused by ionizing radiation exposure
exposure is most closely associated with leukemia, reflecting the high radiosensitivity of bone marrow. Internal exposures tend to cause cancer in the organs
Radiation-induced_cancer
Chemical compound
radiosensitizer in adjunct to radiotherapies, since it can increase the radiosensitivity of tumor cells by inhibiting repair of sublethal radiation damage and
Dactinomycin
Surgical using radiation
treatments). Fractionated radiotherapy relies more heavily on the different radiosensitivity of the target and the surrounding normal tissue to the total accumulated
Radiosurgery
Study of effects of radiation on living tissues
Radiation Laboratory Radioactivity in biology Radiology Radiophobia Radiosensitivity "Radiobiology and Molecular Imaging". Institut Curie. Retrieved 10
Radiobiology
Type of breast cancer lacking certain gene expressions
Cancer. Investigational work has explored whether genomic predictors of radiosensitivity can guide personalized radiation dosing in TNBC. One proposed approach
Triple-negative_breast_cancer
Gray—weeping blistering and ulceration will occur The lungs are the most radiosensitive organ, and radiation pneumonitis can occur leading to pulmonary insufficiency
Effects of nuclear explosions on human health
Effects_of_nuclear_explosions_on_human_health
Protein-coding gene in the species Homo sapiens
Zhou Y (July 2017). "Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening". Oncology Reports
HMBOX1
Pathway that repairs double-strand breaks in DNA
respectively. These syndromes share many features including cellular radiosensitivity, microcephaly and severe combined immunodeficiency (SCID) due to defective
Non-homologous_end_joining
Persons exposed to nuclear test fallout
cancers is much higher than was previously estimated. The increased radiosensitivity of certain organs in women, such as the breast, ovaries, and thyroid
Downwinders
Rare and highly aggressive skin cancer
referring for radiation therapy to eradicate MCC. MCC is exquisitely radiosensitive. The conclusion amongst published studies in the Radiation Oncology
Merkel-cell_carcinoma
Protein-coding gene in the species Homo sapiens
infertile males, are radiosensitive, and are more susceptible to tumors. Knock out MDC1 mice cells and silenced human cells were radiosensitive, failed to initiate
MDC1
Cancer of the throat
investigational strategies that use tumor-intrinsic genomic measures of radiosensitivity, in particular the Genomic Adjusted Radiation Dose (GARD) framework
HPV-positive oropharyngeal cancer
HPV-positive_oropharyngeal_cancer
RNA family
JS, Kim JJ, Byun JY, Kim IA (January 2010). "Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras". International Journal
Let-7_microRNA_family
American geneticist (1915–2006)
With H. P. Riley, "Studies on the mechanism of oxygen effect on the radiosensitivity of Tradescantia chromosomes". Proc. Natl. Acad. Sci. U. S. A. 36:337-344
Norman_Giles
British Professor
she learned over the years. West's research focused on predicting radiosensitivity and hypoxia in tissues of cancer patients post-radiotherapy. She developed
Catharine_West
Enzyme found in humans
biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity". The Journal of Biological Chemistry. 276 (33): 31124–32. doi:10.1074/jbc
DNA_ligase_4
German physicist
local tumour control probability for gliomas exhibiting low dose hyper-radiosensitivity using a pulsed schedule". British Journal of Radiology. 80 (949): 32–37
Wolfgang_A._Tomé
Protein found in humans
polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. A deficiency in expression of a DNA repair gene increases the risk
Ku80
Protein-coding gene in the species Homo sapiens
Zhang L, Yu J (June 2008). "PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome". Cell Stem Cell. 2 (6): 576–83. doi:10
P53 upregulated modulator of apoptosis
P53_upregulated_modulator_of_apoptosis
Protein-coding gene in the species Homo sapiens
translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors: the protein uPAR is a cytoplasmic sequestration
HAND1
Medical intervention
researchers treated people with "cycles" up to four times a week apart. Radiosensitivity may be achieved with hyperthermia, and using heat with every radiation
Hyperthermia_therapy
Genetic recombination between identical or highly similar strands of genetic material
using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity" (PDF). Molecular Cancer Therapeutics. 8 (1): 203–213. doi:10.1158/1535-7163
Homologous_recombination
Form of radiotherapy
American Society for Radiation Oncology Annual Meeting. The increased radiosensitivity of cells in an oxygenated environment compared to a hypoxic one is
FLASH_radiotherapy
Susceptibility of a material to radiation
dating- the radiometric dating technique based on fission fragments Radiosensitivity- the susceptibility of living cells, tissues, organs or organisms to
Radiation_sensitivity
see) nuclear medicine radiodensity radiopharmaceutical radioresistant radiosensitivity radiosity radiosonde (radiostation) radio station radiosurgery (radiotelegraphy)
Index_of_radiation_articles
American surgical pathologist
of Tumors by Aspiration" Am J Pathol. 1933; 9(Suppl): 801–812.3. "RADIOSENSITIVITY OF TUMORS." December 1933 Arch Surg. 1933;27(6):979. The Production
Fred_W._Stewart
Protein-coding gene in the species Homo sapiens
polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. The XRCC3 protein is one of five paralogs of RAD51, including RAD51B
XRCC3
Medical intervention
of cell kinetic parameters for the assessment of intrinsic cellular radiosensitivity to photon and high linear energy transfer neutron irradiation. International
Fast_neutron_therapy
Level of ionizing radiation that organisms are able to withstand
that protects against acute radiation syndrome, during radiotherapy. Radiosensitivity Background radiation Radiation hormesis Radiotrophic fungus Kojic acid
Radioresistance
Group of disorders
hypogammaglobulinemia, the Wiskott–Aldrich syndrome, ataxia telangiectasia, the radiosensitive forms of severe combined immunodeficiency disease (SCID), the autoimmune
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
21:355-361. Richardson RB and Harper M-E. Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy. Oncotarget. 2016;
Oxygen_enhancement_ratio
Protein found in humans
(July 2007). "[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]". AI Zheng = Aizheng = Chinese Journal
DNA-PKcs
Protein-coding gene in the species Homo sapiens
"Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells". Radiat. Res. 159 (6): 748–58. Bibcode:2003RadR..159
KIN_(gene)
Topics referred to by the same term
and Tom Show Radiogram (medicine), a photographic image produced on a radiosensitive surface by radiation other than visible light (especially by X-rays
Radiogram
Medical condition
S2CID 41511848. Bernhard, E J; McKenna, W G; Muschel, R J (1999). "Radiosensitivity and the cell cycle". The Cancer Journal from Scientific American. 5
Radiation_colitis
Species of fungi
Won-Dong; Yu, Jae-Ran; Park, Woo-Yoon (2016). "Cordycepin increases radiosensitivity in cervical cancer cells by overriding or prolonging radiation-induced
Cordyceps_chanhua
Growth of a plasma cell tumour within soft tissue or the axial skeleton
treatment can be used with curative intent because plasmacytoma is a radiosensitive tumor. Surgery is an option for extramedullary plasmacytoma, but for
Plasmacytoma
Medical condition
beneficial for certain cases of oSCC originating from teratomas, given the radiosensitive nature of this tumor. There is no widely accepted chemotherapy regimen
Ovarian squamous cell carcinoma
Ovarian_squamous_cell_carcinoma
British scientist
G2 Phase are more resistant to radiation than cells in the M Phase (Radiosensitivity and Cell cycle). The Committee Examining Radiation Risks of Internal
Christopher_Busby
E=\sum _{j}H_{j}W_{j}\,\!} Wj = weighting factors corresponding to radiosensitivities of matter (dimensionless) ∑ j W j = 1 {\displaystyle \sum _{j}W_{j}=1\
List of equations in nuclear and particle physics
List_of_equations_in_nuclear_and_particle_physics
Protein
polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. The XRCC1 protein does not have enzymatic activity, but acts as a
XRCC1
Protein-coding gene in humans
M, Owaki T, Ishigami S, Aikou T (September 2007). "Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous
RRM2B
American medical physicist
radiomodulatory agents on cell lines derived from patients with the rare radiosensitive genetic disorder Ataxia-Telangiectasia. After graduating from UCLA in
Julianne_Pollard-Larkin
Pharmaceutical compound
"GSK484, an inhibitor of peptidyl arginine deiminase 4, increases the radiosensitivity of colorectal cancer and inhibits neutrophil extracellular traps".
GSK484
Spermatogonia are the most impacted by radiotherapy because they are more radiosensitive than other types of cells such as spermatozoa. This means that the whole
Side effects of radiotherapy on fertility
Side_effects_of_radiotherapy_on_fertility
Renewal cell of interest in pathology
result, clonogenic assays are usually regarded as the gold standard for radiosensitivity studies due to their in vitro ability to sustain viable cells for studying
Clonogens
Protein-coding gene in the species Homo sapiens
"Ataxia-ocular motor apraxia syndrome: an investigation of cellular radiosensitivity of patients and their families". J. Med. Genet. 31 (12): 953–6. doi:10
Aprataxin
radiation; and so people with mutations in the Artemis complex may develop radiosensitive severe combined immune deficiency (RS-SCID). The Artemis protein has
Artemis_complex
Technique to separate DNA or RNA fragments
M; et al. (2000). "Effect of ethidium bromide intercalation on DNA radiosensitivity". Int J Radiat Biol. 76 (1): 1–9. doi:10.1080/095530000138952. PMID 10665952
Gel electrophoresis of nucleic acids
Gel_electrophoresis_of_nucleic_acids
Biopharmeceutical company based in New York City
(2009). "A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe". Investigational New Drugs
Kadmon_Corporation
Protein found in humans
1997). "Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J
Ku70
Medical condition
therapy administered to treat thoracic or lung cancer. The lungs are a radiosensitive organ, and radiation pneumonitis can occur leading to pulmonary insufficiency
Radiation-induced_lung_injury
Protein-coding gene in the species Homo sapiens
expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro". Exp. Cell Res. 318 (8):
Apoptosis-inducing factor, mitochondria-associated 3
Apoptosis-inducing_factor,_mitochondria-associated_3
Protein-coding gene in the species Homo sapiens
Jeggo PA (July 1999). "Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient". Curr. Biol. 9 (13): 699–702. Bibcode:1999CBio..
DNA_ligase_3
Medical condition
not recommended at this point to treat all types. All in all, the radiosensitivity of astroblastoma to therapy remains unclear, since some research advocate
Astroblastoma
American epidemiologist
follow a large cohort of adult survivors of retinoblastoma to describe radiosensitivity and risk of second cancers among patients with the hereditary form
Ruth_A._Kleinerman
Swiss researcher and academic
the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity". British Journal of Cancer. 124 (4): 817–830. doi:10.1038/s41416-020-01167-y
Benedikt_Kessler
Non-coding RNA in the species Homo sapiens
Chen Y, Liu Y, Zhan JF, Chen LH, Yuan YW (August 2010). "[Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma]". Nan
MIR7-1
Specific location in the body containing stem cells
Dewhirst MW (May 2004). "Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules"
Stem-cell_niche
Radioactive biochemical substance used for diagnosis or for study of receptor systems
therapy. Furthermore, individual characteristics affect the exact radiosensitivity to the therapy (thus affecting dosimetry) and are hard to predict without
Radioligand
Protein in humans
and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia–telangiectasia phenotype. TRIM29
TRIM29
priming ability of DNA in the RNA polymerase system [10][dead link] Radiosensitivity of glycolytic enzymes in the nucleus [11][dead link] GSF - Forschungszentrum
Ulrich_Hagen
Rugh, Roberts, et al. (1963). "X-rays: are there cyclic variations in radiosensitivity?." Science. (142)3588: 53–56. Rugh, Roberts. (1964). "Why radiobiology
Roberts_Rugh
Human gene
"Polygenic risk score for prediction of radiotherapy efficacy and radiosensitivity in patients with non-metastatic breast cancer". Radiation Medicine
CIMAP1C
Medical treatment
enough oxygen concentration to be viable, yet not enough to be X-ray-radiosensitive) and cells deficient in oxygen are resistant to killing by X-rays. Thus
Management_of_prostate_cancer
(June 2010). "Inhibition of p21-activated kinase 6 (PAK6) increases radiosensitivity of prostate cancer cells". The Prostate. 70 (8): 807–16. doi:10.1002/pros
PAK6
RADIOSENSITIVITY
RADIOSENSITIVITY
RADIOSENSITIVITY
RADIOSENSITIVITY
Girl/Female
Australian, Polish
Harvester; Guardian
Female
Greek
(Εφθαλία) Modern spelling of Greek Euthalia, EFTHALIA means "blooming, flourishing."
Male
Italian
Italian form of Latin Filbertus, FILBERTO means "very bright."
Male
Italian
Italian, Portuguese and Spanish form of Roman Latin Felicianus, FELICIANO means "happy" or "lucky."
Girl/Female
Arabic, Muslim, Parsi, Sindhi
Precious Stone
Boy/Male
Celebrity, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Husband of Lotus
Boy/Male
Shakespearean
Antony and Cleopatra'. Attendant on Cleopatra.
Girl/Female
Gujarati, Hindu, Indian
Goddess Durga; Grace; Favour; God has Shown Favour
Girl/Female
Indian, Telugu
Like a Pearl
Girl/Female
American, British, English, French, German, Hebrew, Latin
Medieval Male Name Adopted as a Feminine Name; A Member of the German Tribe; The Gauts; Joyful; Happy
RADIOSENSITIVITY
RADIOSENSITIVITY
RADIOSENSITIVITY
RADIOSENSITIVITY
RADIOSENSITIVITY