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Search references for CDC25. Phrases containing CDC25
See searches and references containing CDC25!CDC25
Enzyme
Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. As with other cell cycle
Cdc25
Topics referred to by the same term
CDC25 can refer to: Cdc25, a cell division cycle protein Another name for ras-GRF1, a guanine nucleotide exchange factor This disambiguation page lists
CDC25
Third subphase of interphase
site. The effects of Wee1 and Myt1 are counteracted by phosphatases in the cdc25 family, which remove the inhibitory phosphates on CDK1 and thus convert
G2_phase
Proteins which remove GDP from GTPases
substrates. The CDC25 homology domain, also called the RasGEF domain, is the catalytic domain of many Ras GEFs, which activate Ras GTPases. The CDC25 domain comprises
Guanine nucleotide exchange factor
Guanine_nucleotide_exchange_factor
Cell cycle checkpoint in eukaryotic organisms
CyclinB-Cdc2 activates the phosphatase Cdc25 which in turn deactivates the CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 activates the complex through the
G2-M_DNA_damage_checkpoint
Control mechanism in the eukaryotic cell cycle
additional function of Plk1 is to activate Cdc25 through phosphorylation. The compound effect of Wee1 degradation and Cdc25 activation is the net removal of inhibitory
Cell_cycle_checkpoint
Protein-coding gene in humans
that in humans is encoded by the CDC25B gene. CDC25B is a member of the Cdc25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2
CDC25B
Protein domain
RasGEF domain is domain found in the CDC25 family of guanine nucleotide exchange factors for Ras-like small GTPases. Ras proteins are membrane-associated
RasGEF_domain
Biological factor
dephosphorylation. CDC25 removes a phosphate from residues Threonine-14 (Thr-14) and Tyrosine-15 (Tyr-15) and adds a hydroxyl group. Cyclin B/CDK1 activates CDC25 resulting
Maturation_promoting_factor
Dependence of the state of a system on its history
of more CDK1 molecules by inhibiting Wee1 (an inhibitor) and activating Cdc25 (a phosphatase that activates CDK1). These loops lock the cell into its
Hysteresis
Protein-coding gene in humans
by the cell division cycle 25A (CDC25A) gene. CDC25A is a member of the CDC25 family of dual-specificity phosphatases. Dual-specificity protein phosphatases
CDC25A
Cell division producing haploid gametes
initiate the premeiotic S phase, while cyclin Cdc13 and the CDK activator Cdc25 are necessary for both meiotic divisions. However, the Pat1-Mei2 system
Meiosis
Biological process
p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting
Cell_division
Small protein domain found in some kinases and GTPases
families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of signaling pathways regulating the
SH3_domain
Events leading to cell division
cdc (for "cell division cycle") followed by an identifying number, e.g. cdc25 or cdc20. Cyclins form the regulatory subunits and CDKs the catalytic subunits
Cell_cycle
Protein-coding gene in humans
division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2
CDC25C
phosphorylated Cdc2 to form preMPF, which is activated by Cdc25 to generate MPF. Because Cdc25 itself is also activated by MPF, the conversion of preMPF
Novak–Tyson_model
Nuclear protein
such that Wee1+ activity was critical in preventing premature mitosis in Cdc25+ (a mitotic inducer) yeast cells and increased Wee1+ expression could further
Wee1
Increase of the total mass of a cell
the phosphatase Cdc25 removes the inhibitory phosphorylation, and thus activates Cdc2 to allow mitotic entry. A balance of Wee1 and Cdc25 activity with
Cell_growth
Topics referred to by the same term
former hospital in Novena, Singapore Cell-division cycle in biology cdc20 cdc25 Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin, exotoxins
CDC_(disambiguation)
(CDK1)–cyclin B, and Cdc25 is a phosphatase that dephosphorylates Cdk1 to promote mitotic entry. Plk1 binds to phosphorylated Cdc25 through its PBD. Thus
Polo-like_kinase
stable steady state in G2 (Cdk1 and Cdc25 off, Wee1 on) and a second stable steady state in M phase (Cdk1 and Cdc25 active, Wee1 off). However, Wee1 is
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Cellular process
exhibits hysteresis, as a result of interactions between the cyclin B/Cdk1-Cdc25 positive feedback loop, the cyclin B/Cdk1-Wee1 inhibition positive feedback
Mitotic_trigger_waves
British geneticist
molecules whose functions were regulated by Polo kinase; a germ line specific Cdc25 phosphatase that regulates meiotic entry; and demonstrated the roles of
David_Glover_(geneticist)
Protein domain
terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating
HECT_domain
Intracellular communication process
activates calmodulin-dependent protein kinase II (CaMKII), which triggers Cdc25, a phosphatase that removes inhibitory phosphate groups from Cyclin-dependent
Calcium_signaling
Protein-coding gene in the species Homo sapiens
This dephosphorylation of inhibitory sites is done by the Cdc25 family. In vertebrates, the Cdc25 enzymes are Cdc25A which controls the checkpoints of G1/S
PKMYT1
Protein-coding gene in humans
including CDC25 phosphatases, responsible for dephosphorylating and activating the cyclin-dependent kinases (CDKs). Thus, CHK2's inhibition of the CDC25 phosphatases
CHEK2
Molecule that blocks enzyme activity
spectrometry screening test to evidence reversible and irreversible inhibitors of CDC25 phosphatases". Analytical Biochemistry. 430 (1): 83–91. doi:10.1016/j.ab
Enzyme_inhibitor
Enzyme catalyzing transfer of phosphate groups onto specific substrates
other kinases (such as CDK-activating kinase) and phosphatases (such as Cdc25). Once the CDKs are active, they phosphorylate other proteins to change
Kinase
Protein-coding gene in the species Homo sapiens
Song C, Gao X, Kariya K, Hu CD, Kataoka T (August 2001). "Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent
PLCE1
Protein-coding gene in the species Homo sapiens
RAS was the S. cerevisiae Cdc25 gene product (not to be confused with the S. pombe Cdc25). Genetic analysis indicated that CDC25 is essential for activation
SOS1
Replication of the nuclear genome without mitosis
string/cdc25. Cdh/fzr is responsible for activation of the anaphase-promoting complex (APC) and subsequent proteolysis of the mitotic cyclins. String/cdc25 is
Endoreduplication
Protein-coding gene in humans
2000). "Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1". The
KRAS
Mammalian protein found in Homo sapiens
conserved among all eukaryotes phosphorylates Tyr15, whereas members of the Cdc25 family are phosphatases, counteracting this activity. The balance between
Cyclin-dependent_kinase_1
GTP-binding proteins functioning on cell-cycle regulation
facilitate Ras activation. Well known GEFs include Son of Sevenless (Sos) and cdc25 which include the RasGEF domain. The balance between GEF and GAP activity
Ras_GTPase
Guanine nucleotide exchange factor
control growth in mice. Although it is sometimes known as CDC25, it should not be confused with Cdc25. Ras-GRF1 is a paternally expressed imprinted gene, meaning
Ras-GRF1
Quality of a system having two stable equilibrium states
that activated CDK1 (Cyclin Dependent Kinase 1) activates its activator Cdc25 while at the same time inactivating its inactivator, Wee1, thus allowing
Bistability
Protein-coding gene in the species Homo sapiens
nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates
RASGRF1
Protein-coding gene in humans
cycle arrest. In response to DNA damage, Chk1 primarily phosphorylates Cdc25 which results in its proteasomal degradation. The degradation has an inhibitory
CHEK1
Family of conserved regulatory molecules
to the cytoplasm, inhibiting their function. Raf-1 Bad – see Bcl-2 Bax Cdc25 Akt SOS1 – see RSK YWHAB – "14-3-3 beta" YWHAE – "14-3-3 epsilon" YWHAG
14-3-3_protein
Class of enzymes
phosphotyrosine phosphatase (LMPTP). Cdc25 phosphatases (dTyr and/or dThr) The Class III PTPs contains three members, CDC25 A, B, and C These are members of
Protein_tyrosine_phosphatase
American chemistry professor
Family of Potent Inhibitors of the Dual Specificity Protein Phosphatase Cdc25". Journal of Medicinal Chemistry. 44 (24). American Chemical Society (ACS):
Peter_Wipf
Mitochondrial enzyme which breaks down cyanide
shares evolutionary relationship with a large family of proteins, including: Cdc25 phosphatase catalytic domain non-catalytic domains of eukaryotic dual-specificity
Rhodanese
Protein-coding gene in the species Homo sapiens
kinase. The complex is activated by dephosphorylation by the phosphatase Cdc25. Cdc25 is always present in the cell but must be activated by phosphorylation
Cyclin_B1
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413
PTGES3
Mammalian protein found in Homo sapiens
cardiac muscle troponin T (TnTc), etc. The retinoblastoma protein (pRb) and Cdc25 phosphatase were also suggested as possible substrates. The most important
C-Raf
Protein-coding gene in the species Homo sapiens
this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical
YWHAE
Protein-coding gene in the species Homo sapiens
effects of Pin1 depend upon the system: Pin1 accelerates dephosphorylation of Cdc25 and Tau, but protects phosphorylated cyclin D from ubiquitination and proteolysis
PIN1
Protein-coding gene in the species Homo sapiens
Fransson I, et al. (1997). "The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13". Hum. Genet
RASGRP2
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R2B
Enzyme
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413
PPP2R1A
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Wee1-like_protein_kinase
American geneticist
Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25". Science. 277 (5331): 1497–1501. Bibcode:1997Sci...277.1497S. doi:10.1126/science
Stephen_Elledge
Protein-coding gene in the species Homo sapiens
which is responsible for the activation of Rap, consists of a CDC25 homology domain (CDC25-HD), a Ras exchange motif (REM) domain, and a Ras association
RAPGEF4
the multiple required signaling cascade components, MPF and its activator Cdc25, in the nucleus generates efficient activation of the MPF and produces switch-like
Ultrasensitivity
site subject to Wee1 and/or Myt1 inhibitory kinase phosphorylation and Cdc25 de-phosphorylation in mammals. This reversible phosphorylation at the Gly-rich
Cyclin-dependent kinase complex
Cyclin-dependent_kinase_complex
Protein kinase that detects DNA damage and halts cell division
is essential to regulating replication within a cell; through the Chk1-CDC25 pathway, which effects levels of CDC2, this response is thought to reduce
Ataxia telangiectasia and Rad3 related
Ataxia_telangiectasia_and_Rad3_related
Precursor microRNA family
checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. PMID 9278511
Mir-15 microRNA precursor family
Mir-15_microRNA_precursor_family
Protein-coding gene in the species Homo sapiens
deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1". The Journal of Biological Chemistry. 276 (42): 39448–54.
USP8
Protein-coding gene in the species Homo sapiens
1998). "Transformation suppressor activity of C3G is independent of its CDC25-homology domain". Oncogene. 16 (5): 613–24. doi:10.1038/sj.onc.1201569.
RAPGEF1
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R4
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
YWHAG
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R2C
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Cyclin_B2
Protein-coding gene in the species Homo sapiens
the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. doi:10.1074/jbc.271.9.5118. PMID 8617791
Cyclin_E1
general phosphorylation switch Wee1/Cdc25. Wee1 activity is high in early prophase I and the accumulation of Cdc25 activates M-Cdk by direct phosphorylation
Meiotic recombination checkpoint
Meiotic_recombination_checkpoint
Protein-coding gene in the species Homo sapiens
contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic
DUSP7
Enzyme found in humans
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R2A
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R5B
Enzyme found in humans
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R5A
Protein-coding gene in the species Homo sapiens
(2000). "Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1". J
TNK2
Cdh1 orthologs, but promotes the inactivation of Cdc2 by down-regulating Cdc25 phosphatase. Cdc14 of Candida albicans is also involved in septation and
Cdc14
Protein-coding gene in the species Homo sapiens
and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling
YWHAB
RNA-binding protein in Drosophila
B. A.; Datar, S. A. (1996-08-01). "Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program". Genes & Development
Smaug_(protein)
Protein-coding gene in humans
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
COPS6
Protein domain
pTyr-specific phosphatases dual specificity phosphatases (dTyr and dSer/dThr) Cdc25 phosphatases (dTyr and/or dThr) LMW (low molecular weight) phosphatases
YopH,_N-terminal
the medial node by the presence of Cdr2. The phosphorylated Wee1 allows Cdc25 to dephosphorylate Cdk1 and move the cell into mitosis. Figure 2 depicts
Pom1
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R3A
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R5E
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R5C
Protein-coding gene in humans
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
PPP2R5D
Protein-coding gene in the species Homo sapiens
involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413
PPP2R1B
650.625.700.150 – antigens, cd45 MeSH D08.811.277.352.650.625.700.200 – cdc25 phosphatase MeSH D08.811.277.352.650.625.725 – pyruvate dehydrogenase
List_of_MeSH_codes_(D08)
CDC25
CDC25
CDC25
CDC25
Girl/Female
Hindu, Indian, Marathi, Sanskrit
Sporting; An Angel
Girl/Female
Muslim
Peacemaker
Boy/Male
Tamil
Leader, Senior, First born, Eldest brother
Female
Italian
Italian pet form of Latin Maria, MARIELLA means "obstinacy, rebelliousness" or "their rebellion."
Boy/Male
Arabic, Muslim
Surpassing; Excellent; Superior; Outstanding
Girl/Female
American, Australian
Valley
Girl/Female
French
Of Mars. Mars was mythological Roman god of fertility for whom the month March was named;...
Girl/Female
Tamil
Sudimna | ஸà¯à®¤à¯€à®®à®¨à®¾
The divine power initiated by a rare combination of constellations and stars. last known happening was around the month of Magh february
Girl/Female
Tamil
Lolaksi | லோலாகஸீÂ
A Shakti of Ganesh
Girl/Female
Hindu, Indian, Marathi, Sanskrit
Goddess of Truth
CDC25
CDC25
CDC25
CDC25
CDC25