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Protein-coding gene in humans
M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene. This gene is highly conserved during evolution and it plays a key
CDC25C
Family of conserved regulatory molecules
proteins. Binding of 14-3-3 has little effect on Cdc25C activity, and it is believed that 14-3-3 regulates Cdc25C by sequestering it to the cytoplasm, thereby
14-3-3_protein
Enzyme
model organisms examined have three Cdc25s, designated Cdc25A, Cdc25B, and Cdc25C. An exception is the nematode Caenorhabditis elegans, which has four distinct
Cdc25
Protein-coding gene in humans
checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science. 277 (5331): 1501–5. Bibcode:1997Sci...277.1501P
CHEK2
Class of enzymes
controlled by kinases and phosphatases such as WEE1 kinases, Myt1 kinases, and Cdc25c phosphatases for CDK1. Inhibitory phosphorylation does not significantly
Cyclin-dependent_kinase
Nuclear protein
inactivated by phosphorylation through Wee1 and activated by the phosphatase Cdc25C. Cdc25C in turn is activated by Polo kinase and inactivated by Chk1. Thus in
Wee1
Chemical compound
reproduction. Studies suggest that mouse cells are viable after the CDC25B (and CDC25C) genes are "knocked out", but removal of CDC25A results in non-viable cells
Indirubin
Third subphase of interphase
Specifically, CDK1 phosphorylation inhibits Wee1 kinase activity, activates Cdc25C phosphatase activity via activating the intermediate kinase PLK1, and stabilizes
G2_phase
(approx. 11), and the dephosphorylation step of Ser 287 in Cdc25C (also involved in Cdc25C activation) is even more ultrasensitive, displaying a Hill
Ultrasensitivity
Q9UJX2 2575 CDC25A HGNC:1725; P30304 2576 CDC25B HGNC:1726; P30305 2577 CDC25C HGNC:1727; P30307 2578 CDC26 HGNC:17839; Q8NHZ8 2579 CDC27 HGNC:1728; P30260
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Steroid lactone, mostly found in skin venom glands of toads
arrest. The induced cell cycle arrest occurs through the downregulation of CDC25C and upregulation of p21. Both of these processes are caused by the activation
Resibufogenin
Mitochondrial enzyme which breaks down cyanide
#Structure and mechanism): M-phase inducer phosphatase: CDC25A; CDC25B; CDC25C; Dual specificity protein phosphatase: DUSP; DUSP1; DUSP2; DUSP4; DUSP5;
Rhodanese
Protein-coding gene in humans
checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science. 277 (5331): 1501–5. doi:10.1126/science.277.5331
CHEK1
Human disease
antiangiogenic effects; and the candidate tumor suppressors EGR1, CTNNA1, and CDC25C. This syndrome affects bone marrow cells causing treatment-resistant anemia
Chromosome 5q deletion syndrome
Chromosome_5q_deletion_syndrome
Protein-coding gene in the species Homo sapiens
cycle progression and tumorigenesis. PLK3 has been shown to interact with: CDC25C, CHEK2, and P53. GRCh38: Ensembl release 89: ENSG00000173846 – Ensembl,
PLK3
Mammalian protein found in Homo sapiens
domain Topoisomerase PCNA has been shown to interact with: Annexin A2 CAF-1 CDC25C CHTF18 Cyclin D1 Cyclin O Cyclin-dependent kinase 4 Cyclin-dependent kinase
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Replication of the nuclear genome without mitosis
accompanied by sustained expression of G1/S cyclins and downregulation of cdc25c". Oncogene. 13 (4): 695–703. PMID 8761290. Zhang Y, Wang Z, Ravid K (1996)
Endoreduplication
Protein family
out of M phase of the cell cycle. At the end of S phase the phosphatase cdc25c dephosphorylates tyrosine15 and this activates the cyclin B/CDK1 complex
Cyclin_B
Protein-coding gene in the species Homo sapiens
Cdc25A which controls the checkpoints of G1/S and G2/M as well as Cdc25B and Cdc25C which both control the G2/M checkpoint. Myt 1 and Wee 1 kinases work together
PKMYT1
Class of enzymes
class of PTPs contains three cell cycle regulators, CDC25A, CDC25B and CDC25C, which dephosphorylate CDKs at their N-terminal, a reaction required to
Protein_phosphatase
Protein-coding gene in the species Homo sapiens
involved in cell cycle regulation. Cdc25C (G1/S positive regulator): Activation results in increased G1 → S Cdc25C (G2/M positive regulator): Activation
PIM1
Mammalian protein found in Homo sapiens
establishment of the bipolar spindle. Plk1 phosphorylates and activates cdc25C, a phosphatase that dephosphorylates and activates the cyclinB/cdc2 complex
PLK1
Protein-coding gene in the species Homo sapiens
Pan H, et al. (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj
PLK2
American oncologist
PMC 3295572. PMID 22215748. Lovly, Christine (2001). "Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding". Oncogene
Christine_Lovly
Protein-coding gene in humans
(found e.g. in the fungus species S. pombe), designated Cdc25A, Cdc25B, and Cdc25C. In contrast, some invertebrates harbour two (e.g., the Drosophila proteins
CDC25A
Protein-coding gene in the species Homo sapiens
molecules that facilitated the transition from the G2 to M phase such as Cdk1, Cdc25c, Plk1 and cyclin A. Therefore the delivery of a therapeutic gene to correct
Cyclin_B1
Protein-coding gene in the species Homo sapiens
causes an increase of Chfr and a decrease in PLK1, which activates the CDC25c phosphatase. Thus, this route may be able to regulate cell division independent
STIL
Protein-coding gene in humans
PMID 10403798. Karlsson C, Katich S, Hagting A, et al. (1999). "Cdc25b and Cdc25c Differ Markedly in Their Properties as Initiators of Mitosis". J. Cell Biol
CDC25B
Protein-coding gene in the species Homo sapiens
elemonic acid derivatives Pin1 has been shown to interact with: C-jun, CDC25C, CDC27, CSNK2A2, Casein kinase 2, alpha 1, DAB2, eNOS, FOXO4, MPHOSPH1,
PIN1
Japanese scientist (born 1952)
the mouse: changes in the subcellular localization of cdc2, cyclin B1, cdc25C and wee1, and in the concentration of these proteins and their transcripts"
Hitoshi_Okamura
Taniguchi, E. & Nishida, E. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep. 3, 341–348 (2002). McNally, K. P., Buster, D
Polo-like_kinase
Protein-coding gene in the species Homo sapiens
checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science. 277 (5331): 1501–5. doi:10.1126/science.277.5331
YWHAH
Protein-coding gene in the species Homo sapiens
Farber JL, Donovan PJ, Croce CM (Mar 2007). "Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development".
LZTS1
Protein-coding gene in the species Homo sapiens
Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization"
Wee1-like_protein_kinase
Chemical compound
"Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells". Toxicology and Applied
Xanthatin
Chromatin remodeling complex
Yifan; Zhang, Baoyuan; Shim, Joong Sup (10 August 2018). "Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
Protein-coding gene in the species Homo sapiens
MT, Piwnica-Worms H (1998). "C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding". Cell Growth Differ.
MARK3
Protein-coding gene in the species Homo sapiens
elucidated. MAPK14 has been shown to interact with: AKT1, ATF2, CDC25B, CDC25C, CSNK2A1, DUSP10, DUSP16, DUSP1, FUBP1, HTRA2, KRT8 MAP2K6, TAB1, MAPK1
MAPK14
CDC25C
CDC25C
CDC25C
CDC25C
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CDC25C
CDC25C
CDC25C
CDC25C
CDC25C