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Syndrome causing muscle loss
Cachexia (/kəˈkɛksiə/ ) is a syndrome that occurs in people with certain illnesses, causing muscle loss that cannot be fully reversed with improved nutrition
Cachexia
Loss of skeletal muscle mass
starvation and can be reversed with nutritional therapy. In contrast, cachexia is a wasting syndrome caused by an underlying disease such as cancer that
Muscle_atrophy
International non-profit organization
Cachexia and Wasting Disorders (SCWD) is an international and multidisciplinary non-profit organization, created in 2008 that focuses on cachexia and
Society on Sarcopenia, Cachexia and Wasting Disorders
Society_on_Sarcopenia,_Cachexia_and_Wasting_Disorders
Academic journal
The Journal of Cachexia, Sarcopenia and Muscle is a quarterly peer-reviewed medical journal that covers research relevant to changes in body composition
Journal of Cachexia, Sarcopenia and Muscle
Journal_of_Cachexia,_Sarcopenia_and_Muscle
Early onset muscle loss due to ageing or immobility
to changes in muscle synthesis signalling pathways. It is distinct from cachexia, in which muscle is degraded through cytokine-mediated degradation, although
Sarcopenia
Medical condition
dietary needs of each animal have to be considered to avoid causing harm. Cachexia Anorexia Underweight Malnutrition Undernutrition in children "Emaciation"
Emaciation
Monoclonal antibody
that works as a GDF-15 inhibitor. It is developed by Pfizer for cancer cachexia. In September 2024, Pfizer disclosed that ponsegromab led to significant
Ponsegromab
Reduction of the total body mass
caused by reduction in calorific intake or increase in exercise is called cachexia and may be a symptom of a serious medical condition. Weight loss typically
Weight_loss
Severe malnutrition due to energy deficiency
ways to reduce the risks of developing these deficiencies. Starvation Cachexia Emaciation Kwashiorkor Protein poisoning Appleton & Vanbergen, Metabolism
Marasmus
Chemical compound
under development by Helsinn Healthcare SA for the treatment of cancer cachexia and anorexia. Anamorelin significantly increases plasma levels of growth
Anamorelin
Medical food used to treat muscle wasting associated with AIDS or cancer
clinical trials in individuals with AIDS and cancer, but not rheumatoid cachexia. Clinical trials with Juven for AIDS have also demonstrated improvements
Juven
Desire to eat food
Dysregulation of appetite contributes to ARFID, anorexia nervosa, bulimia nervosa, cachexia, overeating, and binge eating disorder. A limited or excessive appetite
Appetite
German cardiologist
is a German cardiologist who is Head of Field “Tissue Homeostasis and Cachexia" at Charité University, Berlin, Germany. Previously, he was Professor of
Stefan_D._Anker
Physical activity that improves health
people with cancer cachexia are encouraged to engage in physical exercise. Due to various factors, some individuals with cancer cachexia have a limited capacity
Exercise
Androgenic Anabolic steroid
name Durabolin). Nandrolone esters are used in the treatment of anemias, cachexia (muscle wasting syndrome), osteoporosis, breast cancer, and for other indications
Nandrolone
Class of pharmaceutical drugs
been investigated in human studies for the treatment of osteoporosis, cachexia (wasting syndrome), benign prostatic hyperplasia, stress urinary incontinence
Selective androgen receptor modulator
Selective_androgen_receptor_modulator
Pharmaceutical drug
used mainly as an appetite stimulant to treat wasting syndromes such as cachexia. It is also used to treat breast cancer and endometrial cancer, and has
Megestrol_acetate
Investigational selective androgen receptor modulator
development for a variety of other indications, including treatment of cachexia, Duchenne muscular dystrophy, muscle atrophy or sarcopenia, and stress
Enobosarm
Organic mental disorder caused by late-stage syphilis
concentration Later: Delusions, dementia, tremors, hyperreflexia, seizures, cachexia Usual onset 10-30 years after initial infection Causes Meningoencephalitis
General_paresis_of_the_insane
Chemical compound
with AIDS and cancer, but not rheumatoid cachexia. Further research involving the treatment of cancer cachexia with Juven over a period of several months
Β-Hydroxy β-methylbutyric acid
Β-Hydroxy_β-methylbutyric_acid
Group of diseases involving cell growth
inflammatory state that leads to ongoing muscle loss and weakness, known as cachexia. Some cancers, such as Hodgkin's disease, leukemias, and liver or kidney
Cancer
U.S. state
glaucoma, HIV/AIDS, muscle spasms, seizures, severe pain, severe nausea and cachexia, or dramatic weight loss and muscle atrophy". While governor, John Hickenlooper
Colorado
Prion disease of the human brain
neuropathology Symptoms Progressive insomnia, ataxia, double vision, cachexia, high blood pressure, excessive sweating, fever, agrypnia excitata, panic
Fatal_insomnia
Pharmaceutical compound
MC4 receptor antagonist which is under development for the treatment of cachexia. It is a synthetic cyclic peptide and is taken by subcutaneous injection
Mifomelatide
Chemical compound
with hip fracture. It was also under development for the treatment of cachexia, hypogonadism, and osteoporosis, but development for these indications
LGD-4033
Scottish surgeon and cancer specialist
Surgical Oncology at the University of Edinburgh with a special interest in cachexia. He was born in Glasgow on 3 August 1960 the son of Pat and Alfred Fearon
Kenneth_Fearon
Spectrum of conditions caused by HIV infection
conditions that alert to the presence of AIDS are pneumocystis pneumonia (40%), cachexia in the form of HIV wasting syndrome (20%), and esophageal candidiasis.
HIV/AIDS
Chronic disease of the liver, characterized by fibrosis
active compounds. Acute kidney injury (particularly hepatorenal syndrome). Cachexia associated with muscle wasting and weakness. Cirrhosis has many possible
Cirrhosis
Changes in the face as a medical sign
is named after Hippocrates, who first described it. A related term is cachexia, which is the bodily wasting syndrome often associated with death. "Medical
Hippocratic_facies
Opioid medication
profound body fat loss (people with cancer, cardiac or infection-induced cachexia can lose 80% of their body fat). Early carbon dioxide retention causes
Fentanyl
Common condition in chronic disease states such as chronic kidney disease
complex (syndrome) (MICS), also known as malnutrition–inflammation–cachexia syndrome, is a common condition in chronic disease states such as chronic
Malnutrition–inflammation complex
Malnutrition–inflammation_complex
Medical condition
secondary to other conditions such as chronic renal disease or cancer cachexia in which protein energy wasting (PEW) may occur. Protein–energy undernutrition
Protein–energy_malnutrition
Lung disease involving long-term poor airflow
infections, secondary polycythemia, respiratory failure, pneumothorax, and cachexia (muscle wasting). Tuberculosis is a risk factor for the development of
Chronic obstructive pulmonary disease
Chronic_obstructive_pulmonary_disease
Medical condition
FACES syndrome is a syndrome of unique facial features (facies), anorexia, cachexia, and eye and skin anomalies. It is a rare disease and estimated to occur
FACES_syndrome
Medical condition
optimistic, but the disease is lethal if untreated, with death occurring via cachexia, bowel obstruction, or other types of complications. This disease is most
Pseudomyxoma_peritonei
Syndrome of reduced energy intake or utilization in older adults
malnutrition. Malnutrition is closely related to frailty, sarcopenia and cachexia, other syndromes common in older adults and with similar signs, symptoms
Undernutrition in older adults
Undernutrition_in_older_adults
Protein-coding gene in humans
non-alcoholic fatty liver disease, cardiovascular disease and cancer cachexia. Treatment of rodents fed a high-fat diet with recombinant growth differentiating
GDF15
(AN-tee-kuh-KEK-see-uh) is a drug or effect that works against cachexia (loss of body weight and muscle mass). Cachexia#Management National Cancer Institute Dictionary
Anticachexia
Partial or complete wasting away of a part of the body
diseases such as cancer and AIDS induce a body wasting syndrome called cachexia, which is notable for the severe muscle atrophy seen. Other syndromes or
Atrophy
One of three major types of muscle
including cancer, AIDS, and heart failure can cause muscle loss known as cachexia. Myopathies have been modeled with cell culture systems of muscle from
Skeletal_muscle
Immunomodulatory drug
Johns T, Goggin PM (April 2005). "Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial". Gut. 54 (4): 540–545. doi:10.1136/gut
Thalidomide
Dissociative anesthetic and anti-depressant
pain. Chronic ketamine abuse has also been associated with biliary colic, cachexia, gastrointestinal diseases, hepatobiliary disorder, and acute kidney injury
Ketamine
Appetite-suppressant candy
similarity of names and the fact that the disease caused immense weight loss (cachexia) in patients. In a September 1985 newspaper interview titled "AIDS has
Ayds
Medical condition
diarrhea, and eczematous or erythrodermatous rashes. Failure to thrive and cachexia are later signs of a T-cell deficiency. In terms of the normal mechanism
T_cell_deficiency
Antidepressant medication
PMID 21602639. Kast RE, Foley KF (July 2007). "Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea
Mirtazapine
All Latin and Greek roots beginning with G
English examples cac-, kak- bad Greek κακός (kakós), κάκιστος (kákistos) cachexia, cacistocracy, cacodemon, cacoepy, cacography, cacophobia, cacophobe, cacophobic
List of Greek and Latin roots in English/A–G
List_of_Greek_and_Latin_roots_in_English/A–G
Personality disorder involving orderliness
Retrieved 2026-07-08. DuBOIS FS (August 1949). "Compulsion neurosis with cachexia (anorexia nervosa)". The American Journal of Psychiatry. 106 (2): 107–15
Obsessive–compulsive personality disorder
Obsessive–compulsive_personality_disorder
Chemical compound
experimental compound reached Phase I clinical trials for the treatment of cachexia and heart failure. However, as of February 2014, GSK discontinued the development
GSK-2849466
Protein-coding gene in the species Homo sapiens
and have impaired ovulation, while elevated levels are associated with cachexia and certain cancers. The human NRIP1 gene is located on the long arm of
NRIP1
Caloric intake below what is needed to maintain an organism's life
punishment for slaves. 2007–2008 world food price crisis Anorexia mirabilis Cachexia Global Hunger Index Starvation mode Famine scales Hunger strike List of
Starvation
Australian biochemist
is cachexia. In 2015 his team published research showing how mice that do not have the receptor for a protein called Fn14 do not develop cachexia in cancer
Nick_Hoogenraad
Loss of muscle and fat tissue
peas) can assist in controlling the loss of muscle mass. Anorexia Atrophy Cachexia Superior mesenteric artery syndrome Weight loss UNICEF/WHO/The World Bank
Wasting
Class of medications used primarily to treat high blood pressure
enalapril has also been shown to reduce cardiac cachexia in patients with chronic heart failure. Cachexia is a poor prognostic sign in patients with chronic
ACE_inhibitor
American vocal duo (1965–1983)
first item was heart failure, followed by anorexia. The third finding was cachexia, which is extremely low weight and weakness and general body decline associated
The_Carpenters
Pharmaceutical company
company focused on the development of novel treatments for IBS and anorexia/cachexia associated with cancer and other major pathologies. Rose Pharma was formerly
RosePharma
Medical condition
these comorbidities to improve the overall prognosis of ACM. Heart failure Cachexia Arrhythmias Cardioembolism Death There are several complications that can
Alcoholic_cardiomyopathy
Neurodegenerative disorder
feeding tube infections, and aspiration pneumonia. Some deaths are caused by cachexia, also known as wasting syndrome. Multiple system atrophy is estimated to
Multiple_system_atrophy
Chemical compound
(age-related muscle atrophy), osteoporosis, and weight loss due to cancer cachexia, but development for these indications was discontinued. The drug is taken
Vosilasarm
Androgenic and anabolic steroid medication
hypogonadism (as a form of androgen replacement therapy), male osteoporosis, and cachexia (in cancer patients) and in Australia for the treatment of benign prostatic
Androstanolone
Drug used to prevent nausea or vomiting
of age. Hydroxyzine (Vistaril) Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents
Antiemetic
Peptide hormone involved in appetite regulation
with cancer-induced cachexia. There is insufficient evidence to conclude either for or against use of ghrelin in managing cachexia associated with cancer
Ghrelin
Medication
receptor modulator (SARM). It has been investigated for the treatment of cachexia and muscular dystrophy. ACP-105 Enobosarm JNJ-28330835 Ligandrol Nique
GLPG-0492
Chemical compound
medical treatment for the loss of appetite (anorexia) and rapid weight loss (cachexia), which are often associated with cancer. Although it has been marketed
Hydrazine_sulfate
Chemical element with atomic number 30 (Zn)
stimulator – the possible role of zinc in the progression of diseases such as cachexia and sarcopenia". Recent Patents on Food, Nutrition & Agriculture. 3 (3):
Zinc
American medical researcher (born 1963)
dialysis patients, or those with chronic disease states and wasting syndrome (cachexia), whereas normal to low body mass index or normal values of serum cholesterol
Kamyar_Kalantar-Zadeh
Chemical compound
Cord factor isolated from species of Nocardia has been shown to cause cachexia in mice. Severe muscle wasting occurred within 48 hours of the toxin being
Cord_factor
Substance that increases appetite
PMID 20586697. Strasser F, Bruera ED (June 2002). "Update on anorexia and cachexia". Hematology/Oncology Clinics of North America. 16 (3): 589–617. doi:10
Appetite_stimulant
Chemical compound
described in the literature by 2002. It completed phase 1 clinical trials for cachexia in 2003. Three phase 1 trials (1a, 1b, 1c) were completed with the drug
Andarine
Italian Roman Catholic priest
complete and lasting healing of Peter Chungu Shitima by polyineuritis and cachexia in positive HIV subject. "Saint Luigi Scrosoppi of Udine". Saints SQPN
Luigi_Scrosoppi
Mammalian and avian protein
myostatin levels during chronic heart failure have been shown to cause cardiac cachexia. Systemic inhibition of cardiac myostatin with the JA-16 antibody maintains
Myostatin
Genus of bacteria
also found in the bacterial genus Mycobacterium. This toxin can cause cachexia, a form of muscle wasting. The most commonly encountered species are Nocardia
Nocardia
German medical research scientist (born 1965)
hdl:1887/3716274. ISSN 2041-1723. "Eugen Leo: Advancing Cancer Care - Tackling Cachexia and Tumor Resistance - OncoDaily". 2024-12-13. Retrieved 2025-09-29. Melero
Eugen_Leo
Medical condition: obesity and loss of muscle
Normal weight obesity Weight training Waist-to-height ratio Journal of Cachexia, Sarcopenia and Muscle Batsis, John A.; Villareal, Dennis T. (September
Sarcopenic_obesity
Protein-coding gene in the species Homo sapiens
lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung
AZGP1
Consolidating a motor task into memory through repetition
systematic review and meta-analysis of human and animal studies". Journal of Cachexia, Sarcopenia and Muscle. 13 (5): 2276–2297. doi:10.1002/jcsm.13043. PMC 9530508
Muscle_memory
Ionic compound (KBr)
lethargy, somnolence (from daytime sleepiness to coma) loss of appetite and cachexia, nausea/emesis with exicosis (loss of body fluid) loss of reflexes or pathologic
Potassium_bromide
Shoulder muscle
various causes, including aging, disuse, denervation, muscular dystrophy, cachexia and iatrogenic injury. Deltoidal humeral enthesopathy is an exceedingly
Deltoid_muscle
Rare type of blood cancer
bleeding due to inadequate numbers of platelets Increased risk of thrombosis Cachexia (loss of appetite, weight loss, and fatigue) Fatigue Fevers Chills Weight
Primary_myelofibrosis
Eating disorder
Assessment Questionnaire (SNAQ) and Functional Assessment of Anorexia/Cachexia Therapy (FAACT). Specific to the geriatric populace, the interRAI system
Anorexia
Historic pharmaceutical substance of human origin
was also regarded as a panacea for particular diseases associated with cachexia (e.g. tuberculosis). Also an analgesic effect in rheumatoid arthritis was
Human_fat
Endocrine disorder in cats
hyperthyroidism treated. The reasons for this are not currently known. Cachexia is a possible symptom in hyperthyroid cats but due to improved screening
Feline_hyperthyroidism
Chemical compound
supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia". Bone. 162 116467. doi:10.1016/j.bone.2022.116467. PMID 35688360. Candow
Creatine
Cancer associated with asbestos
levels of IL-2 toxicity and the severity of side effects such as fever and cachexia. Nonetheless, other trials involving interferon alpha have proved more
Mesothelioma
Protein-coding gene in the species Homo sapiens
this enzyme often leads to diseases such as maple syrup urine disease and cachexia. BCKDK's structure consists of a characteristic nucleotide-binding domain
BCKDK
Holocaust victim (1928–1943)
death certificate, issued on 23 March, falsely noted that she died of cachexia from intestinal catarrh. Reports indicate that the real cause of death
Czesława_Kwoka
Medical condition
syndrome is used infrequently for acquired hypopituitarism, especially when cachexia (general ill health and malnutrition) predominates. Most of the classic
Hypopituitarism
Breeds of cattle with mutations that result in enhanced muscle growth
that excessive myostatin activity could induce a phenotype resembling cachexia. He further demonstrated that additional molecules within the transforming
Double-muscled_cattle
Canadian gastroenterologist (born 1935)
A. Dave; Pisani, Barbara; Agarwala, Ravi (May 2016). "Malnutrition and Cachexia in Heart Failure". JPEN. Journal of Parenteral and Enteral Nutrition. 40
Khursheed_Jeejeebhoy
Human hormone
result of sarcopenia in isolated mouse skeletal muscle fibres". Journal of Cachexia, Sarcopenia and Muscle. 8 (1): 48–56. doi:10.1002/jcsm.12122. PMC 4863930
Dihydrotestosterone
Common side effects in chemotherapy treatment
Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group"
Chemotherapy-induced nausea and vomiting
Chemotherapy-induced_nausea_and_vomiting
Independent city in Virginia, United States
ignored. Mitchell's official cause of death was a heart condition and cachexia. The allegations stated that Mitchell had been denied many meals and left
Portsmouth,_Virginia
Parasitic disease in cats
hepatomegaly, chronic nasal discharge, upper airway obstructive syndrome, cachexia, polyuria, polydipsia, fever, diarrhea, mastitis, subcutaneous panniculitis
Feline_leishmaniosis
Medical speciality
mainly related to poverty. The main causes of clinical malnutrition are: Cachexia caused by diseases, injuries and/or aging Difficulties with ingestion,
Clinical_nutrition
Australian–British academic cardiologist (born 1958)
patents have formed the basis of companies specialising in the treatment of cachexia (Myotec and PsiOxus). Andrew Stewart Coats was born and raised in Melbourne
Andrew_Stewart_Coats
Injectable form of birth control
Anker SD, Inui A, Nicholson JR (22 December 2005). Pharmacotherapy of Cachexia. CRC Press. pp. 292–. ISBN 978-1-4200-4895-7. Medroxyprogesterone [acetate]
Medroxyprogesterone_acetate
Pharmaceutical compound
gain is desirable, such as treatment of sarcopenia in the elderly and cachexia in patients affected by conditions such as cancer and AIDS. While HTL26119
HTL26119
across the lifespan: a narrative review of the literature". Journal of Cachexia, Sarcopenia and Muscle. 9 (3): 453–464. doi:10.1002/jcsm.12287. PMC 5989853
Management_of_cerebral_palsy
Causes of low blood sugar in humans
stages of diabetes Benign glucosuria Binge drinking Bulimia nervosa Burns Cachexia Carbohydrate-deficient glycoprotein syndrome type 1b Carnitine palmitoyltransferase
List of causes of hypoglycemia
List_of_causes_of_hypoglycemia
Expert in nutrition and malnutrition
designing an enteral tube feeding regimen or mitigating the effects of cancer cachexia. Many dietitians work in hospitals and usually see specific patients where
Dietitian
Exercise to improve strength
(19 November 2017). "Skeletal muscle performance and ageing". Journal of Cachexia, Sarcopenia and Muscle. 9 (1): 3–19. doi:10.1002/jcsm.12238. ISSN 2190-5991
Strength_training
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