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Mammalian protein found in Homo sapiens
Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver
Antithrombin
Medical condition
Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. This deficiency may be inherited or acquired. It is a rare
Antithrombin_III_deficiency
Process of formation of blood clots
Factor V or high levels of FVIII, also may lead to a thrombotic tendency. Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases:
Coagulation
Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed in
Thrombin–antithrombin_complex
Class of drugs
approves Antithrombin as an anticoagulant for preventing clots before, during, or after surgery or birthing in patients with hereditary antithrombin deficiency
Anticoagulant
ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company rEVO Biologics (formerly known as GTC Biotherapeutics)
ATryn
Anticoagulant
polysaccharides. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It
Heparin
Chemical compound
direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa. Fondaparinux
Fondaparinux
Medication
Qfitlia, is a medication used for the treatment of hemophilia. It is an antithrombin-directed small interfering ribonucleic acid. It is given by subcutaneous
Fitusiran
Australian biotechnology company
Rhophylac (Rh(D) immunoglobulin G) Tetanus Immunoglobulin-VF Thrombotrol-VF (antithrombin III) Vivaglobin, sub-cutaneous human immune globulin indicated for the
CSL_Limited
Chemical compound in leeches
principal inhibitor of thrombin in normal blood circulation is antithrombin. Similar to antithrombin, the anticoagulant activity of hirudin is based on its ability
Hirudin
Formation of a blood clot in a deep vein
VTE rates. Genetic factors include non-O blood type, deficiencies of antithrombin, protein C, and protein S and the mutations of factor V Leiden and prothrombin
Deep_vein_thrombosis
Enzyme involved in blood coagulation in humans
the coagulation cascade. In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels
Thrombin
Anticoagulant medication
and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time. However, protamine
Low-molecular-weight_heparin
Complex that catalyzes conversion of prothrombin to thrombin
"Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational
Prothrombinase
Abnormality of blood coagulation increasing the risk of blood clotting (thrombosis)
first major form of thrombophilia to be identified by medical science, antithrombin deficiency, was identified in 1965, while the most common abnormalities
Thrombophilia
Vertebrate organ involved in metabolism
VII, VIII, IX, X, XI, XII, XIII, as well as protein C, protein S and antithrombin. The liver is a major site of production for thrombopoietin, a glycoprotein
Liver
Symptoms resulting from kidney damage
particularly those caused by a decrease in blood antithrombin III levels due to leakage. Antithrombin III counteracts the action of thrombin. Thrombosis
Nephrotic_syndrome
Superfamily of proteins with similar structures and diverse functions
reported in the late 1800s, but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated, with the subsequent recognition
Serpin
Topics referred to by the same term
transaccional (Spanish for "transactional analysis"), a psychological method Antithrombin, a small protein molecule Ataxia–telangiectasia, an immunodeficiency
AT
Soluble protein complex in blood plasma and involved in clot formation
reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial
Fibrinogen
Eradicated viral disease
the elements of the coagulation cascade and an increase in circulating antithrombin. This form of smallpox occurs anywhere from 3% to 25% of fatal cases
Smallpox
Nucleic acid sequence
lead to mutations through intrastrand and interstrand switching. The antithrombin III gene's coding region is an example of an imperfect inverted repeat
Inverted_repeat
Blockage of an artery in the lungs
prothrombin mutation G20210A, protein C deficiency, protein S deficiency, antithrombin deficiency, hyperhomocysteinemia and plasminogen/fibrinolysis disorders)
Pulmonary_embolism
Liquid portion of whole blood
and rechecking laboratory values. Use in antithrombin III deficiency: FFP can be used as a source of antithrombin III in patients who are deficient of this
Fresh_frozen_plasma
Spanish pharmaceutical and chemical manufacturer
chronic obstructive pulmonary disease (COPD). Antithrombin to treat patients with hereditary antithrombin deficiency (a blood-clotting problem). Specific
Grifols
Polysaccharides found in animal tissue
Petitou M, Pike RN, Carrell RW (1997). "The anticoagulant activation of antithrombin by heparin". Proceedings of the National Academy of Sciences of the United
Glycosaminoglycan
Anticoagulant drug
thrombosis-thrombocytopenia syndrome. It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin
Bivalirudin
Enzyme that cleaves other proteins into smaller peptides
excessive protease-triggered activation of its own complement system), antithrombin (which protects the body from excessive coagulation), plasminogen activator
Protease
Class of autoantibodies found in mammals
erythematosus. In mammals, there is normally occurring anti-thrombin activity (antithrombin III), which can be distinguished from autoimmune anti-thrombin. Anti-thrombin
Anti-thrombin_antibodies
Life-threatening response to infection
preparations of IVIG is inconsistent. On the other hand, the use of antithrombin to treat disseminated intravascular coagulation is also not useful. Meanwhile
Sepsis
Laboratory blood test
to thrombin. Unlike thrombin, reptilase is resistant to inhibition by antithrombin III. Thus, the reptilase time is not prolonged in blood samples containing
Reptilase_time
the Antithrombin molecules in neonates and children is larger than in adults. Antithrombin: the levels of antithrombin increase with age. Antithrombin levels
Developmental_Haemostasis
that causes or promote tissue necrosis Prothrombin mutation Malignancy Antithrombin deficiency Pregnancy Immobility Surgery Trauma Thrombocytopenic purpura
Thrombotic_storm
Protein-coding gene in the species Homo sapiens
inhibits IIa, and is a cofactor for heparin and dermatan sulfate ("minor antithrombin"). The product encoded by this gene is a serine protease inhibitor which
Heparin_cofactor_II
Protein family
endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated
Syndecan
Layer of cells that line the inner surface of blood vessels
clotting, including heparan sulfate which acts as a cofactor for activating antithrombin, a protein that inactivates several factors in the coagulation cascade
Endothelium
Mammalian protein found in humans
An extremely rare form of Pi, termed PiPittsburgh, functions as an antithrombin (a related serpin), due to a mutation (Met358Arg). One person with this
Alpha-1_antitrypsin
Blood clot
cascade. Heparin works by binding to and activating the enzyme inhibitor antithrombin III, an enzyme that acts by inactivating thrombin and factor Xa. In contrast
Thrombus
Class of polysaccharides
hydrogen bonding. Some examples of heparin binding proteins include antithrombin III. It is thought that much protein interaction with heparin is not
Heparinoid
Three factors thought to cause internal blood clots (thrombosis)
Leiden mutation, coagulation factor II G2021A mutation, deficiency of antithrombin III, protein C or S deficiency, nephrotic syndrome, changes after severe
Virchow's_triad
Anticoagulant drug
inhibit the activity of factor Xa, indirectly, by binding to circulating antithrombin (AT III) and must be injected, whereas the orally active warfarin, phenprocoumon
Rivaroxaban
Formation of blood clots inside the blood vessels
altered coagulation Elevated factors II, VIII, IX, XI altered coagulation Antithrombin III deficiency altered coagulation Falls and hip fracture related to
Thrombosis
Macromolecule
are divided into two functional subcategories, those that generate an antithrombin III binding site (HS3ST1 and HS3ST5) and those that generate a herpes
Heparan_sulfate
Medical condition
other causes for hypercoagulation, it may be appropriate to check the antithrombin, protein C, protein S, factor V Leiden, prothrombin G20210A, and antiphospholipid
May–Thurner_syndrome
Enzyme used as medication and in food manufacturing
isolated decrease of fibrinogen) and anticoagulant factor (generally antithrombin III; sometimes protein C and S as well), leading to bleeding or thrombotic
Asparaginase
Chemical compound
mediates anticoagulation by inhibiting the activity of the clotting factor antithrombin III. SPS has been a common component of blood culture media since the
Sodium_polyanethol_sulfonate
Processes of separating the various components of blood plasma
immune thrombocytopenic purpura Guillain–Barré syndrome Polyneuropathies antithrombin III congenital deficiency disseminated intravascular coagulation fibrinogen
Blood_plasma_fractionation
Primary female sex hormone
Increase circulating level of factors 2, 7, 9, 10, plasminogen Decrease antithrombin III Increase platelet adhesiveness Increase vWF (estrogen -> Angiotensin
Estrogen
Bleeding into the brain's ventricular system
determine the safety, dosing, and effectiveness of prophylactic heparin and antithrombin treatment for preterm neonates. In infants, germinal matrix haemorrhage
Intraventricular_hemorrhage
British academic
homozygous deficiency of antithrombin III: successful outcome following pulmonary thrombectomy and infusions of antithrombin III concentrate". His most
Reza_Razavi
Pharmaceutical compound
like antithrombin and heparin cofactor II, which prevent clotting when it is not necessary. In contrast, batroxobin is not inhibited by antithrombin and
Batroxobin
Immune disorder leading to increased risk of blood clots
performed using a chromogenic assay based on the inhibition of factor Xa by antithrombin in the presence of heparin.[citation needed] Anti-cardiolipin antibodies
Antiphospholipid_syndrome
Abnormally high platelet count in the blood
Coagulation coagulopathy Bleeding diathesis Clotting By cause Clotting factors Antithrombin III deficiency Protein C deficiency Activated protein C resistance Factor
Thrombocythemia
Medical condition
anticoagulant, decreases. However, the other major anticoagulants, protein C and antithrombin III, remain constant. Fibrinolysis is impaired by an increase in plasminogen
Hypercoagulability in pregnancy
Hypercoagulability_in_pregnancy
transaminase ASX asymptomatic A-T ataxia-telangiectasia AT antithrombin angiotensin AT-III antithrombin III ATA antitransglutaminase antibodies ATB antibiotic
List of medical abbreviations: A
List_of_medical_abbreviations:_A
reliable for measuring ongoing coagulation than other markers like thrombin–antithrombin complexes and fibrinopeptide A. Concentrations of F1+2 in healthy individuals
Prothrombin_fragment_1+2
Pharmaceutical drug
stroke or heart attack. Dalteparin acts by potentiating the activity of antithrombin III, inhibiting formation of both Factor Xa and thrombin. It is normally
Dalteparin_sodium
Biomarkers of blood signals
fibrinolysis. Examples include prothrombin fragment 1+2 (F1+2), thrombin–antithrombin complex (TAT), fibrinopeptide A (FpA), fibrin monomers (FMs), plasmin-α2-antiplasmin
Coagulation_activation_marker
Anticoagulant medication (blood thinner)
bleeding and neurological changes. Enoxaparin binds to and activates antithrombin (a circulating anticoagulant) to form a complex that irreversibly inactivates
Enoxaparin_sodium
Carbohydrate-rich layer at the periphery of a cell
Extracellular superoxide dismutase (SOD3) Angiotensin converting enzyme Antithrombin-III Lipoprotein lipase Apolipoproteins Growth factors Chemokines The
Glycocalyx
Blockage of the hepatic veins that drain the liver
mutation (3%), protein C deficiency (5%), protein S deficiency (4%), and antithrombin III deficiency(1%). Budd–Chiari syndrome may be the presenting sign of
Budd–Chiari_syndrome
Insufficient blood flow due to abnormal distribution in the capillaries
activated monocytes and the endothelial cells lining the blood vessels while antithrombin and fibrinolysis are impaired. Disseminated intravascular coagulation
Distributive_shock
French biologist
blood coagulation in vertebrates, demonstrating the hepatic origin of antithrombin and describing the blood coagulation system of birds. In 1900 he relocated
Camille_Delezenne
Medical condition
screen- to detect chronic venous thromboembolism (proteins C and S, antithrombin III, homocysteine levels) The diagnosis of pulmonary heart disease is
Pulmonary_heart_disease
Common human medical data ranges for blood test results
774–77. PMID 9666418. MedlinePlus Encyclopedia: 003652 Antithrombin III at eMedicine Antithrombin CO000300 Archived 2017-09-09 at the Wayback Machine in
Reference ranges for blood tests
Reference_ranges_for_blood_tests
Mammalian protein found in Homo sapiens
derivatives low molecular weight heparin (LMWH) bind to a plasma cofactor, antithrombin (AT) to inactivate several coagulation factors IIa, Xa, XIa and XIIa
Factor_X
proteins Coagulation: increase circulating level of factors 2, 7, 9, 10, antithrombin III, plasminogen increase platelet adhesiveness Fluid balance: salt (sodium)
List_of_human_hormones
Technique that temporarily takes over the function of the heart and lungs during surgery
requiring CPB. A small percentage of patients, such as those with an antithrombin III deficiency, may exhibit resistance to heparin. In these patients
Cardiopulmonary_bypass
Genetic X-linked recessive bleeding disorder
therapy that utilizes small interfering RNA (siRNA) technology to reduce antithrombin levels, thereby increasing thrombin generation and promoting clot formation
Haemophilia_B
Drug made from biological source
Phillip B. C. Jones. "European Regulators Curdle Plans for Goat Milk Human Antithrombin" (PDF). Archived from the original (PDF) on 2020-10-20. Retrieved 2006-06-23
Biopharmaceutical
Combination of screening laboratory tests
aggregation, or specific factor inhibitor assays, like Protein C, TFPI, Antithrombin etc. Kurbegov, Amethyst C.; Hoffenberg, Edward J. (1 January 2011). "Bloody
Coagulation_screen
Blood clot (thrombus) that forms within a vein
essential thrombocytosis and polycythemia vera Chemotherapy Heart failure Antithrombin deficiency Protein C deficiency Protein S deficiency (type I) Factor
Venous_thrombosis
Pharmaceutical drug
fractions, sulodexide potentiates the antiprotease activities of both antithrombin III and heparin cofactor II simultaneously. Clinically, sulodexide is
Sulodexide
Medical treatment to prevent clotting within blood vessels
tests are being developed. These include the evaluation of the thrombin–antithrombin complexes (TAT), low levels of the anticoagulants ATIII and protein C
Thrombosis_prevention
Protein involved in blood clotting, wound healing and inflammation
on the endothelial surface of blood vessels, thereby inhibiting local antithrombin activity and promoting coagulation. As a strong chemoattractant for neutrophils
Platelet_factor_4
Biologist and chief scientific adviser
"The effect of a reducing-end extension on pentasaccharide binding by antithrombin". The Journal of Biological Chemistry. 275 (12): 8733–8741. doi:10.1074/jbc
Tim_Dafforn
Class of enzymes
serine protease, inhibiting its function. The best-studied serpins are antithrombin and alpha 1-antitrypsin, studied for their role in coagulation/thrombosis
Serine_protease
Protein involved in coagulation
arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by antithrombin. Factor IX expression increases with age in humans and mice. In mouse
Factor_IX
Class of proteins involved in inflammation
include albumin, transferrin, transthyretin, retinol-binding protein, antithrombin, transcortin. The decrease of such proteins may be used as markers of
Acute-phase_protein
Medical condition
ranging from increased tendency to bleed to excessing clotting due to antithrombin III activity Hypertrichosis or excessive hair growth Hypothyroidism Growth
SRD5A3-CDG
American medical researcher
Hopkins School of Medicine, studying blood thinning proteins, such as antithrombin. In 1915, he secured a junior position on the medical staff of the Massachusetts
George_Minot
Exocrine gland in humans and other mammals
pharmaceutical use. Complex glycoproteins such as monoclonal antibodies or antithrombin cannot be produced by genetically engineered bacteria, and the production
Mammary_gland
Topics referred to by the same term
Thematic apperception test, a projective psychological test Thrombin–antithrombin complex, a protein complex Tropine acyltransferase, an enzyme Twin-arginine
Tat
Anticoagulant medication
per day, to co-administering heparin, an anticoagulant that acts upon antithrombin and helps reduce the risk of thrombosis, is beneficial, with warfarin
Warfarin
Inactivate an enormous variety of proteinases α2-macroglobulin α1-antitrypsin Antithrombin III Protein S Protein C Fibrinolysis: Breakdown of fibrin clots Plasminogen
Proteins produced and secreted by the liver
Proteins_produced_and_secreted_by_the_liver
Genetic engineering to produce pharmaceuticals
in genetically modified livestock. The drug is called ATryn, which is antithrombin protein purified from the milk of genetically modified goats. Marketing
Pharming_(genetics)
American biophysicist
the src gene product of Rous avian and Moloney murine sarcoma viruses; antithrombin-III, alpha-antitrypsin, and ovalbumin; epidermal growth factor and the
Margaret_Oakley_Dayhoff
Subphylum of chordates
Chunxin; Liang, Yujun; Gao, Bei; Zhang, Shicui (2012). "A Novel Serpin with Antithrombin-Like Activity in Branchiostoma japonicum: Implications for the Presence
Lancelet
Type of gender-affirming medical treatment
patients is high, prothrombotic mutations (such as factor V Leiden, antithrombin III, and protein C or S deficiency) are not absolute contraindications
Feminizing_hormone_therapy
Medical condition
response, resulting in decreased synthesis of the regulatory proteins antithrombin, protein C and protein S, with increased synthesis of prothrombotic proteins
Purpura_fulminans
American interventional cardiologist
Eugene; Van de Werf, Frans (2002-06-11). "Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial infarction: results of the ENTIRE-Thrombolysis
C._Michael_Gibson
Professor of pharmacy
al. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1.
Jian_Liu_(academic)
Medication
effect of all anticoagulants that act directly through FXa or by binding antithrombin III. The drug is not effective against factor IIa inhibitor dabigatran
Andexanet_alfa
Medical condition
protein S deficiency, activated protein C resistance (Factor V Leiden) and antithrombin III deficiency. Although the above hypothesis is the most commonly accepted
Warfarin_necrosis
Glycoprotein
"Human histidine-rich glycoprotein: simultaneous purification with antithrombin III and characterization of its gross structure". Journal of Biochemistry
Histidine-rich_glycoprotein
Glycosaminoglycan found in animals
moving fraction with a low molecular weight of 7000 Da and affinity for antithrombin III) and 20% dermatan sulfate with a high molecular weight (25,000 Da)
Dermatan_sulfate
Substance that inhibits the growth of new blood vessels
endothelial cells, downregulate bFGF prothrombin (kringle domain-2), antithrombin III fragment inhibit cell proliferation of endothelial cells prolactin
Angiogenesis_inhibitor
Class of enzymes
premature enzymatic degradation (fibrinolysis). In humans, plasmin, antithrombin and TFPI are the most relevant proteolytic inhibitors of the active factor
Factor_XIII
Complication of pregnancy associated with severe pre-eclampsia
(below 100 x 109 L-1) or by testing the levels of fibrin metabolites and antithrombin III.[citation needed] Elevated serum levels of certain proteins, in particular
HELLP_syndrome
ANTITHROMBIN
ANTITHROMBIN
ANTITHROMBIN
ANTITHROMBIN
Boy/Male
Buddhist, Indian
High Above Average
Boy/Male
Tamil
Well defined body
Female
Finnish
Finnish form of Greek Margarites, MARGAREETA means "pearl."
Girl/Female
Muslim
Delighted, Agreed, Happy
Female
English
Old English name QUENBY means "queen's castle."
Surname or Lastname
English
English : variant spelling of Ivey.
Girl/Female
Indian, Tamil
The Highest Degree of Happiness; Divine Joy
Boy/Male
American, Australian, Chinese, French, German, Latin, Portuguese, Spanish, Swedish
Light; Illumination; Form of Luke; Bringer of Light
Female
Celtic
, Cartismandua.
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Lord Shiva
ANTITHROMBIN
ANTITHROMBIN
ANTITHROMBIN
ANTITHROMBIN
ANTITHROMBIN