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Enzyme that cleaves other proteins into smaller peptides
A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides
Protease
Topics referred to by the same term
Protease inhibitor can refer to: Protease inhibitor (pharmacology): a class of medication that inhibits viral protease Protease inhibitor (biology): molecules
Protease_inhibitor
Class of enzymes
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's)
Serine_protease
Pathogenic type of misfolded protein
found in infectious prions has a different structure and is resistant to proteases, the enzymes in the body that can normally break down proteins. The normal
Prion
Topics referred to by the same term
Protease A may refer to one of two enzymes: Streptogrisin A Omptin This disambiguation page lists articles associated with the title Protease A. If an
Protease_A
Antiretroviral medication
therapy (HAART). Ritonavir is a protease inhibitor, though it now mainly serves to boost the potency of other protease inhibitors. It may also be used
Ritonavir
Intramembrane cellular enzymes
Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane
Intramembrane_protease
Class of enzymes
The 3C-like protease (3CLpro) or main protease (Mpro), formally known as C30 endopeptidase, is the main protease found in coronaviruses. It cleaves the
3C-like_protease
Highly specific protease
three proteases: P1 protease (1 cleavage site), helper-component protease (1 cleavage site) and TEV protease (7 cleavage sites). The native TEV protease also
TEV_protease
Set of three coordinated amino acids
triads are most commonly found in hydrolase and transferase enzymes (e.g. proteases, amidases, esterases, acylases, lipases and β-lactamases). An acid-base-nucleophile
Catalytic_triad
Class of antiviral drugs used to treat HIV/AIDS and hepatitis C
and COVID-19. These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic
Protease inhibitor (pharmacology)
Protease_inhibitor_(pharmacology)
Medical condition
Variably protease-sensitive prionopathy (VPSPr) (formerly known as Protease Sensitive Prionopathy) is a sporadic transmissible spongiform encephalopathy
Variably protease-sensitive prionopathy
Variably_protease-sensitive_prionopathy
Protein family
Aspartic proteases (also "aspartyl proteases", "aspartic endopeptidases") are a catalytic type of protease enzymes that use an activated water molecule
Aspartic_protease
Protein family
The PA clan (Proteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology
PA_clan_of_proteases
Class of enzymes
Cysteine proteases, also known as thiol proteases, are hydrolase enzymes that degrade proteins. These proteases share a common catalytic mechanism that
Cysteine_protease
sixth catalytic type of protease. Members of this group of protease had been previously assumed to be an aspartate protease, but structural determination
Glutamic_protease
Subfamily of related G protein-coupled receptors
Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular
Protease-activated_receptor
Proteolytic enzyme found in Bacillus subtilis
is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis. Subtilisins belong to subtilases, a group of serine proteases that
Subtilisin
Protein-coding gene in the species Homo sapiens
Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is
Protease-activated_receptor_2
History of molecular discovery
ligands, like protease inhibitors, that can modulate catalytic activities has an enormous therapeutic effect. Hence, inhibition of the HIV protease is one of
Discovery and development of HIV-protease inhibitors
Discovery_and_development_of_HIV-protease_inhibitors
Enzyme involved with peptide bond hydrolysis in retroviruses
HIV-1 protease or PR is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential
HIV-1_protease
Topics referred to by the same term
Protease VII may refer to: Omptin Caspase 1 This disambiguation page lists articles associated with the title Protease VII. If an internal link incorrectly
Protease_VII
Protein family
In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases (enzymes that aid the breakdown
Protease_inhibitor_(biology)
Class of enzymes
proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme. This enzyme
Proteasome endopeptidase complex
Proteasome_endopeptidase_complex
Topics referred to by the same term
two classes of acidic proteases: Aspartic proteases - that use a catalytic aspartic acid in their active site Glutamic proteases - that use a catalytic
Acidic_protease
Family of enzymes
In molecular biology, the Lon protease family is a family of enzymes that break peptide bonds in proteins resulting in smaller peptides or amino acids
Lon_protease_family
Bacterial protein
OmpT is an aspartyl protease found on the outer membrane of Escherichia coli. OmpT is a subtype of the family of omptin proteases, which are found on
OmpT
Enzyme encoded by hepatitis C virus
NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that
NS2-3_protease
Protein-coding gene in the species Homo sapiens
Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are
Serine_protease_HTRA1
Human protein and coding gene
Lon protease homolog, mitochondrial is a protease, an enzyme that in humans is encoded by the LONP1 gene. The nuclear-gene encoded mitochondrial matrix
LONP1
Cysteine protease enzyme
Zingibain, zingipain, or ginger protease (EC 3.4.22.67) is a cysteine protease enzyme found in ginger (Zingiber officinale) rhizomes. It catalyses the
Zingibain
Protein family
The rhomboid proteases are a family of enzymes that exist in almost all species. They are proteases: they cut the polypeptide chain of other proteins.
Rhomboid_protease
Pandemic caused by SARS-CoV-2
for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor, Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir), to
COVID-19_pandemic
Protein family of cysteine protease enzymes
Papain-like proteases (or papain-like (cysteine) peptidases; abbreviated PLP or PLCP) are a large family of cysteine protease enzymes that share structural
Papain-like_protease
Protein family
Retroviral aspartyl proteases or retropepsins are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses)
Retroviral_aspartyl_protease
Protein-coding gene in the species Homo sapiens
Serine protease 57 is a protein that in humans is encoded by the PRSS57 gene. This gene encodes an arginine-specific serine protease and member of the
Serine_protease_57
Protein family
4.21.92, endopeptidase Ti, caseinolytic protease, protease Ti, ATP-dependent Clp protease, ClpP, Clp protease). This enzyme catalyses the following chemical
Endopeptidase_Clp
Class of enzymes
Picornain 3C (EC 3.4.22.28) is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C’s endopeptidase
Picornain_3C
Superfamily of proteins with similar structures and diverse functions
proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym
Serpin
cysteine and serine proteases are involved in angiogenesis. This article focuses on the important and diverse roles that these proteases play in the regulation
Proteases_in_angiogenesis
Proteases (also sometimes referred to as proteolytic enzymes or peptidases) are in use, or have been proposed or tried, for a number of purposes related
Proteases (medical and related uses)
Proteases_(medical_and_related_uses)
Sub-discipline of biology
study of proteases, their inhibitors, and their substrates on a system-wide scale. This includes the analysis of the protease and protease-substrate
Degradomics
(HIV protease inhibitor) Darunavir (HIV protease inhibitor) Delavirdine (non-nucleoside reverse transcriptase inhibitor) Fosamprenavir (HIV protease inhibitor)
List_of_sulfonamides
Enzyme found in humans
enzyme (IDE) (also known as insulinase, insulin protease, or insulysin) is a large zinc-binding protease of the M16 metalloprotease family of enzymes. It
Insulin-degrading_enzyme
Broad-spectrum serine protease
In molecular biology, Proteinase K (EC 3.4.21.64, protease K, endopeptidase K, Tritirachium alkaline proteinase, Tritirachium album serine proteinase,
Proteinase_K
Class of enzymes
Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme. This enzyme catalyses the following
Ulp1_peptidase
Protein family
deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, or ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins
Deubiquitinating_enzyme
Chemical compound
serine protease inhibitor (serine hydrolase inactivator) commonly used in the preparation of cell lysates. PMSF does not inactivate all serine proteases. The
PMSF
Family of digestive enzymes
Trypsin is a type of serine protease enzyme from the PA clan superfamily found in the digestive system of many vertebrates, where it begins the digestion
Trypsin
COVID-19 antiviral medication
medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor. It is part of a nirmatrelvir/ritonavir combination used to treat
Nirmatrelvir
Protein-targeting ATP-dependent enzyme family
In molecular biology, the CLP protease family is a family of serine peptidases belong to the MEROPS peptidase family S14 (ClpP endopeptidase family, clan
Clp_protease_family
Chemical compound
(a type of brain tumor). Dordaviprone is a protease activator of the mitochondrial caseinolytic protease P. It is dopamine receptor D2 antagonist and
Dordaviprone
Metalloprotease enzyme
type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand
ADAMTS13
Class of enzymes
Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC 3.4.24.85) encoded by the
Membrane-bound transcription factor site-2 protease
Membrane-bound_transcription_factor_site-2_protease
Enzyme found in humans
Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This protein is involved in caspase-dependent apoptosis
Serine protease HTRA2, mitochondrial
Serine_protease_HTRA2,_mitochondrial
host protein substrates for the nsP2 protease of the Venezuelan equine encephalitis virus (VEEV) and the protease from Zika virus. These viruses are Group
SSHHPS
Serine protease
Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, which is a serine protease that activates
Prekallikrein
Pocket in the active site of an enzyme
energy necessary for the reaction, and so promotes catalysis. For example, proteases such as chymotrypsin contain an oxyanion hole to stabilise the tetrahedral
Oxyanion_hole
Mammalian protein found in Homo sapiens
Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme
Membrane-bound transcription factor site-1 protease
Membrane-bound_transcription_factor_site-1_protease
Prohormone-processing protease
Kexin (EC 3.4.21.61) is a prohormone-processing protease, specifically a yeast serine peptidase, found in the budding yeast (S. cerevisiae). It catalyzes
Kexin
Widely used enzyme extracted from papayas
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea
Papain
Protease enzyme
picornavirus endopeptidase 2A, poliovirus protease 2A, rhinovirus protease 2A, 2A protease, 2A proteinase, protease 2A, proteinase 2Apro, picornaviral 2A
Picornain_2A
American politician (born 1954)
nationalities. The virologist Angela Rasmussen said, "Jewish or Chinese protease consensus sequences are not a thing in biochemistry, but they are in racism
Robert_F._Kennedy_Jr.
Class of enzymes
endopeptidase (EC 3.4.22.50, AcNPV protease, BmNPV protease, NPV protease, baculovirus cathepsin, nucleopolyhedrosis virus protease, viral cathepsin) is an enzyme
V-cath_endopeptidase
Class of enzymes
39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family
Chymase
Amylase, lipase, protease and lactase mixture
pancrelipases or pancreatins are commercial mixtures of amylase, lipase, protease and lactase obtained from pigs. The components are digestive enzymes similar
Pancreatic enzymes (medication)
Pancreatic_enzymes_(medication)
Mannose-binding protein-associated serine protease are serine proteases involved in the complement system. Types include: MASP1 MASP2 mannan-binding lectin
Mannose-binding protein-associated serine protease
Mannose-binding_protein-associated_serine_protease
Mammalian protein found in humans
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial is an enzyme that in humans is encoded by the CLPX gene. This protein is a member
ClpX
Protein-coding gene in humans
Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members
TMPRSS2
Class of enzymes
Threonine proteases are a family of proteolytic enzymes harbouring a threonine (Thr) residue within the active site. The prototype members of this class
Threonine_protease
Active region of an enzyme
produce a favourable interaction. Many enzymes including serine protease, cysteine protease, protein kinase and phosphatase evolved to form transient covalent
Active_site
Protein-coding gene in humans
Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is
USP7
Chemical compound
water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin
AEBSF
Independent evolution of similar features
structures too have arisen through convergent evolution. The enzymology of proteases provides some of the clearest examples of convergent evolution. These
Convergent_evolution
Breakdown of proteins into smaller polypeptides or amino acids
years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms
Proteolysis
Molecule that blocks enzyme activity
balance in a cell. Enzyme inhibitors also control essential enzymes such as proteases or nucleases that, if left unchecked, may damage a cell. Many poisons
Enzyme_inhibitor
Serine proteinase inhibitors which inhibit trypsin
A trypsin inhibitor (TI) is a protein and a type of serine protease inhibitor (serpin) that reduces the biological activity of trypsin by controlling the
Trypsin_inhibitor
Papain-like protease protein domain
The nidoviral papain-like protease (PLPro or PLP) is a papain-like protease protein domain encoded in the genomes of nidoviruses. It is expressed as part
Nidoviral papain-like protease
Nidoviral_papain-like_protease
Protein domain
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential
Caspase
Index of enzymes associated with the same name
IgA protease may refer to: IgA specific serine endopeptidase, an enzyme IgA-specific metalloendopeptidase, an enzyme This set index page lists enzyme articles
IgA_protease
Protein-coding gene in the species Homo sapiens
Antileukoproteinase, also known as secretory leukocyte protease inhibitor (SLPI), is an enzyme that in humans is encoded by the SLPI gene. SLPI is a highly
SLPI
Protein-coding gene in humans
Sentrin-specific protease 1 is an enzyme that in humans is encoded by the SENP1 gene. There are six known SUMO proteases in humans that have been designated
SENP1
Enzyme produced by enterobacterium
Serratiopeptidase (Serratia E-15 protease, also known as serralysin, serrapeptase, serratiapeptase, serratia peptidase, serratio peptidase, or serrapeptidase)
Serratiopeptidase
Class of enzymes
22.14, actinidin, Actinidia anionic protease, proteinase A2 of Actinidia chinensis) is a type of cysteine protease enzyme found in fruits, including kiwifruit
Actinidain
Enzyme that cleaves IgA antibodies at certain regions
IgA protease (EC 3.4.21.72, IgA-specific serine endopeptidase, IgA proteinase, IgA-specific proteinase, immunoglobulin A protease, immunoglobulin A proteinase)
IgA specific serine endopeptidase
IgA_specific_serine_endopeptidase
Protein family
inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz-type soybean trypsin inhibitors are usually specific
Kunitz_STI_protease_inhibitor
Enzyme in humans
F19 monoclonal antibody in activated fibroblasts and a Surface Expressed Protease (seprase) in invasive melanoma cells. FAP is a 760 amino acid long type
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Enzyme involved in blood coagulation in humans
Thrombin (factor IIa, EC 3.4.21.5) is a serine protease that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related
Thrombin
Species of bacterium
cysteine protease that acts as a virulence factor. In the absence of this pathway, biofilm formation is enhanced, possibly due to the lack of the protease degrading
Streptococcus_pyogenes
Class of bacterial heat shock proteins
bacteria such as E. coli in response to cell stress. The hslV protein is a protease and the hslU protein is an ATPase; the two form a symmetric assembly of
HslVU
photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme. This enzyme catalyses the following
C-terminal processing peptidase
C-terminal_processing_peptidase
4.21.107, DegP, DegP protease, HtrA, high temperature requirement protease A, HrtA heat shock protein, protease Do, Do protease) is an enzyme. This enzyme
Peptidase_Do
Type of enzyme
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant
Metalloproteinase
Enzyme found in humans
an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it
Caspase_4
Amino acid
Serine /ˈsɪəriːn/ (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated
Serine
Human protein
also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered
Urokinase
Japanese marinade
Soybean agglutinin (lectin) Enzymes Beta-amylase Lipoxygenase Cysteine proteases Trypsin inhibitors Kunitz inhibitor Bowman-Birk inhibitor Other Soy lecithin
Teriyaki
Type of biochemical process
regulates proteases is through protease inhibitors. Protease inhibitors can be other proteins, small peptides, or molecules. There are two types of protease inhibitors:
Protein_metabolism
Protein-coding gene in humans
in binding to BCL10. Activation of MALT1 downstream NF-κB signaling and protease activity occurs when BCL10/MALT1 gets recruited to an activated CARD-CC
MALT1
InterPro Domain
protein degrading enzymes or, more specifically, domains of Kunitz-type are protease inhibitors. They are relatively small with a length of about 50 to 60 amino
Kunitz_domain
PROTEASE
PROTEASE
PROTEASE
PROTEASE
Boy/Male
Hindu, Indian, Sikh, Telugu
God of Guru
Girl/Female
Indian, Telugu
Heavenly
Girl/Female
Hindu
Padmanabhans wife, Goddess Lakshmi, A girl who is always Happy
Boy/Male
Hindu, Indian, Jain
King of Psycho; Moon
Boy/Male
Hindu, Indian
Garland of Forests
Surname or Lastname
English
English : habitational name from places in Northumberland and Yorkshire named Bilton, from an Old English personal name Billa + Old English tūn ‘enclosure’, ‘settlement’. There is also a Bilton in Warwickshire, of which the first element is probably Old English beolone ‘henbane’, but this place does not seem to have yielded any surviving surnames.
Boy/Male
Welsh
Patient.
Surname or Lastname
English and Scottish
English and Scottish : patronyic from Mathers.English and Scottish : Altered form of Matheson.
Boy/Male
Arabic
King of Kingdom
Girl/Female
Bengali, Indian
Honest; Truthful
PROTEASE
PROTEASE
PROTEASE
PROTEASE
PROTEASE