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Academic journal
Ageing Research Reviews is a peer-reviewed scientific journal publishing review articles covering research on ageing, aging-associated diseases, and human
Ageing_Research_Reviews
Biological process of getting older
"The eye as a model of ageing in translational research—molecular, epigenetic and clinical aspects". Ageing Research Reviews. 12 (2): 490–508. doi:10
Ageing
Concept of extending human lifespan
"Artificial intelligence for aging and longevity research: Recent advances and perspectives". Ageing Research Reviews. 49: 49–66. doi:10.1016/j.arr.2018.11.003
Life_extension
Progressive neurodegenerative disease
2020). "Circadian and sleep dysfunction in Alzheimer's disease". Ageing Research Reviews. 60 101046. doi:10.1016/j.arr.2020.101046. hdl:10072/414227. PMID 32171783
Alzheimer's_disease
American biotechnology company
Retrieved 1 May 2022. "Jeff Bezos, Yuri Milner Said to Be Among Backers of Anti-Ageing Startup Altos Labs". gadgets360.com. 8 September 2021. Archived from the
Altos_Labs
Characteristic of biological processes
PMC 8521700. PMID 34086536. Mattson, M. P (2007). "Hormesis defined". Ageing Research Reviews. 7 (1): 1–7. doi:10.1016/j.arr.2007.08.007. PMC 2248601. PMID 18162444
Hormesis
Medical discipline focused on the practical reversal of the aging process
(December 2020). "Fight to the bitter end: DNA repair and aging". Ageing Research Reviews. 64 101154. doi:10.1016/j.arr.2020.101154. PMID 32977059. S2CID 221824975
Rejuvenation
Study of the evolutionary development of ageing processes
Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability
Evolution_of_ageing
Degradation of functioning of the brain
September 2016). "Brain atrophy in Alzheimer's Disease and aging". Ageing Research Reviews. 30: 25–48. doi:10.1016/j.arr.2016.01.002. ISSN 1568-1637. PMID 26827786
Aging_brain
Chemical compound
"Targeting aging with urolithin A in humans: A systematic review". Ageing Research Reviews. 100 (5) 102406. doi:10.1016/j.arr.2024.102406. hdl:1871
Urolithin_A
Proteins that bind lipids to transport them in body fluids
structure, protein function and interaction with dietary factors". Ageing Research Reviews. 37: 146–161. doi:10.1016/j.arr.2017.06.002. PMID 28647612. S2CID 3758905
Apolipoprotein
template at the bottom) Research into centenarians Ageing research projects and prizes Notable events in these fields of research that relate to life extension
Timeline_of_aging_research
Cognitive decline
dysfunction in the pathophysiological continuum of dementia" (PDF). Ageing Research Reviews. 55 100956. doi:10.1016/j.arr.2019.100956. PMID 31479764. S2CID 201742825
Dementia
Type of disease
Alliance for Aging Research Gerontology Senescence Belikov AV (January 2019). "Age-related diseases as vicious cycles". Ageing Research Reviews. 49: 11–26. doi:10
Aging-associated_diseases
British geneticist and biogerontologist
who studies the biology and genetics of ageing (biogerontology). He is Professor of Biogerontology at the Research Department of Genetics, Evolution and
David_Gems
Medical condition
"Cockayne syndrome: Clinical features, model systems and pathways". Ageing Research Reviews. 33: 3–17. doi:10.1016/j.arr.2016.08.002. PMC 5195851. PMID 27507608
Cockayne_syndrome
Concept in health research
definition to intervention: An overview of systematic reviews" (PDF). Ageing Research Reviews. 37: 53–68. doi:10.1016/j.arr.2017.05.003. PMID 28511964
Multimorbidity
English biogerontologist and author (born 1963)
catabolic diversity to aging and several major age-related diseases". Ageing Research Reviews. 4 (3): 315–38. doi:10.1016/j.arr.2005.03.008. PMID 16040282. S2CID 26866787
Aubrey_de_Grey
Cholesterol-transporting protein most notably implicated in Alzheimer's disease
structure, protein function and interaction with dietary factors". Ageing Research Reviews. 37: 146–161. doi:10.1016/j.arr.2017.06.002. PMID 28647612. S2CID 3758905
Apolipoprotein_E
Network or circuit of neurons
neurological disorders: Evidence from in vivo two-photon imaging". Ageing Research Reviews. 87 101933. doi:10.1016/j.arr.2023.101933. ISSN 1568-1637. Intrinsic
Neural_circuit
American health psychologist
Stress, Hormetic Stress, and the Rate of Aging" through the Ageing Research Reviews. Her research team was also named the winner of the inaugural round of
Elissa_S._Epel
Increase in the probability of a person dying after their spouse has died
cognitive decline in adults aged 50 and over A systematic review and meta-analysis". Ageing Research Reviews. 71 101461. doi:10.1016/j.arr.2021.101461. PMID 34534681
Widowhood_effect
Increasing remaining life expectancy faster than time passes
faster than one year per one year of research, as long as that rate of advance is sustainable. Mouse lifespan research has been the most contributive to
Longevity_escape_velocity
Biological concepts and questions with insufficient resolutions
(2021). "From DNA damage to mutations: All roads lead to aging". Ageing Research Reviews. 68: 101316. doi:10.1016/j.arr.2021.101316. PMC 10018438. PMID 33711511
List of unsolved problems in biology
List_of_unsolved_problems_in_biology
Absence of disease-causing microorganisms
aging-related pathologies". Ageing Research Reviews. Damage-associated molecular patterns and their pathological relevance in ageing. 24 (Pt A): 29–39. doi:10
Asepsis
Cell membrane organelle
2016). "The crucial impact of lysosomes in aging and longevity". Ageing Research Reviews. 32: 2–12. doi:10.1016/j.arr.2016.04.009. PMC 5081277. PMID 27125853
Lysosome
Irish neuroscientist, psychologist and actress
functioning of healthy older adults: A systematic review and meta-analysis". Ageing Research Reviews. 15: 28–43. doi:10.1016/j.arr.2014.02.004. hdl:2262/68232
Sabina_Brennan
Loss of skeletal muscle mass
during short-term disuse: implications for age-related sarcopenia". Ageing Research Reviews. 12 (4): 898–906. doi:10.1016/j.arr.2013.07.003. PMID 23948422
Muscle_atrophy
Medical research project
The Women's Healthy Ageing Project (WHAP) is the longest ongoing medical research project examining the health of Australian women. Its landmark studies
Women's Healthy Ageing Project
Women's_Healthy_Ageing_Project
Medication used to treat diabetes
and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis". Ageing Research Reviews. 40: 31–44. doi:10
Metformin
Co-occurrence of two or more diseases
March 2011). "Aging with multimorbidity: A systematic review of the literature". Ageing Research Reviews. 10 (4): 430–439. doi:10.1016/j.arr.2011.03.003. PMID 21402176
Comorbidity
Dietary regime
L (October 2017). "Calorie restriction in humans: An update". Ageing Research Reviews. Nutritional interventions modulating aging and age-associated
Calorie_restriction
Rate of energy expenditure by an endotherm at rest
PMID 29362491. Manini TM (2010). "Energy expenditure and aging". Ageing Research Reviews. 9 (1): 1–11. doi:10.1016/j.arr.2009.08.002. PMC 2818133. PMID 19698803
Basal_metabolic_rate
Psychological ethological theory
inflammation: underpinnings of aging and age-related diseases". Ageing Research Reviews. 8 (1): 18–30. doi:10.1016/j.arr.2008.07.002. PMC 3782993. PMID 18692159
Attachment_theory
Hypothetical process of digitally emulating a brain
original brain and have a sentient conscious mind. Substantial mainstream research in related areas is being conducted in neuroscience and computer science
Mind_uploading
American biotechnology company
ageing process. She stated, "The company was built essentially to prove these therapies work or not." Since then the company has gone into research and
BioViva
Research into causes and treatment of cancer
"Circadian rhythms, time-restricted feeding, and healthy aging". Ageing Research Reviews. 39: 59–67. doi:10.1016/j.arr.2016.12.006. ISSN 1568-1637. PMC 5814245
Cancer_research
Physical activity that improves health
in older adults: A systematic review and network meta-analysis of randomised controlled trials". Ageing Research Reviews. 58 100999. doi:10.1016/j.arr
Exercise
"Artificial intelligence for aging and longevity research: Recent advances and perspectives". Ageing Research Reviews. 49: 49–66. doi:10.1016/j.arr.2018.11.003
Applications of artificial intelligence
Applications_of_artificial_intelligence
Dietary supplement company
The Biomedical Research & Longevity Society, formerly the Life Extension Foundation (LEF), is a company founded in 1980 to extend the healthy human lifespan
Biomedical Research & Longevity Society
Biomedical_Research_&_Longevity_Society
Free-radical aging theory
D, Birdsall J. Flies, worms and the Free Radical Theory of ageing. Ageing Research Reviews. (0). Chatterjee S, Lardinois O, Bhattacharjee S, Tucker J
Free-radical_theory_of_aging
Ageing Research Reviews. 49: 11–26. doi:10.1016/j.arr.2018.11.002. PMID 30458244. S2CID 53567141. de Grey A (2007). "Life Span Extension Research and
List of causes of death by rate
List_of_causes_of_death_by_rate
Partial or total inability to hear
cognitive impairment and dementia – A systematic review and meta-analysis of cohort studies". Ageing Research Reviews. 98 102346. doi:10.1016/j.arr.2024.102346
Hearing_loss
Weakness in elderly person
2011). "Outcome instruments to measure frailty: a systematic review". Ageing Research Reviews. 10 (1): 104–114. doi:10.1016/j.arr.2010.09.001. PMID 20850567
Frailty_syndrome
Types of irreversible biochemical changes
and repair in aging through the prism of Koch-like criteria". Ageing Research Reviews. 12 (2): 661–684. doi:10.1016/j.arr.2012.02.001. PMID 22353384
Hallmarks_of_aging
Speed of the heartbeat, measured in beats per minute
GQ, Zhang W (2009). "Heart rate, lifespan, and mortality risk". Ageing Research Reviews. 8 (1): 52–60. doi:10.1016/j.arr.2008.10.001. PMID 19022405. S2CID 23482241
Heart_rate
Various systems to schedule meals
"Impact of intermittent fasting on health and disease processes". Ageing Research Reviews. 39: 46–58. doi:10.1016/j.arr.2016.10.005. PMC 5411330. PMID 27810402
Intermittent_fasting
American biopharmaceutical company
(2019) Journals Ageing Research Reviews Aging Aging Cell Biogerontology Experimental Gerontology Neurobiology of Aging Rejuvenation Research People Bill Andrews
Life_Biosciences
Indian-American physician, writer b. 1970
5-hydroxymethylcytosine in development, aging and age-related diseases". Ageing Research Reviews. 37: 28–38. doi:10.1016/j.arr.2017.05.002. hdl:10651/44229. PMID 28499883
Siddhartha_Mukherjee
Proposed regenerative medical therapies
Aubrey de Grey. While scientists agreed with de Grey that "research into the basic biology of ageing needs and deserves more support", they also viewed de
Strategies for engineered negligible senescence
Strategies_for_engineered_negligible_senescence
Biochemical test for age
methylation-based biomarkers and the epigenetic clock theory of ageing". Nature Reviews. Genetics. 19 (6): 371–384. doi:10.1038/s41576-018-0004-3. PMID 29643443
Epigenetic_clock
American non-profit organization
"Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports. 6 (11): 1006–8. doi:10.1038/sj.embor.7400555. PMC 1371037
Lifespan_Research_Institute
Chemical compound
extension of lifespan and healthspan across multiple species". Ageing Research Reviews. 64 101188. doi:10.1016/j.arr.2020.101188. PMC 9038119. PMID 33031925
Carbonyl cyanide m-chlorophenyl hydrazone
Carbonyl_cyanide_m-chlorophenyl_hydrazone
Protein-coding gene in the species Homo sapiens
(Dec 2016). "Chaperone Mediated Autophagy: Starve to Prosper". Ageing Research Reviews. 32: 13–21. doi:10.1016/j.arr.2016.07.001. PMID 27484893. S2CID 884595
HSPA8
Health effects of an older father at conception
age-dependent declines in human semen quality: a systematic review and meta-analysis". Ageing Research Reviews. 19: 22–33. doi:10.1016/j.arr.2014.10.007. PMID 25462195
Paternal_age_effect
Venture capitalist
"30 Under 30" by Forbes magazine, and was one of the stars of "The Age of Ageing", a documentary by National Geographic television channel. She also spoke
Laura_Deming
Amino acid
TL (June 2023). "Glycine and aging: Evidence and mechanisms". Ageing Research Reviews. 87 101922. doi:10.1016/j.arr.2023.101922. PMID 37004845. Soh J
Glycine
Dutch ageing research facility
The European Research Institute for the Biology of Ageing (ERIBA) is a nonprofit research facility based in Groningen, Netherlands, concerned with cross-disciplinary
ERIBA
US biomedical research institute
2022, the institute hosted The Longevity Summit, a two-day conference on ageing, the emerging new biotech companies in the field, and their innovations
Buck Institute for Research on Aging
Buck_Institute_for_Research_on_Aging
Protein-coding gene in humans
clues from the Down syndrome-related proteins, DSCR1 and ITSN1". Ageing Research Reviews. 5 (4): 388–401. doi:10.1016/j.arr.2005.11.001. PMID 16442855.
RCAN1
Disorder resulting from low blood levels of vitamin B12
"Inflammation and frailty in the elderly: A systematic review and meta-analysis". Ageing Research Reviews. 31: 1–8. doi:10.1016/j.arr.2016.08.006. hdl:10447/463258
Vitamin_B12_deficiency
Phenomenon characterized by the cessation of cell division
senescent cells to attenuate cardiovascular disease progression". Ageing Research Reviews. 60 101072. doi:10.1016/j.arr.2020.101072. PMC 7263313. PMID 32298812
Cellular_senescence
Late-20th-century demographic phenomenon of population aging
"Senescent cells as promising targets to tackle age-related diseases". Ageing Research Reviews. 66 101251. doi:10.1016/j.arr.2020.101251. ISSN 1568-1637. PMID 33385543
Silver_tsunami
American computer scientist, author and futurist (born 1948)
the SENS Research Foundation's approach to finding a way to repair aging damage, and has encouraged the general public to hasten their research by donating
Ray_Kurzweil
Medication used to treat insomnia
2015). "Sleep disorders, obesity, and aging: the role of orexin". Ageing Research Reviews. 20: 63–73. doi:10.1016/j.arr.2014.11.001. PMC 4467809. PMID 25462194
Suvorexant
Medication used to treat insomnia
2015). "Sleep disorders, obesity, and aging: the role of orexin". Ageing Research Reviews. 20: 63–73. doi:10.1016/j.arr.2014.11.001. PMC 4467809. PMID 25462194
Daridorexant
2019 non-fiction book by David Sinclair and Matthew LaPlante
nonfiction bestseller list on September 28, 2019. The book received mixed reviews from critics. "If you're even mildly hopeful about dunking a basketball
Lifespan: Why We Age – and Why We Don't Have To
Lifespan:_Why_We_Age_–_and_Why_We_Don't_Have_To
Willing abstinence from, or reduced consumption of, food and/or drink
"Impact of intermittent fasting on health and disease processes". Ageing Research Reviews. 39: 46–58. doi:10.1016/j.arr.2016.10.005. PMC 5411330. PMID 27810402
Fasting
Neural, cognitive, and behavioral effects of physical exercise
in older adults: A systematic review and network meta-analysis of randomised controlled trials". Ageing Research Reviews. 58 100999. doi:10.1016/j.arr
Neurobiological effects of physical exercise
Neurobiological_effects_of_physical_exercise
Range of genetic disorders which cause a person to appear to grow older faster
"Cockayne syndrome: Clinical features, model systems and pathways". Ageing Research Reviews. 33: 3–17. doi:10.1016/j.arr.2016.08.002. ISSN 1872-9649. PMC 5195851
Progeroid_syndromes
Increasing median age in a population
Population ageing is an overall change in the ages of a population. This can typically be summarised in a single parameter as an increase in the median
Population_ageing
Type of disease
progress in Marfan syndrome and Marfan-associated disorders". Ageing Research Reviews. 9 (3): 363–368. doi:10.1016/j.arr.2009.09.001. ISSN 1568-1637
Degenerative_disease
Organelle in eukaryotic cells responsible for respiration
2020). "Mitochondria in Ovarian Aging and Reproductive Longevity". Ageing Research Reviews. 63 101168. doi:10.1016/j.arr.2020.101168. PMC 9375691. PMID 32896666
Mitochondria
Neuropeptide that regulates arousal, wakefulness, and appetite
2015). "Sleep disorders, obesity, and aging: the role of orexin". Ageing Research Reviews. 20: 63–73. doi:10.1016/j.arr.2014.11.001. PMC 4467809. PMID 25462194
Orexin
animation Immunisation Gene editing Senolytic Drugs Nanotechnology Evolution of ageing Gerontology Pro-aging trance Altered intercellular communication Cellular
Outline_of_life_extension
author, and researcher known for his work in biogerontology, healthy ageing, hormesis, complexity science, and life-extension studies. His research has focused
Marios_Kyriazis
Non-coding RNA in the species Homo sapiens
(2018). "NAD Metabolism: Implications in Aging and Longevity". Ageing Research Reviews. 47: 1–17. doi:10.1016/j.arr.2018.05.006. PMID 29883761. S2CID 47002665
MIR34A
Recollection of odors
olfactory dysfunction in aging and neurodegenerative disorders". Ageing Research Reviews. 3 (2): 215–232. doi:10.1016/j.arr.2003.10.003. PMID 15177056.
Olfactory_memory
Social movement devoted to eliminating or reversing aging, or reducing its effects
achieve negligible senescence (cancel aging) for younger humans, reverse ageing, or at least significantly delay it. Though some scientists think curing
Anti-aging_movement
American neuroscientist
Medical Research Award, and the Santiago Grisolia Chair Prize. He was as the founding editor and editor-in-chief of NeuroMolecular Medicine and Ageing Research
Mark_Mattson
Influence of a single gene on multiple phenotypic traits
constraint, evolutionary spandrels and antagonistic pleiotropy". Ageing Research Reviews. 101. doi:10.1016/j.arr.2024.102527. PMID 39374830 – via Elsevier
Pleiotropy
Theory of aging
cells during ageing". Nature. 447 (7145): 686–90. Bibcode:2007Natur.447..686N. doi:10.1038/nature05875. PMID 17554302. S2CID 4332976. "Research may reveal
Stem_cell_theory_of_aging
Phenotype of senescent cells which secrete certain substances
"Senescent cells as promising targets to tackle age-related diseases". Ageing Research Reviews. 66 101251. doi:10.1016/j.arr.2020.101251. PMID 33385543. Kim YH
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Class of enzymes
(2018). "NAD metabolism: Implications in aging and longevity". Ageing Research Reviews. 47: 1–17. doi:10.1016/j.arr.2018.05.006. PMID 29883761. S2CID 47002665
Nicotinamide-nucleotide adenylyltransferase
Nicotinamide-nucleotide_adenylyltransferase
Cognitive problems associated with menopause
interventions: Time to move on from the Women's Health Initiative?". Ageing Research Reviews. 48: 79–86. doi:10.1016/j.arr.2018.10.005. ISSN 1568-1637. PMID 30355506
Postmenopausal_confusion
Drug class
indexes: A systematic review and meta-analysis of phase II/III clinical trials in Alzheimer's disease". Ageing Research Reviews. 88 101959. doi:10.1016/j
Anti-amyloid_antibodies
Issues and concerns of older LGBTQ people
differences in the social support systems available for ageing LGBTQ people. Research on LGBTQ ageing is still emerging, as are policy and community-based
LGBTQ_ageing
Form of dementia
consequence on RNA splicing and signalling in health and disease". Ageing Research Reviews. 96 102246. doi:10.1016/j.arr.2024.102246. PMID 38401571. Dickson
Limbic-predominant age-related TDP-43 encephalopathy
Limbic-predominant_age-related_TDP-43_encephalopathy
Amino acid
isomers meta- tyrosine and ortho- tyrosine in oxidative stress". Ageing Research Reviews. 27: 93–107. doi:10.1016/j.arr.2016.03.005. PMC 4841466. PMID 27039887
Tyrosine
Professor of pathology
of Biosphere 2. Walford is credited with significantly furthering aging research by his discovery that laboratory mice, when fed a diet that restricted
Roy_Walford
Medical condition
protective role of exercise against age-related neurodegeneration". Ageing Research Reviews. 74 101543. doi:10.1016/j.arr.2021.101543. ISSN 1568-1637. PMC 8761166
Spinal and bulbar muscular atrophy
Spinal_and_bulbar_muscular_atrophy
Aileen (May 2011). "A review of demographic ageing in the UK: opportunities for rural research: A Review of Demographic Ageing in the UK". Population
Ageing_of_the_United_Kingdom
American biogerontologist
Shell Oil in Emeryville, California. He worked for six years as a Shell research chemist, in part studying free radical reactions in petroleum products
Denham_Harman
Rare autosomal recessive skin condition
Rothmund-Thomson syndrome and related RECQL4 genetic disorders". Ageing Research Reviews. 33: 30–35. doi:10.1016/j.arr.2016.06.002. ISSN 1568-1637. PMID 27287744
Rothmund–Thomson_syndrome
Russian nonprofit organization
is a nonprofit organization that develops a network and community of researchers in the field of life extension, focusing on combining brain emulation
2045_Initiative
Health and Ageing is a research programme set up by the Geneva Association, also known as the International Association for the Study of Insurance Economics
Health_and_Ageing
Multipotent adult stem cells present in multiple tissues
Stolzing A (February 2006). "Aging of mesenchymal stem cells". Ageing Research Reviews. 5 (1): 91–116. doi:10.1016/j.arr.2005.10.001. PMID 16310414. Banerjee
Mesenchymal_stem_cell
Mathematics Advances in Ecological Research Advances in Mathematics Advances in Space Research Ageing Research Reviews Agricultural and Forest Meteorology
List_of_Elsevier_periodicals
and treatment of Alzheimer's disease: Past, present and future". Ageing Research Reviews. 77 101612. doi:10.1016/j.arr.2022.101612. ISSN 1568-1637. PMID 35346852
Alzheimer's disease and COVID-19
Alzheimer's_disease_and_COVID-19
Organisms that live in salt water
longevity in the simplest animals and the quest for immortality". Ageing Research Reviews. 16: 66–82. doi:10.1016/j.arr.2014.05.003. PMC 4133289. PMID 24910306
Marine_life
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