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Genetic loci that regulate pre-mRNA splicing
Splicing quantitative trait loci (abbreviated sQTLs or splicing QTLs) are quantitative trait loci that regulate alternative splicing of pre-mRNA. They
Splicing quantitative trait loci
Splicing_quantitative_trait_loci
Genetic trait
of complex traits has been explored using statistical approaches such as genome-wide association studies (GWAS) and quantitative trait loci (QTL) mapping
Complex_traits
one sample as well. SplicePlot is a tool for visualizing alternative splicing and the effects of splicing quantitative trait loci (sQTLs) from RNA-seq
List of RNA-Seq bioinformatics tools
List_of_RNA-Seq_bioinformatics_tools
Set of methods in genetics
variation in a quantitative trait. Many QTL studies measure molecular traits, such as gene expression, chromatin accessibility, splicing or protein abundance
Fine-mapping
Dependence of a gene mutation's phenotype on mutations in other genes
which the effect of a mutation on a trait is dependent on the presence or absence of mutations at different loci (locations on the genome), that may be
Epistasis
for gene expression should be obtained, such as an expression quantitative trait loci (eQTL), which helps to show gene expression regulation. Using the
Transcriptome-wide association study
Transcriptome-wide_association_study
Sequence of DNA that determines traits in an organism
single large mRNAs, alternative splicing enables a single genomic region to encode multiple distinct products and trans-splicing concatenates mRNAs from shorter
Gene
Gene profile for C10orf88 (aka PAAT)
acid protein. No isoforms or splice variants have been identified. The mature mRNA is 1,497 nucleotides after splicing. The PAAT promoter contains binding
PAAT_(protein)
Repeating sequences of 2–13 base pairs of DNA
other splicing machinery. It is theorized that these sequences form highly stable cloverleaf configurations that bring the 3' and 5' intron splice sites
Microsatellite
Protein-coding gene in the species Homo sapiens
Carcinogenesis. 32 (4): 452–61. doi:10.1093/carcin/bgq273. PMC 3105580. PMID 21177767. FAM193A QTL (quantitative trait loci) Search Result - Rat Genome Database
FAM193A
Lab technique in cellular biology
due to regulatory effects including imprinting and expression quantitative trait loci, and noncoding rare variants. Limitations of RNA variant identification
RNA-Seq
Study of role of genetics in the nervous system
sample sizes, which is a marked advantage in laboratory research. Quantitative trait loci (QTL) mapping is another statistical method used to determine the
Neurogenetics
Protein-coding gene in the species Homo sapiens
region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level[citation needed], and
HBS1-like_protein
Change in the heritable traits of populations
(28 February 1998). "Levels of genetic polymorphism: marker loci versus quantitative traits". Philosophical Transactions of the Royal Society B. 353 (1366):
Evolution
German breed of dog
Fels, L.; Distl, O. (2014). "Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German shepherd dogs".
German_Shepherd
Alteration in the nucleotide sequence of a genome
certain time period in the organism's lifespan. Replication timing quantitative trait loci affects DNA replication. In order to categorize a mutation as such
Mutation
Hypertension occurring during pregnancy
of the reasons why these traits are considered to be a risk factor. Furthermore, ZNF831 (zinc finger protein 831) and its loci on chromosome 20q13 were
Pre-eclampsia
Protein-coding gene in the species Homo sapiens
aerobic running capacity (ARC) have mapped PDLIM3 to respective quantitative trait loci, suggesting that ALP may be involved in molecular networks related
PDLIM3
Single nucleotide in genomic DNA at which different sequence alternatives exist
(2021-09-02). "Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk". Nature Communications. 12
Single-nucleotide polymorphism
Single-nucleotide_polymorphism
Class of ribonucleic acid that is not translated into proteins
from host transcripts; these are called self-splicing RNAs. There are two main groups of self-splicing RNAs: group I catalytic intron and group II catalytic
Non-coding_RNA
Genetic diversity in human populations
Abecasis GR (March 2003). "Using haplotype blocks to map human complex trait loci" (PDF). Trends in Genetics. 19 (3): 135–40. doi:10.1016/S0168-9525(03)00022-2
Human_genetic_variation
Species of fish
initiate RNA splicing. These genes have the DNA base pairs AC and TG as repeated sequences at the ends of each intron. On the 3'ss (3' splicing site), the
Zebrafish
Animal model of absence epilepsy
polygenic inheritance of SWD-related phenotypes was shown and three quantitative trait loci were identified that could control different variables of SWDs
GAERS
Protein found in humans
crossed with non-resistant WKY rats produce subcongenic strains, and quantitative trait loci (QTL) analysis was used to determine which genes co-segregate with
Zinc_transporter_ZIP12
Protein-coding gene in humans
single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". Journal of Human Genetics. 54
ABCB11
metabolism. A change in splicing can be caused by modifying any of the components of the splicing machinery such as splice sites or splice enhancers or silencers
SNP_annotation
Protein-coding gene in the species Homo sapiens
Harada S, Higuchi S, Matsushita S (Aug 2002). "Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism". Alcoholism:
Cholecystokinin_A_receptor
Protein-coding gene in the species Homo sapiens
influence sub cellular targeting, therefore it is probable that alternative splicing codetermines both the function and the intracellular location of DISC1
DISC1
cis-acting. trans-splicing A form of RNA splicing in which different RNA transcripts, synthesized in separate transcription events, are spliced together into
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Protein-coding gene in the species Homo sapiens
Disease Database. Mapping Adipose and Muscle Tissue Expression Quantitative Trait Loci in African Americans to Identify Genes for Type 2 Diabetes and
ATP5SL
Species of fruit fly
1988). "Quantitative Genetics of Drosophila Melanogaster. II. Heritabilities and Genetic Correlations between Sexes for Head and Thorax Traits". Genetics
Drosophila_melanogaster
Computational analysis of large, complex sets of biological data
etiologic and functional implications of genome-wide association loci for human diseases and traits". Proceedings of the National Academy of Sciences of the United
Bioinformatics
Biological process
gene-specific, as certain genetic variants, called methylation quantitative trait loci (meQTLs), can affect methylation. These meQTLs are hypothesized
Sex-chromosome dosage compensation
Sex-chromosome_dosage_compensation
DNA sequence
In the 1980s, while investigating nucleotide sequences in mouse genome loci, the Hogness box sequence was found and "boxed in" at the -31 position. When
TATA_box
Field of study
schizophrenia-associated genes reveals that risk loci are commonly found near DNA methylation quantitative trait loci (which affect CpG methylation), which have
Epigenetics_of_schizophrenia
Protein-coding gene in the species Homo sapiens
A, Hill MR, et al. (September 1996). "A genome-wide search for quantitative trait loci underlying asthma". Nature. 383 (6597): 247–250. Bibcode:1996Natur
MS4A2
MeSH G14.340.024.340.700 – pseudogenes MeSH G14.340.024.340.720 – quantitative trait loci MeSH G14.340.024.340.825 – transgenes MeSH G14.340.024.340.825
List_of_MeSH_codes_(G14)
Part of the study of the genome
derived from microarrays, has been aligned to various behavioural quantitative trait loci (QTLs) and reported in several publications. However, microarray
Neurogenomics
SPLICING QUANTITATIVE-TRAIT-LOCI
SPLICING QUANTITATIVE-TRAIT-LOCI
Boy/Male
American, Anglo, Australian, British, English, Irish, Norse, Polish, Scandinavian
Happy; Measure of Land; Form of Tate; To be Cheerful
Girl/Female
Muslim
To trail a garment
Girl/Female
Biblical
A liar, sliding away.
Girl/Female
Muslim
Good traits excellent disposition
Girl/Female
American, Anglo, Australian, British, English, Polish
Pleasant and Bright; Brings Joy; Cheerful; Happy
Girl/Female
Indian, Sanskrit
Splitting; Breaking
Girl/Female
Muslim/Islamic
Good traits excellent disposition
Surname or Lastname
English (Devon)
English (Devon) : metonymic occupational name for a trapper or hunter, from Middle English trayne, Old French traine ‘guile’, ‘snare’, ‘trap’.English (Devon) : topographic name from Middle English atte trewen ‘at the trees’, or a habitational name from any of the places named with this phrase, for example Train, Traine, or Trewyn, all in Devon.
Boy/Male
Hindu, Indian
Placing Side by Side
Surname or Lastname
English
English : variant of Straight.
Surname or Lastname
English (Devon)
English (Devon) : unexplained.Irish (County Kerry) : reduced form of Tramant, which MacLysaght describes as ‘a family of pre-Norman origin’.
Boy/Male
Norse Swedish English Irish Scandinavian
Happy.
Boy/Male
Indian, Sanskrit
Splitting; Opening; Moving Slowly
Boy/Male
Australian, British, English
Sparkle
Girl/Female
Arabic, Muslim
To Trail a Garment
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Lightning
Girl/Female
Arabic, Muslim, Sindhi
Good Traits; Excellent Disposition
Boy/Male
Indian, Sanskrit
Breaking; Splitting
Male
Vietnamese
Vietnamese name TRAI means "oyster."
Girl/Female
English Anglo Saxon
Brings joy.
SPLICING QUANTITATIVE-TRAIT-LOCI
SPLICING QUANTITATIVE-TRAIT-LOCI
Boy/Male
Arabic, Gujarati, Hindu, Indian, Muslim
Heart; Mind
Girl/Female
Celtic Russian
Pale.
Girl/Female
Arabic, Muslim, Sindhi
One who Makes Clear
Boy/Male
Arabic
Preceding; Advanced
Girl/Female
African, Arabic, Australian, Indian, Iranian, Muslim, Parsi
Inspiration; Revelation
Boy/Male
Tamil
Pushpakar | பà¯à®·à¯à®ªà®•à®°
The Spring season (Vasant), Flower season
Boy/Male
Norse
Brave victory.
Girl/Female
Indian, Tamil
Soft and Sweetness
Boy/Male
Hindu, Indian
Lord Ganesh
Surname or Lastname
English
English : variant spelling of Laycock.Americanized form of French Lecocq, with the feminine definite article that is characteristic of French surnames in Canada and New England.
SPLICING QUANTITATIVE-TRAIT-LOCI
SPLICING QUANTITATIVE-TRAIT-LOCI
SPLICING QUANTITATIVE-TRAIT-LOCI
SPLICING QUANTITATIVE-TRAIT-LOCI
SPLICING QUANTITATIVE-TRAIT-LOCI
a.
Relating to quantity.
v.
Continuity or extension of anything; as, the tract of speech.
a.
Estimable according to quantity; quantitative.
v.
Traits; features; lineaments.
n.
A footpath or road track through a wilderness or wild region; as, an Indian trail over the plains.
a.
A (comparatively) narrow passageway connecting two large bodies of water; -- often in the plural; as, the strait, or straits, of Gibraltar; the straits of Magellan; the strait, or straits, of Mackinaw.
n.
Same as Strait-jacket.
v.
A distinguishing or marked feature; a peculiarity; as, a trait of character.
v. i.
To prepare by exercise, diet, instruction, etc., for any physical contest; as, to train for a boat race.
v.
A roll train; as, a 12-inch train.
a.
Deafening; disagreeably loud or shrill; as, ear-splitting strains.
v. t.
To teach and form by practice; to educate; to exercise; to discipline; as, to train the militia to the manual exercise; to train soldiers to the use of arms.
n.
Anything drawn out to a length; as, the trail of a meteor; a trail of smoke.
v.
The after part of a gun carriage; the trail.
v.
A region or quantity of land or water, of indefinite extent; an area; as, an unexplored tract of sea.
v. t.
To draw along; to trail; to drag.
v.
Regular method; process; course; order; as, things now in a train for settlement.
n.
Anything drawn behind in long undulations; a train.