Reference for ABCB11. Search for ABCB11

AI searches containing ABCB11

ABCB11

ABCB11

Protein-coding gene in humans

11 (ABCB11), also known as the bile salt export pump (BSEP), is a protein which in humans is encoded by the ABCB11 gene. The product of the ABCB11 gene

ABCB11

Intrahepatic cholestasis of pregnancy

Medical condition

glucuronides have been shown to inhibit the bile salt export pump (BSEP) ABCB11, and high levels of progesterone to inhibit the ABCB4 (MDR3) phospholipid

Intrahepatic cholestasis of pregnancy

Intrahepatic_cholestasis_of_pregnancy

Cholestasis

Medical condition

to be involved include APT8B1, which encodes for the FIC1 protein. The ABCB11 gene encodes for the bile salt export pump (BSEP) protein, and the ABCB4

Cholestasis

Liver

Vertebrate organ involved in metabolism

and transporter proteins involved in the metabolism of drugs, such as ABCB11 and SLC2A2. Examples of highly liver-specific proteins include apolipoprotein

Liver

Progressive familial intrahepatic cholestasis

Medical condition

#211600), also called Byler disease Type 2 (OMIM #601847), also called ABCB11 deficiency or BSEP deficiency Type 3 (OMIM #602347), also called ABCB4 deficiency

Progressive familial intrahepatic cholestasis

Progressive_familial_intrahepatic_cholestasis

Hepatocellular carcinoma

Common type of liver cancer

A deficiency in bile salt export resulting from a mutation in the gene ABCB11 (ATP-binding cassette, subfamily B member 11) that encodes the bile salt

Hepatocellular carcinoma

Hepatocellular_carcinoma

Ethinylestradiol

Estrogen medication

jaundice. Glucuronide metabolites of ethinylestradiol, via effects on the ABCB11 (BSEP) and MRP2 (ABCC2) proteins and consequent changes in bile flow and

Ethinylestradiol

Eluxadoline

Chemical compound

found to be transported by OAT3 (SLC22A8), OATP1B1 (SLCO1B1), and BSEP (ABCB11) at the highest concentrations tested (400 ng/ml, which is 162-fold larger

Eluxadoline

ABC transporter

Gene family

transport assay is the detection of the inhibition of taurocholate transport by ABCB11 (BSEP). Efflux transporter-expressing cells actively pump substrates out

ABC transporter

ABC_transporter

Transmembrane domain of ABC transporters

Main transmembrane structural unit of ATP-binding cassette transporter proteins

ABC transporter, permease protein EhuC InterPro: IPR014342 ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12;

Transmembrane domain of ABC transporters

Transmembrane_domain_of_ABC_transporters

Mesaconitine

Chemical compound

indicate a targeted effect.) Mesaconitine inhibits the reaction protein ABCB11 leads to an increase in the transport of taurodeoxycholic acid and ABCB1A

Mesaconitine

ATP-binding domain of ABC transporters

Water-soluble domain of transmembrane ABC transporters

ABCA2; ABCA3; ABCA4; ABCA5; ABCA6; ABCA7; ABCA8; ABCA9; ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12;

ATP-binding domain of ABC transporters

ATP-binding_domain_of_ABC_transporters

List of human protein-coding genes 1

ABCB8 HGNC:49; Q9NUT2 49 ABCB9 HGNC:50; Q9NP78 50 ABCB10 HGNC:41; Q9NRK6 51 ABCB11 HGNC:42; O95342 52 ABCC1 HGNC:51; P33527 53 ABCC2 HGNC:53; Q92887 54 ABCC3

List of human protein-coding genes 1

List_of_human_protein-coding_genes_1