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Class of antiretroviral drug
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit
Reverse-transcriptase inhibitor
Reverse-transcriptase_inhibitor
Enzyme which generates DNA
A reverse transcriptase (RT) is an enzyme that uses an RNA molecule as a template to synthesize a complementary DNA molecule, through a process termed
Reverse_transcriptase
Antiretroviral medication
of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA
Zidovudine
nucleotide reverse-transcriptase inhibitors (NRTIs and NtRTIs) began in the 1980s when the AIDS epidemic hit Western societies. NRTIs inhibit the reverse transcriptase
Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors
Discovery_and_development_of_nucleoside_and_nucleotide_reverse-transcriptase_inhibitors
History of certain antiretroviral drugs
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors
Fixed dose combination HIV drug
inhibitor; emtricitabine, an HIV-1 nucleoside analog reverse transcriptase inhibitor; and tenofovir alafenamide, an HIV-1 nucleotide analog reverse transcriptase
Bictegravir/emtricitabine/tenofovir alafenamide
Bictegravir/emtricitabine/tenofovir_alafenamide
nucleoside reverse-transcriptase inhibitors (NRTI) as a "backbone" along with one non-nucleoside reverse-transcriptase inhibitor (NNRTI), protease inhibitor (PI)
Management_of_HIV/AIDS
Chemical compound
food. Lamivudine is a nucleoside reverse transcriptase inhibitor and works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase
Lamivudine
Pharmaceutical compound
FDA in April 2026. It is classified as a nucleoside reverse transcriptase translocation inhibitor (NRTTI). The fixed-dose combination of doravirine and
Islatravir
Combination medication for HIV
abacavir (reverse transcriptase inhibitor), dolutegravir (integrase inhibitor) and lamivudine (nucleoside analog reverse transcriptase inhibitor). Abacavir
Abacavir/dolutegravir/lamivudine
Abacavir/dolutegravir/lamivudine
Combo medication
a HIV-1 non-nucleoside reverse transcriptase inhibitor; and islatravir, a nucleoside analog reverse transcriptase inhibitor. It is taken by mouth.
Doravirine/islatravir
Chemical compound
Doravirine, sold under the brand name Pifeltro, is a non-nucleoside reverse transcriptase inhibitor medication developed by Merck & Co. for use in the treatment
Doravirine
Spectrum of conditions caused by HIV infection
nucleoside reverse transcriptase inhibitors along with a third ARV, either an integrase strand transfer inhibitor (INSTI), a non-nucleoside reverse transcriptase
HIV/AIDS
Chemical compound
highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class. Didanosine was first described in 1975 and approved
Didanosine
Enzyme that metabolizes substances by oxidation
chlorphenamine; protease inhibitors: indinavir, ritonavir, saquinavir, nelfinavir; non-nucleoside reverse-transcriptase inhibitors (antiretroviral drugs):
CYP3A4
Chemical compound
ddC), also called dideoxycytidine, is a nucleoside analog reverse-transcriptase inhibitor (NRTI) sold under the trade name Hivid. Zalcitabine was the
Zalcitabine
Chemical compound
of HIV-1 infection. Rovafovir etalafenamide is a nucleotide reverse transcriptase inhibitor and prodrug of GS-9148. Rovafovir etalafenamide itself has
Rovafovir_etalafenamide
HIV treatment
treatment of HIV/AIDS. It is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect
Rilpivirine
Formulary by the World Health Organization
Cardiovascular Risk with a Combination of a Cholesterol Lowering Agent, an Inhibitor of the Renin-Angiotensin System, and Aspirin, submitted 2001; awarded
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Pharmaceutical drug classification
ATC code J05 Antivirals for systemic use is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric
ATC_code_J05
Combination drug for HIV
is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir
Efavirenz/emtricitabine/tenofovir
Efavirenz/emtricitabine/tenofovir
Chemical compound
and Hepsera. It is an orally administered nucleotide analog reverse-transcriptase inhibitor (ntRTI). It can be formulated as the pivoxil prodrug adefovir
Adefovir
Chemical compound
It is taken by mouth. Tenofovir alafenamide is a nucleotide reverse transcriptase inhibitor and is a prodrug of tenofovir. It was developed by Gilead Sciences
Tenofovir_alafenamide
HIV reverse transcriptase inhibitor and an integrase inhibitor, and was further used in 2011 by a team of researchers combining an integrase inhibitor with
Portmanteau_inhibitor
Antiviral drug used to treat or prevent HIV and hepatitis infections
during pregnancy and appears to be safe. It is a nucleotide reverse transcriptase inhibitor and works by decreasing the ability of the viruses to replicate
Tenofovir_disoproxil
Medication used for the treatment of HIV
human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor (NNRTI). Unlike agents in the class, resistance to other NNRTIs
Etravirine
Chemical compound
used to treat HIV/AIDS. Similar to other nucleoside analog reverse-transcriptase inhibitors (NRTIs), abacavir is used together with other HIV medications
Abacavir
Antiviral drug
reverse-transcriptase inhibitor and a non-nucleoside reverse-transcriptase inhibitor". The approval text describes it as a dual reverse transcriptase
Azvudine
Chemical compound
It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and works by blocking the function of reverse transcriptase. Nevirapine was approved
Nevirapine
Chemical compound
Ainuovirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) being developed by Kainos Medicine for the treatment of HIV infections. Ainuovirine
Ainuovirine
Class of antiviral drugs used to treat HIV/AIDS and hepatitis C
Proteolysis Map Reverse-transcriptase inhibitor Discovery and development of NS5A inhibitors Discovery and development of HIV-protease inhibitors "The Use of
Protease inhibitor (pharmacology)
Protease_inhibitor_(pharmacology)
Combination drug for HIV
of the nucleoside reverse transcriptase inhibitor (NRTI) class. They work by blocking the action of the enzyme, reverse transcriptase, that the virus requires
Lamivudine/zidovudine
Chemical compound
sometimes abbreviated to ATC) is an experimental nucleoside reverse transcriptase inhibitor (NRTI) against HIV. It is structurally related to lamivudine
Apricitabine
protease inhibitor) Darunavir (HIV protease inhibitor) Delavirdine (non-nucleoside reverse transcriptase inhibitor) Fosamprenavir (HIV protease inhibitor) Tipranavir
List_of_sulfonamides
Antiretroviral drug used to treat HIV infection
with trade name Emtriva (formerly Coviracil), is a nucleoside reverse-transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection in
Emtricitabine
Chemical compound
recommended in pregnancy. Stavudine is in the nucleoside analog reverse-transcriptase inhibitor (NRTI) class of medication. Stavudine was first described in
Stavudine
Antiretroviral medication
It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and works by blocking the function of reverse transcriptase. Efavirenz was approved for
Efavirenz
Reverse-transcriptase inhibitor
Atevirdine is a non-nucleoside reverse transcriptase inhibitor that has been studied for the treatment of HIV. Preparation of the pyridylpiperazine moiety
Atevirdine
Laboratory technique to multiply an RNA sample for study
and nuclease-free water in a PCR tube. Then, add an RNase inhibitor and reverse transcriptase to the PCR tube. Next, place the PCR tube into a thermal
Reverse transcription polymerase chain reaction
Reverse_transcription_polymerase_chain_reaction
Chemical compound
is drug used to treat HIV infection. It is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Elsulfavirine is a prodrug which is metabolized to
Elsulfavirine
Drug combination for HIV/AIDS prophylaxis and treatment
Emtricitabine Nucleoside reverse transcriptase inhibitor Tenofovir disoproxil Nucleotide analogue reverse transcriptase inhibitor Clinical data Trade names
Emtricitabine/tenofovir
Molecule that blocks enzyme activity
Hepatitis C, reverse-transcriptase inhibitors targeting HIV/AIDS, neuraminidase inhibitors targeting influenza, and terminase inhibitors targeting human
Enzyme_inhibitor
Belgian pharmacologist and entrepreneur
Institute would lead to the discovery of the first non-nucleoside reverse transcriptase inhibitor (NNRTI). It was also Janssen who would introduce him to Dr
Rudi_Pauwels
Medication
Racivir is an experimental nucleoside reverse transcriptase inhibitor (NRTI), developed by Pharmasset for the treatment of HIV. It is the enantiomer of
Racivir
Pharmaceutical company
and Switzerland. The company markets 17 products: Nucleoside reverse transcriptase inhibitors (NRTIs): abacavir (brand name Ziagen) lamivudine (brand names
ViiV_Healthcare
Chemical compound
Fosdevirine is an experimental antiviral agent of the non-nucleoside reverse transcriptase inhibitor class that was studied for potential use in the treatment of
Fosdevirine
Combination drug for HIV
reverse transcriptase inhibitor Lamivudine Nucleoside reverse transcriptase inhibitor Tenofovir disoproxil Nucleotide reverse transcriptase inhibitor
Doravirine/lamivudine/tenofovir
Doravirine/lamivudine/tenofovir
Medication used to treat a viral infection
substitution in the reverse transcriptase of HIV-1 severely reduces the efficiency of emtricitabine, a nucleoside reverse transcriptase inhibitor commonly used
Antiviral_drug
Chemical compound
Calanolide A is an experimental non-nucleoside reverse transcriptase inhibitor (NNRTI). This compound was extracted from the tree Calophyllum lanigerum
Calanolide_A
Integrase inhibitor Raphamin Remdesivir COVID-19 viral RNA polymerase inhibitor Ribavirin Hepatitis C nucleoside analogue reverse transcriptase inhibitor Rilpivirine
List_of_antiviral_drugs
Antiretroviral drug
immunodeficiency virus HIV-1 protease inhibitor (Ki = 2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV
Nelfinavir
Chemical compound
Delavirdine (DLV) (brand name Rescriptor) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that was marketed by ViiV Healthcare. It was used as
Delavirdine
Class of HIV/AIDS drugs
treated with a combination of reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry inhibitors. Lenacapavir is approved for
HIV_capsid_inhibition
Medication
Stampidine is an experimental nucleoside reverse transcriptase inhibitor (NRTI) with anti-HIV activity. It is a derivative of stavudine (d4T, brand name
Stampidine
Combination drug
integrase strand transfer inhibitor (INSTI), and 300 mg lamivudine, a nucleoside analogue reverse transcriptase inhibitor (NRTI). It is taken by mouth
Dolutegravir/lamivudine
Catalytic subunit of the enzyme telomerase
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase
Telomerase reverse transcriptase
Telomerase_reverse_transcriptase
Chemical compound
reverse transcriptase inhibitors (NRTIs) family of medications. It prevents the hepatitis B virus from multiplying by blocking reverse transcriptase.
Entecavir
Co-packaged antiretroviral medication
Cabotegravir is an integrase strand transfer inhibitor. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). The safety and efficacy of
Cabotegravir/rilpivirine
Chemical compound
Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer. Both phase
Capravirine
Medical condition
treatment regimens typically combined a protease inhibitor (PI) with two nucleoside reverse transcriptase inhibitors (NRTIs), specifically thymidine analogs like
HIV-associated_lipodystrophy
Family of viruses
cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backward)
Retrovirus
American pharmacologist (born 1981)
HIV is tenofovir (Viread). Tenofovir is a nucleotide analog reverse transcriptase inhibitor that prevents the HIV virus from replicating. Tenofovir is
Namandjé_Bumpus
Combination antiretroviral medication for the treatment of HIV/AIDS
Combination of Lamivudine Nucleoside reverse transcriptase inhibitor Tenofovir disoproxil Nucleotide reverse transcriptase inhibitor Clinical data Trade names Cimduo
Lamivudine/tenofovir
Mixture of chemical compounds
medication for the treatment of HIV/AIDS. It contains three reverse transcriptase inhibitors patented by GlaxoSmithKline and marketed by a joint venture
Abacavir/lamivudine/zidovudine
Abacavir/lamivudine/zidovudine
Chemical compound
experimental agent for the treatment of HIV. It is a non-nucleoside reverse transcriptase inhibitor. While emivirine showed promising antiviral activity in vitro
Emivirine
Chemical compound
Lodenosine is a failed experimental agent for the treatment of HIV. Its development was discontinued on January 11, 2001. "Drug Profile: Lodenosine". AdisInsight
Lodenosine
Functional group
trifluoromethyl groups include efavirenz (Sustiva), an HIV reverse transcriptase inhibitor; fluoxetine (Prozac), an antidepressant; and celecoxib (Celebrex)
Trifluoromethyl_group
Chemical compound
Clevudine (INN) is an antiviral drug for the treatment of hepatitis B (HBV). It is already approved for HBV in South Korea and the Philippines. It is marketed
Clevudine
Medication
research for the treatment of HIV/AIDS. It acts as a nucleoside reverse transcriptase inhibitor (NRTI). The drug was discovered by Raymond F. Schinazi (Emory
Amdoxovir
Chemical compound
Janssen-Cilag) that is active against HIV. Loviride is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that entered phase III clinical trials in the late
Loviride
Chemical compound
It is a cytidine nucleoside analog and nucleoside reverse transcriptase inhibitor. that inhibits HIV-1 replication in vitro. During phase II clinical
Dexelvucitabine
Index of chemical compounds with the same molecular formula
may refer to: Calanolide A, an experimental non-nucleoside reverse transcriptase inhibitor Hydroxyestrone diacetate, a synthetic, steroidal estrogen This
C22H26O5
HIV/AIDS research organization
the Efficacy of Once-Daily PI & Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor - Containing Therapy Combinations for Initial Treatment of
AIDS_Clinical_Trials_Group
Virus mutation
to an allosteric site on it. Cessation of a non-nucleoside reverse transcriptase inhibitor regimen poses a significant danger of selection for a drug-resistant
Resistance mutation (virology)
Resistance_mutation_(virology)
Investigational new anti-HIV drug
"Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly
Censavudine
Class of chemical compounds
potency in inhibiting the activity of HIV reverse transcriptase. Several compounds in this class are non-nucleoside reverse transcriptase inhibitors used clinically
Diarylpyrimidines
Chemical compound
Dapivirine is a non-nucleoside reverse transcriptase inhibitor developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership
Dapivirine
Regular measurement of the viral load of HIV-positive people
non-nucleoside reverse transcriptase inhibitors (NNRTIs) Nucleoside reverse transcriptase inhibitors (NRTIs) protease inhibitors (PIs) entry inhibitors Fusion
Viral_load_monitoring_for_HIV
Accidental puncture of skin causing contamination
nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Needlestick_injury
Japanese pharmaceutical company
anti-viral chemotherapeutic agent Hivid (HIV reverse transcriptase inhibitor) 1997 – Released HIV protease inhibitor Invirase 1999 – Released immunosuppressive
Chugai
Topics referred to by the same term
system, referred to as DLV Delavirdine (DLV), a non-nucleoside reverse transcriptase inhibitor (NNRTI) marketed by ViiV Healthcare DNSSEC Lookaside Validation
DLV_(disambiguation)
Topics referred to by the same term
see Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors Dingxing County, a county in Baoding city, Hebei province,
DXG
Type of enzyme inhibition by forming an irreversible complex with the substrate
inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme
Suicide_inhibition
Private university in Atlanta, Georgia, US
and Woo-Baeg Choi discovered Emtricitabine, a nucleoside reverse-transcriptase inhibitor (NRTI) used in the treatment of HIV. The drug was named as
Emory_University
Antiretroviral vaginal ring
through the provision of the ring. DPV, an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), is slowly released via local intravaginal administration
Dapivirine_Ring
Biochemical compound
large family of nucleoside analogue reverse transcriptase inhibitors, because DNA production by reverse transcriptase is very different from normal human
Nucleoside_analogue
Formulary
alternative Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) Alternatives are 4th level ATC chemical subgroup (D01AC Imidazole
WHO Model List of Essential Medicines for Children
WHO_Model_List_of_Essential_Medicines_for_Children
H (retroviral RNase H) is a catalytic domain of the retroviral reverse transcriptase (RT) enzyme. The RT enzyme is used to generate complementary DNA
Retroviral_ribonuclease_H
adds a second primer through the activity of murine leukemia virus reverse transcriptase. This permits reading full cDNA sequences and can deliver high yield
Template-switching polymerase chain reaction
Template-switching_polymerase_chain_reaction
Topics referred to by the same term
(simulation) Reproductive tract infection Respiratory tract infection Reverse-transcriptase inhibitor, a class of antiretroviral drug Ramp travel index, a measure
RTI
Stomach acid suppressing medication
pantoprazole, and lansoprazole). Rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV, is contraindicated with
Rabeprazole
Chemical compound
treatment of HIV/AIDS. It belongs to the class of nucleoside reverse transcriptase inhibitors. KP-1461 is a prodrug of the active antiviral agent KP-1212
KP-1461
Italian-American virologist (1914–2012)
that could be considered successful against the virus, the reverse-transcriptase inhibitors, of which zidovudine is a well-known example. These drugs are
Renato_Dulbecco
Medication
class of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). By blocking reverse transcriptase enzymes, NRTIs prevent HIV from multiplying
Elvucitabine
Combination drug for HIV
analog reverse-transcriptase inhibitor Rilpivirine Non-nucleoside reverse transcriptase inhibitor Tenofovir disoproxil Nucleotide analog reverse-transcriptase
Emtricitabine/rilpivirine/tenofovir
Emtricitabine/rilpivirine/tenofovir
Combination drug for HIV
appears to be okay. Lamivudine and abacavir are both nucleoside reverse transcriptase inhibitors (NRTI). Abacavir/lamivudine was approved for medical use in
Abacavir/lamivudine
Informal grouping of virus species
cure of a patient in Greece; tenofovir disoproxil (TDF), a reverse-transcriptase inhibitor used for HIV; cepharanthine, an alkaloid from Stephania cephalantha
Primate_T-lymphotropic_virus
South American-born American virologist
containing nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitor (PI), and non-nucleoside reverse transcriptase inhibitors (NNRTI). The HAART
Deborah_Persaud
History of molecular discovery
inhibitor Entry inhibitor Discovery and development of non-nucleoside reverse transcriptase inhibitors Discovery and development of NS5A inhibitors Cuccioloni
Discovery and development of HIV-protease inhibitors
Discovery_and_development_of_HIV-protease_inhibitors
Variants of the human immunodeficiency virus
(ART), nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PI), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) with the
Subtypes_of_HIV
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REVERSE TRANSCRIPTASE-INHIBITOR
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REVERSE TRANSCRIPTASE-INHIBITOR
REVERSE TRANSCRIPTASE-INHIBITOR
REVERSE TRANSCRIPTASE-INHIBITOR
REVERSE TRANSCRIPTASE-INHIBITOR
REVERSE TRANSCRIPTASE-INHIBITOR