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RESMETIROM

  • Resmetirom

    • Chemical compound

    Resmetirom, sold under the brand name Rezdiffra, is a medication used to treat a form of fatty liver disease. Specifically it is used in the treatment

    Resmetirom

    Resmetirom

    Resmetirom

  • Iodine

    • Chemical element with atomic number 53 (I)

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Iodine

    Iodine

    Iodine

  • Levothyroxine

    • Thyroid hormone medication

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Levothyroxine

    Levothyroxine

    Levothyroxine

  • Metabolic dysfunction–associated steatotic liver disease

    • Excessive fat buildup in the liver with other metabolic disease

    pioglitazone, and vitamin E in the treatment of MASLD. In March 2024, resmetirom was the first drug approved by the FDA for MASH. Approval in the EU followed

    Metabolic dysfunction–associated steatotic liver disease

    Metabolic dysfunction–associated steatotic liver disease

    Metabolic_dysfunction–associated_steatotic_liver_disease

  • Propranolol

    • Beta blocker drug

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Propranolol

    Propranolol

    Propranolol

  • VK2809

    • Chemical compound

    agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196)". Expert Opinion on Investigational Drugs. 29 (2): 99–101.

    VK2809

    VK2809

    VK2809

  • Thioureas

    • Organosulfur compounds with an >NC(=S)N< structure

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thioureas

    Thioureas

    Thioureas

  • Perchlorate

    • Ion, and compounds containing the ion

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Perchlorate

    Perchlorate

    Perchlorate

  • Iodine-131

    • Isotope of iodine

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Iodine-131

    Iodine-131

    Iodine-131

  • Propylthiouracil

    • Medication used to treat hyperthyroidism

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Propylthiouracil

    Propylthiouracil

    Propylthiouracil

  • Carbimazole

    • Medication used for hyperthyroidism

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Carbimazole

    Carbimazole

    Carbimazole

  • Thiocyanate

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thiocyanate

    Thiocyanate

    Thiocyanate

  • Elunetirom

    • Pharmaceutical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Elunetirom

    Elunetirom

    Elunetirom

  • Tyrosine

    • Amino acid

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Tyrosine

    Tyrosine

    Tyrosine

  • Thioamide

    • Class of organic compounds

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thioamide

    Thioamide

    Thioamide

  • Desiccated thyroid extract

    • Thyroid gland prepared for medical use

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Desiccated thyroid extract

    Desiccated_thyroid_extract

  • Antithyroid agent

    • Hormone antagonist acting upon thyroid hormones

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Antithyroid agent

    Antithyroid_agent

  • Iopanoic acid

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Iopanoic acid

    Iopanoic acid

    Iopanoic_acid

  • Pertechnetate

    • Chemical compound or ion

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Pertechnetate

    Pertechnetate

    Pertechnetate

  • Thiourea

    • Organosulfur compound (S=C(NH2)2)

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thiourea

    Thiourea

    Thiourea

  • Steatohepatitis

    • Medical condition

    surgery is sometimes used. As of March 2024, there is one medication, resmetirom (Rezdiffra™) commercially available in the US for management of NASH.

    Steatohepatitis

    Steatohepatitis

    Steatohepatitis

  • Liothyronine

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Liothyronine

    Liothyronine

    Liothyronine

  • Thyromimetic

    • toxicity. Thyromimetics selective for TRβ—including eprotirome, sobetirome, resmetirom, and the prodrug VK2809—have been investigated for the treatment of non-alcoholic

    Thyromimetic

    Thyromimetic

    Thyromimetic

  • Thiamazole

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thiamazole

    Thiamazole

    Thiamazole

  • Triiodothyronine

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Triiodothyronine

    Triiodothyronine

    Triiodothyronine

  • Potassium perchlorate

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Potassium perchlorate

    Potassium perchlorate

    Potassium_perchlorate

  • Sobetirome

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Sobetirome

    Sobetirome

    Sobetirome

  • Selenium

    • Chemical element with atomic number 34 (Se)

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Selenium

    Selenium

    Selenium

  • Thyroid peroxidase

    • Enzyme expressed mainly in the thyroid gland

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroid peroxidase

    Thyroid peroxidase

    Thyroid_peroxidase

  • Thyroid hormones

    • Hormones produced by the thyroid gland

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroid hormones

    Thyroid hormones

    Thyroid_hormones

  • Eprotirome

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Eprotirome

    Eprotirome

    Eprotirome

  • Thyroglobulin

    • Protein produced and used by the thyroid

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroglobulin

    Thyroglobulin

    Thyroglobulin

  • Ipodate sodium

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Ipodate sodium

    Ipodate sodium

    Ipodate_sodium

  • Liotrix

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Liotrix

    Liotrix

  • Methylthiouracil

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Methylthiouracil

    Methylthiouracil

    Methylthiouracil

  • ASC41

    • Pharmaceutical drug

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    ASC41

    ASC41

  • List of drugs: Re

    • Rescriptor Rescula Resectisol reserpine (INN) reslizumab (INN, USAN) resmetirom (INN) resminostat (INN) resocortol (INN) resorantel (INN) Respbid RespiGam

    List of drugs: Re

    List_of_drugs:_Re

  • TERN-501

    • Chemical compound

    101153. PMC 8085542. PMID 33359400. Karim, Gres; Bansal, Meena B (2023). "Resmetirom: An Orally Administered, Smallmolecule, Liver-directed, β-selective THR

    TERN-501

    TERN-501

    TERN-501

  • Organic thiocyanates

    • MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Organic thiocyanates

    Organic thiocyanates

    Organic_thiocyanates

  • ATC code A05

    • Pharmaceutical drug classification

    acid (glycyrrhizin) A05BA09 Metadoxine A05BA10 Phospholipids A05BA11 Resmetirom QA05BA90 Methionine Empty group "ATC (Anatomical Therapeutic Chemical

    ATC code A05

    ATC_code_A05

  • 2024 in science

    • 3-trialed R21/Matrix-M vaccine against Malaria (1 Feb), phase 3-trialed resmetirom as first medication against nonalcoholic steatohepatitis of the liver

    2024 in science

    2024_in_science

  • Sodium pertechnetate

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Sodium pertechnetate

    Sodium pertechnetate

    Sodium_pertechnetate

  • List of drugs granted breakthrough therapy designation

    • progressed following treatment or have no satisfactory alternative therapy Resmetirom In conjunction with diet and exercise, for the treatment of adults with

    List of drugs granted breakthrough therapy designation

    List_of_drugs_granted_breakthrough_therapy_designation

  • Thyroxine-binding globulin

    • Mammalian protein found in Homo sapiens

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroxine-binding globulin

    Thyroxine-binding globulin

    Thyroxine-binding_globulin

  • Transthyretin

    • Serum protein related to amyloid diseases

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Transthyretin

    Transthyretin

    Transthyretin

  • Tiratricol

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Tiratricol

    Tiratricol

    Tiratricol

  • Genistein

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Genistein

    Genistein

    Genistein

  • 2-Thiouracil

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    2-Thiouracil

    2-Thiouracil

    2-Thiouracil

  • Iodothyronine deiodinase

    • Class of enzymes

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Iodothyronine deiodinase

    Iodothyronine deiodinase

    Iodothyronine_deiodinase

  • Sodium/iodide cotransporter

    • Mammalian protein found in Homo sapiens

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Sodium/iodide cotransporter

    Sodium/iodide cotransporter

    Sodium/iodide_cotransporter

  • Thyroid hormone receptor beta

    • Protein-coding gene in the species Homo sapiens

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroid hormone receptor beta

    Thyroid hormone receptor beta

    Thyroid_hormone_receptor_beta

  • Thyroid hormone receptor

    • Nuclear protein

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroid hormone receptor

    Thyroid_hormone_receptor

  • Dextrothyroxine

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Dextrothyroxine

    Dextrothyroxine

    Dextrothyroxine

  • Benzylthiouracil

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Benzylthiouracil

    Benzylthiouracil

    Benzylthiouracil

  • Thyroid hormone receptor alpha

    • Protein-coding gene in the species Homo sapiens

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Thyroid hormone receptor alpha

    Thyroid hormone receptor alpha

    Thyroid_hormone_receptor_alpha

  • Omzotirome

    • Chemical compound

    MA-JD21) Eprotirome (KB-2115) KB-141 KB-2611 KB-130015 MB-07344 MB-07811 Resmetirom Sobetirome (GC-1, GRX-431) VK-0214 VK-2809 ZYT1 Antagonists 1-850 NH3

    Omzotirome

    Omzotirome

    Omzotirome

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