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Aromatic compound (C4H4N2)
Pyrimidine (C4H4N2; /pɪˈrɪ.mɪˌdiːn, paɪˈrɪ.mɪˌdiːn/) is an aromatic, heterocyclic, organic compound similar to pyridine (C5H5N). One of the three diazines
Pyrimidine
Type of DNA damage
Pyrimidine dimers are chemical species issued from a photochemical reaction involving two pyrimidine (P) nucleobases (thymine, cytosine, or uracil) through
Pyrimidine_dimer
Biological molecules constituting nucleic acids
The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine (in DNA) and uracil (in RNA)
Nucleotide
Nitrogen-containing biological compounds that form nucleosides
of cytosine, uracil, and thymine is derived of pyrimidine, so those three bases are called the pyrimidine bases. Each of the base pairs in a typical double-helix
Nucleotide_base
Chemical compound of RNA
demethylated form of thymine. Uracil is a common and naturally occurring pyrimidine derivative. The name "uracil" was coined in 1885 by the German chemist
Uracil
Set of biological pathways
Pyrimidine biosynthesis occurs both in the body and through organic synthesis. De Novo biosynthesis of a pyrimidine is catalyzed by three gene products
Pyrimidine_metabolism
Class of enzymes
is called photoreactivation. They mainly convert pyrimidine dimers into a normal pair of pyrimidine bases. Photo reactivation, the first DNA repair mechanism
Photolyase
Index of articles associated with the same name
Pyrimidine phosphorylase may refer to: Thymidine phosphorylase Uridine phosphorylase This set index article includes a list of related items that share
Pyrimidine_phosphorylase
Heterocyclic aromatic organic compound
a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives
Purine
Any of several glycosylamines comprising a nucleobase and a sugar molecule
linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. Nucleotides are the molecular building blocks of DNA and RNA. This list
Nucleoside
Process
to one of two categories: purines or pyrimidines. In complex multicellular animals, both purines and pyrimidines are primarily synthesized in the liver
Nucleic_acid_metabolism
Chemical compound of DNA
adenine, guanine, and cytosine. Thymine is also known as 5-methyluracil, a pyrimidine nucleobase. In RNA, thymine is replaced by the nucleobase uracil. Thymine
Thymine
Chemical compound synthesized in the body via a mitochondrial enzyme
orotidine-5′-monophosphate (OMP). A distinguishing characteristic of pyrimidine synthesis is that the pyrimidine ring is fully synthesized before being attached to the
Orotic_acid
Chemical compound in nucleic acids
RNA, along with adenine, guanine, and thymine (uracil in RNA). It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached
Cytosine
Chemicals that inhibit the use of a metabolite
Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines. Nucleic acids are one of the four types of macromolecules
Pyrimidine_analogue
Biological process
to nucleotide salvage in particular, in which nucleotides (purine and pyrimidine) are synthesized from intermediates in their degradative pathway. Nucleotide
Nucleotide_salvage
Chemical compound
point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. It is a "deliquescent crystal or wax-like solid with a pungent, sweet
Pyrazine
Deoxyribonuclease (pyrimidine dimer) (EC 3.1.25.1, endodeoxyribonuclease (pyrimidine dimer), bacteriophage T4 endodeoxyribonuclease V, T4 endonuclease
Deoxyribonuclease (pyrimidine dimer)
Deoxyribonuclease_(pyrimidine_dimer)
Class of enzymes
nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase. Other names in common use include purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl
Nucleoside deoxyribosyltransferase
Nucleoside_deoxyribosyltransferase
Two rules about the percentage of A, C, G, and T in DNA strands
amount of thymine. Further, a 1:1 stoichiometric ratio of purine and pyrimidine bases (i.e., A+G=T+C) should exist. This pattern is found in both strands
Chargaff's_rules
Two nucleobases bound by hydrogen bonds
single-ringed chemical structures called pyrimidines. Purines are complementary only with pyrimidines: pyrimidine–pyrimidine pairings are energetically unfavorable
Base_pair
Chemical compound of DNA and RNA
formula C5H5N5O, guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. This unsaturated arrangement
Guanine
Class of enzymes
Pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) is an enzyme that catalyzes several phosphorolysis reactions which convert a pyrimidine nucleoside into
Pyrimidine-nucleoside phosphorylase
Pyrimidine-nucleoside_phosphorylase
Chemical compound
Cytidine triphosphate (CTP) is a pyrimidine nucleoside triphosphate. CTP, much like ATP, consists of a ribose sugar, and three phosphate groups. The major
Cytidine_triphosphate
Class of enzymes
Dihydroorotase is a zinc metalloenzyme. Pyrimidine biosynthesis Cooper C, Wilson DW (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194. Lieberman I,
Dihydroorotase
Molecule that carries genetic information
divided into two groups, the single-ringed pyrimidines and the double-ringed purines. In DNA, the pyrimidines are thymine and cytosine; the purines are
DNA
Chemical process of joining two molecular entities by bonds of any kind
radical (C5H5)Cr(CO)3. Pyrimidine dimers (also known as thymine dimers) are formed by a photochemical reaction from pyrimidine DNA bases when exposed
Dimerization
Russian oncologist
who have skin type I and II have higher induction of cyclobutane and pyrimidine dimers than those that have III or IV type. During the study he also mentioned
Vladimir_Bykov
Protein-coding gene in the species Homo sapiens
trifunctional multi-domain enzyme involved in the first three steps of pyrimidine biosynthesis. De-novo synthesis starts with cytosolic carbamoylphosphate
CAD_protein
Chemist
purine and pyrimidine metabolism, publishing more than 400 papers and book chapters. Simmonds was a co-founder of the Purine and Pyrimidine Society, the
Anne_Simmonds
Protein family
endonucleosidase (EC 3.2.2.17, pyrimidine dimer DNA-glycosylase, endonuclease V, deoxyribonucleate pyrimidine dimer glycosidase, pyrimidine dimer DNA glycosylase
Deoxyribodipyrimidine endonucleosidase
Deoxyribodipyrimidine_endonucleosidase
pyrimidine nucleoside + H2O ⇌ {\displaystyle \rightleftharpoons } D-ribose + a pyrimidine base Thus, the two substrates of this enzyme are pyrimidine
Ribosylpyrimidine nucleosidase
Ribosylpyrimidine_nucleosidase
Enzyme involved in pyrimidine biosynthesis
decarboxylase) or orotidylate decarboxylase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the decarboxylation of orotidine monophosphate
Orotidine 5′-phosphate decarboxylase
Orotidine_5′-phosphate_decarboxylase
Biopolymer molecule composed of nucleotide monomers
governed by physico-chemical processes. RNA is composed of purine and pyrimidine nucleotides, both of which are necessary for reliable information transfer
Polynucleotide
Pyrimidine oxygenase (EC 1.14.99.46, RutA) is an enzyme with systematic name uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening). This
Pyrimidine_oxygenase
Class of enzymes
(OPRTase) or orotic acid phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the formation of orotidine 5'-monophosphate
Orotate phosphoribosyltransferase
Orotate_phosphoribosyltransferase
Class of chemical compounds
antitumour agents. A large number of novel carbocyclic nucleosides of pyrimidines and purines have been prepared, and many of these compounds are endowed
Carbocyclic_nucleoside
Class of chemical compounds
Pyrimidinediones are a class of chemical compounds characterized by a pyrimidine ring substituted with two carbonyl groups. Examples include naturally
Pyrimidinedione
Scientific hypotheses on the origin and evolution of DNA
chemicals like pyrimidine, which is found in meteorites, researchers have successfully formed uracil, cytosine, and thymine. Pyrimidine, similar to polycyclic
Origin_of_DNA
Medical condition
decreased ability to synthesize pyrimidines. It was the first described enzyme deficiency of the de novo pyrimidine synthesis pathway. Orotic aciduria
Orotic_aciduria
Chemical compound
moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase
Leflunomide
Chemical compound
acid which serves as an intermediate in pyrimidine biosynthesis. Lacroute F (March 1968). "Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae"
4,5-Dihydroorotic_acid
Chemical compound
dihydroorotate dehydrogenase (DHODH), disrupting the de novo pyrimidine biosynthesis pathway. Pyrimidine is used for DNA/RNA synthesis and metabolising things
Tetflupyrolimet
In enzymology, a pyrimidine-5'-nucleotide nucleosidase (EC 3.2.2.10) is an enzyme that catalyzes the chemical reaction a pyrimidine 5'-nucleotide + H2O
Pyrimidine-5'-nucleotide nucleosidase
Pyrimidine-5'-nucleotide_nucleosidase
Redundancy of codons in the genetic code
mutations (purine to purine or pyrimidine to pyrimidine mutations) are more likely than transversion (purine to pyrimidine or vice versa) mutations, the
Codon_degeneracy
One of the five major nucleosides in nucleic acids
Uridine (symbol U or Urd) is a glycosylated pyrimidine analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a
Uridine
Multicomponent chemical reaction
ISSN 0022-2623. PMID 26824742. Folkers, K.; Johnson, T. B. (1933). "Researches on Pyrimidines. CXXXVI. The Mechanism of Formation of Tetrahydropyrimidines by the Biginelli
Biginelli_reaction
Class of pharmaceutical drugs
cancer when compared to aryl-urea compounds with either quinazoline or pyrimidine moieties. N-substituted phenyl N’-substituted heterocyclic urea compounds
VEGFR-2_inhibitor
Chemical compound
to a pyrimidine ring through a shared nitrogen atom, with a ketone at the 4-position. It is the parent compound of the pyrido[1,2-a]pyrimidine ring system
4H-Pyrido(1,2-a)pyrimidin-4-one
4H-Pyrido(1,2-a)pyrimidin-4-one
Life arising from non-living matter
outer space conditions, using starting chemicals such as pyrimidine from meteorites. Pyrimidine may have formed in red giant stars, interstellar dust, or
Abiogenesis
Chemical compound
acid or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric
Barbituric_acid
Chemical compound
5,10-Methylenetetrahydrofolate (N5,N10-Methylenetetrahydrofolate; 5,10-CH2-THF) is cofactor in several biochemical reactions. It exists in nature as the
5,10-Methylenetetrahydrofolate
5,10-Methylenetetrahydrofolate
Class of enzymes
(6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase. This enzyme catalyses the following chemical reaction: (6-4) photoproduct
(6-4)DNA_photolyase
Class of enzymes
Thiaminase is an enzyme that metabolizes or breaks down thiamine into pyrimidine and thiazole. It is an antinutrient when consumed. The old name was "aneurinase"
Thiaminase
Chemical compound
which has an effect as a fungicide. It belongs to the chemical family of pyrimidine sulfamates. Bupirimate has translaminar mobility and systemic translocation
Bupirimate
Hypothetical stage in the early evolutionary history of life on Earth
RNA only later. On the other hand, the discovery in 2009 that activated pyrimidine ribonucleotides can be synthesized under plausible prebiotic conditions
RNA_world
Life that does not originate on Earth
Methyl acetate Methyl-cyano-diacetylene Methyltriacetylene Propionaldehyde Pyrimidine Deuterated molecules Ammonia Ammonium ion Formaldehyde Formyl radical
Extraterrestrial_life
Class of organic chemical compounds
class of organic chemical compounds that include two amine groups on a pyrimidine ring. They include many dihydrofolate reductase inhibitor drugs (such
Diaminopyrimidine
Chemical compound
Thymidine (symbol dT or dThd), also known as deoxythymidine is a pyrimidine deoxynucleoside. Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine
Thymidine
Combination medication
used for the treatment of thymidine kinase 2 deficiency. It contains the pyrimidine nucleosides, doxecitine (deoxycytidine) and doxribtimine (thymidine).
Doxecitine/doxribtimine
Organic chemical compound
compound consisting of pyridine ring fused orthogonally at any position to a pyrimidine ring. List of pyridopyrimidines "pyridopyrimidine (CHEBI:38932)". www
Pyridopyrimidine
Class of enzymes
pentosyltransferases. The systematic name of this enzyme class is nucleoside:purine(pyrimidine) D-ribosyltransferase. This enzyme is also called nucleoside N-ribosyltransferase
Nucleoside_ribosyltransferase
Antibiotic
urinary tract infections in Finland. Its name is derived from trimethyloxy-pyrimidine. "Trimethoprim". The American Society of Health-System Pharmacists. Archived
Trimethoprim
Class of chemical compounds
(purines) differs from the synthesis of CTP, TTP, and UTP (pyrimidines). Both purine and pyrimidine synthesis use phosphoribosyl pyrophosphate (PRPP) as a
Nucleoside_triphosphate
Index of chemical compounds with the same name
general class organic compounds in which the substituent(s) around a pyrimidine ring include at least one fluorine atom. The term "fluoropyrimidines"
Fluoropyrimidine
Pyrimidine-deoxynucleoside 2'-dioxygenase (EC 1.14.11.3) is an enzyme that catalyzes the chemical reaction deoxyuridine Fe(IV)=O Fe(II) uridine
Pyrimidine-deoxynucleoside 2'-dioxygenase
Pyrimidine-deoxynucleoside_2'-dioxygenase
Nucleic acid pairing variations
a pyrimidine base (C/T) uses its Watson–Crick (anti, N3–C4) face to bind the syn (N6–N7) face of a purine (A/G). Adenine, which is not a pyrimidine, is
Hoogsteen_base_pair
Biomolecular structure of nucleic acids such as DNA and RNA
are pyrimidines, hence the glycosidic bonds form between their 1 nitrogen and the 1' -OH of the deoxyribose. For both the purine and pyrimidine bases
Nucleic_acid_structure
Protein-coding gene in the species Homo sapiens
the CTPS1 gene in humans. CTP synthase 1 is an enzyme in the de novo pyrimidine synthesis pathway that catalyses the conversion of uridine triphosphate
CTP_synthase_1
DNA mutation that exchanges two nucleotides
changes a purine nucleotide to another purine (A ↔ G) or a pyrimidine nucleotide to another pyrimidine (C ↔ T). Transitions are common in genomes; approximately
Transition_(genetics)
Nucleotide containing ribose as its pentose component
nitrogenous bases are classified into two parent compounds, purine and pyrimidine. The general structure of a ribonucleotide consists of a phosphate group
Ribonucleotide
Chemical compound
Diazinon (IUPAC name: O,O-Diethyl O-[4-methyl-6-(propan-2-yl)pyrimidin-2-yl] phosphorothioate, INN - Dimpylate), a colorless to dark brown liquid, is a
Diazinon
Antimicrobial and antiprotozoan drug
mitochondrial cytochrome bc1 complex, thus inhibiting a step of protozoal pyrimidine synthesis. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of both
Atovaquone
Chemical compound
chemicals such as 3-(trifluoromethyl)isoquinoline and 2,4-bis(trifluoromethyl)pyrimidine. Sigma-Aldrich Co., product no. 544078. Marshall H. Parker (2004), "A
Trifluoroacetonitrile
Pyrimidine-rich sequence involved in pre-messenger RNA maturation
process of post-transcriptional modification. The region is rich with pyrimidine nucleotides, especially uracil, and is usually 15–20 base pairs long,
Polypyrimidine_tract
Reaction mechanism in ring systems
reactions of metal amide nucleophiles (such as sodium amide) and substituted pyrimidines (for instance 4-phenyl-6-bromopyrimidine 1) in ammonia at low temperatures
ANRORC_mechanism
Enzyme
TYMP gene and catalyzes several phosphorolysis reactions which convert pyrimidine nucleosides such as thymidine, into their corresponding nucleotide base
Thymidine_phosphorylase
Chemical compound
compound and a nucleoside. It belongs to a class of compounds known as Pyrimidine 2'-deoxyribonucleosides and closely resembles the chemical composition
Deoxyuridine
Chemical compound
antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and
Pemetrexed
Anti-cancer medication
Lazertinib, sold under the brand names Lazcluze and Leclaza among others, is an anti-cancer medication used for the treatment of non-small cell lung cancer
Lazertinib
Meteorite found in Victoria, Australia
the Murchison, Murray and Tagish Lake meteorites. Measured purine and pyrimidine compounds were found in the Murchison meteorite. Carbon isotope ratios
Murchison_meteorite
Protein-coding gene in the species Homo sapiens
5'-nucleotidase 3 (NT5C3), also known as cytosolic 5'-nucleotidase 3A, pyrimidine 5’-nucleotidase (PN-I or P5'NI), and p56, is an enzyme that in humans
NT5C3
Chemical compound
stimulation. Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative: "Prescription medicines: registration of new chemical entities
Avanafil
Class of enzymes
carbamoyl phosphate plus ADP. It represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes, and in the urea
Carbamoyl phosphate synthetase
Carbamoyl_phosphate_synthetase
Chemical compound
(1953). "A revision of the structural formulation of vicine and its pyrimidine aglucone, divicine". Biochim. Biophys. Acta. 12 (1–2): 462–77. doi:10
Divicine
Medical condition
responsible for abnormal folate metabolism. Tea and toast diet Inherited Pyrimidine Synthesis Disorders: Orotic aciduria Inherited DNA Synthesis Disorders
Megaloblastic_anemia
Chemical compound
formation of purine nucleotides via inosine-5-monophosphate, as well as in pyrimidine nucleotide formation. Hence it is a building block for DNA and RNA. The
Phosphoribosyl_pyrophosphate
Process where substrates are converted into more complex products in living organisms
and deoxyribose sugar in DNA; these sugars are linked to a purine or pyrimidine base with a glycosidic bond and a phosphate group at the 5' location of
Biosynthesis
Organic compound (C4H4N2); benzene with two CH groups replaced by N
nitrogen. There are three structural isomers: pyridazine (1,2-diazine) pyrimidine (1,3-diazine) pyrazine (1,4-diazine) 6-membered rings with one nitrogen
Diazine
Anti-cancer medication
Fludarabine#) Nelarabine Rabacfosadine Thiopurine (Mercaptopurine# Tioguanine#) Pyrimidine Thymidylate synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine
Vorasidenib
InterPro Family
that erythrocyte pyrimidine 5′-nucleotidase activity is significantly lowered in patients with lead poisoning, and that pyrimidine 5′-nucleotidase activity
5'-nucleotidase
Heterocyclic organic compound (C4H4N2)
point of 208 °C. It is isomeric with two other diazine (C4H4N2) rings, pyrimidine and pyrazine. Pyridazines are rare in nature, possibly reflecting the
Pyridazine
Organosulfur compound (S=C(NH2)2)
resins, and vulcanization accelerators. Thiourea is building blocks to pyrimidine derivatives. Thus, thioureas condense with β-dicarbonyl compounds. The
Thiourea
Chemical compound
brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine)
Cytidine
Molecule with one or more rings composed of different elements
described, highlighting the role of heterocyclic compounds (purines and pyrimidines) in the genetic code. Heterocyclic compounds are pervasive in many areas
Heterocyclic_compound
Hexagonal lattice made of carbon atoms
Methyl acetate Methyl-cyano-diacetylene Methyltriacetylene Propionaldehyde Pyrimidine Deuterated molecules Ammonia Ammonium ion Formaldehyde Formyl radical
Graphene
Enzymes that catalyze DNA formation
der Waals and electrostatic interactions are lost by the pyrimidine. Pyrimidine:pyrimidine and purine:purine mismatches present less notable changes
DNA_polymerase
Compound analogous to naturally occurring RNA and DNA
structure: Pyrimidines are six-membered heterocyclic with nitrogen atoms in position 1 and 3. Purines are bicyclic, consisting of a pyrimidine fused to
Nucleic_acid_analogue
Gene therapy medication
Fludarabine#) Nelarabine Rabacfosadine Thiopurine (Mercaptopurine# Tioguanine#) Pyrimidine Thymidylate synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine
Nadofaragene_firadenovec
Chemical compound
which N,N-diethylguanidine is reacted with ethyl acetoacetate to form a pyrimidine ring and its hydroxy group is combined with dimethyl chlorothiophosphate
Pirimiphos-methyl
PYRIMIDINE
PYRIMIDINE
PYRIMIDINE
PYRIMIDINE
Girl/Female
Biblical
To finish, complete.
Girl/Female
English French American Scottish
God is gracious.
Girl/Female
Indian
Demon.
Girl/Female
Hindu, Indian
Daughter of Lord Vishnu
Girl/Female
Australian, French
Tender Touch; Beloved
Female
Chinese
respectful.
Boy/Male
Hindu, Indian
Lord of Strength
Girl/Female
Tamil
Story
Girl/Female
Hindu
From a Arabian descent and means jewel
Girl/Female
Arabic, Muslim
To have Mercy Upon
PYRIMIDINE
PYRIMIDINE
PYRIMIDINE
PYRIMIDINE
PYRIMIDINE