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Mammalian protein found in Homo sapiens
MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5
MDA5
Receptor family
characterized receptor within the RIG-I like receptor (RLR) family. Together with MDA5 (melanoma differentiation-associated 5) and LGP2 (laboratory of genetics
RIG-I-like_receptor
Family of cell surface receptors
immune systems. Three RLR helicases have so far been described: RIG-I and MDA5 (recognizing 5'triphosphate-RNA and dsRNA, respectively), which activate
Pattern_recognition_receptor
Hemorrhagic fever caused by ebolaviruses
infected with EBOV, receptors located in the cell's cytosol (such as RIG-I and MDA5) or outside of the cytosol (such as Toll-like receptor 3 (TLR3), TLR7, TLR8
Ebola
Enzyme found in humans
results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production of interferons. RNase L is present
Ribonuclease_L
Medical condition
the ribonuclease H2 enzyme complex), SAMHD1, ADAR1, and IFIH1 (coding for MDA5). This neurological disease occurs in all populations worldwide, although
Aicardi–Goutières_syndrome
Mammalian protein found in humans
Melanoma Differentiation-Associated protein 5 (MDA5) and Laboratory of genetics physiology 2 (LGP2). RIG-I and MDA5 are both involved in activating MAVS and
RIG-I
Branch of phylogeny that analyzes genetic, hereditary molecular differences
how these changes contribute to functional diversification. For example, MDA5 gene has been independently lost in several unrelated vertebrate lineages
Molecular_phylogenetics
Immunity strategy in living beings
located in the endosomal membrane and recognize double-stranded RNA (dsRNA), MDA5 and RIG-I receptors are located in the cytoplasm and recognize long dsRNA
Innate_immune_system
Inherited retrovirus encoded in an organism's genome
state. HERV-derived dsRNA can be recognized by TLR-3, RIG-I, and MDA5; RIG-I and MDA5 are known to induce a type I IFN response. When retrotranscribed
Endogenous_retrovirus
Protein-coding gene in the species Homo sapiens
(RIG-I)-like receptors and melanoma differentiation-associated gene 5 (MDA5). RIG-I and MDA5 differ in the viral RNA that they recognize, but they share many
Mitochondrial antiviral-signaling protein
Mitochondrial_antiviral-signaling_protein
Protein-coding gene in the species Homo sapiens
antiviral responses against many viruses that are recognized by RIG-I and MDA5. Since LGP2 lacks CARD domains, its effect on downstream antiviral signaling
LGP2
Protein-coding gene in the species Homo sapiens
Retrieved 2018-03-23. Parsons KS, Hsu AC, Wark PA (January 2014). "TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial
MAX_dimerization_protein_MGA
Topics referred to by the same term
Misuse of Drugs Act (disambiguation) Missionary Diocese of All Saints (MDAS) MDA5, melanoma differentiation-associated protein 5 2,3-Methylenedioxyamphetamine
MDA
Fabien, Nicole; Coutant, Frédéric (2021-10-20). "Dermatomyositis With Anti-MDA5 Antibodies: Bioclinical Features, Pathogenesis and Emerging Therapies". Frontiers
List_of_autoimmune_diseases
Signaling proteins released by host cells in response to the presence of pathogens
membrane bound toll like receptors or the cytoplasmic receptors RIG-I or MDA5, can trigger release of IFNs. Toll Like Receptor 3 (TLR3) is important for
Interferon
Type of molecules within cells
IL-1R IL-33 ST2 SAP130 Mincle DNA TLR9, AIM2 RNA TLR3, TLR7, TLR8, RIG-I, MDA5 Mitochondria mtDNA TLR9 TFAM RAGE Formyl peptide FPR1 mROS NLRP3 Endoplasmic
Damage-associated molecular pattern
Damage-associated_molecular_pattern
through activating dsRNA expression which leads to the activation of the MDA5/MAVS RNA recognition pathway inducing some sort of viral mimicry inside the
Demethylating_agent
Species of coronavirus causing SARS and COVID-19
(ExoN); N7 MTase adds 5′ cap, ExoN proofreads genome nsp15 Endoribonuclease (NendoU) nsp16 2′-O-Methyltransferase (2-O-MT); protects viral RNA from MDA5
SARS-related_coronavirus
Professor of virology
by DNA curvature. EMBO J. 31, 919-31. Ian C. Berke & Yorgo Modis (2012). MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded
Yorgo_Modis
Japanese immunologist
and later the RNA helicases, RIG-I (retinoic-acid-inducible protein I) and MDA5 (melanoma differentiation-associated protein 5). All molecules belong to
Shizuo_Akira
Transmembrane protein family
the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation". Cell Reports. 35 (12) 109272. doi:10.1016/j.celrep.2021.109272
AMPA_receptor
senescent cells release mt-dsRNA into the cytosol driving the SASP via RIGI/MDA5/MAVS/MFN1, and in turn are hypersensitive to mt-dsRNA-driven inflammation
Timeline_of_aging_research
American virologist
13;185(21):3857-3876. doi: 10.1016/j.cell.2022.09.023. Rodriguez KR, Bruns AM, Horvath CM. MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction. J
Curt_M._Horvath
deficiencies IRAK4 deficiency IRAK1 deficiency MyD88 deficiency TIRAP deficiency MDA5 deficiency Epidermodysplasia verruciformis WHIM syndrome (warts, hypogammaglobulinaemia
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Class of RNA-binding proteins found in viruses
from nucleases and host pattern recognition receptors such as RIG-I and MDA5. RNP Assembly: NP-RNA complexes serve as templates for viral RNA synthesis
Viral_nucleoprotein
Sendai virus, virus of rodents
MJ, et al. (January 2010). "Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in
Murine_respirovirus
Species of virus
Sambhara, Suryaprakash; Vinjé, Jan (2017-05-01). "Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection". Journal of General Virology
Tulane_virus
Enzyme family
can also be caused by mutations in other genes: TREX1, SAMHD1, ADAR, and MDA5/IFIH1, all of which are involved in nucleic acid processing. Characterization
Ribonuclease_H
Musical artist
was reported that she had died on December 30, 2023 after a bout with anti-MDA5 dermatomyositis and rapidly progressing interstitial lung disease in a hospital
Aki_Yashiro
Phenotype of senescent cells which secrete certain substances
double-stranded RNA (mt-dsRNA) into the cytosol driving the SASP via RIGI/MDA5/MAVS/MFN1. Moreover, senescent cells are hypersensitive to mt-dsRNA-driven
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Protein-coding gene in the species Homo sapiens
is also essential for the association of RIG-I-like receptors (RIG-I or MDA5) to VISA. The bridging of these receptors to VISA is an important signaling
ECSIT
Medical condition
involve testing for other myositis-specific autoantibodies such as anti-MDA5 autoantibodies, anti-Mi-2 autoantibodies, and anti-signal recognition particle
Antisynthetase_syndrome
Chinese immunologist
triggered inflammatory signaling; that DAK, a dihydroacetone kinase, can inhibit MDA5; and that ISG56 (IFN-stimulated gene 56) is related to VSV replication, and
Shu_Hongbing
(performed theme songs for The Gokusen, and Tottemo! Luckyman), dies from anti-MDA5 dermatomyositis and interstitial lung disease at age 73. Pineda, Rafael Antonio
2023_in_anime
Genus of viruses
2021). "Bovine viral diarrhea virus NS4B protein interacts with 2CARD of MDA5 domain and negatively regulates the RLR-mediated IFN-β production". Virus
Orthopestivirus
Mammalian protein found in humans
Higuchi M, Hartner JC, et al. (September 2015). "RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself". Science. 349 (6252): 1115–1120.
ADAR
viral protein processing but also cleave cytoplasmic recognition proteins MDA5 and RIG-I, further demonstrating the extent to which viruses can reduce Interferon
Viral strategies for immune response evasion
Viral_strategies_for_immune_response_evasion
Protein domain
Alu elements; this editing is required to prevent the innate immune sensor MDA5 from triggering an interferon response. Mutations in the Z-alpha domain of
Adenosine deaminase z-alpha domain
Adenosine_deaminase_z-alpha_domain
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Huntingtin Huntingtin IBTK IBTK Inhibitor Of Bruton Tyrosine Kinase IFIH1 MDA5 Interferon Induced With Helicase C Domain 1 IGF2BP1 IGF2BP1 Insulin-like
Stress_granule
HIV/AIDS researcher
gene (ISG) responses triggered by viral double-stranded RNA via the sensor MDA5. In 2020, a restriction to primate lentiviruses (HIV and related simian viruses)
Eric_Poeschla
Protein
addition, SNX8 also plays a role in RIG-I containing CARD domain-mediated and MDA5-mediated activation of the IFNβ promoter, since VISA works as an intermediate
SNX8
Interaction motifs found in a wide array of proteins
orthomyxoviridae and rhabdoviridae. Unlike NLRs, these proteins, termed RIG-I and MDA5, contain twin N-terminal CARDs and C-terminal RNA helicase domains that directly
CARD_(domain)
Species of virus
phosphorylation, by inhibiting an unknown intermediate step after RIG-I/MDA5 activation of IKKε and TBK1 kinases. The L protein has been shown to be critical
Theiler's murine encephalomyelitis virus
Theiler's_murine_encephalomyelitis_virus
Yoshiharu; Fujita, Takashi; Akira, Shizuo (2006). "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses". Nature. 441 (7089):
Caetano_Reis_e_Sousa
Mammalian protein found in Homo sapiens
nucleic acids, are recognized by specialized cellular molecules such as RIG-I, MDA5 and some toll-like receptors (TLR). This recognition induces the activation
IFNA2
Biochemical changes to RNA
for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5". Nature Immunology. 12 (2): 137–43. doi:10.1038/ni.1979. PMC 3182538. PMID 21217758
Epitranscriptome
Overview of and topical guide to immunology
Intracellular sensors of viral replication by direct interaction with dsRNA RIG-I MDA5 LGP2 Secreted PRRs Complement system (see complement proteins section) Collectins
Outline_of_immunology
Protein-coding gene in the species Homo sapiens
D, Zhai Z, Zhong B, Tien P, Shu HB (July 2007). "Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone
DAK_(gene)
MDA5
MDA5
MDA5
MDA5
Boy/Male
Greek
Son of Danae.
Boy/Male
British, English
From the Big Town
Boy/Male
Tamil
One who is victorious
Boy/Male
Tamil
Stream
Boy/Male
Hindu, Indian
Lord Shiva's Vehicle
Girl/Female
Arabic, Muslim
Emerald
Boy/Male
Hindu, Indian
Full Moon
Girl/Female
American, Australian, British, English, Greek
Divine; Follower of Dionysius
Boy/Male
English French
Variant of a French surname. American classic western film Destry Rides Again.
Boy/Male
English
Manly; brave. Modern.
MDA5
MDA5
MDA5
MDA5
MDA5