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Molecule formed binding antigens to antibodies
An immune complex, sometimes called an antigen-antibody complex or antigen-bound antibody, is a molecule formed from the binding of multiple antigens to
Immune_complex
Type of allergic reaction
there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an
Type_III_hypersensitivity
Overreaction of the immune system to an antigen
antibody-mediated reaction canonically involving IgG, IgM, or both. Type III, an immune complex-mediated reaction involving IgG, complement system and phagocytes. Type
Hypersensitivity
Subsystem of the immune system
The adaptive immune system (AIS), also known as the acquired immune system or specific immune system, is a subsystem of the immune system that is composed
Adaptive_immune_system
Biological system protecting an organism against disease
The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, such
Immune_system
Process of cells or substances entering places they are not normally present
pulmonary infiltrates, as there are many possible causes. Antibody-antigen immune complexes can sometimes precipitate out of serum and infiltrate tissues surrounding
Infiltration_(medical)
Medical disorders that destroy blood vessels by inflammation
Kawasaki disease (KD). Small vessel vasculitis (SVV) is separated into immune complex SVV and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis
Vasculitis
Immunity strategy in living beings
innate immune system or nonspecific immune system is one of the two main immunity strategies in vertebrates (the other being the adaptive immune system)
Innate_immune_system
Term for several kidney diseases
prognosis. Three subtypes have been proposed: Type 1 MPGN is caused by immune complex deposition in the mesangium and subendothelial space, typically secondary
Glomerulonephritis
Kidney disease
leukemia are less common. MGN is caused by immune complex formation in the glomerulus. The immune complexes are formed by binding of antibodies to antigens
Membranous_glomerulonephritis
Protein(s) forming a major part of an organism's immune system
earliest phases of an immune response to help facilitate clearance of the offending antigen and delivery of the resulting immune complexes to the lymph nodes
Antibody
Medical condition
is unknown. Immune complex disease, anti-neutrophil cytoplasmic antibodies, anti-endothelial cell antibodies, and cell-mediated immunity are examples
Systemic_vasculitis
Cell membrane organelle
degrading neutrophil extracellular traps and immune complexes. The failure to degrade internalized immune complexes rises from irregularly extended activity
Lysosome
Blood disease in which red blood cells are attacked by the immune system
innate immune system. This destructive process occurs due to deficiency of the red blood cell surface protein DAF, which normally inhibits such immune reactions
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Blood disorder in which antibodies target red blood cells
considers "immunohemolytic anemia", "autoimmune hemolytic anemia", and "immune complex hemolytic anemia" to all be synonyms. Symptoms of AIHA may be due to
Autoimmune_hemolytic_anemia
Inflammation of the kidneys
antibodies against double-stranded DNA (anti-dsDNA) form immune complexes with DNA. These complexes build up in areas of the kidney like the mesangium and
Lupus_nephritis
Protein complex
protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the C1 complex. Antibodies
Complement_component_1q
Symptoms resulting from kidney inflammation
(MPGN) - Another type of glomerulonephritis that is caused primarily by immune complex deposition in the glomerular mesangium and glomerular basement membrane
Nephritic_syndrome
Autoimmune disease in which the immune system attacks healthy tissue
lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms
Lupus
Surface protein important to the immune system
monomer), but all Fcγ receptors must bind multiple IgG molecules within an immune complex to be activated. The Fc-gamma receptors differ in their affinity for
Fc_receptor
Medical condition
and lymphadenopathy. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). The term serum sickness–like reaction (SSLR)
Serum_sickness
Medical treatment
several health conditions. These conditions include primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy
Immunoglobulin_therapy
Painful raised skin lesions of the hands and feet
caused by immune complex deposition. Their presence is one definition of Osler's sign. Osler's nodes result from the deposition of immune complexes. The resulting
Osler's_node
Species of virus
stomatitis, some cats may develop a polyarthritis, both probably immune-mediated through immune complex deposition. Stomatitis and polyarthritis can develop without
Feline_calicivirus
similar to those of serum sickness (type III immune complex hypersensitivity) but in which immune complexes are not found. Agents that have been implicated
Serum_sickness-like_reaction
Autoimmune disease of skin and muscle
dermatomyositis involves an autoimmune-mediated process characterized by immune complex deposition and complement activation, leading to microangiopathy in
Dermatomyositis
Cell surface proteins, part of the acquired immune system
bases). About half have known immune functions. The human MHC is also called the HLA (human leukocyte antigen) complex (often just the HLA). Similarly
Major histocompatibility complex
Major_histocompatibility_complex
Aspect of the immune system
system, which is part of the immune system. The classical complement pathway is initiated by antigen-antibody complexes with the antibody isotypes IgG
Classical_complement_pathway
provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems
List_of_autoimmune_diseases
Surface receptor glycoprotein
variety of immune cells. CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 has
CD32
Immune response against an organism's own healthy cells
In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents
Autoimmunity
Medical condition
IgA form polymers and deposit in the mesangium. Subsequently, IgA immune complexes bind to IgA receptors on mesangial cells and induce injury to mesangial
Mesangial proliferative glomerulonephritis
Mesangial_proliferative_glomerulonephritis
Medical condition
Characterized by deposition of immune complexes in glomerular tissues, type II RPGN accounts for 40% of cases. Any immune complex disease—including systemic
Rapidly progressive glomerulonephritis
Rapidly_progressive_glomerulonephritis
(PPDL). The mechanism of pathogenesis is thought to be mediated by immune-complex deposition. Histologically, the lesions are characterised by ischemic
Lucio's_phenomenon
Mammalian protein found in humans
part of the immune system. It regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part
Interleukin_2
Medication used to treat paroxysmal nocturnal hemoglobinuria
benefits in the treatment of patients with C3 glomerulopathy or primary immune complex–mediated membranoproliferative glomerulonephritis. C3 glomerulopathy
Pegcetacoplan
Disorders of adaptive immune system
causing disease that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts
Autoimmune_disease
Part of the innate immune system
considered an important part of the innate immune system. C3b is potent in opsonization: tagging pathogens, immune complexes (antigen-antibody), and apoptotic
C3b
Antibody that plays a crucial role in the immune function of mucous membranes
which is expressed on immune effector cells, to initiate inflammatory reactions. Ligation of FcαRI by IgA containing immune complexes causes antibody-dependent
Immunoglobulin_A
Immune response chemical interaction
high affinity bound by antibodies to form an antigen-antibody complex. The immune complex is then transported to cellular systems where it can be destroyed
Antigen-antibody_interaction
thyroglobulin. The disease can result in deposition of immune complexes or autoimmune disease. Immune complex deposition can cause vasculitis, meningitis, neuritis
List_of_dog_diseases
key pathological driver being the accumulation of immune deposits including antigen-antibody complexes, complement, and Ig within the subendothelial space
Endocapillary proliferative glomerulonephritis
Endocapillary_proliferative_glomerulonephritis
Antibody fragment receptor in humoral immunity
immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes. There
FCGR2B
Type of inflammatory bowel disease
considered a complex, immune-mediated disorder that results from a combination of genetic susceptibility, environmental factors, and a dysregulated immune response
Crohn's_disease
Protein-coding gene in humans
polymeric isoforms of immunoglobulin A and immunoglobulin M (pIg) and immune complexes. pIgRs are mainly located on the epithelial lining of mucosal surfaces
Polymeric immunoglobulin receptor
Polymeric_immunoglobulin_receptor
Excess of prolactin hormone in the blood
pregnancy test shows positive line via the formation of a sandwich immune complex that allows the positive line to be visible, in the occurrence of Hook
Hyperprolactinaemia
average number of approximately 300 being an inherited characteristics. Immune complexes bound to erythrocytes are effectively removed from the circulation
Immune_adherence
Immunologic phenomenon occurring in high antigen or antibody levels
antibodies to form immune complexes can be impaired when concentrations of an antibody or an antigen are very high. The formation of immune complexes stops increasing
Hook_effect
Inflammation of the testicles
PMID 609284. Bigazzi PE, Kosuda LL, Hsu KC, Andres GA (February 1976). "Immune complex orchitis in vasectomized rabbits". The Journal of Experimental Medicine
Orchitis
Ability of the immune system to quickly and specifically recognize an antigen
the immune system to quickly and specifically recognize an antigen that the body has previously encountered and initiate a corresponding immune response
Immunological_memory
Part of the immune system that enhances the ability of antibodies and phagocytic cells
system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic
Complement_system
Aspect of immunity
Humoral immunity is the aspect of immunity that is mediated by macromolecules—including secreted antibodies, complement proteins, and certain antimicrobial
Humoral_immunity
Human protein and coding gene
components have also been identified as components of PANoptosomes (immune complexes mediating PANoptosis) associated with the sensor molecules NLRP12,
NLRP3
Immune cells found in lymph nodes
Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the
Follicular_dendritic_cells
Medical condition
cases the deposition of large immune complexes in the kidney which cannot be cleared by the usual cells of the immune system (e.g. macrophages which
Urticarial_vasculitis
Medical condition
III hypersensitivity reactions are immune complex-mediated, and involve the deposition of antigen/antibody complexes mainly in the vascular walls, serosa
Arthus_reaction
Drug that inhibits activity of immune system
Later during the treatment, some patients develop serum sickness or immune complex glomerulonephritis. Serum sickness arises seven to fourteen days after
Immunosuppressive_drug
Medical condition
239. PMC 1001619. PMID 3985690. Utsinger PD (June 1980). "Systemic immune complex disease following intestinal bypass surgery: bypass disease". Journal
Enteropathic_arthropathy
Antibody isotype
IgG2 are produced. The relative balance of these subclasses, in any immune complexes that form, helps determine the strength of the inflammatory processes
Immunoglobulin_G
Human disease caused by parasitic worms called schistosomes
unknown. It has been hypothesized to be caused by a systemic immune response due to immune complex formation (Type III hypersensivity) with the foreign antigens
Schistosomiasis
Medical condition
extensive, immune complexes create an overall thickening of the capillary wall, resembling rigid "wire loops" on routine light microscopy. Immune complexes can
Diffuse proliferative nephritis
Diffuse_proliferative_nephritis
Chronic disease caused by bacterial infection
are systemic inflammatory episodes linked to high antigen load and immune-complex formation, with fever, tender nodules, neutrophilia, and other organ
Leprosy
Biomedical technique
the antigens, they will bind to the antigens and form an immune complex. The immune complex precipitates in the gel to give a thin white line (precipitin
Ouchterlony double immunodiffusion
Ouchterlony_double_immunodiffusion
T cell that kills infected, damaged or cancerous cells
of cell-mediated immune responses. In different studies, rheumatoid arthritis is strongly linked to major histocompatibility complex (MHC) class II antigens
Cytotoxic_T_cell
Immunoassay that uses radiolabeled molecules
immunoassay that uses radiolabeled molecules in a stepwise formation of immune complexes. A RIA is a very sensitive in vitro assay technique used to measure
Radioimmunoassay
Inflammation of the heart's inner layer (endocardium)
lupus erythematosus and is thought to be due to the deposition of immune complexes. Like NBTE, Libman-Sacks endocarditis involves small vegetations, while
Endocarditis
luminophore or enzyme marker to the antibody, allowing it to form an immune complex with the target antigen. The addition of a luminescent substrate results
Chemiluminescent_immunoassay
Substance that mimics effects of catecholamines
vasculitis and generalized polyarteritis nodosa like diseases involving immune-complex deposition. Known reports of such hypersensitivity reactions include
Sympathomimetic_drug
Cell surface molecules of the immune system triggering changes in the behavior of cells
An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a ligand (usually another protein, such as cytokine)
Immune_receptor
Cell of the adaptive immune system
B cell (MBC) is a type of B lymphocyte that forms part of the adaptive immune system. These cells develop within germinal centers of the secondary lymphoid
Memory_B_cell
Protein of the immune system
to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen displayed with the help of
MHC_class_I
Systemic necrotizing inflammation of medium-sized muscular arteries
hepatitis B and deposits containing HBsAg-HBsAb complexes in affected blood vessels, indicating an immune complex-mediated cause in that subset. Infection with
Polyarteritis_nodosa
Group of proteins
In a normal, healthy individual, cross-linking of CD16 (FcγRIII) by immune complexes induces antibody-dependent cellular cytotoxicity (ADCC) in NK cells
CD16
Blood vessel lining
function in humans, causing increased circulating levels of soluble immune complexes is important in the etiology of autoimmune diseases such as systemic
Liver sinusoidal endothelial cell
Liver_sinusoidal_endothelial_cell
Medical condition
hypersensitivity with resulting tissue and vessel changes rather than an immune-complex mediated disease. Further data has been collected supporting this finding
Granuloma_annulare
Deposition of fibrin within blood vessel walls
damage, resulting in the formation of gaps within the capillary walls. Immune complex deposition, as in leucocytoclastic vasculitis and arthus reaction, activates
Fibrinoid_necrosis
Predisposition towards allergy
Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the environment. Allergic diseases
Atopy
Puerto Rican VTuber
(CVID), an immune disorder that has left her largely bedridden and isolated. It has also led to a lung infection called mycobacterium avium complex as she
Ironmouse
Autoantibody found in rheumatoid arthritis
can recognize different parts of the IgG-Fc. RF and IgG join to form immune complexes that contribute to the disease process such as chronic inflammation
Rheumatoid_factor
Life-threatening allergic reaction
binding to the allergen (i.e., it is a blocking antibody) and its immune complexes (lattices of antigen and antibody, or in this case, allergen and IgG)
Anaphylaxis
Type of cells of the immunological system
cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against
White_blood_cell
Human disease caused by protist parasites
and use in August 2006. Immunity to Leishmania is determined by the interplay of white blood cells, cytokines, immune complexes, and genetic and environmental
Visceral_leishmaniasis
Immune response that does not involve antibodies
Cellular immunity, also known as cell-mediated immunity, is an immune response that does not rely on the production of antibodies. Rather, cell-mediated
Cell-mediated_immunity
Type of autoimmune arthritis
inherent in the immune response. RA primarily starts as a state of persistent cellular activation leading to autoimmunity and immune complexes in joints and
Rheumatoid_arthritis
Medical condition
cardiovascular or immune system disorder. PH1 involves PH with circulating anti-GBM antibodies. PH2 involves PH with immune complex disease such as systemic
Idiopathic pulmonary haemosiderosis
Idiopathic_pulmonary_haemosiderosis
Inflammation of fat tissue under the skin
antibody production in lepromatous leprosy, leading to deposition of immune complexes. There is an association with the HLA-B27 histocompatibility antigen
Erythema_nodosum
Excessive reactions to mosquito bites
reaction. The acquired IgG binds mosquito saliva proteins to form an immune complex-triggered type III hypersensitivity reaction that recruits blood leukocytes
Mosquito_bite_allergy
Mammalian protein found in Homo sapiens
microenvironment by modulating the fate of IgG and immune complexes, which play roles in tumor immunity and immune evasion. FcRn is expressed in certain tumor-associated
Neonatal fragment crystallizable receptor
Neonatal_fragment_crystallizable_receptor
Genes on human chromosome 6
(HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. The HLA
Human_leukocyte_antigen
Immune system messenger protein which induces inflammation
(TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. TNF is produced primarily by activated
Tumor_necrosis_factor
Medical condition
involves complex interactions between an aggressive immune response against the body's own cells, inflammatory changes, and blood vessels. Immune complexes (made
Lupus_vasculitis
Unprogrammed cell death caused by external cell injury
usually caused by immune-mediated vascular damage. It is marked by complexes of antigen and antibodies, referred to as immune complexes deposited within
Necrosis
Gradient in the rates of molecular diffusion
various molecules, especially water molecules Immunodiffusion, which can use diffusion rate differentials to separate multiple immune complex species
Diffusion_gradient
Medical techniques to separate one or more components of blood
the kit is given back to the donor with a process called 'reinfusion'. Immune system effects – "the immediate decreases in blood lymphocyte counts and
Apheresis
Protein found in humans
this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein
Complement_receptor_1
Inflammation of the cerebrum
autoimmune system changes, including the following: Circulating immune complexes. The immune complexes, which consist of DNA and anti-DNA, cause an inflammatory
Cerebritis
Medical condition
category of immune complex-mediated diseases.) There have been recorded cases of C3 deficient patients that suffer only from immune complex-mediated diseases
Complement_3_deficiency
Autoimmune vascular inflammatory disease
(inflammation of blood vessels) and is characterized by deposition of immune complexes containing the antibody immunoglobulin A (IgA); the exact cause for
Henoch–Schönlein_purpura
Italian physician, immunologist, and academic
mesenchymal stem cells and immunosenescence, and focusing on food allergy, immune complex diseases, immunoglobulin deficiencies, T-cell defects, and internal
Roberto_Paganelli
Small red lesions of the hands and feet
are thought to be due to immunologic phenomenon where deposition of immune complexes provoke inflammatory response, leading to swelling, redness and pain
Janeway_lesion
IMMUNE COMPLEX
IMMUNE COMPLEX
Girl/Female
Indian, Punjabi, Sikh
Not Pure; Impure
Boy/Male
Indian, Sanskrit
Immense Fame
Girl/Female
Spanish
Reference to the Holy Trinity.
Girl/Female
British, English, French, German
Enclosure; Protection; Universal Fence
Girl/Female
Australian, Basque, French, Greek
Daughter of Oedipus
Girl/Female
Tamil
Immense Joy, God is gracious
Girl/Female
Latin German
noble.
Girl/Female
Hindu
Immense Joy, God is gracious
Girl/Female
French, German, Latin
Universal; Complete; War Goddess
Girl/Female
Arabic, French, Muslim
Belief
Boy/Male
Indian, Punjabi, Sikh
With Immense Wealth
Boy/Male
Indian, Punjabi, Sikh
Immense Brave
Boy/Male
Hindu, Indian
Created with Immense Power
Boy/Male
Indian, Punjabi, Sikh
Immense Love
Girl/Female
Hindu
Immense Joy, God is gracious
Boy/Male
Indian, Punjabi, Sikh
Immense Light
Girl/Female
Hindu, Indian
A Indian River; Related River Name Jamuna
Boy/Male
Assamese, Gujarati, Hindu, Indian, Malayalam, Marathi, Punjabi, Sikh
Strong; Powerful; Mighty; Immense Strength
Girl/Female
Arabic, Australian, French
Powerful
Girl/Female
Tamil
Immense Joy, God is gracious
IMMUNE COMPLEX
IMMUNE COMPLEX
Boy/Male
Tamil
Good manners
Boy/Male
Hindu
King of serpents
Girl/Female
Hindu
Fast, Clever, The mind
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Blessing of Saibaba
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi
Very Dear Husband
Girl/Female
Arabic, Australian, Chinese, Muslim
Beautiful; Strong
Boy/Male
Indian, Tamil
Man Secure from Ills
Boy/Male
Bengali, Hindu, Indian
Singing at Night
Girl/Female
British, Christian, English, Irish
Little One; A Green Field; The Warm Sandy Color of a Lion's Coat
Boy/Male
Hindu
(Son of Kunti)
IMMUNE COMPLEX
IMMUNE COMPLEX
IMMUNE COMPLEX
IMMUNE COMPLEX
IMMUNE COMPLEX
v. t.
To change or alter.
a.
Unpunished.
v. t.
To inclose whithin walls, or as within walls; hence, to shut up; to imprison; to incarcerate.
a.
Unclean.
a.
Not pure; not clean; dirty; foul; filthy; containing something which is unclean or unwholesome; mixed or impregnated extraneous substances; adulterated; as, impure water or air; impure drugs, food, etc.
a.
Vast; immense.
a.
Exempt; protected by inoculation.
p. pr. & vb. n.
of Immure
imp. & p. p.
of Impute
imp. & p. p.
of Immure
a.
Very great; huge; vast; also, monstrous in character; inhuman; atrocious; fierce.
v. t.
To wall around; to surround with walls.
p. pr. & vb. n.
of Commune
v. t.
To tincture deply; to cause to become impressed or penetrated; as, to imbue the minds of youth with good principles.
a.
Not accurate; not idiomatic; as, impure Latin; an impure style.
p. pr. & vb. n.
of Impute
n.
A wall; an inclosure.
a.
Unchaste; lewd; unclean; obscene; as, impure language or ideas.
a.
Morally impure.
v. t.
To immure.