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Part of the immune system that enhances the ability of antibodies and phagocytic cells
The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies
Complement_system
Binary representation for signed numbers
fixed point binary values. As with the ones' complement and sign-magnitude systems, two's complement uses the most significant bit as the sign to indicate
Two's_complement
Mathematics concept
specific computer represents numbers. A ones' complement system or ones' complement arithmetic is a system in which negative numbers are represented by
Ones'_complement
Biological system protecting an organism against disease
antimicrobial peptides called defensins, RNA interference, and the complement system. Jawed vertebrates, including humans, have a more sophisticated defense
Immune_system
Aspect of immunity
immunity that is mediated by macromolecules—including secreted antibodies, complement proteins, and certain antimicrobial peptides—located in extracellular
Humoral_immunity
Aspect of the immune system
classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway
Classical_complement_pathway
Topics referred to by the same term
Aggregate complementation, the separation of pitch-class collections into complementary sets Complementary color, in the visual arts Complement system (immunology)
Complement
Medical condition
Complement deficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins. Because of redundancies in the
Complement_deficiency
Protein involved in the immune system
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system
Complement_component_4
Immunity strategy in living beings
body aches; and possible dysfunction of involved organs/tissues. The complement system is a key mechanism of innate immunity that utilize proteins to identify
Innate_immune_system
Protein complex
The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together
Complement_component_1q
Protein complex
the activation of the host's complement system, and as such is an effector of the immune system. Antibody-mediated complement activation leads to MAC deposition
Complement membrane attack complex
Complement_membrane_attack_complex
Type of cascade reaction of the complement system
pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections. The
Alternative complement pathway
Alternative_complement_pathway
Protein found in humans
Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the
Complement_component_3
Mammalian protein found in humans
dying cells (and some types of bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors released
C-reactive_protein
formation of a membrane attack complex (MAC) and target cell lysis. Complement system is efficiently activated by human IgG1, IgG3 and IgM antibodies, weakly
Complement-dependent cytotoxicity
Complement-dependent_cytotoxicity
Protein family
A complement receptor is a membrane-bound receptor belonging to the complement system, which is part of the innate immune system. Complement receptors
Complement_receptor
Protein found in humans
protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease, which are a class of enzymes
Complement_component_2
inflammatory function (C3a desarginine). C3a is an effector of the complement system with a range of functions including T cell activation and survival
C3a_(complement)
Protein found in humans
characterized. In primates, CR1 serves as the main system for processing and clearance of complement opsonized immune complexes. It has been shown that
Complement_receptor_1
Life-threatening immune-related blood disease
attack, kidney failure, and death. The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Protein(s) forming a major part of an organism's immune system
recognize multiple distinct (unrelated) antigens. These can work with the complement system in the earliest phases of an immune response to help facilitate clearance
Antibody
Protein found in humans
complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells express CR2 on their surfaces, allowing the complement system
Complement_receptor_2
Complement control proteins are proteins that interact with components of the complement system. The complement system is tightly regulated by a network
Complement_control_protein
Physical effects resulting from activation of the immune system
cascade systems—consisting of preformed plasma proteins—act in parallel to initiate and propagate the inflammatory response. These include the complement system
Inflammation
Protein found in humans
Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved
Complement_component_5
Pharmaceutical drug
nocturnal hemoglobinuria, proteins known as the "complement system", which is part of the immune system, become overactive because of a genetic mutation
Ravulizumab
Protein found in humans
of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system, particularly
Factor_H
Medical diagnostic method
DNA-based methods of pathogen detection, particularly PCR. The complement system is a system of serum proteins that react with antigen-antibody complexes
Complement_fixation_test
Overreaction of the immune system to an antigen
both. Type III, an immune complex-mediated reaction involving IgG, complement system and phagocytes. Type IV, a T cell-mediated, delayed hypersensitivity
Hypersensitivity
Protein domain
Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. Complement components
Anaphylatoxin
Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin
Macrophage-1_antigen
Protein-coding gene in the species Homo sapiens
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway
Complement_factor_B
Type of cascade reaction in the complement system
pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in that, after activation, it proceeds
Lectin_pathway
Class of serine proteases
serine proteases and is necessary in innate immunity as a part of the complement system which eventuate in opsonisation of particles, release of inflammatory
C3-convertase
Medical diagnostic method
Total complement activity (TCA) refers to a series of tests that determine the functioning of the complement system in an individual. A variety of tests
Total_complement_activity
Interactions in the immune system
macrophages and T cells of the immune system migrate into the spinal cord. Production of immune cells of the complement system have also been documented as being
Neuroimmune_system
Protein fragment
cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments. C5b is important in late events of the complement cascade, an
Complement_component_5a
Blood disease in which red blood cells are attacked by the immune system
characterized by destruction of red blood cells by the complement system, a part of the body's innate immune system. This destructive process occurs due to deficiency
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Protein-coding gene in humans
Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the
Complement_component_1r
Class of enzymes
the CFD gene. Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B. The protein encoded by this
Factor_D
Vision loss due to damage to the macula of the eye
10q26 Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:
Macular_degeneration
Lack of or compromised immune system
where there is no function of the spleen Complement deficiency is where the function of the complement system is deficient In reality, immunodeficiency
Immunodeficiency
Protein-coding gene in the species Homo sapiens
Properdin is plasma glycoprotein that activates the complement system of the innate immune system. It is found in plasma and primarily produced by leukocytes
Properdin
Part of the innate immune system
elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization:
C3b
Mammalian protein found in humans
inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major regulator of the contact system (PK, FXIIa, and FXIa)
C1-inhibitor
Protein found in humans
Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system. Once activated, about 12-18
Complement_component_9
Protein complex
complex (complement component 1, C1) is a protein complex involved in the complement system. It is the first component of the classical complement pathway
C1_complex
Cell-Bound Complement Activation Products (CB-CAPs) or complement split products, refers to complement activation fragments, C4d, that are bound covalently
Cell-bound complement activation products
Cell-bound_complement_activation_products
Protein found in humans
Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system
Complement_component_1s
Disease characterized by rapid swelling
angioedema, bradykinin formation is caused by continuous activation of the complement system due to a deficiency in one of its prime inhibitors, C1-esterase (aka:
Angioedema
Pharmaceutical drug
terminal complement inhibitor. It binds to the complement C5 protein and inhibits activation of the complement system, a part of the body's immune system. This
Eculizumab
Greek-American biochemist
including books such as Structural Biology of the Complement System and Current Topics in Complement II. Lambris completed his Bachelor of Science in Biology
John_Lambris
with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation". Journal of Immunology. 183 (11):
Map44
Mammalian protein found in Homo sapiens
protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement system on the cell surface. It recognizes C4b and C3b fragments that are
Decay-accelerating_factor
Thai-German microbiologist (born 1946)
Investigation of the complement system led Bhakdi to the area of atherosclerosis. In 1989 he discovered through animal experiments that the complement component
Sucharit_Bhakdi
Type of immune system molecule
recognized by complement receptor 1, 3, and 4 (CR1, CR3, CR4), which are present on most phagocytes. In this way, the complement system participates in
Opsonin
problem we get an N-dimensional linear system AU = F. The Schur complement method splits up the linear system into sub-problems. To do so, divide Ω into
Schur_complement_method
Antibody that plays a crucial role in the immune function of mucous membranes
effects of other immunoglobulins. IgA is a poor activator of the complement system, and opsonizes only weakly. IgA exists in two isotypes, IgA1 and IgA2
Immunoglobulin_A
Transplantation of cells or tissue across species
antibodies) to the donor endothelium, causing activation of the human complement system, which results in endothelial damage, inflammation, thrombosis and
Xenotransplantation
Term for several kidney diseases
of the complement system. The C3 Nephritic Factor autoantibody stabilizes C3-convertase, which may lead to an excessive activation of complement. Type
Glomerulonephritis
Protein
(factor I) is a protein of the complement system, first isolated in 1966 in guinea pig serum, that regulates complement activation by cleaving cell-bound
Complement_factor_I
Serine protease that plays key role in innate immunity
that play key role in the innate immunity. It participates in the complement system ending with cell death. There are four different C5 convertases able
C5-convertase
Type of allergic reaction
cellular cytotoxicity or anti-receptor activity. The activation of the complement system results in opsonization, the agglutination of red blood cells, cell
Type_II_hypersensitivity
Species of bacteria
interference of factor H at the activation level. This is part of a complement system evasion strategy that leads to downstream blocking of immune response
Borrelia_burgdorferi
Protein-coding gene in the species Homo sapiens
pathway of the complement system and is responsible for activating MASP-2 and MASP-3. It is also involved in the process of cleaving complement proteins, C4
MASP1
Protein found in humans
Complement component 6 is a protein that in humans is encoded by the C6 gene. Complement component 6 is a protein involved in the complement system. It
Complement_component_6
Protein complex involved in the complement system
C4b-binding protein (C4BP) is a protein complex involved in the complement system where it acts as inhibitor. C4BP has an octopus-like structure with
C4b-binding_protein
Classification based on antibodies and antigens on RBC surfaces
can be highly active and can attack RBCs and bind components of the complement system to cause massive hemolysis of the transfused blood. Patients should
Blood_type
Blood disorder in which cold sensitive antibodies target red blood cells
to red blood cells activates the classical pathway of the complement system. If the complement response is sufficient, red blood cells are damaged by the
Cold_agglutinin_disease
Tool in linear algebra and matrix analysis
The Schur complement is a key tool in the fields of linear algebra, the theory of matrices, numerical analysis, and statistics. It is defined for a block
Schur_complement
Mammalian protein found in Homo sapiens
protein is a determinant for the Ok blood group system. There are three known antigens in the Ok system; the most common being Oka (also called OK1), OK2
Basigin
Genes on human chromosome 6
improving. HLAs corresponding to MHC class III encode components of the complement system. HLAs have other roles. They are important in disease defense. They
Human_leukocyte_antigen
Autoimmune disease in which the immune system attacks healthy tissue
RNASEH2C, Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component
Lupus
Protein-coding gene in humans
human complement system subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency
C1QA
Medical condition
mesangium and basement membrane (GBM) thickening, activating the complement system and damaging the glomeruli. MPGN accounts for approximately 4% of
Membranoproliferative glomerulonephritis
Membranoproliferative_glomerulonephritis
Chemical compound
is a complement inhibitor that is injected subcutaneously (under the skin). Zilucoplan is a cyclic peptide that binds to the protein complement component
Zilucoplan
Tail region of an antibody
receptors and some proteins of the complement system. This region allows antibodies to activate the immune system, for example, through binding to Fc
Fragment crystallizable region
Fragment_crystallizable_region
protein-associated serine protease are serine proteases involved in the complement system. Types include: MASP1 MASP2 mannan-binding lectin Dobó, József; Pál
Mannose-binding protein-associated serine protease
Mannose-binding_protein-associated_serine_protease
Protein found in humans
Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which
Complement_component_7
Protein part of the complement system
part of the complement system, a component of the vertebrate immune system. iC3b is produced when complement factor I cleaves C3b. Complement receptors
IC3b
Antibody isotype
of the pathogen itself; IgG activates the classical pathway of the complement system, a cascade of immune protein production that results in pathogen elimination;
Immunoglobulin_G
Mammalian protein found in Homo sapiens
cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit
Integrin_alpha_M
Autoimmune disease of skin and muscle
and skin tissue, potentially causing wider structural damage. The complement system plays a crucial role in the tissue injury of dermatomyositis, through
Dermatomyositis
Immune organ that filters blood
that facilitate phagocytosis either directly or by activating the complement system on the capsule. They are produced by IgM memory B cells (a subtype
Spleen
Inflammation of small blood vessels, accompanied by skin bumps
vessel walls leading to activation of the complement system. C3a and C5a, proteins produced from the complement system, attract neutrophils to the vessels.
Cutaneous small-vessel vasculitis
Cutaneous_small-vessel_vasculitis
Protein involved in the complement system
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC). A hereditary deficiency of C8
C8_complex
Medication
treatment of age-related macular degeneration. Avacincaptad pegol is a complement inhibitor. Avacincaptad pegol was approved for medical use in the United
Avacincaptad_pegol
Blood test used in immunohematology
a condition where the immune system breaks down red blood cells, leading to anemia. It detects antibodies or complement proteins attached to the surface
Coombs_test
needed] MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought
Mannan-binding lectin-associated serine protease-2
Mannan-binding_lectin-associated_serine_protease-2
Cell-mediated killing of other cells mediated by antibodies
to limit and contain infection. ADCC is independent of the immune complement system that also lyses targets but does not require any other cell. ADCC
Antibody-dependent cellular cytotoxicity
Antibody-dependent_cellular_cytotoxicity
Enzyme that cleaves other proteins into smaller peptides
highly regulated cascades (e.g., the blood-clotting cascade, the complement system, apoptosis pathways, and the invertebrate prophenoloxidase-activating
Protease
Protein-coding gene in the species Homo sapiens
Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene. This gene encodes the acidic form of complement
C4A
Concept in music
In music theory, complement refers to either traditional interval complementation, or the aggregate complementation of twelve-tone and serialism. In interval
Complement_(music)
Encoding of negative numbers in binary number systems
extending the binary numeral system to represent signed numbers are: sign–magnitude, ones' complement, two's complement, and offset binary. Some of the
Signed_number_representations
Topics referred to by the same term
College Trinity College Colac Terminal complement complex, the membrane attack complex of the complement system Thermomechanical Cuttings Cleaner Total
TCC
Medical condition
rare genetic disorder of the immune system. CHAPLE stands for "CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and severe
CD55_deficiency
Medication used to treat paroxysmal nocturnal hemoglobinuria
glomerulopathy C3 and membranoproliferative globulonephritis. Pegcetacoplan is a complement inhibitor. The most common side effects include injection-site reactions
Pegcetacoplan
Region on human chromosome 14
antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains
IGH@
Type of cells of the immunological system
that can bind to pathogens, block pathogen invasion, activate the complement system, and enhance pathogen destruction. T cells: CD4+ T helper cells: T
White_blood_cell
COMPLEMENT SYSTEM
COMPLEMENT SYSTEM
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Girl/Female
Tamil
Fit, Competent, Administrator
Boy/Male
Muslim
Competent
Boy/Male
Muslim
Compliments, Happiness
Boy/Male
Japanese
Complacent; satisfied.
Boy/Male
Hindu
Competent, Powerful
Boy/Male
Tamil
Sakshain | ஸாகà¯à®·à¯€à®¨
Competent, Powerful
Sakshain | ஸாகà¯à®·à¯€à®¨
Boy/Male
Muslim
Competent. Well disposed.
Boy/Male
Indian
Compliments, Happiness
Boy/Male
Muslim
Competent. Well disposed.
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Anglo Saxon
Competent.
Girl/Female
Indian
Competent.
Boy/Male
Indian, Sanskrit
Competent
Boy/Male
Hindi
Competent.
Girl/Female
Hindu
Fit, Competent, Administrator
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Muslim/Islamic
Compliments happiness
Girl/Female
Indian
Competent
COMPLEMENT SYSTEM
COMPLEMENT SYSTEM
Boy/Male
Irish American English French
Young wolf.
Surname or Lastname
English, Irish, and French
English, Irish, and French : from a diminutive of Noble. The Irish name is of Huguenot origin.
Girl/Female
Basque
Sunshine.
Boy/Male
Hindu, Indian, Marathi
Strong
Girl/Female
Tamil
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Tamil, Telugu
King of Poet
Male
English
Anglicized form of Hebrew Moshe and Greek Mouses, MOSES means "drawn out." In the bible, this is the name of the leader who brought the Israelites out of bondage and led them to the promised land.Â
Biblical
one that takes, or possesses
Boy/Male
British, English
Interpreter
Boy/Male
Hindu
COMPLEMENT SYSTEM
COMPLEMENT SYSTEM
COMPLEMENT SYSTEM
COMPLEMENT SYSTEM
COMPLEMENT SYSTEM
n.
An expression, by word or act, of approbation, regard, confidence, civility, or admiration; a flattering speech or attention; a ceremonious greeting; as, to send one's compliments to a friend.
v. t.
That which fills up or completes; the quantity or number required to fill a thing or make it complete.
v. t.
To compliment.
v. t.
The whole working force of a vessel.
v. t.
To provide with an implement or implements; to cause to be fulfilled, satisfied, or carried out, by means of an implement or implements.
v. i.
To pass compliments; to use conventional expressions of respect.
n. pl.
Respects; compliments.
n.
Compliments; greetings.
v. t.
Something added for ornamentation; an accessory.
v. t.
A second quantity added to a given quantity to make it equal to a third given quantity.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
v. t.
A compliment.
n.
Compilation.
n.
The nest complement of eggs of a bird.
v. t.
Full quantity, number, or amount; a complete set; completeness.
v. t.
To supply a lack; to supplement.
a.
Self-satisfied; contented; kindly; as, a complacent temper; a complacent smile.
v. t.
To praise, flatter, or gratify, by expressions of approbation, respect, or congratulation; to make or pay a compliment to.
n.
Union; combination; a coupling; a pair.
v. t.
That which is required to supply a deficiency, or to complete a symmetrical whole.