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Type of sperm cell motility
Hyperactivation is a type of sperm motility. Hyperactivated sperm motility is characterised by a high amplitude, asymmetrical beating pattern of the sperm
Hyperactivation
Catecholamine hormone and neurotransmitter
involve dysfunction of the norepinephrine system in the brain or body. Hyperactivation of the sympathetic nervous system is not a recognized condition in
Norepinephrine
X hyperactivation refers to the process in Drosophila by which genes on the X chromosome in male flies become twice as active as genes on the X chromosome
X_hyperactivation
Penultimate step in the activation of mammalian spermatozoa
the cumulus ooporus and the zona pellucida. Capacitation results in hyperactivation of sperm motility, with the acrosome and cortical reaction following
Capacitation
Male reproductive cell
the egg and support it as it grows. The initial change is called "hyperactivation", which causes a change in spermatozoa motility. They swim faster and
Sperm
Set of three serine threonine-specific protein kinases
Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple
Protein_kinase_B
Biological mechanism to control fertilization
Cryptic female choice is a form of mate choice which occurs both in pre- and post-copulatory circumstances in which females of certain species use physical
Cryptic_female_choice
Alleged condition of hair suddenly turning white
PMC 8219384. PMID 34155974. Zhang, B., Ma, S., Rachmin, I. et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature
Canities_subita
Process involved in the controlled movement of a sperm cell
of ovulation, hyperactivation occurs. During this process, the flagella move with high curvature and long wavelength. Hyperactivation is initiated by
Sperm_motility
Biologically based theories about the mechanism of obsessive–compulsive disorder
inhibition, and fear extinction. While hyperactivation of the OFC as a whole during resting is observed in OCD, hyperactivation of the lateral OFC (lOFC) and hypoactivation
Biology of obsessive–compulsive disorder
Biology_of_obsessive–compulsive_disorder
Subfamily of the Rho family of GTPases
reduction of inflammation. The abnormal activities of Rac including its hyperactivation, resistance to degradation, and abnormal localization of its signaling
Rac_(GTPase)
Retention of sperm by female after mating
undergo biochemical transitions, called capacitation and motility hyperactivation, in which they become physiologically capable of fertilizing an oocyte
Female_sperm_storage
Medical condition associated with drug use
causing unpredictable side effects. These effects are attributed to the hyperactivation of CB1 receptors, toxic metabolites, and more. While there is no set
Synthetic cannabinoid use disorder
Synthetic_cannabinoid_use_disorder
Medical condition in which spasm of arteries causes episodes of reduced blood flow
cold atmosphere. In all cases, the primary cause is an underlying hyperactivation of the sympathetic nervous system. Although, with different types,
Raynaud_syndrome
Set of physiological feedback interactions
immune system is unclear; studies have found both immunosuppression and hyperactivation of the immune response. Activation of the HPA axis causes release of
Hypothalamic–pituitary–adrenal axis
Hypothalamic–pituitary–adrenal_axis
Type of allergic reaction
Inflammatory bowel disease Enteric microbiota and/or self antigens Hyperactivation of T-cells, cytokine release, recruitment of macrophages and other
Type_IV_hypersensitivity
Chronic multi-symptomatic pain disorder
overactive "threat" system and an underactive "soothing" system. This hyperactivation, along with other mechanisms, may contribute to fibromyalgia. Neuroimaging
Fibromyalgia
AntiViral-HyperActivation Limiting Therapeutics (AV-HALTs) are an investigational class of antiretroviral drugs used to treat Human Immunodeficiency Virus
AV-HALT
Family of transport proteins
and regulation of hyperactivation in sperm. Catsper2 is localized in the sperm tail and is responsible for regulation of hyperactivation. Catsper3 and Catsper4
Cation_channels_of_sperm
blot Wild type Wilms' tumor Wobble Wolfram syndrome X chromosome X hyperactivation X linkage X linked X-and-Y linkage X-inactivation X:A ratio Xenograft
Index_of_genetics_articles
Heightened sense of empathy
hyper-empathy might arise as a consequence of a lack of emotion regulation and hyperactivation of the amygdala. A paper published in 2013 reported on a case of a
Hyper-empathy
Protein-coding gene in the species Homo sapiens
strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg. It
ABHD2
Anomaly of self-awareness
in metabolic activity in the sensory association cortex, prefrontal hyperactivation, and limbic inhibition in response to aversive stimuli. Neurochemically
Depersonalization
Central nervous system disease
death. For example, type III PCD might be caused by trophotoxicity, or hyperactivation of trophic factor receptors. Cytotoxins that induce PCD can cause necrosis
Neurodegenerative_disease
Toxin harmful to nervous tissue
This reorganization may lead to neuronal cytotoxicity both through hyperactivation of postsynaptic neurons and through induced addiction to continuous
Neurotoxin
Rare form of epilepsy causing ecstatic and mystical experiences
insula. It is thought that the ecstatic feelings result from ictal hyperactivation of the anterior insular cortex. The epilepsy is often caused by epileptogenic
Ecstatic_seizures
Condition of reduced emotional reactivity in an individual
affective systems; it is argued that dorsal hypoactivation and ventral hyperactivation may be the source of flat affect. Further, the authors found deficits
Reduced_affect_display
Cytokine
(December 2019). "Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction". Science
Transforming growth factor beta
Transforming_growth_factor_beta
Medical condition
downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation". British Journal of Cancer. 97 (5): 659–69. doi:10.1038/sj.bjc.6603906
Mastitis
Union of opposite-sex gametes in sexual reproduction to form a zygote
Intracellular calcium influx contributes to sperm capacitation and hyperactivation, causing a more violent and rapid non-linear motility pattern as sperm
Fertilisation
in rather straight lines interrupted by turns and brief episodes of hyperactivation. Each such episode results in swimming in a new direction. When the
Sperm_thermotaxis
Group of regulatory cell surface receptors
costimulation with the Tat protein can contribute to chronic immune hyperactivation seen among HIV-infected individuals. Thus, CD28 is an essential part
CD28_family_receptor
Cell cycle regulation pathway
other tumour types, mutations in key genes of this pathway can lead to hyperactivation of this pathway, for example in PIK3CA, Increases in the copy number
PI3K/AKT/mTOR_pathway
Type of spinal cancer
Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V (March 2009). "Aberrant Hyperactivation of Akt and Mammalian Target of Rapamycin Complex 1 Signaling in Sporadic
Chordoma
Guidance of sperm
frequency of turns and hyperactivation events. On the basis of these observations and the finding that the level of hyperactivation events is reduced when
Sperm_chemotaxis
Steroidal alkaloid found in plants of the lily family
increase sperm progressive motility (although it does not produce hyperactivation by itself). It has the potential of enhancing protein tyrosine phosphorylation
Veratridine
Biological study Of bipolar disorder
find hyperactivation of the basal ganglia, amygdala, and thalamus. Prefrontal abnormalities are less consistently reported, although hyperactivation in
Biology_of_bipolar_disorder
Family of regulator genes
Inactivation of SUMO-activating enzyme (SAE1 / SAE2) in the presence of Myc hyperactivation results in mitotic catastrophe and cell death in cancer cells. Hence
Myc
Process of synapse elimination
these spines during development; these changes have been linked to hyperactivation of the mTOR pathway and defective autophagy in neurons. Neuroplasticity
Synaptic_pruning
German virologist (born 1964)
McCloskey, Thomas; Pahwa, Savita; Verdin, Eric (7 March 1997). "Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway". Science
Melanie_Ott
Sensory system that receives and integrates information from the body
disorders experience heightened interoceptive accuracy, suggested by hyperactivation in the anterior cingulate cortex—a region of the brain associated with
Interoception
Mammalian protein found in Homo sapiens
cytotoxicity, leading to uncontrolled antigen presentation, T-cell hyperactivation, interferon-γ–driven macrophage activation, and severe hyperinflammation
Perforin-1
Structure in the basal ganglia of the brain
S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M (June 2006). "Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed
Substantia_nigra
Protein-coding gene in humans
caused upregulation in E-selectin, a factor in metastasis of cancers. Hyperactivation of STAT3 occurs in COVID-19 infection and other viral infections. Loss-of-function
STAT3
Medical condition
mutations are autosomal dominant gain-of-function mutations, which cause hyperactivation of the protein, and it inhibits replication much longer through CDT1
Meier-Gorlin_syndrome
Genetic abnormality in leukemia cancer cells
factors in all higher eukaryotic cells in response to external stimuli. Hyperactivation of this pathway therefore promotes pro-survival intracellular signalling
Philadelphia_chromosome
Compulsion to engage in a non-substance related behavior
highlighting the role of hyperactivation in the bilateral caudate nucleus, a part of the basal ganglia. Likewise, hyperactivation of the right inferior frontal
Behavioral_addiction
(surgical procedure) Hybristophilia Hydatid of Morgagni Hydrocele testis Hyperactivation Hypergamy Hypergonadism Hypersexual disorder Hypersexuality Hypoactive
Index of human sexuality articles
Index_of_human_sexuality_articles
Biological process
frequency of turns and hyperactivation events. On the basis of these observations and the finding that the level of hyperactivation events is reduced when
Sperm_guidance
Chemical compound
2019). "Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients". J Clin Med. 8
Bromopyruvic_acid
Class of enzymes
reduction in cytosolic RNA:DNA hybrid molecules and a concomitant hyperactivation of the IRF3 pathway, with consequent overproduction of type I interferons
DNA polymerase alpha catalytic subunit
DNA_polymerase_alpha_catalytic_subunit
Series of chemical reactions resulting in a cell response
the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction". Molecular and Cellular Endocrinology. 374
Biochemical_cascade
Protein complex
such as type 2 diabetes mellitus. In many types of human cancer, hyperactivation of mTORC2 caused by mutations and aberrant amplifications of mTORC2
MTORC2
Medication
also known as CHAPLE disease. CHAPLE—which stands for complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy—is an inherited
Pozelimab
Protease enzyme present in mammals and other organisms
identified as a tumour suppressor for gastric cancer. Moreover, the hyperactivation of calpains is implicated in a number of pathologies associated with
Calpain
Neuroscientist
A, Newmark R, Castrillón G, Lopera F, Stern CE. (2010) Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease. Ann Neurol. 68(6):865-75
Chantal_Stern
Protein-coding gene in the species Homo sapiens
activity is implicated in the development of abnormal cell growth and hyperactivation of YAP and TAZ has been observed amongst many cancers. Hence YAP1 represents
YAP1
Mammalian protein found in humans
isotype, and have low CTLA-4 protein expression in T regulatory cells, hyperactivation of effector T cells, low switched memory B cells, and progressive loss
Cytotoxic T-lymphocyte associated protein 4
Cytotoxic_T-lymphocyte_associated_protein_4
American immunologist and researcher
to the identification of a novel state of dendritic cell activation—hyperactivation. Hyperactive dendritic cells display activities similar to classically
Jonathan_C._Kagan
Protein-coding gene in the species Homo sapiens
mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells. Since phospholipase A2 is required for the biosynthesis
Annexin_A1
Medical condition
downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation". British Journal of Cancer. 97 (5): 659–669. doi:10.1038/sj.bjc.6603906
Inflammatory_breast_cancer
numerous signalling proteins in the NHEJ signalling cascade. DNA-PK hyperactivation induces pan-nuclear phosphorylation of histone H2AX among all the chromatin
SiDNA
Development CATSPERB Cation Channel Sperm-Associated Protein Subunit Beta 0.573 Cell Membrane, Cilium Sperm cell hyperactivation, motility, spermatogenesis
TMEM238
Brain function imaging
identify abnormalities in network performance - including neuronal hyperactivation, neuronal hypoactivation, insufficient blood-volume compensation, and
Functional_neuroimaging
It has been suggested as an alternative to Freund's adjuvant for hyperactivation of the immune response in rabbits (Leenaars et al. 1994). Specol can
Specol
Protein found in humans
common mutations that affect its proline-rich domain, resulting in its hyperactivation. This upregulation of SH3BP2 increases osteoclast formation and activity
SH3BP2
Medical condition
progressiva HRAS the mutation that involved in ILVEN is a RAS-MAPK pathway hyperactivation (RASopathy-related). KRT10 mutation causes keratinocyte differentiation
Inflammatory linear verrucous epidermal nevus
Inflammatory_linear_verrucous_epidermal_nevus
Protein-coding gene in the species Homo sapiens
"Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". The Journal of Biological
MTF1
American research scientist
early days of the AIDS epidemic, the Zolla-Pazner lab described the hyperactivation of B lymphocytes in the blood of HIV-infected individuals. This discovery
Susan_Zolla-Pazner
Protein-coding gene in the species Homo sapiens
patients had evidence of increased NRG1 and ErbB4 gene expression and hyperactivation. To test this, the authors used transgenic mice, or mice with altered
Neuregulin_1
Mammalian protein found in Homo sapiens
SARS-CoV-2 entry receptor of platelets and megakaryocytes, leading to hyperactivation and thrombosis, that differs from common cold coronavirus CoV-OC43
Basigin
Protein and coding gene in humans
overload. TRPC6 activates calcineurin, which impedes the NMDAR activity. Hyperactivation of NMDAR is a critical event in glutamate-driven excitotoxicity that
TRPC6
Israeli biochemist
and another via melanopsin and phospholipase C. Eisenbach linked hyperactivation (a vigorous motility pattern characterized by large amplitudes of head
Michael_Eisenbach
Protein-coding gene in the species Homo sapiens
glucose intolerance, and are resistant to cancer brought about by hyperactivation of the PI3K pathway (PTEN+/-). Plant PDK1 plays an important role in
Phosphoinositide-dependent kinase-1
Phosphoinositide-dependent_kinase-1
Protein-coding gene in humans
with increased fibrosis, those cardiac effects are mediated through hyperactivation of WNT/β-catenin signaling. CDON has been shown to interact with CDH1
CDON
Human protein and coding gene
and motor learning disabilities. These changes are associated with hyperactivation of the mTOR signaling pathway in the brain and can be ameliorated by
Basic helix-loop-helix ARNT-like protein 1
Basic_helix-loop-helix_ARNT-like_protein_1
Protein-coding gene in the species Homo sapiens
cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication". Proceedings of the National Academy of
PDE4A
Cytosolic multiprotein complex that mediates the activation of Caspase 1
Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation". Immunity. 47 (4): 697–709.e3. doi:10.1016/j.immuni.2017.09.010. PMC 5747599
Inflammasome
Protein-coding gene in the species Homo sapiens
(muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation"
MLIP_(gene)
production (see below). These antigonadotropic effects are mediated by hyperactivation of the PR. Progestogens have antigonadotropic effects at sufficiently
Pharmacodynamics of progesterone
Pharmacodynamics_of_progesterone
Australian pathologist (born 1937)
Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes". Journal of Bone and Mineral Research. 37 (10): 1876–1890
Thomas_Martin_(pathologist)
Genetic element in the species Homo sapiens
required for, cancer invasion/metastasis. Mig-7 induces EMT through hyperactivation of Akt and extracellular regulated Kinase ERK1/2 by inhibiting the
Migration-inducting_gene_7
Protein-coding gene in humans
inhibiting mTORC1 association and preventing apoptosis induced by mTORC1 hyperactivation. Because astrin is frequently upregulated in tumors, it is a potential
RPTOR
followed by a phase of leucocyte hyperactivation [20]. Rather, prolonged viral replication and leucocyte hyperactivation phases may occur concurrently,
Keertan_Dheda
disorder in Mexican Americans. These Mexican Americans experienced hyperactivation of the hypothalamic-pituitary-adrenal axis due to significant stress
Transmembrane_protein_151A
Protein-coding gene in the species Homo sapiens
patients. This can be exploited by therapeutic agents, including by the hyperactivation of ClpP to cause selective cancer cell lethality. Intracellular proteases
ATP-dependent Clp protease proteolytic subunit
ATP-dependent_Clp_protease_proteolytic_subunit
Any type of cell death eliciting an immune response
response components, mainly poly(ADP-ribose) polymerase 1(PARP1). PARP1 hyperactivation leads to ATP depletion, redox and bioenergetic collapse as well as
Immunogenic_cell_death
Chemical compound
2019). "STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition". Cell. 178 (2): 290–301.e10. doi:10.1016/j.cell.2019
Cyclic_di-AMP
Field of study
glucocorticoid-responsive gene. Thus, chronic stress may cause demethylation and hyperactivation of a stress-related gene, causing increased stress response. Additionally
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
Protein found in humans
stage, metastasis, recurrence, and poorer prognosis. Notably, its hyperactivation is implicated in endocrine resistance, suggesting a crucial role in
Zinc_transporter_SLC39A7
American neuroscientist, immunologist, and author
cells of the immune system, where TAM receptors were shown to mitigate hyperactivation of these antigen-presenting cells, preventing autoimmunity. The receptors
Greg_Lemke
Protein-coding gene in the species Homo sapiens
importantly, AGK expression was significantly correlated with JAK2/STAT3 hyperactivation in ESCC, as well as in lung and breast cancer. In prostate cancer,
AGK_(gene)
Protein found in humans
"Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade". J. Biol. Chem. 277 (41): 38988–97. doi:10
Caveolin_3
Form of amenorrhea and chronic anovulation
increased cortisol release and elevated β-endorphin concentrations. Hyperactivation of the hypothalamic-pituitary system appears to be manifested through
Functional hypothalamic amenorrhea
Functional_hypothalamic_amenorrhea
Protein-coding gene in the species Homo sapiens
cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication". Proceedings of the National Academy of
PDE4B
Belgian-British biomedical scientist
Redenbaugh, Vyanka; Coulter, Tanya (2021). "Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated
Bart_Vanhaesebroeck
Class of transmembrane transporter protein
have neurofibrillary tangles contain high levels of calcium and show hyperactivation of calcium-dependent proteins. The abnormal calcium handling of atypical
Antiporter
Protein complex
(2009). "Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity". Mol Cell. 120 (Pt 7): 1245–1255
Condensin
American scientist
coupled this intervention with mindfulness meditation to mitigate DMN hyperactivation/hyperconnectivity and the associated clinical symptoms in patients
Susan_Whitfield-Gabrieli
genomic signatures such as CDKN2A and ATM deletions, along with NF-κB hyperactivation, have been implicated in promoting CNS tropism. Elevated levels of
Central nervous system prophylaxis
Central_nervous_system_prophylaxis
HYPERACTIVATION
HYPERACTIVATION
HYPERACTIVATION
HYPERACTIVATION
Girl/Female
Indian
Earth
Boy/Male
Arabic
Servant of the capable.
Girl/Female
Muslim
Bunch of flowers
Girl/Female
Muslim
Affection, Love, Friendliness
Boy/Male
American, Australian, British, Chinese, Christian, English, Scottish, Swedish
A Ruddy Complexion; Red Haired; Surname
Female
English
English variant spelling of French Jeannine, JEANINE means "God is gracious."
Girl/Female
Indian, Telugu
Softened
Boy/Male
German, Kurdish, Latin
The Lord's; Belonging to the Lord
Girl/Female
Australian, British, English, Greek, Swedish
Form of Ivy; Ivy Plant; Ivy Tree
Female
Hungarian
Pet form of Hungarian Ilona, probably ILONKA means "torch."
HYPERACTIVATION
HYPERACTIVATION
HYPERACTIVATION
HYPERACTIVATION
HYPERACTIVATION