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X hyperactivation refers to the process in Drosophila by which genes on the X chromosome in male flies become twice as active as genes on the X chromosome
X_hyperactivation
Type of sperm cell motility
consist of these two processes of hyperactivation and the acrosome reaction. Hyperactivation is a term also used to express an X chromosome gene dosage compensation
Hyperactivation
Wilms' tumor Wobble Wolfram syndrome X chromosome X hyperactivation X linkage X linked X-and-Y linkage X-inactivation X:A ratio Xenograft XYY XYY syndrome
Index_of_genetics_articles
Catecholamine hormone and neurotransmitter
involve dysfunction of the norepinephrine system in the brain or body. Hyperactivation of the sympathetic nervous system is not a recognized condition in
Norepinephrine
Penultimate step in the activation of mammalian spermatozoa
the cumulus ooporus and the zona pellucida. Capacitation results in hyperactivation of sperm motility, with the acrosome and cortical reaction following
Capacitation
Biological mechanism to control fertilization
Insects". Biological Reviews. 66 (1): 1–31. doi:10.1111/j.1469-185X.1991.tb01133.x. S2CID 85822041. Brennan, Patricia LR; et al. (2007). "Coevolution of male
Cryptic_female_choice
Male reproductive cell
the egg and support it as it grows. The initial change is called "hyperactivation", which causes a change in spermatozoa motility. They swim faster and
Sperm
Medical condition in which spasm of arteries causes episodes of reduced blood flow
cold atmosphere. In all cases, the primary cause is an underlying hyperactivation of the sympathetic nervous system. Although, with different types,
Raynaud_syndrome
Set of three serine threonine-specific protein kinases
Pharmacology. 160 (1): 116–29. doi:10.1111/j.1476-5381.2010.00677.x. PMC 2860212. PMID 20412069. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al
Protein_kinase_B
Subfamily of the Rho family of GTPases
reduction of inflammation. The abnormal activities of Rac including its hyperactivation, resistance to degradation, and abnormal localization of its signaling
Rac_(GTPase)
Guidance of sperm
frequency of turns and hyperactivation events. On the basis of these observations and the finding that the level of hyperactivation events is reduced when
Sperm_chemotaxis
Rare form of epilepsy causing ecstatic and mystical experiences
insula. It is thought that the ecstatic feelings result from ictal hyperactivation of the anterior insular cortex. The epilepsy is often caused by epileptogenic
Ecstatic_seizures
Protein-coding gene in the species Homo sapiens
strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg. It
ABHD2
(surgical procedure) Hybristophilia Hydatid of Morgagni Hydrocele testis Hyperactivation Hypergamy Hypergonadism Hypersexual disorder Hypersexuality Hypoactive
Index of human sexuality articles
Index_of_human_sexuality_articles
Biological process
frequency of turns and hyperactivation events. On the basis of these observations and the finding that the level of hyperactivation events is reduced when
Sperm_guidance
Anomaly of self-awareness
in metabolic activity in the sensory association cortex, prefrontal hyperactivation, and limbic inhibition in response to aversive stimuli. Neurochemically
Depersonalization
Biological study Of bipolar disorder
find hyperactivation of the basal ganglia, amygdala, and thalamus. Prefrontal abnormalities are less consistently reported, although hyperactivation in
Biology_of_bipolar_disorder
Retention of sperm by female after mating
undergo biochemical transitions, called capacitation and motility hyperactivation, in which they become physiologically capable of fertilizing an oocyte
Female_sperm_storage
Medical condition
mutations are autosomal dominant gain-of-function mutations, which cause hyperactivation of the protein, and it inhibits replication much longer through CDT1
Meier-Gorlin_syndrome
Condition of reduced emotional reactivity in an individual
affective systems; it is argued that dorsal hypoactivation and ventral hyperactivation may be the source of flat affect. Further, the authors found deficits
Reduced_affect_display
numerous signalling proteins in the NHEJ signalling cascade. DNA-PK hyperactivation induces pan-nuclear phosphorylation of histone H2AX among all the chromatin
SiDNA
Steroidal alkaloid found in plants of the lily family
increase sperm progressive motility (although it does not produce hyperactivation by itself). It has the potential of enhancing protein tyrosine phosphorylation
Veratridine
Set of physiological feedback interactions
immune system is unclear; studies have found both immunosuppression and hyperactivation of the immune response. Activation of the HPA axis causes release of
Hypothalamic–pituitary–adrenal axis
Hypothalamic–pituitary–adrenal_axis
Cell cycle regulation pathway
other tumour types, mutations in key genes of this pathway can lead to hyperactivation of this pathway, for example in PIK3CA, Increases in the copy number
PI3K/AKT/mTOR_pathway
Compulsion to engage in a non-substance related behavior
highlighting the role of hyperactivation in the bilateral caudate nucleus, a part of the basal ganglia. Likewise, hyperactivation of the right inferior frontal
Behavioral_addiction
Type of spinal cancer
Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V (March 2009). "Aberrant Hyperactivation of Akt and Mammalian Target of Rapamycin Complex 1 Signaling in Sporadic
Chordoma
Process of synapse elimination
these spines during development; these changes have been linked to hyperactivation of the mTOR pathway and defective autophagy in neurons. Neuroplasticity
Synaptic_pruning
Chronic multi-symptomatic pain disorder
overactive "threat" system and an underactive "soothing" system. This hyperactivation, along with other mechanisms, may contribute to fibromyalgia. Neuroimaging
Fibromyalgia
Union of opposite-sex gametes in sexual reproduction to form a zygote
Intracellular calcium influx contributes to sperm capacitation and hyperactivation, causing a more violent and rapid non-linear motility pattern as sperm
Fertilisation
Medical condition
downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation". British Journal of Cancer. 97 (5): 659–69. doi:10.1038/sj.bjc.6603906
Mastitis
Structure in the basal ganglia of the brain
S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M (June 2006). "Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed
Substantia_nigra
Class of enzymes
reduction in cytosolic RNA:DNA hybrid molecules and a concomitant hyperactivation of the IRF3 pathway, with consequent overproduction of type I interferons
DNA polymerase alpha catalytic subunit
DNA_polymerase_alpha_catalytic_subunit
Protein-coding gene in humans
caused upregulation in E-selectin, a factor in metastasis of cancers. Hyperactivation of STAT3 occurs in COVID-19 infection and other viral infections. Loss-of-function
STAT3
Family of regulator genes
Inactivation of SUMO-activating enzyme (SAE1 / SAE2) in the presence of Myc hyperactivation results in mitotic catastrophe and cell death in cancer cells. Hence
Myc
Sensory system that receives and integrates information from the body
disorders experience heightened interoceptive accuracy, suggested by hyperactivation in the anterior cingulate cortex—a region of the brain associated with
Interoception
Medical condition
progressiva HRAS the mutation that involved in ILVEN is a RAS-MAPK pathway hyperactivation (RASopathy-related). KRT10 mutation causes keratinocyte differentiation
Inflammatory linear verrucous epidermal nevus
Inflammatory_linear_verrucous_epidermal_nevus
Protein and coding gene in humans
overload. TRPC6 activates calcineurin, which impedes the NMDAR activity. Hyperactivation of NMDAR is a critical event in glutamate-driven excitotoxicity that
TRPC6
Protein-coding gene in the species Homo sapiens
activity is implicated in the development of abnormal cell growth and hyperactivation of YAP and TAZ has been observed amongst many cancers. Hence YAP1 represents
YAP1
Genetic abnormality in leukemia cancer cells
factors in all higher eukaryotic cells in response to external stimuli. Hyperactivation of this pathway therefore promotes pro-survival intracellular signalling
Philadelphia_chromosome
Mammalian protein found in humans
isotype, and have low CTLA-4 protein expression in T regulatory cells, hyperactivation of effector T cells, low switched memory B cells, and progressive loss
Cytotoxic T-lymphocyte associated protein 4
Cytotoxic_T-lymphocyte_associated_protein_4
Mammalian protein found in Homo sapiens
cytotoxicity, leading to uncontrolled antigen presentation, T-cell hyperactivation, interferon-γ–driven macrophage activation, and severe hyperinflammation
Perforin-1
American immunologist and researcher
to the identification of a novel state of dendritic cell activation—hyperactivation. Hyperactive dendritic cells display activities similar to classically
Jonathan_C._Kagan
Group of regulatory cell surface receptors
costimulation with the Tat protein can contribute to chronic immune hyperactivation seen among HIV-infected individuals. Thus, CD28 is an essential part
CD28_family_receptor
Cytokine
(December 2019). "Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction". Science
Transforming growth factor beta
Transforming_growth_factor_beta
Protein-coding gene in the species Homo sapiens
"Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". The Journal of Biological
MTF1
Field of study
glucocorticoid-responsive gene. Thus, chronic stress may cause demethylation and hyperactivation of a stress-related gene, causing increased stress response. Additionally
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
Toxin harmful to nervous tissue
This reorganization may lead to neuronal cytotoxicity both through hyperactivation of postsynaptic neurons and through induced addiction to continuous
Neurotoxin
Israeli biochemist
and another via melanopsin and phospholipase C. Eisenbach linked hyperactivation (a vigorous motility pattern characterized by large amplitudes of head
Michael_Eisenbach
Medical condition
downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation". British Journal of Cancer. 97 (5): 659–669. doi:10.1038/sj.bjc.6603906
Inflammatory_breast_cancer
Protein-coding gene in the species Homo sapiens
glucose intolerance, and are resistant to cancer brought about by hyperactivation of the PI3K pathway (PTEN+/-). Plant PDK1 plays an important role in
Phosphoinositide-dependent kinase-1
Phosphoinositide-dependent_kinase-1
Central nervous system disease
death. For example, type III PCD might be caused by trophotoxicity, or hyperactivation of trophic factor receptors. Cytotoxins that induce PCD can cause necrosis
Neurodegenerative_disease
Protein-coding gene in the species Homo sapiens
importantly, AGK expression was significantly correlated with JAK2/STAT3 hyperactivation in ESCC, as well as in lung and breast cancer. In prostate cancer,
AGK_(gene)
Protein complex
such as type 2 diabetes mellitus. In many types of human cancer, hyperactivation of mTORC2 caused by mutations and aberrant amplifications of mTORC2
MTORC2
Series of chemical reactions resulting in a cell response
the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction". Molecular and Cellular Endocrinology. 374
Biochemical_cascade
Protease enzyme present in mammals and other organisms
identified as a tumour suppressor for gastric cancer. Moreover, the hyperactivation of calpains is implicated in a number of pathologies associated with
Calpain
American academic and chemical biologist
2019). "STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition". Cell. 178 (2): 290-301.e10. doi:10.1016/J.CELL.2019
Lingyin_Li
Protein-coding gene in the species Homo sapiens
patients. This can be exploited by therapeutic agents, including by the hyperactivation of ClpP to cause selective cancer cell lethality. Intracellular proteases
ATP-dependent Clp protease proteolytic subunit
ATP-dependent_Clp_protease_proteolytic_subunit
Cytosolic multiprotein complex that mediates the activation of Caspase 1
Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation". Immunity. 47 (4): 697–709.e3. doi:10.1016/j.immuni.2017.09.010. PMC 5747599
Inflammasome
Protein-coding gene in the species Homo sapiens
patients had evidence of increased NRG1 and ErbB4 gene expression and hyperactivation. To test this, the authors used transgenic mice, or mice with altered
Neuregulin_1
Protein-coding gene in the species Homo sapiens
mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells. Since phospholipase A2 is required for the biosynthesis
Annexin_A1
American research scientist
early days of the AIDS epidemic, the Zolla-Pazner lab described the hyperactivation of B lymphocytes in the blood of HIV-infected individuals. This discovery
Susan_Zolla-Pazner
Chemical compound
2019). "STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition". Cell. 178 (2): 290–301.e10. doi:10.1016/j.cell.2019
Cyclic_di-AMP
Class of transmembrane transporter protein
have neurofibrillary tangles contain high levels of calcium and show hyperactivation of calcium-dependent proteins. The abnormal calcium handling of atypical
Antiporter
Protein complex
(2009). "Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity". Mol Cell. 120 (Pt 7): 1245–1255
Condensin
Genetic element in the species Homo sapiens
required for, cancer invasion/metastasis. Mig-7 induces EMT through hyperactivation of Akt and extracellular regulated Kinase ERK1/2 by inhibiting the
Migration-inducting_gene_7
"GDS5801 / ILMN_1748827". www.ncbi.nlm.nih.gov. Retrieved 2024-12-04. He H, Chen X, Hou N (August 2023). "P845: Deciphering Plasma Cell Heterogeneity and Transcriptome
TMEM238
production (see below). These antigonadotropic effects are mediated by hyperactivation of the PR. Progestogens have antigonadotropic effects at sufficiently
Pharmacodynamics of progesterone
Pharmacodynamics_of_progesterone
Protein found in humans
stage, metastasis, recurrence, and poorer prognosis. Notably, its hyperactivation is implicated in endocrine resistance, suggesting a crucial role in
Zinc_transporter_SLC39A7
American scientist
coupled this intervention with mindfulness meditation to mitigate DMN hyperactivation/hyperconnectivity and the associated clinical symptoms in patients
Susan_Whitfield-Gabrieli
Protein-coding gene in humans
inhibiting mTORC1 association and preventing apoptosis induced by mTORC1 hyperactivation. Because astrin is frequently upregulated in tumors, it is a potential
RPTOR
American neuroscientist, immunologist, and author
cells of the immune system, where TAM receptors were shown to mitigate hyperactivation of these antigen-presenting cells, preventing autoimmunity. The receptors
Greg_Lemke
Human protein and coding gene
and motor learning disabilities. These changes are associated with hyperactivation of the mTOR signaling pathway in the brain and can be ameliorated by
Basic helix-loop-helix ARNT-like protein 1
Basic_helix-loop-helix_ARNT-like_protein_1
Protein-coding gene in humans
2019). "Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients". Journal of Clinical
ACP1
Mammalian protein found in Homo sapiens
SARS-CoV-2 entry receptor of platelets and megakaryocytes, leading to hyperactivation and thrombosis, that differs from common cold coronavirus CoV-OC43
Basigin
Adverse reaction to HIV/AIDS treatment
deficiency, etc. In addition, it is also thought to be caused by immune hyperactivation, altered immunoregulatory pathways, reactivation of comorbid herpes
HIV disease–related drug reaction
HIV_disease–related_drug_reaction
Chemical compound
mycolactone and the analgesic effect of Buruli ulcer are associated with hyperactivation of the neuronal isoform N-WASP. Another inhibition is the mTOR, which
Mycolactone
Enzyme found in humans
in proteasome-inhibited megakaryocytes was due to upregulation and hyperactivation of the small GTPase, RhoA. It appears that proteasome function, through
PSMC1
Protein-coding gene in the species Homo sapiens
total kinase activity. The increased WNK4 kinase activity leads to the hyperactivation of NCC through WNK4-SPAK/OSR1-NCC cascade, ultimately resulting in
WNK4
disorder in Mexican Americans. These Mexican Americans experienced hyperactivation of the hypothalamic-pituitary-adrenal axis due to significant stress
Transmembrane_protein_151A
X HYPERACTIVATION
X HYPERACTIVATION
Biblical
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Surname or Lastname
English
English : topographic name for someone who lived by a grove or thicket, Middle English grove, Old English grÄf.English (Huguenot) : Americanized spelling of the French surname Le Grou(x) or Le Greux (see Groulx).North German form of Grob.North German : habitational name from any of several places named Grove or Groven in Schleswig-Holstein, which derive their name from Middle Low Germany grÅve ‘ditch’, ‘channel’. In some cases the name is a Dutch or Low German form of Grube.Altered form of German Graf.The surnames Grove and Groves are common mainly in the West Midlands. A Huguenot family who acquired the name Grove are descended from a certain Isaac Le Greux or Grou(x) or his brother. They fled from Tours in France in the late 17th century and settled in Spitalfields, London. Their children were known as Grou(x) or Grove; their grandchildren also used the form Grew; but their great-grandchildren, born at the end of the 18th century, were universally Grove.
Surname or Lastname
English
English : from the personal name Perceval, first found as the name of the hero of an epic poem by the 12th-century French poet Crestien de Troyes, describing the quest for the holy grail. The origin of the name is uncertain; it may be associated with the Gaulish personal name Pritorīx or it may be an alteration of the Celtic name Peredur (see Priddy). It seems to have been altered as the result of folk etymological association with Old French perce(r) ‘to pierce or breach’ + val ‘valley’.English : Norman habitational name from either of the two places in Calvados named Perceval.
X HYPERACTIVATION
X HYPERACTIVATION
Girl/Female
Hebrew
Protected.
Surname or Lastname
English (West Midlands)
English (West Midlands) : unexplained.
Surname or Lastname
English
English : habitational name from places called Oxendean in East Sussex and Kent or Oxenden in Kent, all named in Old Englsih as ‘valley of the oxen’.
Male
Irish
 Irish Gaelic form of Greek ThÅmas, TOMÃS means "twin." Compare with another form of Tomás.
Boy/Male
English
Mythical hunter.
Boy/Male
Gujarati, Hindu, Indian, Kannada, Marathi, Telugu
Lord of Heart
Boy/Male
Anglo Saxon
Exalts.
Boy/Male
African, Hindu, Indian
God; People
Boy/Male
Arabic
Ox.
Girl/Female
Arabic, Assamese, French, Indian, Kannada, Marathi, Muslim, Sindhi
Flower; The One who Guards Herself; White Flower
X HYPERACTIVATION
X HYPERACTIVATION
X HYPERACTIVATION
X HYPERACTIVATION
X HYPERACTIVATION
n.
Expressing number; representing number; as, numeral letters or characters, as X or 10 for ten.
n.
A writing paper made in sheets, ordinarily 16 x 13 inches, and folded so as to make a page 13 x 8 inches. See Paper.
n.
A species of armadillo of the genus Xenurus (X. unicinctus and X. hispidus); the tatouay.
n.
A symbol representing ten units, as 10, x, or X.
n.
A name given to the factors of a continued product when the former are derivable from one and the same function F(x) by successively imparting a constant increment or decrement h to the independent variable. Thus the product F(x).F(x + h).F(x + 2h) . . . F[x + (n-1)h] is called a factorial term, and its several factors take the name of factorials.
adv.
Crosswise; in the form of an X.
v. t.
To cross at an acute angle; to cut or divide in the form of X; to intersect; -- said of lines in geometrical figures, rays of light, nerves, etc.
n.
Act of crossing at an acute angle, or state of being thus crossed; an intersection in the form of an X; as, the decussation of lines, nerves, etc.
n.
Exact agreement between two expressions or magnitudes with respect to quantity; -- denoted by the symbol =; thus, a = x signifies that a contains the same number and kind of units of measure that x does.
v.
A St. Andrew's cross, or cross in the form of an X, -- one of the honorable ordinaries.
n.
A descendant of Ham, Noah's second son. See Gen. x. 6-20.
n.
A tree or wood of the Bible (2 Chron. ii. 8; 1 K. x. 11).
n.
Same as Wiver. X () X, the twenty-fourth letter of the English alphabet, has three sounds; a compound nonvocal sound (that of ks), as in wax; a compound vocal sound (that of gz), as in example; and, at the beginning of a word, a simple vocal sound (that of z), as in xanthic. See Guide to Pronunciation, // 217, 270, 271.
n.
A mysterious composite being, the winged footstool and chariot of the Almighty, described in Ezekiel i. and x.
n.
A quantity consisting of three terms, connected by the sign + or -; as, x + y + z, or ax + 2b - c2.
n.
A partisan of Charles X. of France, or of Don Carlos of Spain.
n.
A quantity so connected with another quantity, that if any alteration be made in the latter there will be a consequent alteration in the former. Each quantity is said to be a function of the other. Thus, the circumference of a circle is a function of the diameter. If x be a symbol to which different numerical values can be assigned, such expressions as x2, 3x, Log. x, and Sin. x, are all functions of x.
n.
A figure or character used to express a number; as, the Arabic numerals, 1, 2, 3, etc.; the Roman numerals, I, V, X, L, etc.
a.
Of or relating to Alphonso X., the Wise, King of Castile (1252-1284).