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Class of enzymes
Histamine N-methyltransferase (HNMT) is a protein encoded by the HNMT gene in humans. It belongs to the methyltransferases superfamily of enzymes and plays
Histamine_N-methyltransferase
Monoamine neurotransmitter
amine. Once formed, histamine is either stored or rapidly inactivated by its primary degradative enzymes, histamine N-methyltransferase or diamine oxidase
Histamine
Presumed set of adverse reactions
that metabolize histamine: diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). Still, the exact prevalence of histamine intolerance is unknown
Histamine_intolerance
Medication
against the protozoan's cell membrane. It is known to act as a histamine N-methyltransferase inhibitor. It also inhibits NF-κB and activates p53. Mepacrine
Mepacrine
Group of methylating enzymes
epinephrine, and histamine N-methyltransferase (HNMT), which methylates histamine in the process of histamine metabolism. Catechol-O-methyltransferase (COMT) degrades
Methyltransferase
Index of enzymes associated with the same name
Dimethylhistidine N-methyltransferase Glycine N-methyltransferase Guanidinoacetate N-methyltransferase Histamine N-methyltransferase Histone methyltransferase (cytochrome
N-methyltransferase
Class of enzymes
Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found primarily in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine
Phenylethanolamine N-methyltransferase
Phenylethanolamine_N-methyltransferase
Class of enzymes
2013 and 2015. In birds and reptiles, the enzyme is encoded by histamine N-methyltransferase-like gene (HNMT-like). Importantly, the HNMT-like gene is absent
Carnosine_N-methyltransferase
Chemical compound
SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels. α-Fluoromethylhistidine
SKF-91488
Class of enzymes
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine
Catechol-O-methyltransferase
Chemical compound
Albert at the University of Sydney in 1949. It also acts as a histamine N-methyltransferase inhibitor. Tacrine was the prototypical cholinesterase inhibitor
Tacrine
Anti-hypertension medication
Retrieved 26 February 2017. Singh V, Sharma P, Capalash N (May 2013). "DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer". Current Cancer
Hydralazine
Enzyme
negative feedback loop. This reaction is Nτ-methylation of histamine by the histamine N-methyltransferase (HNMT) enzyme. The Nτ-methylhistamine, unless excreted
Diamine_oxidase
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Furazolidone
Antihistamine medication
rats. The drug has also been found to act as an inhibitor of histamine N-methyltransferase (HNMT). Oral bioavailability of diphenhydramine is in the range
Diphenhydramine
Blue dye also used as a medication
hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. Tiller N (2022-04-20). "When Medicines Go Rogue, Part 1: Methylene Blue". Skeptical
Methylene_blue
Topics referred to by the same term
HMT may refer to: Science Hexamethylenetetramine Histamine N-methyltransferase Histone methyltransferase Host modulatory therapy Places Ham Street railway
HMT
Chemical compound often used as medication
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Benserazide
Experimental enzyme inhibitor
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Vafidemstat
Agricultural product processed from the leaves of plants in the genus Nicotiana
of tobacco are known, but the chief commercial crop is N. tabacum. The more potent variant N. rustica is also used in some countries. Dried tobacco leaves
Tobacco
Chemical compound
is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT). When taken together with levodopa (L-DOPA) and carbidopa,
Entacapone
Chemical compound
avoid amodiaquine. It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine
Amodiaquine
Class of enzymes
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Tryptophan_hydroxylase
Chemical compound
difluoromethyldopa, and α-methyldopa. Carbidopa is chemically designated as N-amino-α-methyl-3-hydroxy-L-tyrosine monohydrate, with the empirical formula
Carbidopa
Class of enzymes
L-Tyrosine to tyramine – a trace amine neuromodulator L-Histidine to histamine – a neurotransmitter L-Tryptophan to tryptamine – a trace amine neuromodulator
Aromatic L-amino acid decarboxylase
Aromatic_L-amino_acid_decarboxylase
Combination medication
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Foscarbidopa/foslevodopa
Type of white blood cell
Diamine oxidase Eosinophil Food intolerance Histamine Histamine intolerance Histamine N-methyltransferase or HNMT Mast cell List of distinct cell types
Basophil
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Ampyzine
South American psychoactive decoction
Cumming P, Scheidegger M (September 2024). "Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO)
Ayahuasca
Adenosine A2A receptor antagonist and MAO-B inhibitor
= 54 nM and 28,000 nM for the rat receptors, respectively). Its affinities for the adenosine A2B and A3 receptors are similarly low (Ki = 8,200 nM and
3-Chlorostyrylcaffeine
Organic compound (C11H10Cl2N4)
inhibit histamine-N-methyltransferase (HNMT), an enzyme involved in histamine degradation. This led to its use as a research tool for studying histamine's role
Metoprine
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Bulbocapnine
Immune cell found in connective tissue
Diamine oxidase Food intolerance Granulocyte Histamine intolerance Histamine N-methyltransferase or HNMT Histamine List of distinct cell types in the adult
Mast_cell
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Α-Methyl-p-tyrosine
Medication used to treat high blood pressure
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Methyldopa
Human enzyme
β-hydroxylase, which can be further modified by the enzyme phenylethanol N-methyltransferase to obtain epinephrine. Since L-DOPA is the precursor for the neurotransmitters
Tyrosine_hydroxylase
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Salsolidine
Endogenous enzyme
IA, Alpert JE (August 2009). "Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive
Monoamine_oxidase_A
Family of enzymes
endogenous substrates of MAO include telemethylhistamine, a metabolite of histamine, and N-acetylputrescine, a metabolite of putrescine and a precursor and metabolic
Monoamine_oxidase
Antidepressant
involves AcMe which results in the formation of N'-(propan-2-ylidene)isonicotinohydrazide. Subsequently, the C=N linkage is selectively hydrogenated in the
Iproniazid
Chemical compound
γ-aminobutyraldehyde (GABAL or GABA aldehyde) and N-acetylputrescine into N-acetyl-γ-aminobutyraldehyde (N-acetyl-GABAL or N-acetyl-GABA aldehyde), metabolic products
Rasagiline
Abandoned cardiovascular drug
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Etamicastat
Chemical compound
synthesis of tropolone. One involves bromination of 1,2-cycloheptanedione with N-bromosuccinimide followed by dehydrohalogenation at elevated temperatures
Tropolone
Chemical compound
pyridine ring with a carboxylic acid group (COOH) at the 2-position and an n-butyl side chain at the 5-position . The carboxylic acid group acts as a proton
Fusaric_acid
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Amezinium_metilsulfate
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Ladostigil
Irreversible non-selective MAO inhibitor and antidepressant drug
doi:10.5607/en.2011.20.1.1. PMC 3213739. PMID 22110357. Kennedy SH, Piran N, Warsh JJ, Prendergast P, Mainprize E, Whynot C, et al. (December 1988). "A
Isocarboxazid
Chemical compound
to act as a weak inhibitor of arylalkyl acylamidase and of histamine N-methyltransferase. In contrast to selegiline, pargyline does not appear to show
Pargyline
Substance related to dopamine functions
deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors". CNS Drugs. 21 (7): 535–557. doi:10.2165/00023210-200721070-00002
Dopaminergic
Irreversible non-selective MAO inhibitor and antidepressant drug
derivative. It is the hydrazide of β-phenethylamine and can also be referred to as N-aminophenethylamine. The chemical synthesis of phenelzine has been described
Phenelzine
Chemical compound
marketed. List of investigational Parkinson's disease drugs Catechol-O-methyltransferase inhibitor F.. Macdonald (1997). Dictionary of Pharmacological Agents
Nitecapone
Antibiotic for treatment of tuberculosis
StatPearls Publishing. PMID 32491549. Retrieved June 22, 2025. Gegia M, Winters N, Benedetti A, van Soolingen D, Menzies D (February 2017). "Treatment of isoniazid-resistant
Isoniazid
Pharmaceutical compound
does not contribute to DA degradation [39]. KDS2010 is a potent (IC50 = 7.6 nM), and selective MAOB inhibitor named shows no known off-target effect (no
Tisolagiline
Antibiotic medication
identified in Streptococcus pneumoniae (including mutations in an RNA methyltransferase that methylates G2445 of the 23S rRNA and mutations causing increased
Linezolid
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Histidine_methyl_ester
Medication
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Levodopa/benserazide
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Aminoguanidine
Enzyme that converts histidine to histamine
2, and catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission
Histidine_decarboxylase
Hexoprenaline Higenamine Indacaterol Isoetarine Isoprenaline (isoproterenol) N-Isopropyloctopamine Isoxsuprine Labetalol Levonordefrin Levosalbutamol Mabuterol
List_of_adrenergic_drugs
Anti Parkinson medicine
an aromatic amino acid; and entacapone, an inhibitor of catechol-O-methyltransferase for the treatment of Parkinson's disease. In the United States,
Carbidopa/levodopa/entacapone
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
9-Methyl-β-carboline
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Telotristat_ethyl
Protein-coding gene in the species Homo sapiens
γ-aminobutyraldehyde (GABAL or GABA aldehyde) and N-acetylputrescine into N-acetyl-γ-aminobutyraldehyde (N-acetyl-GABAL or N-acetyl-GABA aldehyde). These findings
Monoamine_oxidase_B
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
4-Fluoroselegiline
Stimulant and entactogen designer drug
para-Methoxymethamphetamine (PMMA), also known as 4-methoxy-N-methylamphetamine (4-MMA), is a serotonergic drug of the amphetamine family related to
Para-Methoxymethamphetamine
Chemical compound
methylation under the action of neutral N-methyltransferase. In rats and humans, the biosynthesis of the neurotoxin N-methylnorsalsolinol is carried out by
N-Methylnorsalsolinol
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Mebanazine
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Metfendrazine
Chemical compound
"Tetrahydrocarbazole derivatives and their antitubercular activity in vitro. I. N-Substituted hexahydro-1H-pyrazino[3,2,1-j,k]carbazoles". Khimiko-Farmatsevticheskii
Pirlindole
Pharmaceutical compound
as harmine (IC50Tooltip half-maximal inhibitory concentration = 457 nM and 506 nM, respectively). The alkaloid was isolated from Banisteriopsis caapi
Harmalacidine
Psychedelic drug
Lin R, Narasimhachari N (June 1975). "N-Methylation of 1-methyltryptamines by indolethylamine N-methyltransferase". Biochemical Pharmacology. 24 (11–12):
Dimethyltryptamine
Irreversible non-selective MAO inhibitor and antidepressant drug
Metabolites of tranylcypromine include 4-hydroxytranylcypromine, N-acetyltranylcypromine, and N-acetyl-4-hydroxytranylcypromine, which are less potent MAO inhibitors
Tranylcypromine
Chemotherapy medication used for several cancer types
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Procarbazine
Mammalian protein found in Homo sapiens
The PAH monomer (51.9 kDa) consists of three distinct domains: a regulatory N-terminal domain (residues 1–117) that contains a Phe-binding ACT subdomain
Phenylalanine_hydroxylase
Medication
It is also known as (R)-(–)-N,α-dimethyl-N-(2-propynyl)phenethylamine, (R)-(–)-N-methyl-N-2-propynylamphetamine, or N-propargyl-L-methamphetamine. Selegiline
Selegiline
Chemical compound
serine residue on the active site of HDC. Due to its efficacy in reducing histamine levels in tissue mast cells, it has many applications in the study of
Α-Fluoromethylhistidine
Abandoned COMT inhibitor
Nebicapone (developmental code name BIA 3-202) is a catechol O-methyltransferase (COMT) inhibitor which was under development for the treatment of Parkinson's
Nebicapone
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
3,4-Dihydroxystyrene
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Metralindole
Chemical compound
has been found to bind with high affinity to the σ1 receptor (Ki = 3.2–510 nM) and with very high affinity to the imidazoline I2 receptor (Ki = 40 pM)
Clorgiline
COMT inhibitor
Neluxicapone (INNTooltip International Nonproprietary Name) is a catechol O-methyltransferase (COMT) inhibitor which has not been marketed as of 2024. The drug
Neluxicapone
Chemical compound
alkaloids might potentiate the effects of mescaline and related compounds like N-methylmescaline via monoamine oxidase inhibition. The compound was first isolated
Carnegine
Monoamine oxidase inhibitor; racemic form of rasagiline
AGN-1135 (also known as racemic rasagiline or as N-propargyl-1-aminoindane) is a monoamine oxidase inhibitor (MAOI) that was never marketed. It is the
AGN-1135
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Tritoqualine
Antidepressant
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Nialamide
Pharmaceutical compound
Histamine acts postsynaptically via H1, H2, H3, and H4 receptors, and it is inactivated by methylation through neuronal histamine N-methyltransferase
Imidazoleacetic_acid
Experimental antiparkinsonian agent and adamantane derivative
Hemantane, or hymantane, also known as N-(2-adamantyl)hexamethyleneimine, is an experimental antiparkinsonian agent of the adamantane family that was
Hemantane
Chemical compound
and 5-HT2C receptors (Ki = 267 nM and 1,135 nM, respectively), but not for the serotonin 5-HT2A receptor (Ki = >10,000 nM). It has been found to be inactive
Harmane
Pharmaceutical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Adarigiline
Chemical compound
levodopa in people with Parkinson's disease. Opicapone is a catechol-O-methyltransferase (COMT) inhibitor. The most common side effects are dyskinesia (difficulty
Opicapone
Chemical compound
values for monoamine release are 28.3 nM for serotonin, 23.5 to 26.2 nM for norepinephrine, and 42.2 to 68.5 nM for dopamine in rat brain synaptosomes
Para-Chloroamphetamine
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Sercloremine
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Amiflamine
Chemical compound
is known to compete with catecholamines for binding to catechol O-methyltransferase and tyrosine hydroxylase and to directly and competitively inhibit
2-Hydroxyestradiol
Chemical compound
Institute, Oregon State University. 2025. Retrieved 9 April 2025. Mohajer N, Culty M (2025). "Impact of human-relevant doses of endocrine-disrupting chemical
Genistein
Chemical compound
Meciadanol Naringenin Tritoqualine HNMTTooltip Histamine N-methyltransferase Substrates→Products: Histamine→N-Methylhistamine Inhibitors: Amodiaquine Diphenhydramine
Meciadanol
Chemical compound
N-Methylheliamine, also known as O-methylcorypalline or as 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline, is a tetrahydroisoquinoline and cyclized
N-Methylheliamine
Type of medication
PMID 37601082. Mallinger AG, Frank E, Thase ME, Barwell MM, Diazgranados N, Luckenbaugh DA, Kupfer DJ (2009). "Revisiting the effectiveness of standard
Monoamine_oxidase_inhibitor
Pharmaceutical compound
4-Fluorodeprenyl, or p-F-deprenyl, also known as fludeprenyl or as N-methyl-N-propargyl-4-fluoroamphetamine, is a stimulant and monoamine oxidase inhibitor
4-Fluorodeprenyl
Pharmacology of the antiparkinsonian and antidepressant selegiline
γ-aminobutyraldehyde (GABAL or GABA aldehyde) and N-acetylputrescine into N-acetyl-γ-aminobutyraldehyde (N-acetyl-GABAL or N-acetyl-GABA aldehyde), metabolic products
Pharmacology_of_selegiline
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HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
HISTAMINE N-METHYLTRANSFERASE
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