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Chemical compound
para-Chloroamphetamine (PCA), also known as 4-chloroamphetamine (4-CA), is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) and serotonergic
Para-Chloroamphetamine
Serotonergic neurotoxin
amphetamine family and a serotonergic neurotoxin related to para-chloroamphetamine (PCA; 4-chloroamphetamine). The drug is a potent serotonin–norepinephrine–dopamine
3-Chloroamphetamine
Chemical compound
drug that is a structural analog of para-chloroamphetamine, lacking a methyl group at the α-position. para-Chlorophenethylamine acts primarily as a serotonin-releasing
Para-Chlorophenethylamine
Pharmaceutical compound
monoaminergic drug of the amphetamine family related to para-chloroamphetamine (PCA; 4-chloroamphetamine). It was studied by József Knoll and colleagues in
Para-Bromomethamphetamine
Serotonergic neurotoxin
neurotoxin related to para-chloroamphetamine (PCA; 4-chloroamphetamine). It is also a potent monoamine oxidase inhibitor. 3-Chloroamphetamine (3-CA) 3,4-Dichloroamphetamine
2,4-Dichloroamphetamine
Chemical compound
inhibitor (SSRI) which was never marketed. It is an analogue of para-chloroamphetamine (PCA) and 6-chloro-2-aminotetralin (6-CAT). Metazocine – structural
Org_6582
Pharmaceutical compound
amphetamine para-Iodoamphetamine para-Bromoamphetamine para-Bromomethamphetamine para-Chloroamphetamine para-Chloromethamphetamine para-Fluoroamphetamine para
Para-Iodomethamphetamine
Chemical compound
4-Bromomethcathinone (4-BMC) 4-Fluoroamphetamine (4-FA) para-Chloroamphetamine (PCA) para-Iodoamphetamine (PIA) para-Bromomethamphetamine (PBMA) Magyar K, Tekes K
Para-Bromoamphetamine
Compounds that damage or destroy monoaminergic neurons
Examples of monoamine neurotoxins include the serotonergic neurotoxins para-chloroamphetamine (PCA), methylenedioxymethamphetamine (MDMA), and 5,7-dihydroxytryptamine
Monoamine_neurotoxin
Chemical compound
that is the N-methyl derivative and prodrug of the neurotoxic drug para-chloroamphetamine (4-CA). It has been found to decrease serotonin in rats. Further
Para-Chloromethamphetamine
Pharmaceutical compound
brain in rats in vivo. In contrast to amphetamine and para-chloroamphetamine (PCA; 4-chloroamphetamine), 2-CA does not appear to produce hyperlocomotion in
2-Chloroamphetamine
Topics referred to by the same term
Cultural Association, a British political music group para-Chloroamphetamine or 4-Chloroamphetamine Principal component analysis, a statistical procedure
PCA
Chemical compound
4-methylthioamphetamine (4-MTA), 4-methylamphetamine (4-MA), 4-hydroxyamphetamine, para-chloroamphetamine (PCA), 2-methoxyamphetamine (OMA), 3-methoxyamphetamine (MMA),
Para-Methoxyamphetamine
Stimulant and entactogen designer drug
para-Methoxymethamphetamine (PMMA), also known as 4-methoxy-N-methylamphetamine (4-MMA), is a serotonergic drug of the amphetamine family related to
Para-Methoxymethamphetamine
Chemical compound
and serotonergic neurotoxin of the amphetamine family related to para-chloroamphetamine (PCA). PIA acts as a serotonin releasing agent (SRA). In animal
Para-Iodoamphetamine
Medication
agent (SRA) and serotonin reuptake inhibitor (SRI) similarly to para-chloroamphetamine (PCA). In addition, viqualine displaces diazepam from the GABAA
Viqualine
Pharmaceutical compound
increase latency to ejaculation in male rats treated acutely with para-chloroamphetamine (PCA) to induce ejaculation. The pharmacokinetics of KH-001 in humans
KH-001
Chemical compound
investigate the effects of serotonin depletion. α-Methyl-para-tyrosine (AMPT, metirosine) para-Chloroamphetamine (PCA) Telotristat ethyl (Xermelo) AGN-2979 "Fenclonine"
Fenclonine
Stimulant and anorectic drug of the amphetamine class
4-MA produces the head-twitch response in rodents similarly to para-chloroamphetamine (PCA). 4-Methylamphetamine occurs naturally as an alkaloid in Thymus
4-Methylamphetamine
Chemical compound
2010. Fuller RW, Snoddy HD (July 1980). "Comparative effects of p-chloroamphetamine and 1-(p-chlorophenyl)piperazine on 5-hydroxyindole concentration
Para-Chlorophenylpiperazine
Chemical compound
2,5-Dimethoxy-4-chloroamphetamine (DOC) is a psychedelic drug of the phenethylamine, amphetamine, and DOx families. It is taken orally. The drug acts
2,5-Dimethoxy-4-chloroamphetamine
2,5-Dimethoxy-4-chloroamphetamine
Stimulant designer drug
toxicity of this compound origin in analogies to chloro-amphetamines (para-chloroamphetamine) which have confirmed neurotoxic effects. B-keto substitution in
3-Chloromethcathinone
Class of compounds
increase locomotor activity, other SRAs, including MDMA, MDEA, MBDB, para-chloroamphetamine (PCA), (S)-MDA, α-methyltryptamine (αMT), and α-ethyltryptamine
Serotonin_releasing_agent
Pharmaceutical compound
as cyclized analogues of amphetamine appetite suppressants like para-chloroamphetamine, chlorphentermine, and fenfluramine. 7-Chlorolorcaserin is the (R)-
7-Chlorolorcaserin
Class of compounds based upon the amphetamine structure
4-Hydroxyamphetamine 1 para-Bromoamphetamine (PBA, 4-BA) 4-Bromoamphetamine 1 para-Chloroamphetamine (PCA, 4-CA) 4-Chloroamphetamine 1 para-Fluoroamphetamine
Substituted_amphetamine
Investigational sexual dysfunction drugs
DERIVED FROM SCELETIUM TORTUOSUM DELAYS EJACULATION IN THE RAT PARA-CHLOROAMPHETAMINE (PCA) MODEL". The Journal of Sexual Medicine. 20 (Supplement_4)
List of investigational sexual dysfunction drugs
List_of_investigational_sexual_dysfunction_drugs
Weight loss medication
closely structurally related to the amphetamine derivatives para-chloroamphetamine (PCA) and para-chloromethamphetamine (PCMA) as well. Chlorphentermine was
Chlorphentermine
Entactogen and stimulant drug of the phenethylamine class
amphetamine, and phenylisobutylamine families. It is an analogue of para-chloroamphetamine (PCA) where the alpha position methyl has been replaced with an
4-Chlorophenylisobutylamine
Pharmaceutical compound
psychedelic drug DOI, by mCPP, and by the serotonin releasing agent para-chloroamphetamine (PCA). Analogues of LY-53857 have also been described and include
LY-53857
Head movement in rodents upon 5-HT2A receptor activation
(5-HTP), serotonin releasing agents (SRAs) like fenfluramine and para-chloroamphetamine (PCA), and other agents like 1-methylpsilocin and 3,4-dimethoxyphenethylamine
Head-twitch_response
Drug that releases serotonin and dopamine in the brain
induction of serotonin release of either 25% or 50% relative to MDMA or para-chloroamphetamine (PCA) (which are 100% or full releasers). Although 4-MTDMA might
Serotonin–dopamine releasing agent
Serotonin–dopamine_releasing_agent
Psychoactive research chemical
neurotoxicity of 4-chloroamphetamine (and its brominated derivative), and the increased serotonergic toxicity of 4-methylamphetamine suggest that para-substitution
4-Fluoroamphetamine
Chemical compound
selective serotonergic neurotoxin in a similar manner to the related para-chloroamphetamine (PCA), though with slightly lower potency. It is also a monoamine
3,4-Dichloroamphetamine
Pharmaceutical compound
either 25% or 50% relative to the full serotonin releasers MDMA or para-chloroamphetamine (PCA). In addition to its MRA activity, 4-MTDMA is a fairly potent
N,N-Dimethyl-4-methylthioamphetamine
N,N-Dimethyl-4-methylthioamphetamine
Protein found in humans
amphetamines, including ephedrine, 4-methylamphetamine (4-MA), para-chloroamphetamine (PCA), para-methoxyamphetamine (PMA), 4-methylthioamphetamine (4-MTA)
TAAR1
Antiobesity drug
derivative. The chemical structure of lorcaserin is similar to that of para-chloroamphetamine (PCA). It is also similar to that of 7-AB. On 22 December 2009,
Lorcaserin
Chemical compound
Ifoxetine Indalpine Methylenedioxyphentermine Omiloxetine Panuramine para-Chloroamphetamine para-Chloromethamphetamine Phentermine Pirandamine Seproxetine Viqualine
Cericlamine
Chemical compound
and is a putative entactogen in humans. It is a rigid analogue of para-chloroamphetamine (PCA). According to Nichols et al., 6-CAT is a non-neurotoxic analog
6-CAT
Chemical compound
(MDMA) is a potent agonist of the mouse TAAR1, whereas the MRA para-chloroamphetamine (PCA) is not a significant agonist of the human TAAR1 or presumably
O-Phenyl-3-iodotyramine
Group of stereoisomers
Geyer 2013). By contrast, the 5-HT releasing drugs fenfluramine and p-chloroamphetamine (PCA) do produce a robust HTR (Singleton and Marsden 1981; Darmani
4-Hydroxyamphetamine
Pair of enantiomers
similar potencies to other amphetamines like d-amphetamine and p-chloroamphetamine. In addition, on account of its high lipophilicity, iofetamine rapidly
Iofetamine_(123I)
Chemical compound
previous studies have found that TAAR1 agonism blunted MDMA- and para-chloroamphetamine (PCA)-induced dopamine release in both the ventral and dorsal striatum
EPPTB
Pharmaceutical compound
Although N-hydroxy-p-chloroamphetamine did deplete serotonin, it was metabolized rapidly and almost quantitatively to p-chloroamphetamine (Fuller et al. 1974)
N-Hydroxyamphetamine
Chemical compound
N-Dimethyl-4-methylthioamphetamine Aleph (psychedelic) para-Methoxyamphetamine 4-Fluoroamphetamine para-Chloroamphetamine Anvisa (2023-07-24). "RDC Nº 804 - Listas
4-Methylthioamphetamine
Chemical compound
produce serotonergic neurotoxicity similar to that of MDMA and para-chloroamphetamine (PCA) in rats. This has included long-lasting reductions in serotonin
Α-Ethyltryptamine
Simulant drug of the cathinone class
3-Chloromethcathinone 3-Methylmethcathinone 4-Bromomethcathinone 4-Chloroamphetamine 4-Cl-3-MMC 4Cl-PVP 4-Ethylmethcathinone 4-Methylmethcathinone Substituted
4-Chloromethcathinone
Chemical compound
4-dichloro derivative of the well known psychedelic drug 2,5-dimethoxy-4-chloroamphetamine (DOC). DODC was first officially published in a patent filed by Gilgamesh
DODC
Book about phenethylamines
DOBU 2,5-Dimethoxy-4-butylamphetamine [53] 54 DOC 2,5-Dimethoxy-4-chloroamphetamine [54] 55 DOCN 2,5-Dimethoxy-4-cyanoamphetamine [55] 56 DOET 2
The_Shulgin_Index
Chemical compound
inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology. 200 (1): 9–16. doi:10
5-IAI
Substituted amphetamine derivative invented in the 1960s
compounds now termed psychedelics and those now termed empathogens. 3-Chloroamphetamine 3-Chlorocathinone 3-Chloromethcathinone 4-Chloromethamphetamine
3-Chloromethamphetamine
Entactogen and psychedelic drug of the phenethylamine and amphetamine classes
inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". Eur J Pharmacol. 200 (1): 9–16. doi:10.1016/0014-2999(91)90659-e
3-Methoxy-4-methylamphetamine
Chemical compound
inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology. 200 (1): 9–16. doi:10
MDAI
1971 UN treaty to regulate recreational drugs
25I-NBOMe 2,5-Dimethoxy-4-bromoamphetamine (DOB) 2,5-Dimethoxy-4-chloroamphetamine (DOC) 2,5-Dimethoxy-4-ethylamphetamine (DOET) 2,5-Dimethoxy-4-methylamphetamine
Convention on Psychotropic Substances
Convention_on_Psychotropic_Substances
Chemical compound
is known to be a serotonergic neurotoxin similarly to MDMA and para-chloroamphetamine (PCA). 2-Oxo-αMT, 6-hydroxy-αMT, 7-hydroxy-αMT, and 1′-hydroxy-αMT
Α-Methyltryptamine
Chemical compound
Placement of 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4-chloroamphetamine (DOC) in Schedule I". www.regulations.gov. Hu JC (17 May 2024), "Revisions
2,5-Dimethoxy-4-iodoamphetamine
2,5-Dimethoxy-4-iodoamphetamine
Chemical compound
inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology. 200 (1): 9–16. doi:10
MMAI
Type of drug
potentially more well-balanced NDRAs, including levomethcathinone (l-MC), 3-chloroamphetamine (3-CA; PAL-304), 3-chloromethcathinone (3-CMC; clophedrone; PAL-434)
Dopamine_releasing_agent
Hallucinogenic class of psychoactive drug
PMID 28224459. [...] the 5-HT releasing drugs fenfluramine and p-chloroamphetamine (PCA) do produce a robust HTR (Singleton and Marsden 1981; Darmani
Psychedelic_drug
Chemical class of organic compounds
5-dimethoxy-4-bromoamphetamine Psychedelic DOC CH3 OCH3 Cl OCH3 2,5-dimethoxy-4-chloroamphetamine Psychedelic DOI CH3 OCH3 I OCH3 2,5-dimethoxy-4-iodoamphetamine Psychedelic
Substituted_phenethylamine
Monoamine neurotransmitter
prefrontal cortex neurons resulted in the serotonin releasing agent para-chloroamphetamine (PCA), which did not otherwise show psychedelic-like effects, being
Serotonin
with additional substitutions. 4-BA, 4-Bromoamphetamine, PBA 4-CA, 4-Chloroamphetamine, PCA 4-CMA, 4-Chloromethamphetamine, PCMA 4-FA, 4-Fluoroamphetamine
List_of_designer_drugs
Class of compounds
[...] TAR1 is not activated by all psychoactive amphetamines (p-chloroamphetamine, for instance, is inactive); stimulation of TAR1 actually reduces
Monoamine_releasing_agent
Medication
affect or potentiated the serotonergic neurotoxicity caused by para-chloroamphetamine (PCA). In addition, findings are mixed and conflicting on whether
Selegiline
Class of chemical compounds
5-Dimethoxy-4-fluoroamphetamine 41.7–378 227 28.7–792 DOCTooltip 2,5-Dimethoxy-4-chloroamphetamine 1.4–12 31.8 2.0–143 DOBTooltip 2,5-Dimethoxy-4-bromoamphetamine 0
DOx
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