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Protein-coding gene in the species Homo sapiens
Growth/differentiation factor 9 is a protein that in humans is encoded by the GDF9 gene. Growth factors synthesized by ovarian somatic cells directly
Growth differentiation factor 9
Growth_differentiation_factor_9
Protein or other substance that stimulates cellular proliferation
growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation.
Growth_factor
Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly
Growth_differentiation_factor
Protein-coding gene in humans
Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. GDF15 was first identified as Macrophage inhibitory cytokine-1
GDF15
Protein that stimulates cell division and differentiation
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has
Epidermal_growth_factor
Family of proteins involved in anatomical development
(GDF8) Growth differentiation factor 9 (GDF9) Gyrification Neurogenesis Burgess WH, Maciag T (1989). "The heparin-binding (fibroblast) growth factor family
Fibroblast_growth_factor
Cytokine
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different
Transforming growth factor beta
Transforming_growth_factor_beta
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Signaling glycoprotein regulating cell proliferation
and differentiation, MSCs were shown to have stronger osteogenic differentiation into bone-forming cells when stimulated by epidermal growth factor (EGF)
Platelet-derived growth factor
Platelet-derived_growth_factor
Growth factor and signaling protein otherwise known as FGF2
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by
Fibroblast_growth_factor_2
Mammalian protein found in Homo sapiens
Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the
Leukemia_inhibitory_factor
Biomarker indicative of breast cancer patients' prognosis
regeneration, cell differentiation, embryonic development, and regulation of the immune system. Isoforms of transforming growth factor-beta (TGF-β1) are
Transforming_growth_factor
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Protein-coding gene in the species Homo sapiens
controls proliferation, differentiation, and other functions in many cell types. TGF-β acts synergistically with transforming growth factor-alpha (TGF-α) in
TGF_beta_1
Receptor protein that binds to a growth factor protein
differentiation and proliferation begins. Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor
Growth_factor_receptor
Formation of blood vessels
differentiation. These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth factor,
Vascularisation
Cell surface receptors
PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Gene involved in the most common form of dwarfism
fibroblast growth factors, setting in motion a cascade of downstream signals which ultimately influence cell mitogenesis and differentiation. This particular
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Protein-coding gene in the species Homo sapiens
designated as CD334 (cluster of differentiation 334). The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Family of biomolecules
is controversial. Nerve growth factor (NGF) uses the high-affinity receptor TrkA to promote myelination and the differentiation of neurons. Studies have
Neurotrophic_factors
Mammalian and avian protein
Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine
Myostatin
Transmembrane protein
epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Academic journal
Development Growth & Differentiation is a peer-reviewed scientific journal published by Wiley on behalf of the Japanese Society of Developmental Biologists
Development, Growth & Differentiation
Development,_Growth_&_Differentiation
Protein-coding gene in the species Homo sapiens
Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor is a member of the VEGF (vascular endothelial
Placental_growth_factor
Factor that stimulates the growth of bone tissue
A bone growth factor is a growth factor that stimulates the growth of bone tissue. Known bone growth factors include insulin-like growth factor-1 (IGF-1)
Bone_growth_factor
Protein family
morphogenetic proteins and the growth differentiation factors The activin and inhibin subfamilies The left-right determination factors A group encompassing various
Transforming growth factor beta superfamily
Transforming_growth_factor_beta_superfamily
Mammalian protein found in Homo sapiens
Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells
Hepatocyte_growth_factor
Protein-coding gene in the species Homo sapiens
Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene. GDF1 belongs to the transforming growth factor beta superfamily
GDF1
Protein-coding gene in the species Homo sapiens
IL-6 which promotes plasma cell growth and of immunoglobulins in B lymphocytes. XBP1 is also essential for differentiation of plasma cells (a type of antibody
XBP1
Protein-coding gene in the species Homo sapiens
involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily
Transforming growth factor, beta 3
Transforming_growth_factor,_beta_3
Mammalian protein found in Homo sapiens
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified
Fibroblast_growth_factor_18
Bone- or cartilage-forming cells
for the osteochondroprogenitor to undergo chondrocytic differentiation. The transcription factor Sox9 can be found in multiple sites in the body (pancreas
Osteochondroprogenitor_cell
terminally differentiate when treated with nerve growth factor or dexamethasone. This makes PC12 cells useful as a model system for neuronal differentiation and
PC12_cell_line
Protein found in humans
gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain
Neurotrophin-3
Mammalian protein found in humans
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival
Nerve_growth_factor
Biological process in primates
induce the expression of growth factors, such as amphiregulin, epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF), which in turn have
Breast_development
Protein involved in blood vessel growth
specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Family of proteins
differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 is the third neurotrophic factor
Neurotrophin
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast growth factor
Fibroblast_growth_factor_8
Protein
growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and
TGF_alpha
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Mammalian protein found in humans
gene. M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages,
Macrophage colony-stimulating factor
Macrophage_colony-stimulating_factor
(2013). "Dynamic medium containing growth differentiation factor-9 and FSH maintains survival and promotes in vitro growth of caprine preantral follicles
Ovarian_culture
Protein-coding gene in humans
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation
GDF11
Form of localized cell signaling
receptor. Growth and differentiation factors (GDFs) Growth factor and clotting factors are paracrine signaling agents. The local action of growth factor signaling
Paracrine_signaling
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding
Kinase_insert_domain_receptor
Protein involved in blood vessel growth
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. The chemical formula is C3914H6252N1212O1278S52
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
Cell line used for scientific research
unit (r) was 0.25 ± 0.05, and the multiplication factor (V) was 3.49 ± 1.21. SH-SY5Y cells show growth-related parameters that were typical or even superior
SH-SY5Y
Mammalian protein found in Homo sapiens
factor NR4A1 is stably expressed at high levels in tolerant T cells. Overexpression of Nuclear receptor 4A1 inhibits effector T cell differentiation,
Nuclear_receptor_4A1
Protein found in humans
neurotrophic factor (Bdnf), or abrineurin, is a protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin family of growth factors
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Class of proteins
Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor cells. Made available through recombinant DNA technology
Hemopoietic_growth_factor
Class of enzymes
(RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified
Receptor_tyrosine_kinase
Cell receptor protein found in humans
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Series of chemical reactions resulting in a cell response
PMC 3025001. PMID 20555408. Peng, J.; Li, Q. (4 February 2013). "Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators
Biochemical_cascade
Family of four EGF proteins
heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor. Multiple
Neuregulin
Chemical compound
number of differentiated dopaminergic neurons and produced higher levels of transcription factors associated with dopaminergic differentiation. 9-Me-BC also
9-Methyl-β-carboline
Mammalian protein found in Homo sapiens
chemotherapy. Trials of a modified recombinant form, megakaryocyte growth and differentiation factor (MGDF), were stopped when healthy volunteers developed autoantibodies
Thrombopoietin
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene
Fibroblast_growth_factor_1
Formation of blood cellular components
erythropoietin (an erythrocyte-differentiation factor), a subpopulation of cells (as defined by the levels of Sca-1) differentiated into erythrocytes at a sevenfold
Haematopoiesis
Mammalian protein found in humans
initiates proliferation and differentiation into mature granulocytes. G-CSF stimulates the survival, proliferation, differentiation, and function of neutrophil
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Protein-coding gene in the species Homo sapiens
Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2
GDF2
Protein domain
conserved protein domain, which derives its name from the epidermal growth factor where it was first described.[citation needed] It comprises about 30
EGF-like_domain
Neural stem cell culture system
substrates but containing necessary growth factors, such as epidermal growth factor and fibroblast growth factor. This allows the neural stem cells to
Neurosphere
Protein found in humans
Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is
Insulin-like growth factor 2 receptor
Insulin-like_growth_factor_2_receptor
Embryonic carcinoma cell line
role in muscle differentiation in P19 cells which might explain why cells need to aggregate first to process the muscle differentiation. In order to elucidate
P19_cell
Mammalian protein found in Homo sapiens
cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene
RANKL
Protein-coding gene in the species Homo sapiens
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six
IGFBP3
Process of stem cells differentiating into fat cells
other transcription factors function in the progression of differentiation. Adipocyte determination and differentiation factor 1 (ADD1) and sterol regulatory
Adipogenesis
Protein-coding gene in the species Homo sapiens
crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9). These two protein signaling molecules and their BMPR2-mediated
BMPR2
Polyfunctional cytokine
CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor (LIF) is a polyfunctional
Leukemia inhibitory factor receptor
Leukemia_inhibitory_factor_receptor
transforming growth factor beta (TGF-beta). The combination of interleukin-21 (IL-21) and interleukin-23 (IL-23) can also induce the differentiation of naive
Th22_cell
Protein-coding gene in the species Homo sapiens
heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic
ERBB4
Chemical compound
derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound
Dihexa
Follicles moving from inactive to growing phase
primordial follicle activation such as transforming growth factor-beta (TGF-B), growth differentiation factor 9 (GDF9) and bone morphogenic protein 15 (BMP15)
Ovarian_follicle_activation
Protein-coding gene in the species Homo sapiens
Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene. The protein encoded by this gene is closely related to the bone
GDF5
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Colony forming unit that generates myeloid cells in the bone marrow
SR1, a known transcription factor, UM171 allowed for suppression of differentiation and led to increased CFU-GEMM growth. These results suggest that
CFU-GEMM
Group of protein families
Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors). Two
Neurotrophic_factor_receptor
Protein found in humans
Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate
Fibroblast_growth_factor_23
Mammalian protein found in humans
C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded
C-fos-induced_growth_factor
Substances isolated from the mycelium of lion's mane mushrooms
and neurite growth(potent cytotoxicity against HL-60 cell lines: IC50: 8.9 μmol/L) Z2- Promote PC12 cell differentiation and neurite growth(potent cytotoxicity
Erinacine
Protein-coding gene in humans
S2CID 6500889. de Castro FC, Cruz MH, Leal CL (August 2016). "Role of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Ovarian Function and Their
Bone_morphogenetic_protein_15
Protein-coding gene in the species Homo sapiens
protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation". J. Cell. Biochem. 68
TGF_beta_2
Transformation of a stem cell to a more specialized cell
and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape
Cellular_differentiation
Human colon cancer cell line
demonstrated induced differentiation in response to forskolin, Colchicine, nocodazole, and taxol, with galactose-mediated differentiation also strengthening
HT-29
Protein-coding gene in the species Homo sapiens
Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2
GRB2
Genetic disorder of the skull and face
transmembrane proteins are two of four fibroblast growth factor receptors involved in osteoblast differentiation during embryonic development; mutations amongst
Crouzon_syndrome
Intracrine signaling is a mode of hormone and growth factor action in which signaling molecules exert their effects within the same cell that produces
Intracrine_signaling
Protein-coding gene in humans
encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation. It has also been suggested that Runx2 plays a cell
RUNX2
Group of cytokines
(lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and
Interleukin
Protein-coding gene in the species Homo sapiens
(cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). These proteins
Cellular communication network factor 6
Cellular_communication_network_factor_6
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
AP-1 transcription factor has been shown to have a hand in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. AP-1
AP-1_transcription_factor
Human immortalised myelogenous leukemia cell line
Institute. Many factors and components play a role in the cell cycle of K562 cells in terms of growth, cell differentiation, and apoptosis. The growth of these
K562_cells
Primary type of cell found in the epidermis
preventing differentiation. These factors include: The transcription factor p63, which prevents epidermal stem cells from differentiating into keratinocytes
Keratinocyte
Protein-coding gene in humans
molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains
PTPN11
Protein-coding gene in the species Homo sapiens
induced by growth factors, mitogens, or cytokines into intracellular phosphorylation cascades, which regulate cell proliferation, differentiation, stress
USF1
Protein-coding gene in the species Homo sapiens
Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene. GRCm38: Ensembl release 89: ENSMUSG00000023046
IGFBP6
Series of events that restore integrity to damaged tissue after an injury
(hemostasis), inflammation, tissue growth (cell proliferation), and tissue remodeling (maturation and cell differentiation). Blood clotting may be considered
Wound_healing
Protein found in humans
neurotrophin, nerve growth factor (NGF). As a kinase, TrkA mediates the multiple effects of NGF, which include neuronal differentiation, neural proliferation
Tropomyosin_receptor_kinase_A
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GROWTH DIFFERENTIATION-FACTOR-9
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GROWTH DIFFERENTIATION-FACTOR-9
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