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Chemotherapy medication
Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. By intravenous
Fluorouracil
Chemotherapy regimen
Cyclophosphamide Methotrexate Fluorouracil (CMF) is a commonly used regimen of breast cancer chemotherapy that combines three anti-cancer agents: cyclophosphamide
CMF_(chemotherapy)
Derivative of folic acid used in cancer treatment
methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, and may be used to
Folinic_acid
Medical treatment in addition to a primary treatment to maximise effectiveness
survival outcomes that accompanied use of cyclophosphamide methotrexate fluorouracil (CMF) after the initial mastectomy. In 1976, shortly after Bonadonna's
Adjuvant_therapy
Treatment of cancer using drugs that inhibit cell division or kill cells
ribonucleotide formyltransferase. The fluoropyrimidines include fluorouracil and capecitabine. Fluorouracil is a nucleobase analogue that is metabolised in cells
Chemotherapy
Chemotherapy regimen
colorectal cancer, made up of the drugs folinic acid (leucovorin, FOL), fluorouracil (5-FU, F), and oxaliplatin (Eloxatin, OX). Adjuvant treatment in patients
FOLFOX
Rough skin induced by UV exposure
by illumination with a strong light source. Topical creams, such as 5-fluorouracil or imiquimod, may require daily application to affected skin areas over
Actinic_keratosis
Most common type of skin cancer
generally responsive to topical chemotherapy, such as imiquimod, or fluorouracil, although surgical treatment is better able to ensure complete removal
Basal-cell_carcinoma
Chemotherapy regimen for colorectal cancer treatment
applications, which in this context decreases the cytotoxicity of 5-fluorouracil; F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates
FOLFIRI
Medical condition
symptoms. This may include salicylic acid, cryotherapy, chemo-based fluorouracil or bleomycin, and surgical removal. The skin atop the lesion should generally
Plantar_wart
Cancer medication
small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is used with cisplatin. It is given intravenously
Irinotecan
Chemotherapy regimen for advanced colorectal cancer treatment
derivative that modulates/potentiates/reduces the side effects of fluorouracil; F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates
FOLFOXIRI
Chemical compound
cancers. In vitro uses of floxuridine include 5-minute treatments of fluorouracil, floxuridine, and mitomycin to increase cell proliferation in Tenon's
Floxuridine
Chemical compound
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil
Tegafur
Chemical compound
harm to the fetus. Capecitabine, inside the body, is converted to 5-fluorouracil (5-FU) through which it acts. It belongs to the class of medications
Capecitabine
Chemotherapy regimen
a vitamin B derivative that enhances the effects of 5-fluorouracil (5-FU); F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates
FOLFIRINOX
Small, rough growth resembling a cauliflower or a solid blister
bottled concentrated salicylic acid and lactic acid solution. Fluorouracil — Fluorouracil cream, a chemotherapy agent sometimes used to treat skin cancer
Wart
Pharmaceutical drug
retinopathy of prematurity. Aflibercept (Zaltrap), in combination with fluorouracil, leucovorin, and irinotecan (known as FOLFIRI), is indicated for the
Aflibercept
Chemical compound of RNA
When elemental fluorine reacts with uracil, they produce 5-fluorouracil. 5-Fluorouracil is an anticancer drug (antimetabolite) used to masquerade as
Uracil
Medical condition involving uncontrolled growth of skin cells
less commonly, involve radiation therapy or topical medications such as fluorouracil. Treatment of melanoma may involve some combination of surgery, chemotherapy
Skin_cancer
Hospital in New York, United States
have been given. Biochemist Marie Hakala, PhD first observed that 5-fluorouracil becomes more effective in treating cancer cells when calcium leucovorin
Roswell Park Comprehensive Cancer Center
Roswell_Park_Comprehensive_Cancer_Center
Natural cell death phenomenon
anticancer agents, such as trimethoprim, sulfamethoxazole, methotrexate and fluorouracil. The phenomenon was first reported in 1954 by Hazel D. Barner and Seymour
Thymineless_death
Chemical compound
HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil, being a lipophilic-masked
Carmofur
Chemical compound
tested in combination with fluorouracil to treat colon cancer. Evidence from clinical trials support its addition to fluorouracil therapy to benefit patients
Levamisole
Anal cancer treatment
The Nigro protocol is the preoperative use of chemotherapy with 5-fluorouracil and mitomycin and medical radiation for squamous cell carcinomas of the
Nigro_protocol
Drugs that are useful against cancer
Cladribine Clofarabine Cytarabine Decitabine Doxifluridine Fludarabine Fluorouracil Gemcitabine Hydroxyurea Mercaptopurine Methotrexate Nelarabine Pemetrexed
List of chemotherapeutic agents
List_of_chemotherapeutic_agents
Enzyme found in humans
is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur. It participates in beta-alanine metabolism and pantothenate
Dihydropyrimidine dehydrogenase (NADP+)
Dihydropyrimidine_dehydrogenase_(NADP+)
Index of chemical compounds with the same name
medications, which include: Capecitabine Carmofur (HCFU) Doxifluridine Fluorouracil (5-FU) Tegafur Some metabolites of these drugs, such as 5-fluorodeoxyuridylate
Fluoropyrimidine
Medical condition
condition may develop life-threatening toxicity following exposure to 5-fluorouracil (5-FU), a chemotherapy drug that is used in the treatment of cancer.
Dihydropyrimidine dehydrogenase deficiency
Dihydropyrimidine_dehydrogenase_deficiency
Chemotherapy medication
(cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone) and FAC (5-fluorouracil, adriamycin, cyclophosphamide). Its activity is inhibited by certain
Doxorubicin
Chemical compound
encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite. It has also been used in diatom selection. 2-FA
5-Fluoroorotic_acid
Chemical compound
ZOOR-ə-den); to treat people following an overdose of chemotherapy drugs 5-fluorouracil (5-FU) or capecitabine regardless of the presence of symptoms, or who
Uridine_triacetate
Pharmaceutical drug
colorectal cancer, typically along with folinic acid (leucovorin) and fluorouracil in a combination known as FOLFOX or along with capecitabine in a combination
Oxaliplatin
Cancer of the colon or rectum
condition may include capecitabine, fluorouracil, irinotecan, oxaliplatin and UFT. The drugs capecitabine and fluorouracil are interchangeable, with capecitabine
Colorectal_cancer
Malignant neoplastic disease of the esophagus
cisplatin-based (or carboplatin or oxaliplatin) every three weeks with fluorouracil (5-FU) or capecitabine either continuously or every three weeks. In more
Esophageal_cancer
Species of fern
that water extract of the fern was as toxic as the anticancer drug 5-fluorouracil against human chronic myelogenous leukemia cell line (K562). "Christella
Christella_dentata
Combination drug
converted to the medicine fluorouracil in the body, but more is converted in tumor cells than in normal tissues. Fluorouracil is very similar to pyrimidine
Tegafur/gimeracil/oteracil
Medical condition
Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by
Actinic_cheilitis
Chemical compound and pharmaceutical drug
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Cisplatin
Medication used as chemotherapy and to suppress the immune system
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Cyclophosphamide
Synthetic organic compounds
reactivity can be altered significantly. For example, both uracil and 5-fluorouracil are colourless, high-melting crystalline solids, but the latter is a
Hydrofluorocarbon
Regimen commonly used in chemotherapy
as AC) breast cancer CAF cyclophosphamide, doxorubicin (Adriamycin), fluorouracil (5-FU) breast cancer CAPOX or XELOX capecitabine and oxaliplatin colorectal
Chemotherapy_regimen
1193–21–1 C4H3Cl2N3 2-amino-4,6-dichloropyrimidine 56–05–3 C4H3FN2O2 fluorouracil 51–21–8 C4H4 vinylacetylene C4H4FN3O flucytosine 2022–85–7 C4H4N2O2 uracil
Glossary_of_chemical_formulae
Topics referred to by the same term
F5U may refer to 5-FU or f5U, technical name of the drug Fluorouracil uranium pentafluoride (F5U), see Glossary of chemical formulae Vought XF5U "Flying
F5U
Anti-cancer medication
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Vorasidenib
Medical condition
cancer treatment, about 5–15% of patients get mucositis. However, with 5-fluorouracil (5-FU), up to 40% get mucositis, and 10–15% get grade 3–4 oral mucositis
Mucositis
Mammalian protein found in Homo sapiens
cancer (CRC) as well. Treatment for CRC includes administration of 5-Fluorouracil (5-FU), chemotherapy also used to treat other cancers, such as pancreatic
Zbtb7
Impairment that can result from chemotherapy treatment
particularly vulnerable to the cytotoxic effects of chemotherapy agents. 5-fluorouracil has been demonstrated to reduce the viability of neural progenitor cells
Post-chemotherapy cognitive impairment
Post-chemotherapy_cognitive_impairment
Disease of the skin of human fingers
surgery; however, there has been some effectiveness with intralesional fluorouracil. Knuckle pads are benign subcutaneous fibrotic nodules that are seen
Knuckle_pads
Compound that is metabolized into a pharmacologically active drug
I Intracellular Type IA Therapeutic target tissues/cells Aciclovir, fluorouracil, cyclophosphamide, diethylstilbestrol diphosphate, L-DOPA, mercaptopurine
Prodrug
Chemical element with atomic number 9 (F)
Lu; Chang-Jiang, Lin; Xin, Wang; Chui-Hua, Kong (4 January 2003). "5-Fluorouracil Derivatives from the Sponge Phakellia fusca". J. Nat. Prod. 2 (66): 285–288
Fluorine
Molecular structures of several fluorine-containing pharmaceuticals Lipitor (atorvastatin) 5-FU (fluorouracil) Florinef (fludrocortisone) Isoflurane
Fluorine_in_biology
Chemotherapy regimen
cancer, and gastroesophageal junction cancer; made up of the medications fluorouracil, leucovorin, oxaliplatin, and docetaxel. "FLOT". Cancer Research UK.
FLOT_(chemotherapy)
Accumulation of mutations
methotrexate. A common cytotoxic chemotherapy used in a variety of cancers, 5-fluorouracil (5-FU), targets the TYMS pathway and resistance can evolve through the
Somatic_evolution_in_cancer
Egyptian-American medical researcher
variability in 5-fluorouracil plasma levels in patients with colorectal cancer. El-Deiry showed that pharmacokinetically guided dosing of 5-fluorouracil chemotherapy
Wafik_El-Deiry
Chemical that inhibits the use of a metabolite
drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda) Cytarabine (Ara-C)
Antimetabolite
Oncologist, clinical researcher (b. 1910, d. 1996)
American pioneer of medical oncology. He was a leader in applying 5-FU (5-Fluorouracil) to humans, demonstrating its effectiveness as a chemotherapy drug. Ansfield
Fred_J._Ansfield
Medical intervention
leucovorin (folinic acid), and fluorouracil. It is similar to the FOLFIRI regimen and uses the same drugs. However, the fluorouracil component is given as a
IFL_(chemotherapy)
Chemical compound of DNA
inhibit normal function. Thymine could also be a target for actions of 5-fluorouracil (5-FU) in cancer treatment. 5-FU can be a metabolic analog of thymine
Thymine
Unusual presence of neutrophils
leukemia (CML) Chronic infections Chemotherapeutic & Cytotoxic drugs 5-fluorouracil Hydroxyurea Hydroxycarbamide Methotrexate Following Granulocyte colony
Hypersegmented_neutrophil
Glycopeptide antibiotic used to treat various cancers
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Pingyangmycin
Class of chemical compounds
carbonyl groups. Examples include naturally occurring metabolites: drugs: Fluorouracil Idoxuridine Primidone Trifluridine and pesticides: Bromacil Saflufenacil
Pyrimidinedione
Topics referred to by the same term
for chemotherapy protocol used in the USA (FOLFLOX in EU), containing Fluorouracil, Leucovorin, Oxaliplatin Fl-Ox, a fluorine, liquid oxygen mixture (also
Flox
Branch of pharmacology
Antiviral (HIV) medication Coagulation factors Theophylline Methotrexate 5-Fluorouracil Irinotecan + Efavirenz Tenofovir Ritonavir Factor VIII, Factor IX, Factor
Pharmacokinetics
Fluomine Fluorine Fluoroacetamide Fluoroacetic acid Fluoroacetyl chloride Fluorouracil Fonofos Formaldehyde Formaldehyde cyanohydrin Formetanate hydrochloride
EPA list of extremely hazardous substances
EPA_list_of_extremely_hazardous_substances
Gene therapy medication
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Obecabtagene_autoleucel
Enzyme
phosphate group (Figure 2). [Stroud and Finer-Moore][citation needed] 5-Fluorouracil (5-FU) is an inhibitor of TS. In the cell, 5-FU is converted to a variety
Thymidylate_synthase
American physician
Cancer Center. Klein developed a topical treatment for skin cancer with 5-fluorouracil, developed one of the first effective treatments for Kaposi's sarcoma
Edmund_Klein
Study of chemical compounds containing fluorine-carbon bonds
reactivity can be altered significantly. For example, both uracil and 5-fluorouracil are colourless, high-melting crystalline solids, but the latter is a
Organofluorine_chemistry
Upward spreading of abnormal cells in the epidermis
surgery to ensure complete removal. Topical therapies: imiquimod or 5-fluorouracil for superficial cases. Radiotherapy: considered for non-surgical candidates
Pagetoid
Group of eye diseases related to poor retinal and nerve perfusion
Traditionally, chemotherapeutic adjuvants, such as mitomycin C (MMC) or 5-fluorouracil (5-FU), are applied with soaked sponges on the wound bed to prevent filtering
Glaucoma
Type of endocrine gland cancer
known as NALIRIFOX, comprising liposomal irinotecan with oxaliplatin, fluorouracil, and leucovorin, was approved by the United States Food and Drug Administration
Pancreatic_cancer
President of the American University of Beirut
selectively replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Another study highlights
Fadlo_R._Khuri
Chemical compound
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Navitoclax
Common side effects in chemotherapy treatment
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Chemotherapy-induced nausea and vomiting
Chemotherapy-induced_nausea_and_vomiting
Gene therapy medication used to treat multiple myeloma
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Ciltacabtagene_autoleucel
Chemotherapy drug used in the treatment of cancer
inhibitor of dihydropyrimidine dehydrogenase), and tegafur (a bioavailable 5-fluorouracil (5-FU) prodrug) in a 4:1 molar ratio. Uracil has also been stated to
Tegafur/uracil
Gland of the male reproductive system
studied in the 1970s. The initial regimen of cyclophosphamide and 5-fluorouracil was quickly joined by multiple regimens using a host of other systemic
Prostate
Group of antibiotics
JC, Schlottmann PG, Evans JR (November 2015). "Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery". The Cochrane Database of Systematic
Mitomycins
Medical condition
cryosurgery (freezing), radiation, pulsed dye laser (PDL), interferon (IFN), fluorouracil (5-FU) and surgical excision as well as a multitude of extracts and topical
Keloid
Chemical element with atomic number 54 (Xe)
production of microelectromechanical systems (MEMS). The anticancer drug 5-fluorouracil can be produced by reacting xenon difluoride with uracil. Xenon is also
Xenon
Chemical compound
pyrimidine analogue family of medications. It works by being converted into fluorouracil inside the fungus, which impairs its ability to make protein. Flucytosine
Flucytosine
Human colon cancer cell line
"Inhibition of Growth and Metastasis of Colon Cancer by Delivering 5-Fluorouracil-loaded Pluronic P85 Copolymer Micelles". Scientific Reports. 6 20896
HCT116_cells
Sexually transmitted infection caused by certain types of human papillomaviruses
effective, but it is also expensive and its effect is inconsistent. A 5% 5-fluorouracil (5-FU) cream was used, but it is no longer considered an acceptable treatment
Genital_wart
Drug for treatment of breast cancer
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Utidelone
Chemical compound
"Transplatin, a cisplatin trans-isomer, may enhance the anticancer effect of 5-fluorouracil". Journal of Experimental & Clinical Cancer Research. 25 (2): 195–200
Transplatin
Chemical compound; chemotherapy medication
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Vincristine
Medical condition
matrix and of the bed. Clobetasol nail lacquer and tacalcitol ointment 5-fluorouracil. A reported side-effect is yellow nails Calcipotriol Calcipotriol plus
Psoriatic_onychodystrophy
Industrial chemical and medication
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Arsenic_trioxide
Skin rash resulting from excess exposure to heat
erythema ab igne lesions demonstrate pre-cancerous changes, the use of 5-fluorouracil cream has been recommended.[medical citation needed] Abnormally pigmented
Erythema_ab_igne
Chemical compound
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Vepdegestrant
Topics referred to by the same term
transcription factor, an asexual sporulation gene of Neurospora crassa Fluorouracil (5-FU), and leucovorin (folinic acid), a chemotherapy regimen Follicular
FL
Mammalian protein found in humans
developing treatments for cancer. DHFR is one such target. A regimen of fluorouracil, doxorubicin, and methotrexate was shown to prolong survival in patients
Dihydrofolate_reductase
Pharmaceutical drug
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Tebentafusp
Tumor of the pancreas which secretes insulin
Combination chemotherapy is used, either doxorubicin and streptozotocin, or fluorouracil and streptozocin in patients where doxorubicin is contraindicated. In
Insulinoma
Chemical compound
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Dactinomycin
(uncommon/rare), renal tubular acidosis and hypokalaemia. Capecitabine PO Fluorouracil prodrug Breast, colorectal, gastric and oesophageal cancer Myelosuppression
List_of_antineoplastic_agents
Medication
synthase inhibitor (Capecitabine# Carmofur Doxifluridine Floxuridine Fluorouracil# Tegafur (+gimeracil/oteracil)) DNA polymerase inhibitor (Cytarabine#
Vusolimogene_oderparepvec
Chemoproteomics method
thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil". Nature Communications. 7 (1): 1–11. doi:10.1038/ncomms11040. ISSN 2041-1723
Cellular_thermal_shift_assay
Cancer of the bile ducts
possible. Chemotherapy agents used to treat cholangiocarcinoma include 5-fluorouracil with leucovorin, gemcitabine as a single agent, or gemcitabine plus cisplatin
Cholangiocarcinoma
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