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Chemotherapy medication
Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder
Doxorubicin
Doxorubicin (DXR) is a 14-hydroxylated version of daunorubicin, the immediate precursor of DXR in its biosynthetic pathway. Daunorubicin is more abundantly
Biosynthesis_of_doxorubicin
Chemical compound
anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II
Pirarubicin
Chemical compound
Zoptarelin doxorubicin (developmental code names AEZS-108, AN-152) consists of doxorubicin linked to a small peptide agonist to the luteinizing hormone-releasing
Zoptarelin_doxorubicin
Class of antibiotics
of Actinomycetota. Clinically the most important anthracyclines are doxorubicin, daunorubicin, epirubicin and idarubicin. The anthracyclines are among
Anthracycline
Pharmaceutical compound
cBR96-doxorubicin immunoconjugate (BMS-182248/SGN-15; also known as cBR96-Dox) is an antibody-drug conjugate or (ADC) directed to the Lewis-Y antigen
CBR96-doxorubicin immunoconjugate
CBR96-doxorubicin_immunoconjugate
Biopharmaceutical research company in Los Angeles, California, USA
doxorubicin conjugate. Specifically, it is the (6-Maleimidocaproyl) hydrazone of doxorubicin. Essentially, this chemical name describes doxorubicin (DOXO)
CytRx
Intensive chemotherapy regimen
alkylating antineoplastic agent; Hydroxydaunorubicin, also known as doxorubicin: an anthracycline antibiotic that is able to intercalate DNA, damaging
EPOCH_(chemotherapy)
Treatment of cancer using drugs that inhibit cell division or kill cells
prominent with the use of anthracycline drugs (doxorubicin, epirubicin, idarubicin, and liposomal doxorubicin). The cause of this is most likely due to the
Chemotherapy
Chemical compound
radicals that cause cell and DNA damage. Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it
Epirubicin
Chemotherapy regimen for Hodgkin disease patients
liposomal formulation of doxorubicin. Repeated every 21 days (3 weeks). Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen
GVD_(chemotherapy)
Targeted drug delivery systems
in 2013 Micelles Doxorubicin Cancer cells Experimental Micelles Paclitaxel Breast cancer Experimental Silica nanoparticles Doxorubicin Cancer cells Experimental
Stimuli-responsive drug delivery systems
Stimuli-responsive_drug_delivery_systems
Drugs that are useful against cancer
chemotherapy). For example, the CHOP regimen consists of cyclophosphamide, doxorubicin, vincristine and prednisone. Besides chemotherapy, medical oncology (pharmacotherapy
List of chemotherapeutic agents
List_of_chemotherapeutic_agents
Cancer of blood vessel lining
splenectomy followed by Doxorubicin did better than dogs treated with splenectomy and mushroom agent. Combination of Doxorubicin with the Turkey Tail mushroom
Hemangiosarcoma
Medication
a tumor-targeted doxorubicin conjugate in development by CytRx. Specifically, it is the (6-maleimidocaproyl) hydrazone of doxorubicin. Essentially, this
Aldoxorubicin
Loss of skeletal muscle mass
causing glucocorticoid myopathy or medications toxic to muscle such as doxorubicin. Disorders of the endocrine system such as Cushing's disease or hypothyroidism
Muscle_atrophy
discovery with Rhone-Poulenc of daunorubicin and subsequent discovery of doxorubicin. Farmitalia had been founded in 1935 as a joint venture by Rhone-Poulenc
Farmitalia
Class of drugs used to treat malignant tumors
antineoplastic drugs. Commonly used antineoplastic drugs include cisplatin, doxorubicin, paclitaxel, and imatinib. Traditional cytotoxic drugs, due to their
Antineoplastic
Systematic naming of drugs
name has one widely agreed pronunciation in each language. For example, doxorubicin is consistently /ˌdɒksoʊˈruːbɪsɪn/ in English. Trade names almost always
Drug_nomenclature
Regimen commonly used in chemotherapy
promyelocytic leukemia ABVD doxorubicin (Adriamycin), bleomycin, vinblastine, dacarbazine Hodgkin's lymphoma AC doxorubicin (Adriamycin), cyclophosphamide
Chemotherapy_regimen
Species of bacterium
Streptomyces, yielded the medicines doxorubicin (Doxil), daunorubicin (DaunoXome), and streptozotocin (Zanosar). Doxorubicin is the precursor to valrubicin
Streptomyces_isolates
Anti-cancer medication
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Vorasidenib
Medical treatment in addition to a primary treatment to maximise effectiveness
chemotherapy regimens used include: Doxorubicin and cyclophosphamide Doxorubicin and cyclophosphamide followed by docetaxel Doxorubicin and cyclophosphamide followed
Adjuvant_therapy
Gene therapy medication used to treat multiple myeloma
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Ciltacabtagene_autoleucel
Depicted above is the structure of an ELP-Doxorubicin conjugate. The ELP is coupled to Doxorubicin with a hydrolysable hydrazone linker.
Elastin-like_polypeptides
Medical technique
properties and thus have difficulty entering the brain. For example, doxorubicin, a common chemotherapeutic, is ~540 Da in size and trastuzumab, a monoclonal
Focused ultrasound for intracranial drug delivery
Focused_ultrasound_for_intracranial_drug_delivery
Peptide fragment of human growth hormone
"Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells". Drug
HGH_Fragment_176–191
Reddening, swelling, numbness and skin peeling due to chemotherapy
chemotherapy drugs, particularly cabozantinib, cytarabine, doxorubicin (including pegylated liposomal doxorubicin, PLD), and fluorouracil and its prodrug capecitabine
Chemotherapy-induced acral erythema
Chemotherapy-induced_acral_erythema
Chemotherapy medication
pain management and other symptoms. The treatment of breast cancer with doxorubicin and cyclophosphamide is enhanced by adjuvant treatment with docetaxel
Docetaxel
Chemical compound
RGD to target the chemotherapeutic doxorubicin to cancer cells. Like other chemotherapeutics of its class, doxorubicin causes hair loss, nausea, vomiting
Arginylglycylaspartic_acid
Chemotherapy regimen used to treat Hodgkin lymphoma
concurrent treatment with the chemotherapy drugs: Adriamycin (also known as doxorubicin/hydroxydaunorubicin, designated as H in CHOP) Bleomycin Vinblastine Dacarbazine
ABVD
Disease in dogs and other canines
most common chemotherapy agents used are vincristine, vinblastine, and doxorubicin. Use of autohaemotherapy in treatment of TVTs also showed promising results
Canine transmissible venereal tumor
Canine_transmissible_venereal_tumor
Chemotherapy medication
for semi-synthetic manufacturing of doxorubicin, epirubicin and idarubicin.[citation needed] Similar to doxorubicin, daunorubicin interacts with DNA by
Daunorubicin
Skin condition
chemotherapy drugs. Sticky skin can be caused by the chemotherapy medications doxorubicin and ketoconazole. List of syndromes Hall, John (2014). Skin diseases
Sticky_skin_syndrome
Treatment for non-Hodgkin lymphoma
causing the formation of cross-links Hydroxydaunorubicin (also called doxorubicin or adriamycin), an intercalating agent which damages DNA by inserting
CHOP_(chemotherapy)
Chemical compound
been previously treated with doxorubicin. In a randomised controlled trial with 133 STS patients, olaratumab plus doxorubicin improved the median of progression-free
Olaratumab
Microtubule depolymerizing drug
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Nocodazole
Pharmaceutical drug
patients, mifamurtide was combined with the chemotherapeutic agents doxorubicin and methotrexate, with or without cisplatin and ifosfamide. The mortality
Mifamurtide
Scottish breed of dog
adverse reactions to many drugs, including acepromazine, butorphanol, doxorubicin, erythromycin, ivermectin, loperamide, milbemycin, moxidectin, rifampin
Shetland_Sheepdog
Topics referred to by the same term
Anthracycline drugs due to their red color and cytotoxic effects, particularly Doxorubicin. Search for "Red Death" on Wikipedia. All pages with titles beginning
Red_Death
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Demecolcine
Class of prescription drugs in India
HYDROCHLORIDE 166. DOXAZOSIN MESYLATE 167. DOXEPIN HYDROCHLORIDE 168. DOXORUBICIN HYDROCHLORIDE 169. DROTRECOGIN-ALPHA 170. EBASTINE 171. ECONOZOLE 172
Schedule_H
Poisoning of heart electrophysiology or muscle
substances vary and are not all identical. Source: Anthracyclines, such as doxorubicin Alkylating agents, such as cyclophosphamide HER2 inhibitors Tyrosine
Cardiotoxicity
Investigational oral small-molecule drug
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Pelabresib
Compounds that inhibit the activity of DNA topoisomerases
four main anthracyclines in medical use: Doxorubicin Daunorubicin (doxorubicin precursor) Epirubicin (a doxorubicin stereoisomer) Idarubicin (a daunorubicin
Topoisomerase_inhibitor
Type of large B-cell lymphoma
vincristine, doxorubicin, dexamethasone and high dose methotrexate and cytarabine); CODOX-M/IVAC (i.e. cyclophosphamide, vincristine, doxorubicin, high-dose
Plasmablastic_lymphoma
Family of chemical compounds
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Nitrogen_mustard
Chemical compound
replication. This agent is similar to doxorubicin in chemotherapeutic activity, but unlike anthracyclines like doxorubicin, it exhibits little cardiotoxicity
Bisantrene
Species of bacterium
peucetius produces the anthracycline antitumor antibiotics daunorubicin and doxorubicin (also known as adriamycin). Recent work has identified an antibacterial
Streptomyces_peucetius
Species of flowering plant
2010). "Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells". Journal of Natural Products. 73
Salvia_miltiorrhiza
Type of malignant cancer
"ATLANTIS: a Phase III study of lurbinectedin/doxorubicin versus topotecan or cyclophosphamide/doxorubicin/vincristine in patients with small-cell lung
Small-cell_carcinoma
Chemical compound
enhance the efficacy of one of the most widely used anticancer agents, doxorubicin, and alleviate its main adverse effect, cardiac damage. Thuaud, F.; Bernard
FL3_(flavagline)
Pharmaceutical drug
bladder cancer. Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder. It was originally
Valrubicin
Class of enzymes
arising from specific genomic translocations, mainly involving topo IIβ. Doxorubicin (Fig. 7) and the related derivatives daunorubicin, epirubicin, and idarubicin
Topoisomerase
Leakage of intravenously-infused medications into surrounding tissue
registered antidote for extravasation of anthracyclines (daunorubicin, doxorubicin, epirubicin, idarubicin, etc.). The only FDA approved treatment for vasopressor
Extravasation_(intravenous)
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Azacitidine
Acute myelogenous leukemia induction therapy regimen
an anthracenedione, most often daunorubicin (can be substituted for doxorubicin or idarubicin or mitoxantrone). There were attempts to intensify the
7+3_(chemotherapy)
Monoclonal antibody
doxorubicin, an antibody-drug conjugate or ADC, have demonstrated anti-lymphoma activity in-vivo. hLL1-Dox Milatuzumab has been linked to doxorubicin
Milatuzumab
Protein-coding gene in the species Homo sapiens
acid stimulus steroid metabolic process daunorubicin metabolic process doxorubicin metabolic process androgen metabolic process retinoid metabolic process
AKR1C4
Cell cycle regulator
of cancer cells to ionizing radiation and anticancer agents such as doxorubicin and camptothecin. Conversely, reduction in EMI1 expression decreases
Early_Mitotic_Inhibitor_1
Medication
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Imetelstat
One of a pair of diastereomers
compounds are epi-inositol and inositol, and lipoxin and epilipoxin. Doxorubicin and epirubicin are two epimers that are used as drugs. Epimerization
Epimer
Enzymes that block actions of protein kinases
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Protein_kinase_inhibitor
Cancer medication
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Temozolomide
Two molecules of the chemotherapeutic drug doxorubicin intercalated between the bases of a DNA molecule
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Class of medications
Lutrelin Nafarelin Peforelin Salmon GnRH Triptorelin Zoptarelin Zoptarelin doxorubicin Antagonists: Peptides: Abarelix Acyline Azaline B Cetrorelix Degarelix
Gonadotropin-releasing hormone antagonist
Gonadotropin-releasing_hormone_antagonist
Formulary by the World Health Organization
Cytarabineα Dacarbazineα Dactinomycinα Daunorubicinα Docetaxelα Doxorubicinα Doxorubicin (as pegylated liposomal)α Etoposideα Fludarabineα Fluorouracilα Gemcitabineα
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Combination medication
Lutrelin Nafarelin Peforelin Salmon GnRH Triptorelin Zoptarelin Zoptarelin doxorubicin Antagonists: Peptides: Abarelix Acyline Azaline B Cetrorelix Degarelix
Relugolix/estradiol/norethisterone acetate
Relugolix/estradiol/norethisterone_acetate
Chemical compound
Two-Dimensional Dose-Finding Study of Ixazomib in Combination With Gemcitabine and Doxorubicin, Followed by a Phase II Extension to Assess the Efficacy of This Combination
Ixazomib
Cancer treatment
for pH-responsive tumor-targeted drug delivery. PEGylated liposomal doxorubicin has been studied and show results of high drug loading capacity and pH-responsive
PH-responsive tumor-targeted drug delivery
PH-responsive_tumor-targeted_drug_delivery
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Nelarabine
Cancer originating in smooth muscle
therapies are the first choices. Chemotherapy regimens include doxorubicin/ifosfamide and doxorubicin combination/gemcitabine and docetaxel/trabectedin; pazopanib
Leiomyosarcoma
Chemical compound
deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells". Cancer Chemotherapy and Pharmacology. 67 (2):
Abexinostat
Edward T. H. (November 2012). "Identification of the molecular basis of doxorubicin-induced cardiotoxicity". Nature Medicine. 18 (11): 1639–1642. doi:10
Pharmacological cardiotoxicity
Pharmacological_cardiotoxicity
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Melphalan
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Belzutifan
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Temoporfin
Cancer treatment medicine
combining sorafenib with doxorubicin, the median time to progression was not significantly delayed compared with doxorubicin alone in patients with advanced
Sorafenib
Indian materials scientist
Chakravortty, Dipshikha (11 January 2013). "Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules". International
Ashok_M._Raichur
Medical condition
cyclophosphamide, doxorubicin, vincristine, prednisolone) or DA-EPOCH-R (dose-adjusted etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin, rituximab)
Primary mediastinal B-cell lymphoma
Primary_mediastinal_B-cell_lymphoma
Human prostate cancer cell line
PC3 cells. PC3-Dox Cells PC3-Dox cells are modified to be resistant to Doxorubicin. This cell line is used to study multidrug resistance (MDR) in PC3. Specifically
PC3
Presence of blood in urine
may cause urine to appear red include: Phenazopyridine Nitrofurantoin Doxorubicin Rifampicin Foods that may cause urine to appear red include: Blackberries
Hematuria
Gene therapy medication
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Idecabtagene_vicleucel
Cinacalcet Citalopram Clemastine Clomipramine Cocaine Diphenhydramine Doxepin Doxorubicin Duloxetine Escitalopram Fluoxetine Halofantrine Haloperidol Hydroxyzine
List of cytochrome P450 modulators
List_of_cytochrome_P450_modulators
Manufactured (artificial) injectable hormone
Lutrelin Nafarelin Peforelin Salmon GnRH Triptorelin Zoptarelin Zoptarelin doxorubicin Antagonists: Peptides: Abarelix Acyline Azaline B Cetrorelix Degarelix
Leuprorelin
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Alpelisib
Chemical compound
doxorubicin and showed an in vitro antiproliferative activity against melanoma and nonmelanoma cell lines, including those resistant to doxorubicin.
Betulinic_acid
modification is particularly attractive for Doxil, a lipid formulation of Doxorubicin already in clinical use. An analysis of nanoparticle infiltration due
Microbubble
Chemotherapy medication
lymphoma, it is often used together with vinblastine, bleomycin, and doxorubicin. It is given by injection into a vein. Common side effects include loss
Dacarbazine
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Talazoparib
Medical intervention
regimen that replaces the mercaptopurine of the original combination with doxorubicin. All these regimens take advantage of the synergistic effects of combining
VAMP_regimen
infection. Despite traditional chemotherapy with CHOP (cyclophosphamide, doxorubicin, prednisone, vincristine), and the possible addition of antiviral therapy
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
Large_B-cell_lymphoma_arising_in_HHV8-associated_multicentric_Castleman's_disease
Medical condition
methotrexate, doxorubicin combined with dacarbazine, or adriamycin combined with dacarbazine or single drug regimens such as doxorubicin, methotrexate
Gardner_fibroma
Protein-coding gene in the species Homo sapiens
process cellular aldehyde metabolic process daunorubicin metabolic process doxorubicin metabolic process carbohydrate metabolic process electron transport chain
AKR7A2
Tumor originating in adipose (fat) tissue
treated with front-line chemotherapy comparing doxorubicin to doxorubicin plus ifosfamide or doxorubicin to gemcitabine plus docetaxel. Other studies have
Liposarcoma
Movement of whole mitochondria between cells
exchange. On the other hand, certain types of stress agents such as doxorubicin or ethidium bromide increase TNT formation. Other proposed mechanisms
Horizontal transfer of mitochondria
Horizontal_transfer_of_mitochondria
Type of blood and immune-system cancer
esc vs. 8x BEACOPP-14 baseline (HD15-trial). Chlormethine Doxorubicin Doxorubicin Doxorubicin Oncovin Bleomycin Bleomycin Bleomycin Prednisone Vinblastine
Hodgkin_lymphoma
Undifferentiated male germ cell
genetic mutations can lead to infertility in men. Anticancer drugs such as doxorubicin and vincristine can adversely affect male fertility by damaging the DNA
Spermatogonium
Folding of DNA to create two- and three-dimensional shapes at the nanoscale
than doxorubicin in free form. The enhancement of cell killing activity was observed not only in regular MCF-7, more importantly, also in doxorubicin-resistant
DNA_origami
Chemical compound
II+Intercalation Anthracyclines (Aclarubicin Amrubicin† Daunorubicin# (+cytarabine) Doxorubicin# Epirubicin Idarubicin Pirarubicin Valrubicin Zorubicin) Anthracenediones
Teniposide
DOXORUBICIN
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DOXORUBICIN