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Database of spliced mRNA sequences
The Exon-Intron Database (EID) is a database of spliced mRNA sequences. Alternative splicing Exon Intron Saxonov, S; Daizadeh I; Fedorov A; Gilbert W (Jan
Exon-intron_database
Region of a transcribed gene present in the final functional mRNA molecule
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The
Exon
Part of a gene that is spliced away
become joined by this RNA processing to form the mature RNA are called exons. Introns are found in the genes of most eukaryotes and many eukaryotic viruses
Intron
Process by which a gene can code for multiple proteins
several introns and exons. (In nematodes, the mean is 4–5 exons and introns; in the fruit fly Drosophila there can be more than 100 introns and exons in one
Alternative_splicing
protein-coding exons observed in eukaryotic genes, whereas the intervening sequences with numerous stop codons could have formed long non-coding introns. In this
Split_gene_theory
Japanese manga artist (born 1961)
2007–2010) Intron Depot 7: Barb Wire 02 (2013) (illustrations for novels 2007–2010) Intron Depot 8: Bomb Bay (2018) (illustrations 1992–2009) Intron Depot
Masamune_Shirow
Mutation at a location where intron splicing takes place
that drive exon recognition are located at the very termini of introns. The deletion of the splicing site results in one or more introns remaining in
Splice_site_mutation
RNA processing within a biological cell
often contains both exons (coding sequences) and introns (non-coding sequences); splicing removes the introns and links the exons directly, while the
Post-transcriptional modification
Post-transcriptional_modification
Large self-splicing ribozymes
group at the upstream exon and the exoG being attached to the 5' end of the intron. Then the terminal G (omega G) of the intron swaps out the exoG and
Group_I_catalytic_intron
Class of self-catalyzing ribozymes
machinery is required for splicing in vivo, and long-range intron-intron and intron-exon interactions are important for splice site positioning, as well
Group_II_intron
exon skipping, intron retention, and cryptic splice site activation. A splice site defines the boundary between a coding exon and a non-coding intron
Shapiro–Senapathy_algorithm
sense. More complex minigenes can be constructed containing multiple exons and intron(s). Minigenes provide a valuable tool for researchers evaluating splicing
Minigene
Type of RNA found in cells
introns. In eukaryotes, as a gene is transcribed from DNA into a messenger RNA (mRNA) transcript, intervening introns are removed, leaving only exons
Circular_RNA
Lab technique in cellular biology
tRNA, and ribosomal profiling. RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene boundaries
RNA-Seq
SpliceInfo is a database for the four major alternative-splicing modes (exon skipping, 5'-alternative splicing, 3'-alternative splicing and intron retention)
SpliceInfo
Type of enzyme
end, cardinal position 2 (CP2) marks the intron–exon boundary. In Eukarya and Archaea the anticodon-intron (A-I) interaction and bulge-helix-bulge (BHB)
TRNA-intron_endonuclease
Wenk M, Erickson JL, Schattat MH, Grau J, Hartung F (May 2016). "Using intron position conservation for homology-based gene prediction". Nucleic Acids
List of gene prediction software
List_of_gene_prediction_software
alternative splicing (AS) events from a given genomic annotation of exon-intron gene coordinates. By comparing all given transcripts, AStalavista detects
List of RNA-Seq bioinformatics tools
List_of_RNA-Seq_bioinformatics_tools
Protein found in humans
three introns in between four exons. Exon 1 is 36 nucleotides long, exon 2 is 25 nucleotides long, exon 3 is 23 nt, and exon 4 is 346 nt. Intron 1 is 115
60S_ribosomal_protein_L41
Software program to identify complete gene structures in genomic DNA
program that can be used to predict the location of genes and their exon-intron boundaries in genomic sequences from a variety of organisms. The GENSCAN
GENSCAN
DNA that does not code for proteins
telomeres. Some non-coding regions appear to be mostly nonfunctional, such as introns, pseudogenes, intergenic DNA, and fragments of transposons and viruses
Non-coding_DNA
alternative splicing events then result in skipped exons, intron retention, and delaying of introns. As a result due to variations in alternative splicing
Conjoined_gene
Sequence of DNA that determines traits in an organism
Marais G, Nouvellet P, Keightley PD, Charlesworth B (May 2005). "Intron size and exon evolution in Drosophila". Genetics. 170 (1): 481–485. Bibcode:2005Genet
Gene
Process in computational biology
domain GC composition/uniformity/entropy, sequence and frame length, Intron/Exon/Donor/Acceptor/Promoter and Ribosomal binding site vocabulary, Fractal
Gene_prediction
Protein-coding gene in the species Homo sapiens
followed by exon 1, then a large intron followed by exon 2, a small intron then exon 3. The rest of the protein follows exon 3 with a large intron, exon 4 a small
TMEM249
Protein-coding gene in the species Homo sapiens
base pairs long, contains one gt-ag intron, and is oriented on the minus strand of DNA. The pre-messenger has 2 exons, and the predicted protein is 570
SEPTIN4
Maturation process joining exons from different pre-mRNAs into a mature mRNA
Eperon IC, Samani NJ (January 2007). "Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript
Trans-splicing
DNA sequence that jumps/transposes within a genome
to merged exons in a process called exon shuffling. Shuffling two unrelated exons can create a novel gene product or, more likely, an intron. Some non-autonomous
Transposable_element
Protein found in humans
S2CID 1214598. Quinones S, Bernal D, García-Sogo M, et al. (1992). "Exon/intron structure of the human alpha 3(IV) gene encompassing the Goodpasture
Collagen,_type_IV,_alpha_3
DNA section marked with start and stop codon of different length
made during translation. In eukaryotic genes with multiple exons, introns are removed and exons are then joined together after transcription to yield the
Open_reading_frame
Region of non-coding DNA that regulates the transcription of neighboring genes
same molecule of DNA and can be found upstream, downstream, within the introns, or even relatively far away from the gene they regulate. Multiple enhancers
Cis-regulatory_element
Gene prediction algorithm
identifies intron-less genes in long transcript sequences assembled from RNA-Seq reads. In eukaryotic genomes modeling of exon borders with introns and intergenic
GeneMark
Human Protein 53 intron 1
Human protein 53 intron 1 (Hp53int1) is a protein encoded by the Hp53int1 gene in humans. The Hp53int1 gene is located on chromosome 17p.13, encoded by
Hp53int1
Genome browser hosted by the University of California, Santa Cruz
Regions with an exon-intron structure can be customized to set the minimum ratio of alignment blocks or exons that must map and set; if an exon is not mapped
UCSC_Genome_Browser
Horse coat color and its genetics
horse ancestors. The cause is a splice site mutation on intron 17. W14 is a deletion mutation on exon 17, found in Thoroughbreds. The founder is suspected
Dominant_white
Aspect of genetics
exons and introns that can be split apart and rearranged in many different ways. Historically, exons are considered the coding sequence and introns are
Chimeric_RNA
Protein-coding gene in humans
gene is composed of two exons which are separated by an intron. Exon 1 of the gene encodes a 5′ sequence of the 5′UTR while exon 2 includes the remaining
BLCAP
Elimination of mRNA with premature stop codons in eukaryotes
up-frameshift (UPF) proteins. In mammals, UPF2 and UPF3 are part of the exon–exon junction complex (EJC) that remains bound to mRNA after splicing, along
Nonsense-mediated_decay
Type of protein
increased with the increase in the number of introns. Diversity enabled eukaryotic cells to utilize RNA exons in various arrangements, giving rise to a unique
RNA-binding_protein
is located in the fourth intron of RELN. The gene RELN has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs
Rs7341475
Description of the structure and function of a genome
genome, such as open reading frames (ORFs), coding sequences (CDS), exons, introns, repeats, splice sites, regulatory motifs, start and stop codons, and
DNA_annotation
splice sites, coding exons, introns, translation stop sites, polyadenylation signals, and 3' UTRs. People may reference this database for haplotype information
Functional element SNPs database
Functional_element_SNPs_database
All genetic material of an organism
and chloroplasts have a circular chromosome. Unlike prokaryotes where exon-intron organization of protein coding genes exists but is rather exceptional
Genome
(September 1997). "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs". Nucleic Acids Research. 25 (17): 3389–402. doi:10.1093/nar/25
List of sequence alignment software
List_of_sequence_alignment_software
Protein-coding gene in the species Homo sapiens
alternative splicing of human splicing factor SF-1 deduced from the exon-intron structure of the gene". Gene. 211 (1): 29–37. doi:10.1016/S0378-1119(98)00058-4
SF1_(gene)
such as alternative splicing. Since a genome contains the sum of all introns and exons that may be present in a transcript, spliced variants that do not
De novo transcriptome assembly
De_novo_transcriptome_assembly
homing endonucleases are a special type of restriction enzymes encoded by introns or inteins. They act on the cellular DNA of the cell that synthesizes them;
List of homing endonuclease cutting sites
List_of_homing_endonuclease_cutting_sites
Catalogue of protein-coding genes
duplicability and loss profiles, divergence rates, sibling groups, and gene intron-exon architectures. In comparative genomics, the importance of scale cannot
OrthoDB
Protein-coding gene in the species Homo sapiens
aliases, including BA85G2.1, MGC23884, and DJ416F21.23. The gene contains 14 exons and spans approximately 29,942 base pairs. C6orf118 spans from 29,941 base
C6orf118
Biochemical changes to RNA
in Mettl3 knock-out mice, resulting in increased frequency of exon skipping and intron retention. However, m6A is not a general unspecific splicing factor
Epitranscriptome
Protein-coding gene in the species Homo sapiens
chromosome (10p14). It is oriented on the plus strand of DNA and has 5 exons. The orthologous space for PROSER2 is fairly large, as 143 organisms are
Proser2
Protein-coding gene in the species Homo sapiens
spans 29 kb on the plus strand of the DNA. ERICH5 contains three exons and two introns. ERICH5 is also known as C8orf47 and glutamate rich 5. The ERICH5
Glutamate_rich_5
Protein-coding gene in the species Homo sapiens
exon within intron 20. The promoter has been identified 2.5 kilobase pairs upstream of the transcription start site, and the 5'- untranslated exons may
SCN1A
titled "Exons, Introns and Evolution". Research based on the split gene theory sheds lights on other basic questions of exons and introns. The exons of eukaryotes
Periannan_Senapathy
Mammalian protein found in humans
distributed within the gene, although exons 3, 5, and 27 are common sites for mutations. The Human Gene Mutation Database contains 1,347 NF1 mutations, but
Neurofibromin
Identification and study of genomic sequences
modification sites, gene-structures, reading frames, distributions of introns and exons and regulatory elements Identification of sequence differences and
Sequence_analysis
Protein-coding gene in the species Homo sapiens
approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor
RBP3
Protein found in humans
of type VII collagen, including the non-collagenous NC-2 domain and intron/exon organization of the corresponding region of the COL7A1 gene". Human Molecular
Collagen,_type_VII,_alpha_1
Mammalian protein found in Homo sapiens
Briend-Sutren MM, Strosberg AD, Emorine LJ (1993). "The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes". Eur
Beta-3_adrenergic_receptor
Protein found in humans
the short (p) arm of chromosome 11 near the telomere. The protein has 27 introns, which allows for many isoforms of this gene. It has several aliases, the
Chitinase domain-containing protein 1
Chitinase_domain-containing_protein_1
Pairwise sequence alignment algorithm
onto the genome, using each base only once and can be used to identify intron-exon boundaries (i.e. splice sites). BLAT is less sensitive than BLAST. BLAT
BLAT_(bioinformatics)
Evolution of novel genes from non-genic DNA sequence
"starter type" exons. Using the sequence data available at the time, a 1991 review estimated the number of unique, ancestral eukaryotic exons to be < 60,000
De_novo_gene_birth
Type of DNA library
cells, the mature mRNA is already spliced; hence, the cDNA produced lacks introns and can be readily expressed in a bacterial cell. While information in
CDNA_library
Protein-coding gene in the species Homo sapiens
transcript variant of NHLRC2; this non-coding isoform is 522 bp of retained intron.[failed verification] The translated NHLRC2 protein is 726 amino acids long
NHLRC2
Cell adhesion molecule found on the surface of T cells and natural killer
PMID 2883656. Diamond DJ, Clayton LK, Sayre PH, Reinherz EL (1988). "Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes"
CD2
Human protein
located on the minus strand at 1p22.3. The gene is 9,720 base pairs and has 3 exons. The gene neighborhood of C1orf52 consists of B-cell lymphoma 10 (BCL10)
C1orf52
Serotonin receptor protein distributed mainly in the choroid plexus
in the exon complementary sequence (ECS) of intron 5. The ECS required for formation of double stranded RNA structure is found within intron 5. RNA editing
5-HT2C_receptor
Protein-coding gene in the species Homo sapiens
encoded by the SPRED1 gene located on chromosome 15q13.2 and has seven coding exons. SPRED-1 is a member of the Sprouty family of proteins and is phosphorylated
SPRED1
American biochemist, physicist and Nobel laureate (born 1932)
biological weapons site. Gilbert first proposed the terms introns (intragenic regions) and exons (expressed regions) in reference to recently discovered
Walter_Gilbert
Enzyme
aldo-keto-reductase family members and contain at least nine conserved exon-intron boundaries. Regardless of a particular isoform, the 3α-hydroxysteroid
3α-Hydroxysteroid dehydrogenase
3α-Hydroxysteroid_dehydrogenase
Protein-coding gene in the species Homo sapiens
X chromosome, loci position Xq22.2. This gene contains 3 exons and 2 distinct gt-ag introns, being transcribed into 3 alternatively spliced mRNAs. However
ZCCHC18
Mammalian protein involved in blood clotting
1987). "Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region". The Journal
Factor_XII
Protein found in humans
the region covered with different colors are the introns. Exons are located at both ends of the intron. Their lengths can be estimated from the calibrator
CCDC190
Toxin present in the venom of the South American rattlesnake
2003, consists of about three exons separated by one short phase-2 (140 bp) and one long phase-1 (900 bp) intron. Exon 1 codes for the first 19 amino
Crotamine
Genome research project
uncovered, including alternative splicing (where a series of exons are separated by introns), intergenic transcriptions, and the complex patterns of dispersed
GENCODE
complementary proteins and are called exons. Exons are known to make up 1 percent of a human's genome. All the exons in a genome together are called the
Personalized_genomics
Human NKAPD1 Protein
074,086 to 112,085,150, spanning a total of 11,065 base pairs, including introns. It can be transcribed into 7 different transcript variants resulting in
NKAPD1
Protein-coding gene in the species Homo sapiens
spans 6 kb and contains 12 exons, though the first exon is an untranslated region and, thus, non-coding. This first intron, along with the 5'-flanking
ENO3
Class of drugs
from a class of pyridazine small molecules and enhances the inclusion of exon 7, resulting in a full-length and functional protein product.[citation needed]
RNA-targeting small molecule drugs
RNA-targeting_small_molecule_drugs
Enzyme for controlling the production of melanin
implicated in melanin synthesis which are the common regulatory elements of exon/intron structure. The development of the three types of vertebrate pigment cells
Tyrosinase
Protein-coding gene in the species Homo sapiens
total of 10 exons and 9 introns. All intron-exon splice junctions follow the standard GT/AG rule. There was an Alu family found in introns 2 and 8. The
Pyruvate dehydrogenase (lipoamide) beta
Pyruvate_dehydrogenase_(lipoamide)_beta
Sporadic biological phenomenon at the molecular scale
Few NUMT pseudogenes associated with diseases are found within exons or at the exon–intron boundaries of human genes. For example, patients with mucolipidosis
Nuclear mitochondrial DNA segment
Nuclear_mitochondrial_DNA_segment
Protein-coding gene in the species Homo sapiens
though both genes possess ten exons and nine introns, the sizes of their introns may differ by ~2 kb, with the largest intron in PCK2 spanning 2.5 kb. Altogether
PCK2
DNA sequences not present in a genome of a species
Non-Uniform Distribution of Guanine in Introns of Human Genes: Possible Protection of Exons against Oxidation by Proximal Intron Poly-G Sequences". The Journal
Nullomers
Protein-coding gene in the species Homo sapiens
produced by alternative splicing: species differences due to altered intron-exon organization". Journal of Neurochemistry. 68 (4): 1372–81. doi:10.1046/j
5-HT7_receptor
Protein-coding gene in the species Homo sapiens
composed of 11 exons. The POTEB gene can be transcribed to create four potential mRNAs. However, only one of these mRNAs, possessing all 11 exons, is capable
POTEB
Protein-coding gene in the species Homo sapiens
A "shorter" ERICH3 transcript consisted of seven exons, of which its first exon mapping to intron 6 of the reference ERICH3 transcript, was predominantly
Glutamate-rich_protein_3
Genetics database
non-synonymous. Sequence viewer shows the position of the variant in relation to introns, exons, and other distant and close variants. 3D structure mapping, which shows
DbSNP
Human gene
Chromosome 14 from nucleotides 77,394,021-77,423,523. It has a total of 9 exons and 8 introns, and it spans a total of 29,502 bases. The gene neighborhood of NOXRED1
NOXRED1
Conversion of a gene's sequence into a mature gene product or products
remove an intron and release it in form of lariat structure, and then splice neighbouring exons together. In certain cases, some introns or exons can be
Gene_expression
Hormone used in regulating the cardiovascular system
ANP and BNP, is located on chromosome 2 and consists of just two exons and one intron. The CNP gene is also located on chromosome 2 in mice. The 126 amino
Natriuretic_peptide
Mammalian protein
these mutations alter RNA splicing, often leading to the exclusion of an exon or use of cryptic splice sites. The resulting defective protein is the cause
Collagen,_type_III,_alpha_1
Medical condition
and Dennis Lubahn et al. published its intron-exon boundaries. 1994: The androgen receptor gene mutations database was created to provide a comprehensive
Androgen insensitivity syndrome
Androgen_insensitivity_syndrome
Protein-coding gene in the species Homo sapiens
encoding tryptophanyl-tRNA synthetase: interferon-response elements and exon-intron organization". Gene. 128 (2): 237–245. doi:10.1016/0378-1119(93)90568-N
WARS1
discovery 2012 4. Physico-chemical fingerprinting of RNA genes 2016 5. Intron exon boundary junctions in human genome have in-built unique structural and
Supercomputing Facility for Bioinformatics and Computational Biology
Supercomputing_Facility_for_Bioinformatics_and_Computational_Biology
Class of enzymes
Reue K, Xia YR, Lusis AJ, Langin D, Tornqvist H, Holm C (July 2001). "Exon-intron organization and chromosomal localization of the mouse monoglyceride
Monoacylglycerol_lipase
Human Gene/Protein
exons and two introns, with a total gene length of 6,145 base pairs. There are three isoforms of UBALD1 in humans, all of which contain three exons.
UBALD1
French geneticist
they could be directly involved in the splicing mechanism by defining exon-intron junctions. In addition, they discovered that two different intronic structures
Bernard_Dujon
DNA sequencing
genes consisting of introns that may undergo AS. In particular, it has been estimated that AS occurs in 95% of all human multi-exon genes. AS has undeniable
Third-generation_sequencing
Protein-coding gene in the species Homo sapiens
the membrane arm of mitochondrial Complex I. A frameshift mutation in an intron of this gene has been shown to cause failure to thrive, retardation of psychomotor
TIMMDC1
EXON INTRON-DATABASE
EXON INTRON-DATABASE
Male
German
 German form of Greek Antonios, possibly ANTON means "invaluable." Compare with other forms of Anton.
Surname or Lastname
English
English : habitational name from Kinton in Herefordshire, Kineton in Warwickshire (both named with Old English cyne- ‘royal’ + tūn ‘settlement’), or Kineton in Gloucestershire, which is named with Old English cyning ‘king’ + tūn.
Male
Romanian
 Romanian form of Greek Antonios, possibly ANTON means "invaluable." Compare with other forms of Anton.
Boy/Male
Irish Gaelic Teutonic German
Fiery.
Boy/Male
Indian
Ill starred
Surname or Lastname
English
English : habitational name from places so called in Devon, Hampshire, Leicestershire, and Somerset. The first and last derive their name from the Celtic river name Exe, while the place in Hampshire, recorded in 940 as East Seaxnatune, is named from Old English Ēastseaxe ‘East Saxon’, and the Leicestershire place name is from Old English oxa ‘of the oxen’. In each case the final element is from Old English tūn ‘settlement’.
Girl/Female
Biblical
Cloud, mass of darkness, fountain, eye.
Boy/Male
Shakespearean
King Richard The Second' Sir Pierce of Exton.
Male
Russian
(Ðнтон) Russian form of Greek Antonios, possibly ANTON means "invaluable." Compare with other forms of Anton.
Male
Greek
Variant spelling of Greek Aeton, ETON means "swift as an eagle." In mythology, this is the name of one of Pluto's four night-black steeds.
Boy/Male
Spanish
Lofty or inspired.
Boy/Male
Hindu
Call
Boy/Male
African American Biblical
Spirit.
Boy/Male
African
Strong.
Girl/Female
German French
Archer.
Surname or Lastname
English
English : most probably the Middle English surname Ackeson, a patronymic from the Middle English personal name Acke (Old English Acca). It may also be from Anketin or Asketin, Norman forms of the Old Norse personal name Asketill (see Haskell), or even a variant of Ashton.
Boy/Male
Welsh
Variant of a Gaelic name anglicized as John.
Surname or Lastname
English
English : unexplained; possibly a variant of Fenton.John Vinton was a resident of Lynn, MA, as early as 1648. He had numerous prominent descendants, including Samuel Finley Vinton, who was born in South Hadley, MA, in 1792, and became on OH congressman.
Male
Finnish
Finnish name INTO means "enthusiasm."
Male
German
Old German name derived from the word eg, EGON means "edge."
EXON INTRON-DATABASE
EXON INTRON-DATABASE
Girl/Female
Tamil
Vishalni | விஷாலநீ
Beautiful, Loveable
Surname or Lastname
English
English : unexplained.Southern Italian : unexplained.
Boy/Male
Arabic, Muslim
Servant of the Withholder
Girl/Female
Indian
Newly risen Sun
Surname or Lastname
English
English : probably a habitational name either from a lost or unidentified place, or a variant of Hagley.Possibly a variant of German Hackler.
Girl/Female
Biblical
The vale of trial or searching.
Boy/Male
Indian, Sanskrit
Pervding the Consciousness
Male
English
Anglicized form of Hebrew Chanan, HANAN means "compassionate, merciful." In the bible, this is the name of many characters, including a chief of the tribe of Benjamin. Compare with feminine Hanan.
Surname or Lastname
English
English : from a pet form of Matthew.Dutch : from a derivative of Mattheus (see Matthew).German : from a shortened form of Matthäus (see Matthew).
Girl/Female
Muslim
A person who gives the honor, Respect
EXON INTRON-DATABASE
EXON INTRON-DATABASE
EXON INTRON-DATABASE
EXON INTRON-DATABASE
EXON INTRON-DATABASE
n.
A flying fish of California (Exoc/tus Californicus): -- called also volator.
v. t.
To utter with a musical or prolonged note or tone; to chant; as, to intone the church service.
n.
One of four officers of the Yeomen of the Royal Guard, having the rank of corporal; an Exon.
n.
Native carbonate of soda; natron.
v. t.
To be a patron of; to patronize; to favor.
n.
A citron melon.
n.
One who encourages or helps a person, a cause, or a work; a furtherer; a promoter; as, a patron of art.
n.
A native or inhabitant of Exeter, in England.
a.
Born in or with; implanted by nature; innate; as, inborn passions.
n.
Any one of a series of hydrocarbons containing the nitro and the nitroso or isonitroso group united to the same carbon atom.
a.
Like ebony, especially in color; black; dark.
n.
A fruit resembling a lemon, but larger, and pleasantly aromatic. The thick rind, when candied, is the citron of commerce.
n.
A guardian saint. -- called also patron saint.
n.
Ebony.
a.
Doing the duty of a patron; giving aid or protection; tutelary.
a.
Consisting of ebony.
n.
Resembling iron in color; as, iron blackness.
n.
An officer of the Yeomen of the Guard; an Exempt.
n.
A citron tree.