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Compound that activates dopamine receptors
A dopamine agonist is a compound that activates dopamine D2 receptors and belong to one of two different subclasses: ergoline and non-ergoline. Examples
Dopamine_agonist
Class of drug
actually be acting as dopamine releasing agent (DRA)-like agents that have been referred to as dopamine transporter (DAT) "inverse agonists" rather than as
Dopamine_reuptake_inhibitor
Disorder of diminished motivation
pathway, which transmits dopamine. Some patients with akinetic mutism have shown to improve with levodopa or dopamine agonist therapy, or by increasing
Akinetic_mutism
Neuralogical disorder caused by long-term use of dopaminergic drugs
Parkinson's disease (PD) or restless legs syndrome (RLS) who have taken dopamine agonist medications for an extended period of time. The most common symptom
Dopamine dysregulation syndrome
Dopamine_dysregulation_syndrome
Dopamine agonist medication
pregnancy and breastfeeding is of unclear safety. It is a dopamine agonist and works by triggering dopamine D2 receptors. It was approved for medical use in the
Ropinirole
Long-term psychological symptoms following drug withdrawal
eight weeks post cessation of alprazolam. After long-term use of dopamine agonists, a withdrawal syndrome may occur during dose reduction or discontinuation
Post-acute-withdrawal syndrome
Post-acute-withdrawal_syndrome
Medical condition
with long-term dopamine agonist therapy. Pramipexole and ropinirole, both dopamine agonists, along with aripiprazole, a dopamine modulator, have been linked
Restless_legs_syndrome
Dopamine agonist medication
or together with levodopa. It is taken by mouth. Pramipexole is a dopamine agonist of the non-ergoline class. Pramipexole was approved for medical use
Pramipexole
Main receptor for most antipsychotic drugs
manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over
Dopamine_receptor_D2
Progressive neurodegenerative disease
Initial treatment typically includes levodopa, MAO-B inhibitors, or dopamine agonists. As the disease progresses, these medications become less effective
Parkinson's_disease
Treatment of Parkinson's disease
families of drugs useful for treating motor symptoms are levodopa, dopamine agonists, and MAO-B inhibitors. The most commonly used treatment approach varies
Management of Parkinson's disease
Management_of_Parkinson's_disease
Dopamine agonist medication
the brand name Parlodel among others, is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease
Bromocriptine
Protein-coding gene in humans
selectivity with dopamine receptors. Dinapsoline – full agonist with 5-fold selectivity for D1-like receptors over D2 Dinoxyline – full agonist with approximately
Dopamine_receptor_D1
Excess growth of certain parts of the body
whose pituitary tumours also secrete prolactin. Side effects of these dopamine agonists include gastrointestinal upset, nausea, vomiting, light-headedness
Acromegaly
Protein found in humans
neurotransmitters dopamine and serotonin, and the thyronamine 3-iodothyronamine (3-IT) are all agonists of the TAAR1 in different species. Other endogenous agonists are
TAAR1
Chemical which binds to and activates a biochemical receptor
the endogenous agonist for serotonin receptors is serotonin, and the endogenous agonist for dopamine receptors is dopamine. Full agonists bind to and activate
Agonist
Atypical antipsychotic medication
pharmacological action is as a functionally selective partial agonist at dopamine D2 receptors, stabilizing dopamine activity by enhancing signaling when levels are
Aripiprazole
Excess of prolactin hormone in the blood
to dopamine agonist therapy, such that prolactin levels are still high or the tumor is not shrinking as expected, the dose of the dopamine agonist can
Hyperprolactinaemia
Pharmaceutical compound
synthetic dopamine receptor agonist related to the catecholamine neurotransmitter dopamine which has been used in scientific research. It is a dual agonist of
Dipropyldopamine
Dopamine agonist medication
ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine synthesis
Pergolide
Dopaminergic medication
centrally permeable monoamine precursor and prodrug of dopamine and hence acts as a dopamine receptor agonist. Chemically, levodopa is an amino acid, a phenethylamine
Levodopa
Compounds to increase women's capacity to conceive
postsynaptic dopamine 2 receptors of anterior pituitary cells and inhibits the secretion of prolactin. Cabergoline is a dopamine 2 receptor agonist which is
Female_fertility_agents
Pharmaceutical compound
7-Hydroxyropinirole (developmental code name SK&F-89124 or SKF-89124) is a dopamine receptor agonist and active metabolite of the antiparkinsonian agent ropinirole
7-Hydroxyropinirole
Chemical compound
Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's disease in Japan by Boehringer Ingelheim; it was introduced
Talipexole
Dopamine receptor agonist compound
7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype, and low affinity for
7-OH-DPAT
Pituitary gland tumor which secretes the hormone prolactin
supplementary role, and MRI is the only definitive diagnostic tool available. Dopamine agonist testing can, however, be used to determine the effectiveness of DAs
Prolactinoma
Pharmaceutical compound
Nonproprietary Name; developmental code name CF 25-397) is a dopamine receptor agonist of the ergoline family which was never marketed. It is an analogue
Tiomergine
Class of G protein-coupled receptors
targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. The existence of
Dopamine_receptor
Pharmaceutical compound
is a dopamine receptor agonist of the phenethylamine family related to dopamine. It is a selective dopamine D2-like receptor agonist. Subsequently
RU-24213
Drug increasing motivation in humans
vanoxerine (GBR-12909) Dopamine releasing agents (DRAs) like amphetamine, methamphetamine, and lisdexamfetamine Dopamine D1 receptor agonists like SKF-81297 and
Motivation-enhancing_drug
Protein-coding gene in the species Homo sapiens
than ABT-724 FAUC 316: partial agonist, > 8600-fold selective over other dopamine receptor subtypes FAUC 299: partial agonist F-15063: antipsychotic with
Dopamine_receptor_D4
Chemical substance that enables neurotransmission
clozapine act primarily as antagonists at dopamine receptors in the brain. In contrast, receptor agonists bind to receptors and mimic the effects of
Neurotransmitter
Pharmaceutical compound
known as 6-methylamino-4,5,6,7-tetrahydrobenzothiazole, is a dopamine receptor agonist which was under development for the treatment of Parkinson's disease
Etrabamine
Chemical compound
Tavapadon (developmental code names CVL-751, PF-06649751) is a dopamine receptor agonist which is under development for the treatment of Parkinson's disease
Tavapadon
Chemical compound
sold under the brand names Almirid and Cripar among others, is a dopamine agonist of the ergoline group that is used as an antiparkinson agent in the
Dihydroergocryptine
Chemical compound
which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype
A-412997
Pharmaceutical compound
or BD-179, is a dopamine receptor agonist and partial ergoline closely related to the clinically used dopamine receptor agonist and antiparkinsonian
DPAI
Pharmaceutical compound
serotonin and dopamine receptors, acting as an antagonist of some receptors and as an agonist of others, and additionally acts as a dopamine reuptake inhibitor
Nuciferine
Dopamine agonist medication
Rotigotine, sold under the brand name Neupro among others, is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of
Rotigotine
receptor activation. These include both photoisomerizable agonists/antagonists and caged dopamine derivatives that release the active compound upon irradiation
List_of_dopaminergic_drugs
Organic chemical that functions both as a hormone and a neurotransmitter
of dopamine receptors, the prominent cardiovascular effects result from dopamine acting at α1, β1, and β2 adrenergic receptors as a weak agonist. Side
Dopamine
Pharmaceutical compound
Atherosperminine, or atherospermine, is a dopamine receptor agonist, alkaloid found in Fissistigma glaucescens and other species, and the Hofmann degradation
Atherosperminine
Chemical compound
code names IP-202 and DAR-0100) is a moderately selective full agonist at the dopamine D1 and D5 receptors. It has approximately 10-fold selectivity for
Dihydrexidine
Movement disorder
by the use of other treatments such as bromocriptine (Parlodel), a dopamine agonist, appears to be ineffective. In order to avoid dyskinesia, patients
Levodopa-induced_dyskinesia
an indirect agonist of dopamine receptors. Cocaine binds the dopamine transporter (DAT), blocking the protein's ability to uptake dopamine from the synaptic
Indirect_agonist
Chemical compound
N-Arachidonoyl dopamine (NADA) is an endocannabinoid that acts as an agonist of the CB1 receptor and the transient receptor potential V1 (TRPV1) ion channel
N-Arachidonoyl_dopamine
Chemical compound
Ciladopa (developmental code name AY-27,110) is a dopamine agonist with a similar chemical structure to dopamine. It was under investigation as an antiparkinsonian
Ciladopa
Pharmaceutical compound
and dopamine receptor agonist of the partial ergoline family. Its affinity (KD) for the dopamine D2high receptor was 72 nM and for the dopamine D2low
RU-27251
Hormone used as a medication
Dopamine, sold under the brand name Intropin among others, is a medication most commonly used in the treatment of very low blood pressure, a slow heart
Dopamine_(medication)
Pharmaceutical compound
Debenzergoline, or propyldebenzergoline, is a dopamine receptor agonist and partial ergoline. It is an analogue of ergoline in which the A ring of the
Debenzergoline
Pharmaceutical compound
is a dopamine receptor agonist which is under development for the treatment of Parkinson's disease. It is taken orally. The drug is a dopamine D2 receptor
XC-130
Chemical compound
taken by mouth. Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist. Cabergoline was patented in 1980 and approved for medical use
Cabergoline
Serotonin receptor protein distributed in the cerebrum and raphe nucleus
5-HT1A receptor partial agonists, and this property has been shown to enhance their clinical efficacy. Enhancement of dopamine release in these areas may
5-HT1A_receptor
Atypical antipsychotic medicine
antagonist by blocking dopamine receptors. When endogenous dopamine levels are low, cariprazine acts more as an agonist, increasing dopamine receptor activity
Cariprazine
Detailed analysis of management techniques for bipolar disorders
inconclusive. In a single controlled study of twenty one patients, the dopamine D3 receptor agonist pramipexole was found to be highly effective in the treatment
Treatment_of_bipolar_disorder
Chemical compound
in scientific research which acts as a potent selective dopamine D3 receptor partial agonist with an in vitro intrinsic activity of ~0.6 and ~70x greater
BP-897
Dopaminergic & serotonergic drug developed for schizophrenia treatment
functional studies on EMD 49,980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems". European Journal of Pharmacology
Roxindole
Chemical compound
compound which acts as a partial agonist at both dopamine D2 receptors and 5-HT2A receptors. It acts as a dopamine stabilizer in a similar manner to
OSU-6162
Chemical compound
which acts as a dopamine agonist selective for the D1 subtype. The N-desmethyl derivative SKF-89,626 is also a selective D1 agonist with similar potency
SKF-89,145
(HLD-900, HLD-100) – norepinephrine–dopamine releasing agent Dopamine [intranasal] (DopaMat, MPP-18) – dopamine receptor agonist Eltoprazine (DU-28853) – serotonin
List of investigational attention deficit hyperactivity disorder drugs
List_of_investigational_attention_deficit_hyperactivity_disorder_drugs
Dopamine agonist medication
[medical citation needed] Dopamine antagonists reduce the effect of piribedil.[medical citation needed] Dopamine receptor agonist, selective for subtypes
Piribedil
Pharmaceutical compound
cyclized tryptamine and simplified or partial ergoline. It is a dopamine D2-like receptor agonist and shows affinity for the serotonin 5-HT1 and 5-HT2 receptors
RU-28251
Class of drugs
Alpha-adrenergic agonists are a class of sympathetic agents that selectively stimulate alpha adrenergic receptors. The alpha-adrenergic receptor has two
Alpha-adrenergic_agonist
Subtype of Dopamine Receptor
regulates dopamine release and modulates neuronal excitability. Preclinical and clinical studies implicate it in: Parkinson's disease – D3 agonists such as
Dopamine_receptor_D3
Chemical compound
used in scientific research which acts as a potent and selective agonist for the dopamine D2 and D3 receptors. It is used for studying the role of these
PD-128,907
Chemical compound
Lindberg P, Hacksell U, Arvidsson LE, Johansson A (1983). "Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP". Psychopharmacology
3-PPP
Medical condition
levodopa or other dopamine agonists, such as pramipexole, may also trigger the condition. The underlying mechanism involves blockage of dopamine receptors. Diagnosis
Neuroleptic malignant syndrome
Neuroleptic_malignant_syndrome
Pharmaceutical compound
receptor, and serotonin 5-HT2 receptor. It acts as a weak partial agonist of the dopamine D2 and D3 receptors. SDZ 208-912 inhibits dextroamphetamine-induced
SDZ_208-912
Chemical compound
(2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 224
RDS-127
Chemical compound
development by Pfizer which acts as a potent and highly selective agonist for the dopamine D3 receptor. It was under development as a potential medication
PF-219,061
Drug that inhibits the reuptake of norepinephrine and dopamine
norepinephrine–dopamine reuptake inhibitor (NDRI) is a type of drug that inhibits the reuptake of the monoamine neurotransmitters norepinephrine and dopamine and
Norepinephrine–dopamine reuptake inhibitor
Norepinephrine–dopamine_reuptake_inhibitor
Pharmaceutical compound
Nonproprietary Name; developmental code names AM006 and KDT-3594) is a dopamine receptor agonist which is under development for the treatment of Parkinson's disease
Matsupexole
Protein family
Mivazerol Oxymetazoline (also α1 agonist) Rilmenidine (also I agonist) Romifidine Talipexole (also dopamine agonist) Tasipimidine TDIQ (MDTHIQ, MDA-CR)
Alpha-2_adrenergic_receptor
Chemical compound
used in scientific research which acts as a potent and selective agonist for the dopamine D3 receptor. Scheideler MA, Martin J, Hohlweg R, Rasmussen JS,
8-OH-PBZI
Synthetic drug, a stimulant
SKF-81,297 is a dopamine D1-like receptor agonist and stimulant-like drug of the 3-benzazepine family which was under development for the treatment of
SKF-81,297
Investigational sexual dysfunction drugs
sexual dysfunction [41] Apomorphine intranasal – non-selective dopamine receptor agonist, other actions – erectile dysfunction, female sexual dysfunction
List of investigational sexual dysfunction drugs
List_of_investigational_sexual_dysfunction_drugs
Medication used for the treatment of excessive sleepiness
100 μM). In addition to its dopamine and norepinephrine reuptake inhibition, solriamfetol has been found to act as an agonist of the human and rodent TAAR1
Solriamfetol
Chemical compound
6-Br-APB is a synthetic and selective dopamine D1 receptor agonist and stimulant-like drug of the 3-benzazepine family. It is a cyclized phenethylamine
6-Br-APB
Symptoms associated with the extrapyramidal system of the brain
diphenhydramine, and trihexyphenidyl. Certain medications such as dopamine agonists are not used, as they may worsen psychotic symptoms to those taking
Extrapyramidal_symptoms
Pharmaceutical compound
BP1.4979 is a selective dopamine D3 receptor agonist which is under development for the treatment of binge-eating disorder, obsessive–compulsive disorder
BP1.4979
Pharmaceutical compound
pramipexole, which acts as a highly potent and selective full agonist for the dopamine D3 receptor. It has a Ki of 3.61 nM and is over 1000x selective
CJ-1639
Pharmaceutical compound
known as 6-propylterguride or 6-propyl-9,10-dihydrolisuride, is a dopamine agonist of the ergoline family described as a prolactin inhibitor and antiparkinsonian
Proterguride
Psychology term
that dopamine agonists and antagonists modulate LI in rats and in normal humans. Dopamine agonists, such as amphetamines, abolish LI whereas dopamine antagonists
Latent_inhibition
Synthetic dopamine prodrug
derivative of dopamine in which both of the hydroxyl groups have been acetylated. It was developed as a lipophilic prodrug of dopamine that would allow
O,O′-Dipivaloyldopamine
Medical condition
rates or multiple pregnancy rates. Cabergoline, as well as other dopamine agonists, might reduce the severity of OHSS by interfering with the VEGF system
Ovarian hyperstimulation syndrome
Ovarian_hyperstimulation_syndrome
Chemical compound
scientific research which acts as a potent and reasonably selective agonist of the dopamine receptor D2, with lower affinity for the related D3 and D4 subtypes
PNU-91356A
Pharmaceutical compound
N-ethyl-9-oxaergoline, is a dopamine receptor agonist of the 9-oxaergoline family. It is a potent dopamine receptor agonist and produces effects in animals
6-Ethyl-9-oxaergoline
Syndrome that causes episodes of increased activity of the sympathetic nervous system
a dopamine agonist that helps lower blood pressure. Its effects are modest, but they are not well understood. Baclofen is a GABAB receptor agonist that
Paroxysmal sympathetic hyperactivity
Paroxysmal_sympathetic_hyperactivity
Psychoactive drug, often called ecstasy
and dopamine release, with consequent uptake of dopamine into serotonergic neurons and breakdown into toxic species. Serotonin 5-HT2 receptor agonists or
MDMA
5-HT2B receptor antagonist and 5-HT2C receptor agonist Atomoxetine (Strattera) Norepinephrine–dopamine reuptake inhibitors include: Bupropion (Wellbutrin
List_of_antidepressants
Act of suppressing lactation
currently approved for lactation suppression in the US and the UK. Dopamine agonists are routinely prescribed to women following a stillbirth in the UK
Lactation_suppression
Field of study
patient. This is due to the fact that dopamine cannot cross the blood–brain barrier, and L-dopa can. Some dopamine agonists are also given to Parkinson's patients
Neuropharmacology
Chemical compound
treatment of Parkinson's disease, that acts as a selective full agonist at the dopamine D1 receptor. Gulwadi AG, Korpinen CD, Mailman RB, Nichols DE, Sit
Dinapsoline
Sustained-release levodopa prodrug
sustained-release levodopa (L-DOPA) prodrug and hence a dopamine precursor and non-selective dopamine receptor agonist which was under development for the treatment
XP-21279
Substance related to dopamine functions
into dopamine and hence act as non-selective dopamine receptor agonists. Dopamine receptor agonists can be divided into non-selective dopamine receptor
Dopaminergic
Class of pharmaceutical drugs
partial agonist and clinical goal, the clinician may aim for a different level of receptor occupancy. For example, aripiprazole will act as a dopamine agonist
Atypical_antipsychotic
Type I cytokine receptor and coding gene in humans
developed. Dopamine agonists are currently the most common method used for treating hyperprolactinemia. However, since dopamine agonists only negatively
Prolactin_receptor
Investigational narcolepsy and hypersomnia drugs
receptor 1 (TAAR1) agonist and serotonin 5-HT1A and 5-HT1D receptor partial agonist – narcolepsy [56] Mevidalen (LY-3154207; D1 PAM) – dopamine D1 receptor positive
List of investigational narcolepsy and hypersomnia drugs
List_of_investigational_narcolepsy_and_hypersomnia_drugs
Chemical compound
ABT-724 is a drug which acts as a dopamine agonist, and is selective for the D4 subtype. It was developed as a possible drug for the treatment of erectile
ABT-724
Drug that releases serotonin and dopamine in the brain
also acting as serotonin receptor agonists, were described. A closely related type of drug is a serotonin–dopamine reuptake inhibitor (SDRI), for instance
Serotonin–dopamine releasing agent
Serotonin–dopamine_releasing_agent
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DOPAMINE AGONIST
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