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Search references for CYP2C8. Phrases containing CYP2C8
See searches and references containing CYP2C8!CYP2C8
Gene-coded protein involved in metabolism of xenobiotics
Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome
CYP2C8
Allergy medication
desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine N-glucuronide by CYP2C8; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide
Desloratadine
Medication used in asthma or COPD
enzyme CYP2C8, part of the cytochrome P450 system. Therefore, it is theoretically possible that the combination of montelukast with a CYP2C8 substrate
Montelukast
Chemical compound
enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. CYP2C8*1 is
Amodiaquine
Nonsteroidal anti-inflammatory drug
protons, NADPH CYP3A4, CYP2C19, CYP2C8, CYP2C9 2-hydroxyibuprofen NADP, water ibuprofen oxygen, protons, NADPH CYP2C8, CYP2C9, CYP2C19 3-hydroxyibuprofen
Ibuprofen
Central nervous system stimulant
Protein binding 10–36% Metabolism Primary: CYP1A2 Minor: CYP2E1, CYP3A4, CYP2C8, CYP2C9 Metabolites Paraxanthine 84% Theobromine 12% Theophylline 4% Onset
Caffeine
Nonsteroidal anti-inflammatory drug
More than 99% Metabolism Liver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation;
Diclofenac
Chemical compound
with its formation from morphine catalyzed by the liver enzymes CYP3A4 and CYP2C8. Normorphine is a controlled substance listed under the Single Convention
Normorphine
Antiandrogen medication used in treatment of prostate cancer
concentrations of enzalutamide may be altered by inhibitors and inducers of CYP2C8 and CYP3A4, and should be avoided if possible. In a clinical study of enzalutamide
Enzalutamide
Opioid used to treat pain and opioid use disorder
low affinity. Buprenorphine is metabolized by the liver, via CYP3A4 (also CYP2C8 seems to be involved) isozymes of the cytochrome P450 enzyme system, into
Buprenorphine
Chemical compound
Union, use of selexipag together with strong inhibitors of the liver enzyme CYP2C8, such as gemfibrozil, is contraindicated because it increases concentrations
Selexipag
Antiarrhythmic medication
amiodarone is by cytochrome P450 (CYP) enzymes, particularly CYP3A4 and CYP2C8. The metabolism of amiodaron can be characterized by two phases: phase I
Amiodarone
Class of drugs
hydrophilicity and are predominantly detectable in the urine. CYP3A4 or CYP2C8 are likely to be involved in N-deethylation. Reduction of the nitro group
Nitazenes
Chemical compound
caffeine into 1,3,7-trimethyluric acid in humans include CYP1A2, CYP2E1, CYP2C8, CYP2C9, and CYP3A4. "1,3,7-trimethyluric acid". PubChem Compound. National
1,3,7-Trimethyluric_acid
Drugs used to achieve relief from pain
mostly via CYP3A4, CYP2B6 and to a lesser extent: CYP2C9, CYP2C19, CYP2D6 & CYP2C8; half-life = 5–130 hours (mean: 20–35 hours); excretion = urine (20–50%)
Analgesic
Enzyme protein
to form epoxide products that act as signaling molecules. It along with CYP2C8, CYP2C19, CYP2J2, and possibly CYP2S1 are the principle enzymes which metabolizes
CYP2C9
Chemical compound
OATP1B1 and OATP1B3. It is partly degraded by the liver enzymes CYP2B6, CYP2C8 and CYP3A4. Substances that are transported or inactivated by these proteins
Velpatasvir
Class of drugs to lower cholesterol
Pitavastatin Alipza, Livalo, Livazo, Pitava, Zypitamag Synthetic CYP2C9 and CYP2C8 (minimally) Pravastatin Aplactin, Lipostat, Prasterol, Pravachol, Pravaselect
Statin
Chemical compound
CYP2C8 or CYP3A4 inhibitors may increase levels of apalutamide or its major active metabolite N-desmethylapalutamide, while mild to moderate CYP2C8 or
Apalutamide
Chemical compound
inhibitory effects on the cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2D6, CYP2C8, CYP2C9, and CYP2C19. As a result, it is thought that drug interactions
Anastrozole
Peripheral D2 receptor antagonist
metabolized by CYP3A4/5, though minor contributions by CYP1A2, CYP2D6, and CYP2C8 have been reported. CYP3A4 is the major enzyme involved in the N-dealkylation
Domperidone
Chemical compound
via 2-hydroxylation into 2-hydroxyestradiol, and by CYP2C9, CYP2C19, and CYP2C8 via 17β-hydroxy dehydrogenation into estrone, with various other cytochrome
Estradiol
Antiviral drug
Remdesivir is at least partially metabolized by the cytochrome P450 enzymes CYP2C8, CYP2D6, and CYP3A4. Blood plasma concentrations of remdesivir are expected
Remdesivir
Medication
Gemfibrozil inhibits the activation of the liver's Cytochrome P450 system and CYP2C8, reducing hepatic metabolism of many drugs, and prolonging their half lives
Gemfibrozil
Chemical compound
is formed from enzalutamide in the liver by the cytochrome P450 enzymes CYP2C8 and CYP3A4. It has a longer terminal half-life than enzalutamide (7.8 days
N-Desmethylenzalutamide
Chemical compound
Quercetin is a plant flavonol from the flavonoid group of polyphenols. It is found in many fruits, vegetables, leaves, seeds, and grains; capers, red onions
Quercetin
Chemical compound
lead to hypoglycemia. Co-administration of repaglinide and clopidogrel (a CYP2C8 inhibitor) may lead to a significant decrease in blood glucose levels due
Repaglinide
Set of cytochrome P450 enzymes
CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP2S1, CYP3A4, CYP4F2, CYP4F3A, CYP4F3B, CYP4A11, CYP4F8, and CYP4F12. CYP2C8 and CYP2C9
Epoxygenase
Medication used for cancer
Bioavailability 6.5% (by mouth) Protein binding 89 to 98% Metabolism Liver (CYP2C8 and CYP3A4) Elimination half-life 5.8 hours Excretion Oral administration
Paclitaxel
Chemical compound
Possible pharmacokinetic interactions are with substrates of the liver enzyme CYP2C8, such as repaglinide, and the transporter protein SLCO1B1, such as simvastatin
Opicapone
Chemical compound
glucuronidation. It is minimally metabolized by the CYP450 enzymes CYP2C9 and CYP2C8, but not by CYP3A4 (which is a common source of interactions in other statins)
Pitavastatin
Chemical compound
metabolizing the drug is CYP3A4; and there are minor contributions from CYP1A2 and CYP2C8. Metabolites identified in tests with human liver cells and microsomes include
Pazopanib
Antibiotic
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travellers' diarrhoea
Trimethoprim
Antiplatelet medication
Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those
Clopidogrel
Pharmaceutical drug
by the CYP3A4 enzyme (about 90%), and to a lesser degree by CYP3A5 and CYP2C8. It is also a substrate of the P-glycoprotein (P-gp) efflux pump. It has
Sirolimus
Chemical compound
proteins. Several cytochrome P450 enzymes (mainly CYP2C9, but also CYP3A4 and CYP2C8) are involved in the metabolism of fluvastatin, which makes is less liable
Fluvastatin
Chemical compound
enzymes CYP2C8 and CYP3A4, which generates a metabolite that is known as M-1 in the cerivastatin metabolite pathway. Hydroxylation is catalysed by CYP2C8, which
Cerivastatin
Serotonin modulator antidepressant
in the metabolism of vortioxetine, but others including CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4/5 are also involved. It is also metabolized
Vortioxetine
Antibiotic medication
the hepatic cytochrome P450 enzyme system, including isoenzymes CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7. It increases metabolism of
Rifampicin
Chemical compound
Pharmacokinetic data Bioavailability 99% Protein binding 99.8% Metabolism Liver (CYP2C8-mediated) Elimination half-life 3–4 hours Excretion Kidney (64%) and fecal
Rosiglitazone
Chemical compound
is formed from apalutamide in the liver by the cytochrome P450 enzymes CYP2C8 and CYP3A4. "ERLEADATM (apalutamide) tablets, for oral use" (PDF). Janssen
N-Desmethylapalutamide
Chemical compound
Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections
Miconazole
Barbiturate medication used to treat seizures and tremors
such as bupropion, efavirenz, promethazine, selegiline, and sertraline; CYP2C8 substrates such as amiodarone, paclitaxel, pioglitazone, repaglinide, and
Primidone
Toxic plant alkaloid
indicate that aconitine was mainly metabolized by CYP3A4, 3A5 and 2D6. CYP2C8 and 2C9 had a minor role to the aconitine metabolism, whereas CYP1A2, 2E1
Aconitine
Drug dictionary by WHO
also defined based on interaction, for example, drugs interacting with CYP2C8 or drugs interacting with UGT. R,Lee Lindquist M. Vigibase, the WHO Global
WHO_Drug_Dictionary
Diabetes medication
data Bioavailability 87% Protein binding 38% Metabolism Liver (CYP3A4- and CYP2C8-mediated) Elimination half-life 8 to 14 h Excretion Kidney (80%) Identifiers
Sitagliptin
Medication used to treat malaria
et al. (June 2003). "In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine
Chloroquine
Medical condition
CYPs which are important in toluene metabolism, CYP1A2, CYP2B6, CYP2E1, CYP2C8, and CYP1A1. The first four seem to be involved in the hydroxylation of
Toluene_toxicity
List of Cytochrome P450 enzymes
pharmaceuticals. The fluctuation in the amount of CYP450 enzymes (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) in phase 1 (detoxification)
Cytochrome P450 (individual enzymes)
Cytochrome_P450_(individual_enzymes)
Chemical compound
℞ (Prescription only) Pharmacokinetic data Protein binding >99% Metabolism Liver (CYP2C8) Elimination half-life 3–7 hours Excretion Bile duct Identifiers IUPAC name
Pioglitazone
Chemical compound
the major pathway being by CYP3A and minor pathways including by CYP2D6, CYP2C8, and UDP-glucuronosyltransferases. The terminal half-life of elagolix is
Elagolix
Medication
EU: Rx-only Pharmacokinetic data Protein binding 97.9% Metabolism Liver (CYP2C8, 2C9, 3A4) Elimination half-life 30 hours Excretion Feces (82%), kidneys
Etrasimod
Chemical compound
(Hypercium perforatum). They are also taking medications that are strong CYP2C8 inhibitors (gemfibrozil). They meet contraindication criteria for ombitasvir
Dasabuvir
Chemical compound
~52% Protein binding >99% Metabolism extensive liver (through CYP1A2 and CYP2C8) Elimination half-life 21–35 hours Excretion feces (59%), urine (31%) Identifiers
Eltrombopag
Mixture of pineapple protease (fruit and stem)
under standard treatment. The enzymes in NexoBrid inhibit the liver enzymes CYP2C8 and CYP2C9 when ingested. These are involved in the breaking down of a number
Bromelain_(pharmacology)
Chemical compound
data Bioavailability 94% Protein binding 95% Metabolism CYP1A1, CYP3A4, CYP2C8, CYP2J2 Metabolites N-desmethylriociguat (active), glucuronide (inactive)
Riociguat
Antibiotic against tuberculosis
includes rifampicin and rifabutin. Rifapentine induces metabolism by CYP3A4, CYP2C8 and CYP2C9 enzymes. It may be necessary to adjust the dosage of drugs metabolized
Rifapentine
Class of drugs that hinder the action of leukotriene
montelukast and zafirlukast are extensive. Montelukast is mainly metabolized CYP2C8 and zafirlukast by CYP2C9. The half-life of montelukast is 2,7-5,5 hours
Cysteinyl-leukotriene type 1 receptor antagonists
Cysteinyl-leukotriene_type_1_receptor_antagonists
somnifera (Ashwagandha) Carbamazepine Phenobarbital Phenytoin Rifampicin CYP2C8 Gemfibrozil Letermovir Montelukast Perampanel Quercetin Teriflunomide Thiazolidinediones
List of cytochrome P450 modulators
List_of_cytochrome_P450_modulators
Chemical compound
Approved in India Pharmacokinetic data Protein binding 99% Metabolism Liver (CYP2C8, CYP3A4) Elimination half-life 5.6 hours Excretion Bile duct Identifiers
Saroglitazar
Chemical compound
metabolized by glucuronidation (UGT2B7, UGT1A1, UGT1A9) and O-demethylation (CYP2C8, CYP2C9). Once bound to a β2 receptor, an olodaterol molecule stays there
Olodaterol
Pharmaceutical drug
sofosbuvir/velpatasvir with strong inducers of the liver enzymes CYP2B6, CYP2C8 or CYP3A4, or with P-glycoprotein, is contraindicated because such substances
Sofosbuvir/velpatasvir
Mammalian protein found in humans
various epoxyeicosatetraenoic acids (also termed EEQs). Along with CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and
CYP2C19
Medication
sulfation and glucuronidation) metabolism. CYP3A and to a lesser extent CYP2C8, CYP2C9, and CYP2C19 are the CYP450 enzymes involved in fruquintinib metabolism
Fruquintinib
Class of pharmaceutical drugs
increase plasma concentration of other drugs. The same goes for the CYP2B6 and CYP2C8 pathways, they are inhibited by sorafenib. Giving sorafenib in combination
VEGFR-2_inhibitor
Group of chemical compounds
CYP2C, CYP2E, CYP2J, and within the CYP3A subfamily, CYP3A4. In humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 isoforms appear to be the
Epoxydocosapentaenoic_acid
Class of compounds
reaction. The human cytochrome P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize arachidonic
Eicosanoid
predominant isoform involved in metabolism of Fluvastatin, but CYP3A4 and CYP2C8 isoenzymes also contribute to the metabolism of Fluvastatin. Rosuvastatin
Discovery and development of statins
Discovery_and_development_of_statins
Chemical compound
than clinical concentrations: CYP3A4 42.3%, CYP1A2 26.1%, CYP2B6 16.0%, CYP2C8 6.0%, CYP2D6 4.8%, CYP2C9 4.8%, CYP2C9 <1%) as well as non-CYP enzymes,
Ixazomib
Chemical compound
Investigational Pharmacokinetic data Bioavailability 75% Metabolism Liver via CYP2C8, CYP2C9, CYP2C19 and CYP2D6 Elimination half-life 3 hours Excretion Urine
Rolipram
Antidepressant pharmacology hypotheses
Urine (76%; 58% as unchanged drug & 18% as N-desmethyl metabolite) CYP3A4 CYP2C8 CYP2C19 CYP2D6 CYP2J2 ? Milnacipran 85-90% 6-8 (L-isomer), 8-10 (D-isomer)
Pharmacology of antidepressants
Pharmacology_of_antidepressants
Chemical compound
with food. The liver's CYP3A4 enzymes mainly break down simeprevir, but CYP2C8 and CYP2C19 enzymes can also play a role. Its half-life in the plasma is
Simeprevir
Chemical compound
Cabazitaxel is metabolized in the liver by [cytochrome P450 (CYP)3A4/5 > CYP2C8], which result in seven plasma metabolites and excreted 20 metabolites.
Cabazitaxel
Class of fatty acids
CYP2C, CYP2E, CYP2J, and within the CYP3A sub family, CYP3A4; in humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 isoforms are the main producers
Epoxyeicosatrienoic_acid
Chemical compound
data Bioavailability <5% Protein binding >98% Metabolism Liver (CYP3A and CYP2C8 substrate) Elimination half-life 2–5 hours Excretion Faeces (83%), urine
Lovastatin
Mexican biologist
506(7488). Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer. Pharmacogenomics
Hugo_Barrera_Saldaña
Swedish physician and academic
Magnus; Pääbo, Svante; Zeberg, Hugo (July 30, 2022). "The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals". The Pharmacogenomics
Hugo_Zeberg
Pharmaceutical drug
Concurrent use of moderate to strong inducers of CYP3A and strong inducers of CYP2C8 reduce efficacy Post-market surveillance reports show hepatic decompensation
Ombitasvir/paritaprevir/ritonavir
Ombitasvir/paritaprevir/ritonavir
Cellular molecules that help resolve inflammation
alternatively, DHA may be first metabolized to 22-hydroxy-DHA by CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1, or CYP3A4 and then metabolized through the cited
Specialized pro-resolving mediators
Specialized_pro-resolving_mediators
Chemical compound
subfamilies, and within the CYP3A subfamily, CYP3A4. In humans, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP3A4, and CYP2S1 metabolize
Epoxyeicosatetraenoic_acid
major hepatic pathway for estradiol metabolism, as mediated by CYP1A2, CYP2C8, CYP2C9, and CYP3A4. Extrahepatic 2-hydroxylation is chiefly mediated by
Hydroxylation_of_estradiol
Gene of the species Homo sapiens
epoxyeicosatetraenoic acids (also termed EEQs). CYP2J2, along with CYP219, CYP2C8, CYP2C9, and possibly CYP2S1 are the main producers of EETs and, very likely
CYP2J2
Protein-coding gene in the species Homo sapiens
Dekker SJ, Vermeulen NP, Commandeur JN (March 2018). "Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism". Toxicology Letters. 284: 70–78
UGT2B7
P20853 3867 CYP2A13 HGNC:2608; Q16696 3868 CYP2B6 HGNC:2615; P20813 3869 CYP2C8 HGNC:2622; P10632 3870 CYP2C9 HGNC:2623; P11712 3871 CYP2C18 HGNC:2620;
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Anti-nausea group of medications
μg/kg Vortioxetine Phenylpiperazine 5-HT3 receptor antagonist Antidepressant 66 hours CYP 2D6/ 2A6/CYP2B6/CYP2C8/9, CYP2C19 5 mg, 10 mg, 20 mg doses
5-HT3_antagonist
Pharmacology of the antiparkinsonian and antidepressant selegiline
vitro studies. Other cytochrome P450 enzymes, including CYP1A2, CYP2A6, CYP2C8, CYP2D6, CYP2C19, and CYP2E1, may also be involved. One review concluded
Pharmacology_of_selegiline
Zimbabwean professor of clinical pharmacology
"Amodiaquine Clearance and Its Metabolism toN-Desethylamodiaquine Is Mediated by CYP2C8: A New High Affinity and Turnover Enzyme-Specific Probe Substrate". Journal
Collen_Masimirembwa
Protein-coding gene in the species Homo sapiens
various epoxyeicosatetraenoic acids (also termed EEQs). While CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and
CYP2C18
CYP2C8
CYP2C8
CYP2C8
CYP2C8
Girl/Female
Hindu
Flower that blossoms in december
Boy/Male
Hindu
Male
Hebrew
(דּï‹×‘) Hebrew name DOV means "bear."
Girl/Female
Indian, Malayalam
Beauty
Boy/Male
Hindu, Indian, Telugu
Be Friendly
Boy/Male
Tamil
Shape
Boy/Male
Tamil
Girl/Female
Australian, Greek, Latin
Farmer; Similar to Georgia
Boy/Male
Muslim
Decree. Edict.
Boy/Male
Danish American French Swedish Scandinavian
CYP2C8
CYP2C8
CYP2C8
CYP2C8
CYP2C8