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Gene of the species Homo sapiens
Cytochrome P450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene. CYP2J2 is a member of the cytochrome P450 superfamily of enzymes
CYP2J2
Alkaloid responsible for the pungency of black pepper
pepper has pungency effects via activation of TRPV1. Piperine also inhibits CYP2J2. It has been used in some forms of traditional medicine. It can be acutely
Piperine
antioxidant, and cytotoxic against a variety of cell lines. It inhibits CYP2J2. Miltirone (rosmariquinone) Lee WY, Cheung CC, Liu KW, et al. (May 2010)
Tanshinone
Chemical compound
Nepenthes. It is also a component of the black walnut drupe. Plumbagin inhibits CYP2J2. Juglone Black Walnut. Drugs.com. Jemal Demma; Karl Hallberg; Björn Hellman
Plumbagin
Species of plant
decursin, that may have anti-androgenic properties in vitro. It also inhibits CYP2J2. In 2013, the main substance decursin, decursinol angelate (its isomer)
Angelica_gigas
Chemical compound
to bind to tubulin and inhibit its polymerization. Miconazole inhibits CYP2J2. After application to the skin, miconazole can be measured in the skin for
Miconazole
Blood pressure medication
artery disease. Telmisartan activates PPAR-α in vitro. Telmisartan inhibits CYP2J2. The substance is quickly but to varying degrees absorbed from the gut.
Telmisartan
Chemical compound
ventricular tachycardia and torsades de pointes). Terfenadine also inhibits CYP2J2. Terfenadine was synthesized by chemists at Richardson–Merrell in 1973 as
Terfenadine
Beta blocker medication
Metoprolol also prevents electrical wave propagation. Metoprolol inhibits CYP2J2. Metoprolol is mostly absorbed from the intestine with an absorption fraction
Metoprolol
Chemical compound
themselves. Some albendazole is also converted to hydroxyalbendazole, mainly by CYP2J2. For systemic parasites, albendazole acts as a prodrug, while ricobendazole
Albendazole
Anticoagulant drug
Bioavailability 80–100%; Cmax = 2–4 hours (10 mg oral) Metabolism CYP3A4, CYP2J2 and CYP-independent mechanisms Elimination half-life 5–9 hours in healthy
Rivaroxaban
Chemical compound
steroidogenesis inhibitor, and a functional antiestrogen. Danazol also inhibits CYP2J2. Danazol is described as a possessing high affinity for the androgen receptor
Danazol
Minor cannabinoid
animals and to a lesser extent in humans. CBG is metabolized in the liver by CYP2J2, similarly to other cannabinoids as well as endocannabinoids. CBG is a highly
Cannabigerol
Antihypertensive drug of the calcium channel blocker class
antihypertensive effect, with little increase in heart rate. Azelnidipine inhibits CYP2J2. Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (September 1989)
Azelnidipine
Class of fatty acids
within the CYP3A sub family, CYP3A4; in humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 isoforms are the main producers of EETs although CYP2C9
Epoxyeicosatrienoic_acid
List of Cytochrome P450 enzymes
epoxydocosapentaenoic acids (i.e. EDPs). CYP2C8, CYP2C9, CYP2C18, CYP2C19, and CYP2J2 metabolize endogenous PUFAs to signaling molecules: they metabolize AA to
Cytochrome P450 (individual enzymes)
Cytochrome_P450_(individual_enzymes)
Antifungal chemical compound
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number
Ketoconazole
Set of cytochrome P450 enzymes
PUFAs include CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP2S1, CYP3A4, CYP4F2, CYP4F3A, CYP4F3B, CYP4A11, CYP4F8, and CYP4F12
Epoxygenase
Class of compounds
epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize arachidonic acid to the non-classic epoxyeicosatrienoic
Eicosanoid
Group of chemical compounds
within the CYP3A subfamily, CYP3A4. In humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 isoforms appear to be the principal epoxygenases responsible
Epoxydocosapentaenoic_acid
Chemical compound
Bioavailability 94% Protein binding 95% Metabolism CYP1A1, CYP3A4, CYP2C8, CYP2J2 Metabolites N-desmethylriociguat (active), glucuronide (inactive) Elimination
Riociguat
Drug discovery
and edoxaban. Rivaroxaban Apixaban Edoxaban Metabolism CYP3A4/5 (major), CYP2J2 (minor) CYP3A4 (major), CYP1A2, 2C8, 2C19, 2J2 (all minor) CYP34A (major)
Discovery and development of direct Xa inhibitors
Discovery_and_development_of_direct_Xa_inhibitors
Antihypertensive drug of the calcium channel blocker class
Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It was patented in 1982 and approved for
Manidipine
Atypical antipsychotic medication
Pharmacokinetic data Protein binding 94–97% Metabolism Hepatic (CYP3A4, CYP3A5, CYP2J2) Metabolites N-Desmethyl-pimavanserin Onset of action TmaxTooltip Time to
Pimavanserin
Mammalian protein found in humans
epoxyeicosatetraenoic acids (also termed EEQs). Along with CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely EEQs
CYP2C19
Chemical compound
CYP3A4. In humans, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, CYP3A4, and CYP2S1 metabolize EPA to EEQs, in most cases forming principally
Epoxyeicosatetraenoic_acid
Chemical compound
Bioavailability ~100% Protein binding ≥99% Metabolism hepatic (CYP3A4 and CYP2J2) Elimination half-life 5–13 days Excretion feces (58%), urine (25%) Identifiers
Vorapaxar
Enzyme found in humans
Following proteins became known as potential direct binders of PTGIS: CYP2J2, GST, GSTA1, GLRX3, AKR1A1. Protein–protein and protein-peptide interactions
Prostacyclin_synthase
Antidepressant pharmacology hypotheses
unchanged drug & 18% as N-desmethyl metabolite) CYP3A4 CYP2C8 CYP2C19 CYP2D6 CYP2J2 ? Milnacipran 85-90% 6-8 (L-isomer), 8-10 (D-isomer) 400 L ? 2–4 hr 13%
Pharmacology of antidepressants
Pharmacology_of_antidepressants
Enzyme protein
products that act as signaling molecules. It along with CYP2C8, CYP2C19, CYP2J2, and possibly CYP2S1 are the principle enzymes which metabolizes 1) arachidonic
CYP2C9
Gene-coded protein involved in metabolism of xenobiotics
epoxyeicosatetraenoic acids (also termed EEQs). Along with CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely, EEQs
CYP2C8
Chemical compound
amounts of 20-HETE, and, in the case of the sheep enzyme, 18-HETE; human CYP2J2, however, is an epoxygenase, metabolizing arachidonic acid to epoxide products
20-Hydroxyeicosatetraenoic acid
20-Hydroxyeicosatetraenoic_acid
Class of enzymes
(sulfoxide-forming), which in humans is known to be carried out by CYP3A4 and CYP2J2. Enzyme 1.14.13.32 at KEGG Pathway Database. Fargetton X, Galtier P, Delatour
Albendazole_monooxygenase
A0A087X1C5 3875 CYP2E1 HGNC:2631; P05181 3876 CYP2F1 HGNC:2632; P24903 3877 CYP2J2 HGNC:2634; P51589 3878 CYP2R1 HGNC:20580; Q6VVX0 3879 CYP2S1 HGNC:15654;
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Chemical compound
by a hydroperoxide isomerase activity, possibly a cytochrome P450, i.e. CYP2J2. Metabolized by cytochrome P450 (CYP) enzymes such as CYP1A1, CYP1A2, CYP1B1
15-Hydroxyeicosatetraenoic acid
15-Hydroxyeicosatetraenoic_acid
Protein-coding gene in the species Homo sapiens
epoxyeicosatetraenoic acids (also termed EEQs). While CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely EEQs
CYP2C18
CYP2J2
CYP2J2
CYP2J2
CYP2J2
Boy/Male
Hindu
One of the kauravas
Boy/Male
Tamil
A part of the mind
Boy/Male
Hindu
Prabhedaka destroyer of enemies missions
Boy/Male
Indian
Gold
Girl/Female
Australian, Kurdish, Turkish
Musical; Melody
Girl/Female
Tamil
Saffron, A lion
Boy/Male
Arabic
Father of a Toothless Old Woman
Boy/Male
Arabic, Muslim
Confident; Believer; Faithful Friend
Boy/Male
Irish
A name with two sources, St. Malachi (1095-1148 AD) was the Bishop of Armagh who adopted the name from the Hebrew prophet “â€Malachiâ€â€ whose name means “â€my angelâ€â€ or “â€messenger of God.â€â€ It is also linked to the High King Maoilseachlainn “â€devotee of St. Sechnallâ€â€ one of Saint Patrick’s first companions.
Boy/Male
Hindu
Name of a poet
CYP2J2
CYP2J2
CYP2J2
CYP2J2
CYP2J2