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Protein-coding gene in the species Homo sapiens
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway
Complement_factor_B
Part of the immune system that enhances the ability of antibodies and phagocytic cells
of complement component 3, complement factor B, and complement factor I, as well as deletion of complement factor H-related 3 and complement factor H-related
Complement_system
Chemical compound
of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth. Iptacopan
Iptacopan
Membrane-bound complement regulators Membrane Cofactor Protein, MCP (CD46) Decay Accelerating Factor, DAF (CD55) Protectin (CD59) Complement C3b/C4b Receptor
Complement_control_protein
Protein
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein
Complement_factor_I
Class of enzymes
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein
Factor_D
Topics referred to by the same term
basalt, large volumes of dominantly tholeiitic basalt on continents Complement factor B, a protein Compact fluorescent bulb Current feedback, a type of electronic
CFB
Protein found in humans
Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein
Factor_H
Vision loss due to damage to the macula of the eye
location 10q26 Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:
Macular_degeneration
Mammalian protein found in humans
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement
Decay-accelerating_factor
Pharmaceutical compound
Ciprocopan (INN) is a small-molecule inhibitor of complement factor B used for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). It was developed
Ciprocopan
Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3
Alternative-complement-pathway C3/C5 convertase
Alternative-complement-pathway_C3/C5_convertase
Protein found in humans
agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. In the alternative complement pathway
Complement_component_3
Type of cascade reaction of the complement system
activation process: Complement Receptor 1 (CR1 or CD35) and DAF (decay accelerating factor also known as CD55) compete with Factor B in binding with C3b
Alternative complement pathway
Alternative_complement_pathway
Blood disease in which red blood cells are attacked by the immune system
of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth. Iptacopan
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Class of serine proteases
complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B (a
C3-convertase
Protein domain
Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins
Von Willebrand factor type C domain
Von_Willebrand_factor_type_C_domain
regulated without C3b inactivation, through complement control proteins, including decay-accelerating factors that function to speed up C3 convertase half-lives
C3a_(complement)
Protein involved in the immune system
autoimmunity with the other numerous members of the complement system. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall
Complement_component_4
Protein-coding gene in the species Homo sapiens
encoded by the CFP (complement factor properdin) gene. Properdin and factor H are regulatory proteins in the alternative complement pathway. Properdin
Properdin
Topics referred to by the same term
chemical reactions Factor B, and factor D, peptides involved in the alternate pathway of immune system complement activation Transcription factor, a protein that
Factor
inhibition - complement 3A - complement 5A - complement factor B - complement membrane attack complex - complement receptor - complex - computational biology
Index of biochemistry articles
Index_of_biochemistry_articles
Protein part of the complement system
cannot associate with factor B, thus preventing amplification of the complement cascade through the alternative pathway. Complement factor I can further cleave
IC3b
British protein biochemist, immunologist, and academic
Prosser, B. E., Johnson, S., Roversi, P., Herbert, A. P., Blaum, B. S., Tyrrell, J., ... & Lea, S. M. (2007). Structural basis for complement factor H–linked
Simon_J._Clark
Genetic process
Complementation is the capacity of a segment of genetic material, such as DNATooltip Deoxyribonucleic acid, to restore the normal phenotype associated
Complementation_(genetics)
Protein Domain
Pfam clan). The vWA domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
Medical diagnostic method
classical complement pathway and thus requires functioning C1-C9 factors. If an individual has deficient or malfunctioning complement factors, then at
Total_complement_activity
Protein found in humans
glycoprotein of the complement system; decay-accelerating factor (DAF: CD55: Cromer antigen) protects host cells from complement-mediated damage by regulating
Complement_receptor_1
Life-threatening immune-related blood disease
complement regulatory proteins (e.g., factor H, factor HR1 or HR3, membrane cofactor protein, factor I, factor B, complement C3, and thrombomodulin). This results
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Part of the innate immune system
Additionally, C3b plays a role in forming a C3 convertase when bound to Factor B (C3bBb complex), or a C5 convertase when bound to C4b and C2b (C4b2b3b
C3b
American stealth bomber aircraft
the B-21 is meant to complement the Rockwell B-1 Lancer and Northrop B-2 Spirit, replace them by 2040, and possibly replace the 1950s Boeing B-52 Stratofortress
Northrop_Grumman_B-21_Raider
Protein found in humans
Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system
Complement_component_1s
Macrophage-1 antigen (hereafter complement receptor 3 or CR3) (CD11b/CD18) is a human cell surface receptor found on B and T lymphocytes, polymorphonuclear
Macrophage-1_antigen
Serine protease that plays key role in innate immunity
(C3bBbC3b) of complement system. Two fluid phase C5 convertases have been described: the classical pathway enzyme, C4b2boxy3b and the cobra venom factor-dependent
C5-convertase
Protein found in humans
"Structure and activation of complement components C2 and factor B". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Complement_component_2
Topics referred to by the same term
(protein), an initialism for B factor, a triggering protein of the alternative pathway of complement activation Bayes factor, a ratio used in Bayesian statistics
BF
760.198 – complement factor b MeSH D08.811.277.656.300.760.200 – complement factor d MeSH D08.811.277.656.300.760.210 – complement factor i MeSH D08
List_of_MeSH_codes_(D08)
Japanese molecular biologist
Immunology at the University of Tokyo where he investigated the complement factor B for HIV infection. In 1992, he participated in the first large-scale
Makoto_Furutani-Seiki
Number format for specifying provision
can be seen as a 16-bit signed (two's complement) integer, that is implicitly multiplied by the scaling factor 2 − 12 {\displaystyle 2^{-12}} . In particular
Q_(number_format)
Protein domain
and b-fragments. A-fragments form distinct structural domains of approximately 76 amino acids, coded for by a single exon within the complement protein
Anaphylatoxin
Computer format for representing real numbers
fixed-point formats as a signed integer in two's complement representation with an implicit scaling factor as above. The sign of the value will always be
Fixed-point_arithmetic
Overview of and topical guide to immunology
Region Fc Region Polyclonal B cell response Cell-mediated immunity Innate immune system Complement system Classical complement pathway Mannan-binding lectin
Outline_of_immunology
Protein-coding gene in humans
Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the
Complement_component_1r
Mammalian protein found in Homo sapiens
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans
B-cell_activating_factor
486.274.860.450 – complement factor d MeSH D12.776.124.486.274.900 – complement factor b MeSH D12.776.124.486.274.920 – complement inactivator proteins
List of MeSH codes (D12.776.124)
List_of_MeSH_codes_(D12.776.124)
Antibody isotype
elimination of the pathogen itself; IgG activates the classical pathway of the complement system, a cascade of immune protein production that results in pathogen
Immunoglobulin_G
American strategic bomber aircraft
will allow B-52s to quickly scan vast Pacific Ocean areas. This radar will complement the Litening infrared targeting pod already used by B-52s for inspecting
Boeing_B-52_Stratofortress
Protein
over. ClfA also interacts with complement factor I, an enzyme that cleaves C3b into its inactive form, iC3b. When factor I is recruited to the bacterial
Clumping_factor_A
and B. ∁ {\displaystyle \complement } 1. With a subscript, denotes a set complement: that is, if B ⊆ A {\displaystyle B\subseteq A} , then ∁ A B =
Glossary of mathematical symbols
Glossary_of_mathematical_symbols
Aspect of the immune system
classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway
Classical_complement_pathway
Quantity in relativistic physics
The Lorentz factor or Lorentz term (also known as the gamma factor) is a dimensionless quantity expressing how much the measurements of time, length, and
Lorentz_factor
Mammalian protein found in humans
bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors released by macrophages, T cells and
C-reactive_protein
Autoimmune disease in which the immune system attacks healthy tissue
RNASEH2C, Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component
Lupus
Protein fragment
mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system such as sepsis, rheumatoid
Complement_component_5a
Mammalian protein found in humans
signals transduced by complement". Molecular Immunology. 41 (6–7): 583–597. doi:10.1016/j.molimm.2004.04.007. PMID 15219997. Li B, Chu X, Gao M, Xu Y (2011)
CD59
Disease of blood and kidneys after bacterial infection
for several complement regulatory proteins. Later, mutations in complement factor H, complement factor I, membrane cofactor protein, factor B, C3, and thrombomodulin
Hemolytic–uremic_syndrome
Protein found in humans
Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved
Complement_component_5
Protein-coding gene in the species Homo sapiens
APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene. Alternative splicing occurs at this locus and three full-length
A1CF
Medical condition
Schlötzer-Schrehardt U, Kirschfink M, Zipfel PF, Hoppe B (January 2007). "MPGN II--genetically determined by defective complement regulation?". Pediatr. Nephrol. 22 (1):
Membranoproliferative glomerulonephritis
Membranoproliferative_glomerulonephritis
Crewed full ocean depth rated submersible
DSV. Limiting Factor was used to identify the wrecks of the destroyers USS Johnston at a depth of 6,469 m (21,224 ft), and USS Samuel B. Roberts at 6
DSV_Limiting_Factor
Reaction occurring within an organism as a defence against a pathogen
neutrophils, macrophages, and monocytes, and soluble factors including cytokines and complement. On the other hand, the adaptive branch is the body's
Immune_response
Protein domain
proteins. Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a), Es(a), Tc(a/b/c)
Sushi_domain
Mathematical set formed from two given sets
A×(B∖C)=(A×B)∖(A×C), (A×B)∁=(A∁×B∁)∪(A∁×B)∪(A×B∁), where A∁ denotes the absolute complement of A. Other properties related with subsets are: if A⊆B, then A×C⊆B×C;
Cartesian_product
Protein-coding gene in the species Homo sapiens
humans is encoded by the C4B gene. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed
Complement_component_4B
Medical condition
characterized by complement-mediated autoimmune hemolysis and paroxysmal nocturnal hemoglobinuria. The protein CD55 (also called decay-accelerating factor) helps
CD55_deficiency
American actor (born 1973)
In 2012, he co-hosted the second season of the American version of The X Factor with Khloé Kardashian, and was the sole host for the third and final season
Mario_Lopez
Buhmann, R; Simoes, B; Stanglmaier, M; Yang, T; Faltin, M; Bund, D; Lindhofer, H; Kolb, HJ; et al. (2008). "Immunotherapy of recurrent B–cell malignancies
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Term for several kidney diseases
of the complement system. The C3 Nephritic Factor autoantibody stabilizes C3-convertase, which may lead to an excessive activation of complement. Type
Glomerulonephritis
Species of bacteria
plasminogen binding proteins for interference of factor H at the activation level. This is part of a complement system evasion strategy that leads to downstream
Borrelia_burgdorferi
One of the four basic arithmetic operations
ones' complement is very easily obtained by inverting each bit (changing "0" to "1" and vice versa). And adding 1 to get the two's complement can be
Subtraction
Immune cells found in lymph nodes
tissue, where they transfer complement opsonized antigen to the FDCs. FDCs, in turn, attract B cells with chemoattractant CXCL13. B cells lacking CXCR5, the
Follicular_dendritic_cells
Mammalian protein found in Homo sapiens
beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A and cluster of differentiation
Integrin_alpha_M
Mammalian protein found in humans
complement system. The encoded protein has cofactor activity for inactivation (through cleavage) of complement components C3b and C4b by serum factor
Membrane_cofactor_protein
Vitamin K-dependent plasma glycoprotein synthesized in the liver
Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by
Protein_S
American heavy bomber aircraft
B-17 a key bomber aircraft of the war. Other factors such as combat effectiveness and political issues also contributed to the B-17's success. The B-17
Boeing_B-17_Flying_Fortress
Protein-coding gene in humans
(D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53
Winged_helix_repair_factor_1
Clumping of abnormal cold-sensitive proteins in blood
cryoglobulinemic disease have rheumatoid factor activity, meaning they bind to polyclonal immunoglobulins and activate the blood complement system. They therefore form
Cryoglobulinemia
RNA family
innate immune response by binding Factor H, Complement component 3 and IgG. Protein A SprX Chabelskaya S, Gaillot O, Felden B (June 2010). "A Staphylococcus
SprD
Species of bacterium that can cause meningitis
Factor H binding protein (fHbp) that is exhibited in N. meningitidis and some commensal species is the main inhibitor of the alternative complement pathway
Neisseria_meningitidis
Protein found in humans
Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system. Once activated, about 12-18
Complement_component_9
of -Arg103-Ser- and -Ile124-Ile- bonds in limulus clotting factor B to form factor overbar B. Cleavage of -Pro-Arg- bonds in synthetic substrates This
Limulus_clotting_factor_C
mediated psoriasis (CAMPS) Cherubism COPA defect Otulipenia/ORAS The complement system is part of the innate as well as the adaptive immune system; it
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Algebraic manipulation of "true" and "false"
enters via complement ¬ as follows. The complement operation is defined by the following two laws. Complementation 1 x ∧ ¬ x = 0 Complementation 2 x ∨ ¬
Boolean_algebra
Evolutionarily-conserved protein domain
"The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence
Von Willebrand factor type D domain
Von_Willebrand_factor_type_D_domain
Technology used to validate protein interactions
Bimolecular fluorescence complementation (also known as BiFC) is a technology typically used to validate protein interactions. It is based on the association
Bimolecular fluorescence complementation
Bimolecular_fluorescence_complementation
Framework to analyse level of competition within an industry
products/services cannot be a standalone factor because it's not necessarily bad or good for the industry's profitability. Complements occur when a customer benefits
Porter's_five_forces_analysis
Protein-coding gene in the species Homo sapiens
Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene. The human complement subcomponent
C1QBP
Protein domain
calcium. Mammalian complement-activating component of Ra-reactive factor (RARF), a protease that cleaves the C4 component of complement. Vertebrate enteropeptidase
CUB_domain
Form of musical chord
common practice period, "the root, 3rd, 7th, and 9th are the most common factors present in the V9 chord," with the 5th, "typically omitted". The ninth
Ninth_chord
Standard for miniature computer expansion cards
2 (pronounced "em-dot-two"), formerly known as the Next Generation Form Factor (NGFF), is a specification for internally mounted computer expansion cards
M.2
Every element in L has a complement (not necessarily unique). A complement of an element a is an element b with a ∧ b = 0, a ∨ b = 1, where 0 and 1 are
Continuous_geometry
Species of bacterium
B. cereus and B. thuringiensis. PlcR is a global transcriptional regulator which controls most of the secreted virulence factors in B. cereus and B.
Bacillus_anthracis
Combinational digital circuit
A (or B) appears at Y in two's complement form. Increment: A (or B) is increased by one and the resulting value appears at Y. Decrement: A (or B) is decreased
Arithmetic_logic_unit
Protein found in humans
(D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53
Negative_elongation_factor_E
Immunity strategy in living beings
infection sites by producing chemical factors, including chemical mediators called cytokines activate the complement cascade to identify bacteria, activate
Innate_immune_system
Protein-coding gene in humans
Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene. CFHR5 is structurally related to complement factor H which
CFHR5
Disease characterized by rapid swelling
reduced complement factor C4, rather than the C1-INH deficiency itself, that is detected. The former is used during the reaction cascade in the complement system
Angioedema
Lock-and-key pairing between two structures
complementary bases (i.e. guanine = b, cytosine = q, adenine = n, and thymine = u), which makes it is possible to complement entire DNA sequences by simply
Complementarity (molecular biology)
Complementarity_(molecular_biology)
Proteins similar to insulin that stimulate cell proliferation
be an anabolic factor for bone. Since at high concentrations it is capable of activating the insulin receptor, it can also complement for the effects
Insulin-like_growth_factor
Computational method
possible linear factors are of the form b 1 x − b 0 {\displaystyle b_{1}x-b_{0}} , where b 1 {\displaystyle b_{1}} is an integer factor of a n {\displaystyle
Factorization_of_polynomials
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COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
Boy/Male
Arabic, Muslim
Competent
Male
Spanish
Spanish name derived from Latin Pastor, PASTOR means "shepherd." St. Pastor was a 9-year-old boy who along with his 13-year-old brother, Justus, was martyred at Alcalá de Henares in the early 4th century.
Boy/Male
Muslim
Compliments, Happiness
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Male
Icelandic
Perhaps a modern form of Icelandic Fylkir, FALKOR means "people, tribe."Â
Male
Arthurian
, sir Hector de Maris; (defender).
Male
Greek
(ÎαχώÏ) Greek form of Hebrew Nachowr, NACHOR means "snoring" or "snorting." In the bible, this is the name of the son of Terah and brother of Abraham.
Boy/Male
Hindi
Competent.
Male
Greek
(ΚάστωÏ) Greek name KASTOR means "beaver." In mythology, Castor/Kastor and Pollux/Polydeukes ("very sweet") are the twin sons of Leda and are known as the Gemini twins.
Boy/Male
Indian, Sanskrit
Competent
Boy/Male
Latin
Son of Azeus.
Surname or Lastname
French and Italian
French and Italian : occupational name from French, northern Italian sartor ‘tailor’ (Latin sartor).English : topographic name denoting someone who lived on land which had been cleared for cultivation, Old French assart, essart ‘woodland cleared for cultivation’ + the habitational suffix -er.
Boy/Male
English American
Doctor; teacher.
Boy/Male
Anglo Saxon
Competent.
Male
English
Roman Latin name VICTOR means "conqueror."Â
Male
English
 Anglicized form of Scottish Gaelic Eachann, HECTOR means "brown horse." Compare with another form of Hector.
Male
Spanish
Spanish form of Roman Latin Victor, VÃCTOR means "conqueror."
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
COMPLEMENT FACTOR-B
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