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Medical condition
Chemotherapy-induced peripheral neuropathy (CIPN) is a nerve-damaging side effect of antineoplastic agents in the common cancer treatment, chemotherapy
Chemotherapy-induced peripheral neuropathy
Chemotherapy-induced_peripheral_neuropathy
Nervous system disease affecting nerves beyond the brain and spinal cord
inflammation (neuritis), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy). The affected nerves are found in an EMG
Peripheral_neuropathy
Treatment of cancer using drugs that inhibit cell division or kill cells
2010). "Chemotherapy-induced Peripheral Neuropathy". NCI Cancer Bulletin. 7 (4): 6. Grisold W, Oberndorfer S, Windebank AJ (2012). "Chemotherapy and polyneuropathies"
Chemotherapy
Impairment that can result from chemotherapy treatment
drugs cisplatin, oxaliplatin and carboplatin often cause chemotherapy-induced peripheral neuropathy, a progressive and enduring tingling numbness, intense
Post-chemotherapy cognitive impairment
Post-chemotherapy_cognitive_impairment
SNRI medication
G, et al. (June 2014). "Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical
Duloxetine
Method of measuring skin conductance
sudomotor function can be helpful in daily practice. Chemotherapy-induced peripheral neuropathy is a common, potentially severe and dose-limiting adverse
Electrochemical skin conductance
Electrochemical_skin_conductance
Dermal sensation with no physical cause
neurological disorder. Neuropathy is also a side effect of some chemotherapies, such as in the case of chemotherapy-induced peripheral neuropathy. Chronic paresthesia
Paresthesia
Cancer of plasma cells
myelosuppression, and thalidomide causes more sedation. Chemotherapy-induced peripheral neuropathy and thrombocytopenia are major side effects of bortezomib
Multiple_myeloma
Chemical compound; chemotherapy medication
vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. Vincristine-induced neuropathy is the main dose-limiting
Vincristine
Pain affecting the somatosensory nervous system
peripheral nerves (e.g., compression by a tumor). It is also common as an adverse effect of chemotherapy (chemotherapy-induced peripheral neuropathy)
Neuropathic_pain
Microtubules in nervous tissue neurons
supporting the 13 protofilament structure of neurotubule. Chemotherapy-induced peripheral neuropathy is a pathological change in neurons caused by the disruption
Neurotubule
Chemical compound
stroke, optic nerve injury, intracerebral hemorrhage, and chemotherapy-induced peripheral neuropathy. Chaubey, Kalyani; et al. (2025). "Pharmacologic reversal
P7C3-A20
Type of pain relief therapy
there is tentative evidence that it may be effective for chemotherapy-induced peripheral neuropathy. There is preliminary evidence that is effective for chronic
Scrambler_therapy
Unpleasant, abnormal sense of touch
gangliosidosis may also present as burning dysesthesia. Chemotherapy-induced peripheral neuropathy is a progressive, enduring and often irreversible tingling
Dysesthesia
Form of L-carnitine
caused a pain reduction after 6 to 12 months of treatment. Chemotherapy-induced peripheral neuropathy (CIPN): A review of two studies concluded that ALC may
Acetylcarnitine
Pharmaceutical drug
has a number of side effects that can limit its use: Chemotherapy-induced peripheral neuropathy (a progressive, enduring and often irreversible tingling
Vinorelbine
Medical condition
Patients with cancer may develop gastroparesis because of chemotherapy-induced peripheral neuropathy, immunosuppression followed by viral infections involving
Gastroparesis
Medical condition
peripheral body, is diseased or damaged. Peripheral neuropathy is a general term that indicates any disorder of the peripheral nervous system. The name of the
Peripheral_mononeuropathy
Injection into the cerebrospinal fluid
models include chronic post-ischemia pain (CPIP) and paclitaxel-induced peripheral neuropathy. Additionally, the peptide was injected using three routes of
Intracerebroventricular injection
Intracerebroventricular_injection
Chemotherapy regimen used to treat Hodgkin lymphoma
round of ABVD to screen for patients who may be allergic. Chemotherapy-induced peripheral neuropathy, a progressive and enduring tingling numbness, intense
ABVD
Antibiotic medication
Long-term use of linezolid has also been associated with chemotherapy-induced peripheral neuropathy, a progressive and enduring often irreversible tingling
Linezolid
disorders A neuropathy affects the peripheral nerves. Guillain–Barré syndrome Charcot–Marie–Tooth disease Chemotherapy-induced peripheral neuropathy Median
List of neuromuscular disorders
List_of_neuromuscular_disorders
Chemotherapeutic agents used to treat cancer
side effects which include neurotoxicity, which is manifested by peripheral neuropathies including polyneuropathy. As studied mainly on cisplatin, but presumably
Platinum-based_antineoplastic
Type of nerve damage
Radiation-induced lumbar plexopathy (RILP) or radiation-induced lumbosacral plexopathy (RILSP) is nerve damage in the pelvis and lower spine area caused
Radiation-induced lumbar plexopathy
Radiation-induced_lumbar_plexopathy
T cell that kills infected, damaged or cancerous cells
develop diabetes. CD8+ T cells may be necessary to resolve chemotherapy-induced peripheral neuropathy (CIPN). Mice without CD8+ T cells show prolonged CIPN
Cytotoxic_T_cell
Chemotherapy medication used for several cancer types
cheeses; this appears to be rare. Procarbazine rarely causes chemotherapy-induced peripheral neuropathy, a progressive, enduring, often irreversible tingling
Procarbazine
Autoimmune disease affecting the peripheral nervous system
of neuropathy (e.g., hereditary, vasculitic) cannot be excluded, or when profound axonal involvement is observed on EMG. Ultrasound of the peripheral nerves
Chronic inflammatory demyelinating polyneuropathy
Chronic_inflammatory_demyelinating_polyneuropathy
Neuromuscular disease
as hereditary motor and sensory neuropathy (HMSN), is an inherited neurological disorder that affects the peripheral nerves responsible for transmitting
Charcot–Marie–Tooth_disease
American biopharmaceutical company
Pennsylvania Biotechnology Center of Bucks County to treat Chemotherapy-induced peripheral neuropathy, Hepatic encephalopathy, Parkinson's disease, Mild Traumatic
Neuropathix
Types of pain associated with cancer
myelopathy, bone necrosis, neuropathy or plexopathy; chemotherapy, often associated with chemotherapy induced peripheral neuropathy, mucositis, joint pain
Cancer_pain
Pharmaceutical compound
Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy". The Journal of Pain. 25 (7): 104470. doi:10.1016/j.jpain.2024
ART26.12
Pharmaceutical drug
treatment can potentially include: Neurotoxicity leading to chemotherapy-induced peripheral neuropathy, a progressive, enduring and often irreversible tingling
Oxaliplatin
Medical treatment in addition to a primary treatment to maximise effectiveness
such as chemotherapy-induced peripheral neuropathy, leukoencephalopathy, bladder damage, constipation or diarrhea, hemorrhage, or post-chemotherapy cognitive
Adjuvant_therapy
Pharmaceutical drug
adverse reactions (≥20%), regardless of causality, were chemotherapy-induced peripheral neuropathy (a progressive, enduring and often irreversible tingling
Brentuximab_vedotin
Pharmaceutical and medical company
Pennsylvania Biotechnology Center of Bucks County to treat Chemotherapy-induced peripheral neuropathy, Hepatic encephalopathy, Parkinson's disease, Mild Traumatic
KannaLife
Cancer Pain 101
Chemotherapy-induced peripheral neuropathy Between 30 and 40 percent of patients undergoing chemotherapy experience chemotherapy-induced peripheral neuropathy (CIPN):
Causes_of_cancer_pain
metoclopramide, and cyclizine. Vincristine sometimes causes chemotherapy-induced peripheral neuropathy, a progressive and persistent condition involving tingling
Hyper-CVAD
Type of spreading cancer
progression. Taxanes are associated with increased risk of chemotherapy-induced peripheral neuropathy, myelosuppression, and hypersensitivity reaction. They
Metastatic_breast_cancer
Antibiotic for treatment of tuberculosis
to minimize the risk of peripheral nerve damage. Vitamin B6 is used to prevent isoniazid-induced B6 deficiency and neuropathy in people with a risk factor
Isoniazid
Cell division inhibitor
marine-derived candidate for treating certain cancers. chemotherapy-induced peripheral neuropathy, a progressive, enduring, often irreversible tingling
Mitotic_inhibitor
Pharmaceutical compound
has also been found to reverse cognitive impairment induced by cisplatin, also known as chemotherapy cognitive impairment, in rodents. The pharmacokinetics
Ricolinostat
"Effect of TRO19622 in the Treatment of Patients With Chemotherapy Induced Peripheral Neuropathy". ClinicalTrials.gov. 5 February 2010. Retrieved 3 October
Trophos
Medical condition
J. Grierson. Erythromelalgia Small fiber peripheral neuropathy Tarsal tunnel syndrome Chemotherapy-induced acral erythema Hennekam, RC; van Noort, G;
Burning_feet_syndrome
Antibacterial drug
Chemotherapy. 70 (9): 2456–2464. doi:10.1093/jac/dkv147. PMID 26066581. Williams EM, Triller DM (May 2006). "Recurrent acute nitrofurantoin-induced pulmonary
Nitrofurantoin
Blood cancer characterized by overproduction of lymphoblasts
typically treated initially with chemotherapy aimed at bringing about remission. This is then followed by further chemotherapy, typically over some years.
Acute_lymphoblastic_leukemia
– Chemosensitizer – Chemotherapeutic agent – Chemotherapy – Chemotherapy-induced peripheral neuropathy – Chest X-ray – Chiasma (genetics) – Child-life
Index_of_oncology_articles
Traditional East Asian herbal medicine
"Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice". European Journal of Pain. 13 (1): 22–27. doi:10
Shakuyaku-kanzo-to
polyneuropathy Chronic post radiotherapy pain Chronic painful radiation-induced neuropathy Chronic postcancer surgery pain Chronic postsurgical or posttraumatic
List of chronic pain syndromes
List_of_chronic_pain_syndromes
American biologist and academic (born 1952)
patients with polycystic kidney disease or leading to drug-induced peripheral neuropathy. The Ehrlich team hypothesizes that these abnormalities in function
Barbara_E._Ehrlich
Chemotherapy regimen
treatment completion. However some patients report debilitating peripheral neuropathy that lasts for years. Feelings of nausea occur among approximately
FOLFOX
Fluoroquinolone antibiotic
higher doses. Like other fluoroquinolones, it is also known to cause peripheral neuropathy that may be irreversible, such as weakness, burning pain, tingling
Ciprofloxacin
American-Greek film producer and designer
neurodegenerative diseases, including Parkinson's disease, CTE and Chemotherapy-induced peripheral neuropathy. In 2014, he appeared on Bloomberg TV's Taking Stock with
Thoma_Kikis
Protein that stimulates red blood cell production
are used in treating anemia resulting from chronic kidney disease, chemotherapy induced anemia in patients with cancer, inflammatory bowel disease (Crohn's
Erythropoietin
Chemical compound
is associated with peripheral neuropathy in 30% of people resulting in pain. This can be worse in people with pre-existing neuropathy. In addition, myelosuppression
Bortezomib
Distortion of the sense of taste
the only symptoms. A major cause of dysgeusia is chemotherapy for cancer. Chemotherapy often induces damage to the oral cavity, resulting in oral mucositis
Dysgeusia
American breast oncologist
survivorship care, prevention of chemotherapy-induced peripheral neuropathy, and early detection of chemotherapy induced cardiotoxicity in breast cancer
Maryam_Lustberg
Chemotherapy medication
(DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast
Docetaxel
Pharmaceutical drug
chemotherapy with vincristine, saying that "repurposing anakinra may be an effective co-treatment strategy to prevent vincristine-induced peripheral neuropathy"
Anakinra
Therapy using ionizing radiation, usually to treat cancer
the irradiated zone, late effect neuropathy may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS). In the CNS for
Radiation_therapy
Class of drugs used to treat malignant tumors
system toxicity. Neurotoxicity: Vincristine is most likely to cause peripheral neuropathy. Cisplatin, methotrexate, and 5-fluorouracil may occasionally cause
Antineoplastic
Tricyclic antidepressant
patients. It is recommended only as a second-line therapy for non-chemotherapy-induced neuropathic or mixed neuropathic pain if opioids did not provide
Amitriptyline
Autonomic nervous system control of sweat gland activity
non-invasive and quantitative assessment of small fiber neuropathy in patients receiving chemotherapy". Journal of Neuro-Oncology. 127 (2): 373–380. doi:10
Sudomotor
Disease treatment
period, Isoniazid is taken alongside pyridoxal phosphate to obviate peripheral neuropathy. Isoniazid is then taken concurrently with rifampicin for the remaining
Management_of_tuberculosis
Chemical compound (chemotherapy medication)
ocular toxicity, pulmonary toxicity, severe GI ulceration and peripheral neuropathy (rare).[citation needed] To prevent the side effects and improve
Cytarabine
Japanese pharmaceutical company
(lecanemab) - Alzheimer's disease Methylcobal (methylcobalamin) - Peripheral neuropathy Myonal (eperisone) - Muscle relaxant Selbex (teprenone) - Gastric
Eisai_(company)
Medical intervention
intravenously, with a dose limiting toxicity of peripheral neuropathy. Peripheral sensory neuropathy presents with numbness and tingling in a stocking-and-glove
Treatment_of_lung_cancer
Class of antibacterial drugs, subgroup of quinolones
updates to the labels to describe the potential for irreversible peripheral neuropathy (serious nerve damage).[citation needed] In November 2015, an FDA
Quinolone_antibiotic
Chemical compound
that telbivudine put patients at greater risk for myopathy and peripheral neuropathy than the comparator drug lamivudine. FDA required a required a risk
Telbivudine
Medical condition
failure and peripheral neuropathy or autonomic neuropathy. Whereas wild-type transthyretin amyloidosis usually causes heart failure, with neuropathy being more
Cardiac_amyloidosis
Medical effects of tumors besides mass effect
scientists have found that paraneoplastic peripheral nerve disorders (autoantibodies linked to multifocal motor neuropathy) may provide important clinical manifestations
Paraneoplastic_syndrome
Abnormal formation of clumps of inflammatory cells (granulomata)
hypothalamic and pituitary abnormalities, chronic meningitis, and peripheral neuropathy. Myelopathy, that is spinal cord involvement, occurs in about 16–43%
Sarcoidosis
Chemical compound, antibiotic
reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Tendon problems may manifest long after therapy had been completed
Norfloxacin
Abnormal intolerance to visual perception of light
needed] Ankylosing spondylitis Albinism Ariboflavinosis Benzodiazepines Chemotherapy Chikungunya Cystinosis Drug withdrawal Ehlers–Danlos syndrome Infectious
Photophobia
Protein-coding gene in the species Homo sapiens
of traumatic brain injury, chemotherapy-induced neuropathy, diabetic neuropathy, degenerative eye conditions, drug-induced Schwann cell death, Charcot-Marie-Tooth
SARM1
Type of blood cancer
weight loss, and chronic oozing of blood from the nose and gums. Peripheral neuropathy occurs in 10% of patients. Enlargement of the lymph nodes, spleen
Waldenström_macroglobulinemia
Medications to reversibly block pain
anesthetic nerve block), paralysis (loss of muscle function) also can be induced. LAs are of 2 types: Clinical LAs: amino amide LAs amino ester LAs Synthetic
Local_anesthetic
2014. "Pralatrexate", LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Bethesda (MD): National Institute of Diabetes and Digestive
List_of_antineoplastic_agents
Cancer arises in the head or neck region
include difficulty sleeping, tiredness, depression, and nerve damage (peripheral neuropathy). Gastrointestinal symptoms are typically nausea and vomiting. Symptoms
Head_and_neck_cancer
American football player and coach (born 1983)
mini-camp, but struggled with peripheral neuropathy in his feet, a result of his chemotherapy. The chemotherapy-induced neuropathy caused numbness that kept
Kenechi_Udeze
Medical condition
Wernicke–Korsakoff syndrome also have peripheral neuropathy, and many people who consume excess alcohol have this neuropathy without other neurologic signs or
Wernicke_encephalopathy
Cancer that originates in mammary glands
people treated. Taxanes cause peripheral neuropathy, which is permanent in up to 5% of those treated. The same chemotherapy agents can be given before surgery
Breast_cancer
Chemotherapy-induced acral erythema (palmoplantar erythrodysesthesia syndrome) Chemotherapy-induced hyperpigmentation Drug-induced acne Drug-induced angioedema
List_of_skin_conditions
Protein-coding gene in the species Homo sapiens
phenotype that involves the central and peripheral nervous system. The impairment of the former is rarer while neuropathy forms are more frequent and severe
MFN2
Hormone and medication
Low or absent concentrations of adrenaline can be seen in autonomic neuropathy or following adrenalectomy. Failure of the adrenal cortex, as with Addison's
Adrenaline
Chemical compound
(TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy". The Journal of Pharmacology and Experimental Therapeutics
Olesoxime
Spectrum of blood disorders
hyperviscosity of blood, lymphadenopathy, hepatomegaly, splenomegaly, peripheral neuropathy, cryoglobulinemia, or constitutional symptoms. There may be a modest
Plasma_cell_dyscrasias
Medication used for cancer
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer,
Paclitaxel
Antibiotic
occur as a result of moxifloxacin therapy include irreversible peripheral neuropathy, spontaneous tendon rupture and tendonitis, hepatitis, psychiatric
Moxifloxacin
Side effects on the lungs
toxicity of chemotherapy. Semin Oncol. 2006 Feb;33(1):98-105. Review. Abid SH, Malhotra V, Perry MC. Radiation-induced and chemotherapy-induced pulmonary
Pulmonary_toxicity
Male reproductive organ cancer
prostate cancer, is treated with continued hormone therapy alongside the chemotherapy drug docetaxel. Some tumors metastasize (spread) to other areas of the
Prostate_cancer
Clumping of abnormal cold-sensitive proteins in blood
tissues can cause symptoms of confusion, headache, hearing loss, and peripheral neuropathy. Interruption of blood flow to other tissues in type I disease can
Cryoglobulinemia
Antibiotic to treat bacterial infections
prescribing information contains a warning regarding uncommon cases of peripheral neuropathy, which can be permanent. Other nervous system effects include insomnia
Ofloxacin
Type of inflammatory bowel disease
these are seizures, stroke, myopathy, peripheral neuropathy, headache, and depression. Central and peripheral neurological disorders are described in
Crohn's_disease
Cancer treatment medicine
Anorexia (weight loss) Hypocalcaemia Hypokalaemia Depression Peripheral sensory neuropathy Tinnitus Congestive heart failure Myocardial infarction Myocardial
Sorafenib
Antibiotic medication
headache, and rash (which are common), and insomnia, psychosis, and peripheral neuropathy. Effects on the lung occur rarely and may be serious, though are
Dapsone
Artificial stimulation of the immune system to treat cancer
common side effects when used with other cancer medicines include peripheral neuropathy (nerve damage in the hands and feet), nausea, anemia (low red blood
Cancer_immunotherapy
Protein-coding gene in the species Homo sapiens
(October 1996). "Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24". Nature Genetics. 14 (2): 214–217. doi:10.1038/ng1096-214
NDRG1
Most common soft-tissue cancer in children
received the high dose chemotherapy had experienced an increase in adverse events such as myelosuppression, peripheral neuropathy and later required a dose
Embryonal_rhabdomyosarcoma
American biologist
disturb the NAD system including cancer diabetic and chemotherapeutic peripheral neuropathy, heart failure, central brain injury, inflammation, mitochondrial
Charles_Brenner_(biochemist)
Medical subspecialty
injection of chemotherapy and embolic agents into the arterial blood supply of a tumor, with the goal of both local administration of chemotherapy, slowing
Interventional_radiology
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CHEMOTHERAPY INDUCED-PERIPHERAL-NEUROPATHY
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