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OLESOXIME

  • Olesoxime

    • Chemical compound

    Olesoxime (TRO19622) is an experimental drug formerly under development by the now-defunct French company Trophos as a treatment for a range of neuromuscular

    Olesoxime

    Olesoxime

    Olesoxime

  • Trophos

    • entrepreneurs: Antoine Beret and Michel Delaage. Trophos' lead compound was olesoxime (TRO19622), a mitochondrial targeted compound developed to treat neurodegenerative

    Trophos

    Trophos

  • Diazepam

    • Benzodiazepine sedative

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Diazepam

    Diazepam

    Diazepam

  • Roche

    • Swiss multinational healthcare company

    deal will centre on the Phase II and III spinal muscular atrophy drug olesoxime (TRO19622). In April 2015, Roche acquired CAPP Medical, and its chief

    Roche

    Roche

    Roche

  • Diazepam binding inhibitor

    • Protein-coding gene in the species Homo sapiens

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Diazepam binding inhibitor

    Diazepam binding inhibitor

    Diazepam_binding_inhibitor

  • Spinal muscular atrophy

    • Rare congenital neuromuscular disorder

    enabling the survival of motor neurons even with low levels of SMN protein. Olesoxime was a proprietary neuroprotective compound developed by the French company

    Spinal muscular atrophy

    Spinal muscular atrophy

    Spinal_muscular_atrophy

  • Translocator protein

    • Human protein

    DPA-713 DPA-714 Emapunil Etifoxine Gidazepam FGIN-127 FGIN-143 GML-1 Olesoxime (TRO19622) SSR-180,575 PK-11195 - potent and selective antagonist for

    Translocator protein

    Translocator protein

    Translocator_protein

  • Etifoxine

    • Anxiolytic medication

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Etifoxine

    Etifoxine

    Etifoxine

  • Emapunil

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Emapunil

    Emapunil

    Emapunil

  • Dithranol

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Dithranol

    Dithranol

    Dithranol

  • DPA-713

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    DPA-713

    DPA-713

    DPA-713

  • DPA-714

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    DPA-714

    DPA-714

    DPA-714

  • Deuterated etifoxine

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Deuterated etifoxine

    Deuterated_etifoxine

  • GML-1

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    GML-1

    GML-1

    GML-1

  • Ro5-4864

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Ro5-4864

    Ro5-4864

    Ro5-4864

  • VDAC1

    • Protein-coding gene in the species Homo sapiens

    models of Huntington's disease, treatment with the VDAC-targeting compound olesoxime improved disease-associated phenotypes, possibly by modulating calcium

    VDAC1

    VDAC1

    VDAC1

  • PK 11195

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    PK 11195

    PK 11195

    PK_11195

  • DAA-1097

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    DAA-1097

    DAA-1097

    DAA-1097

  • DAA-1106

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    DAA-1106

    DAA-1106

    DAA-1106

  • Amyotrophic lateral sclerosis research

    • Medical research on ALS

    mitochondria function (creatine, acetyl-L-carnitine, dexpramipexole, and olesoxime). Other drugs with a variety of mechanisms were tested in clinical trials

    Amyotrophic lateral sclerosis research

    Amyotrophic_lateral_sclerosis_research

  • Alpidem

    • Anxiolytic medication

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    Alpidem

    Alpidem

    Alpidem

  • W-18 (drug)

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    W-18 (drug)

    W-18 (drug)

    W-18_(drug)

  • SSR-180,575

    • Chemical compound

    binding inhibitor (DBI) DPA-713 DPA-714 Emapunil Etifoxine FGIN-1-27 FGIN-1-43 GML-1 Olesoxime Ro5-4864 SSR-180,575 W-18 YL-IPA08 Antagonists PK-11195

    SSR-180,575

    SSR-180,575

    SSR-180,575

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