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Chemical compound
Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge)
Bradykinin
Disease characterized by rapid swelling
minutes to hours. The underlying mechanism typically involves histamine or bradykinin. The version related to histamine is due to an allergic reaction to agents
Angioedema
Protein found in humans
Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans. The B2 receptor (B2R) is a G protein-coupled
Bradykinin_receptor_B2
Class of medications used primarily to treat high blood pressure
enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin which would normally be degraded. Bradykinin produces prostaglandin
ACE_inhibitor
Group of G-protein coupled receptors
The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin. There are two Bradykinin receptors:
Bradykinin_receptor
Protein-coding gene in the species Homo sapiens
Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide
Bradykinin_receptor_B1
Mammalian protein found in humans
cardiovascular diseases. Other lesser known functions of ACE are degradation of bradykinin, substance P and amyloid beta-protein. ACE hydrolyzes peptides by the
Angiotensin-converting_enzyme
Pharmaceutical compound
treatment of hereditary angioedema (HAE). It is a bradykinin receptor B2 antagonist which blocks bradykinin-driven swelling attacks which is a characteristic
Deucrictibant
Activation of coagulation cascade
HK to form cHK, releasing a peptide known as bradykinin (BK). BK and its derivatives bind to bradykinin receptors B1 and B2 to mediate inflammation. Artificial
Contact_activation_system
Disorder resulting in severe swelling
(type 2), this leads to bradykinin disinhibition and bradykinin mediated activation of bradykinin B1 receptor and bradykinin B2 receptor on endothelial
Hereditary_angioedema
Pharmaceutical drug
activation of bradykinin B2 receptors. Icatibant acts as a bradykinin inhibitor by blocking the binding of native bradykinin to the bradykinin B2 receptor
Icatibant
Hormone system
blood pressure control, coagulation and pain. Its important mediators bradykinin and kallidin are vasodilators and act on many cell types. Clinical symptoms
Kinin–kallikrein_system
Bodily fluid secreted by salivary glands
that proteolytically cleaves high-molecular-weight kininogen to produce bradykinin; it is secreted by the acinar cells of all three major salivary glands
Saliva
Chemical compound
angiotensin II and may potentiate some of the pharmacological actions of bradykinin. It has been investigated as an antihypertension agent. The antihypertensive
Teprotide
Chemical compound
XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule. In the early 1940s, researcher Eugen Werle worked extensively
Kallidin
bradykinin produced through factor XII activation by negatively charged surfaces such as filters. When mechanisms for the degradation of bradykinin are
Hypotensive transfusion reaction
Hypotensive_transfusion_reaction
Protein-coding gene in the species Homo sapiens
protein → bradykinin peptide (9 amino acids) HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide
Kininogen_1
Genus of snakes
release substances such as bradykinin and kallikrein inducing hypotension. Bradykinin-enhancing peptides interfere with the bradykinin metabolism causing it
Lachesis_(genus)
COX-2 selective NSAID medication
selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors. It was approved for use in Japan
Zaltoprofen
Brazilian physician and pharmacologist (1934–2016)
Brazilian physician and pharmacologist noted for the discovery of the bradykinin potentiating factor, which led to new and widely used anti-hypertension
Sérgio_Henrique_Ferreira
Chemical compound
use in heart failure on July 7, 2015. Sacubitril increases levels of bradykinin, which is responsible for the edema seen sometimes in patients with the
Sacubitril
Species of amphibian
skin secretion have established the presence of canonical bradykinin and multiple bradykinin-related peptides. Due to its poison, most mammals, birds,
Pickerel_frog
Group of peptides
A kinin is any of various structurally related peptides, such as bradykinin and kallidin. They are members of the autacoid family. Kinins are peptides
Kinin
Brazilian physician, biomedical scientist and pharmacologist. He discovered bradykinin, an endogenous polypeptide involved in the physiology, pharmacology and
Maurício_Rocha_e_Silva
Class of proteins
and is produced mostly by the liver. It is also a precursor protein for bradykinin. Low-molecular-weight-kininogen (LK) is mainly a precursor protein for
Kininogen
Chemical compound
Safotibant (INN) also known by the research code LF22-0542 is a non-peptide bradykinin B1 antagonist. It displayed binding Ki values of 0.35 and 6.5 nM at cloned
Safotibant
Brazilian scientist
Hungarian-Brazilian physician and biomedical scientist, one of the co-discoverers of bradykinin, together with Maurício Rocha e Silva and Wilson Teixeira Beraldo, in
Gastão_Rosenfeld
initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the kallikrein-kinin system. HMWK is inactive until it either adheres
High-molecular-weight kininogen
High-molecular-weight_kininogen
Semipermeable capillary interface between blood and the brain
means, or biochemically by the use of vasoactive substances, such as bradykinin, or even by localized exposure to high-intensity focused ultrasound (HIFU)
Blood–brain_barrier
Anabolic steroid
lipoxygenases (LOX) (also known as: EC 1.13.11.34, EC 1.13.11.33, etc.). The bradykinin peptide is well known to promote a cough reaction associated with ACE
Trenbolone
Class of opioid peptides
dynorphin A activates bradykinin receptors and thus stimulates pain response. According to this mechanism, dynorphin activates bradykinin receptors, which
Dynorphin
Medication
production of bradykinin. The inhibition of FXIIa therefore prevents the activation of prekallikrein into kallikrein and the generation of bradykinin, which
Garadacimab
Class of enzymes
zinc-activated enzyme found in plasma. It inactivates proteins such as bradykinin and anaphylatoxins in the blood in order to prevent toxic buildup. Lysine
Lysine_carboxypeptidase
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
g., light and olfactory stimulatory molecules); adenosine, bombesin, bradykinin, endothelin, γ-aminobutyric acid (GABA), hepatocyte growth factor (HGF)
G_protein-coupled_receptor
Antihypertensive drug of the ACE inhibitor class
angiotensin II and the inactivation of bradykinin were thought to be mediated by the same enzyme. In 1970, using bradykinin potentiating factor (BPF) provided
Captopril
Spice extracted from Vanilla orchids
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Vanilla
Species of flowering plant
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Stevia_rebaudiana
Widening of blood vessels
by local paracrine agents from endothelial cells (e.g., nitric oxide, bradykinin, potassium ions, and adenosine), and by the autonomic nervous system and
Vasodilation
Chemical compound
inhibiting plasma kallikrein, sebetralstat reduces the production of bradykinin, thereby halting the progression of hereditary angioedema attacks. It
Sebetralstat
Chemical compound
synthase) and lipoxygenase (LOX) (EC 1.13.11.34, EC 1.13.11.33, etc.). The bradykinin peptide is well known to promote a cough reaction associated with ACE
Trenbolone_acetate
Red, circular lesions of the skin on the limbs or trunk
such as urticaria and systemic lupus erythematosus. An association with bradykinin has been proposed in the case of hereditary angioedema. Since the margin
Erythema_marginatum
Enlargement of the heart
ACE is also the enzyme that degrades bradykinin, ACE inhibitors increase circulating and tissue levels of bradykinin (Fig. 8.4). "Management of Hypertension
Cardiomegaly
molecule substrates, acting to highly selectively release kallidin (lysyl-bradykinin, a bioactive kinin) from kininogen (a kinin protein precursor). Fiedler
Renal_tissue_kallikrein
Brand name of an aerosol self-defense spray
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Mace_(spray)
Spice from Cinnamomum trees
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Cinnamon
Chemical compound
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Allicin
Overreaction of the immune system to an antigen
common pathomechanisms, distinct ones are also possible (for example, bradykinin contributes to anaphylaxis and angioedema, but is not prominent as a general
Hypersensitivity
Topics referred to by the same term
subgroup of the Anatomical Therapeutic Chemical Classification System Bradykinin receptor B2, a human gene Proanthocyanidin B2, a B type proanthocyanidin
B2
ACE inhibitor medication
lowering the production of angiotensin II and decreasing the breakdown of bradykinin. The decrease in angiotensin II results in relaxation of arteriole smooth
Ramipril
Antihistamine medication
2013. Brunton L, Chabner B, Knollmann B (2011). "Chapter 32. Histamine, Bradykinin, and Their Antagonists". In Brunton L (ed.). Goodman & Gilman's The Pharmacological
Diphenhydramine
Physical effects resulting from activation of the immune system
Celsus (c. 30 BC–38 AD). Pain is due to the release of chemicals such as bradykinin and histamine that stimulate nerve endings. Heat and redness are due to
Inflammation
Cell surface receptors
Parthenolide Syringing Taxifoliol Antagonists Peptide ADP-400 Agonists Bradykinin Kallidin Antagonists FR-173657 Icatibant LF22-0542 Agonists Amylin CGRP
Signaling_peptide_receptor
Species of plant used as a spice
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Ginger
Mammalian protein found in Homo sapiens
early endosome plasma membrane Biological process endothelin maturation bradykinin catabolic process regulation of systemic arterial blood pressure by endothelin
Endothelin converting enzyme 1
Endothelin_converting_enzyme_1
Medical condition
1%. The reason this adverse effect may occur is due to the build-up of bradykinin, a vasodilator. This causes blood vessels to dilate and allows for fluid
Drug-induced_angioedema
Accumulation of molecules in tumor tissue
extravasation of macromolecules in solid tumor tissues. For instance, bradykinin, nitric oxide / peroxynitrite, prostaglandins, vascular permeability factor
Enhanced permeability and retention effect
Enhanced_permeability_and_retention_effect
Postural hypotension due to taking an alpha blocker drug
better known side effect of dry cough (due to decreased breakdown of bradykinin), though there is no clear relationship between the two side effects.
First-dose_phenomenon
Chemical compound
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Eugenol
Species of plant cultivated for use as spice
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Long_pepper
Plant species in the mint family
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Monarda_fistulosa
Chemical compound
noscapine prevented the progression of bradykinin-induced inflammation in the rat's foot by antagonising bradykinin receptors. In addition, Zughaier et al
Noscapine
Plant used as spice
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Turmeric
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
Sphingosine-1-phosphate receptor
Sphingosine-1-phosphate_receptor
Species of reptile
extracellular matrix leading to blisters and platelet function impairment, bradykinin-potentiating peptides with hypotension, enzymes that degrade fibrinogen
Bothriechis_schlegelii
Species of tree
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Camphora_officinarum
InterPro Family
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
Vasoactive intestinal peptide receptor
Vasoactive_intestinal_peptide_receptor
Antihypertensive drug of the ACE inhibitor class
a combination of angiotensin II inhibition and bradykinin proliferation. Increased levels of bradykinin stimulate in the production of prostaglandin E2
Moexipril
Capital city of Minas Gerais, Brazil
Teixeira Beraldo (1917–1998), physician and physiologist, discoverer of bradykinin Joana Fomm Cristiano da Matta (born 1973), former racing driver and 2002
Belo_Horizonte
American neurosurgeon
aspects of his medical research, including his discovery that the peptide bradykinin can be effective in opening the blood–brain barrier. In 2009 Black published
Keith_Black_(surgeon)
Spice made from flower buds
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Clove
Topics referred to by the same term
Bronchopleural fistula, a disease of the lungs Bradykinin-potentiating factor, of the inflammatory mediator bradykinin British Pacific Fleet, a Royal Navy fleet
BPF
Chemical weapon
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Tear_gas
Topics referred to by the same term
program TU Delft Faculty of Architecture (Dutch: Faculteit Bouwkunde) Bradykinin, a peptide targeted by ACE inhibitors Bekasi Line, a light rapid transit
BK
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
Membrane glucocorticoid receptor
Membrane_glucocorticoid_receptor
Species of reptile endemic to the southeastern US
containing a large phosphodiesterase fraction. It stimulates the release of bradykinin that can result in severe pain, as well as profound, transient hypotension
Eastern diamondback rattlesnake
Eastern_diamondback_rattlesnake
Predatory order of arachnids
analgesic, anti-cancer, antibacterial, antifungal, antiviral, antiparasitic, bradykinin-potentiating, and immunosuppressive drugs. As of 2020, no scorpion toxin-based
Scorpion
Protein-coding gene in the species Homo sapiens
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
P2RY1
Primary organ of the respiratory system
substances, such as a few types of prostaglandins, leukotrienes, serotonin and bradykinin, are excreted through the lungs. Drugs and other substances can be absorbed
Lung
Culinary herb
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Basil
Monoterpenoid and alcohol that is the primary component of citronella oil
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Geraniol
Applied research centre in São paulo, Brazil since 1924
control of the coffee borer beetle in the 1920s in Brazil, the discovery of bradykinin, and the production of vaccines that combat the Newcastle disease, foot-and-mouth
Biological Institute (São Paulo)
Biological_Institute_(São_Paulo)
Protein-coding gene in the species Homo sapiens
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
TAAR9
Hyperirritable spots in skeletal muscle
contained inflammatory cytokines and CGRP. Concentrations of protons (H+), bradykinin, calcitonin gene-related peptide, substance P, tumor necrosis factor-β
Myofascial_trigger_point
Species of edible plant
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Wasabi
Chemical compound
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Vanillin
Compounds formed from phosphate monomeric units
initiates fibrin formation and the generation of a proinflammatory mediator, bradykinin, that contributes to leakage from the blood vessels and thrombosis. Bacterial-derived
Polyphosphate
Chemical stimulant produced by some plants
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Nicotine
Inflammation of the pancreas
inhibitors cause angioedema of the pancreas through the accumulation of bradykinin. Birth control pills and HRT cause arterial thrombosis of the pancreas
Pancreatitis
Ground fruit of the family Piperaceae
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Black_pepper
Genus of flowering plants
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Mentha
Protein-coding gene in humans
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
ADGRG4
Small arteries in the microcirculation
as angiotensin II (vasoconstrictive), endothelin (vasoconstrictive), bradykinin (vasodilation), atrial natriuretic peptide (vasodilation), and prostacyclin
Arteriole
Protein-coding gene in humans
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
CMKLR2
Chemical compound
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Shogaol
Protein-coding gene in the species Homo sapiens
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
S1PR5
Synthetic opioid pain medication
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Tramadol
Species of reptile
fibrinogen-clotting enzyme that can produce defibrination syndrome, and a bradykinin-releasing enzyme. CroFab antivenom, while not specific for C. horridus
Timber_rattlesnake
Protein-coding gene in the species Homo sapiens
Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Chemokine Cholecystokinin A B Endothelin A B Formyl
ADGRF2P
Medication used for cancer
isothiocyanate (mustard, radish, horseradish, wasabi) AM404 ASP-7663 Bradykinin Cannabichromene (cannabis) Cannabidiol (cannabis) Cannabigerol (cannabis)
Paclitaxel
Decrease in heart rate, breathing, and blood pressure due to chemical stimuli
by many biologically active chemicals, including nicotine, capsaicin, bradykinin, atrial natriuretic peptide, prostanoids, nitrovasodilators, angiotensin
Bezold–Jarisch_reflex
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