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Class of opioid peptides
release of big dynorphin, a 32-amino acid molecule consisting of both dynorphin A and dynorphin B. Dynorphin A, dynorphin B, and big dynorphin all contain
Dynorphin
Chemical compound
Dynorphin A is a dynorphin, an endogenous opioid peptide that activates the κ-opioid receptor. Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-
Dynorphin_A
Opioid peptide
Big dynorphin is an endogenous opioid peptide of the dynorphin family. It forms when a precursor protein prodynorphin is not fully processed, resulting
Big_dynorphin
Class of peptides that bind to opioid receptors
Comments: Dynorphin A and big dynorphin are the highest potency endogenous ligands ... Principal endogenous agonists (Human) [are] big dynorphin (PDYN, P01213)
Opioid_peptide
Protein-coding gene in the species Homo sapiens, named for ketazocine
and motor control. KOR is one of the two opioid receptors that bind dynorphin opioid peptides as the primary endogenous ligands, the other being newly
Κ-opioid_receptor
BW373U86 DPI-221 DPI-287 DPI-3290 SNC-80 AZD-2327 Structures Big dynorphin Dynorphin A Dynorphin B Leumorphin Structures Endomorphin-1 Endomorphin-2 α-Endorphin
List_of_opioids
Pentapeptide
of opioid peptides produced by the body: enkephalins, β-endorphin, and dynorphins. The met-enkephalin peptide sequence is coded for by the enkephalin gene;
Enkephalin
Chemical compound
Leumorphin, also known as dynorphin B1–29, is a naturally occurring endogenous opioid peptide. Derived as a proteolytic cleavage product of residues 226-254
Leumorphin
Class of opioid receptors found in humans
high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(mu)-opioid peptide (MOP) receptors. The
Mu-opioid_receptor
Chemical compound
Dynorphin B, also known as rimorphin, is a form of dynorphin and an endogenous opioid peptide with the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg
Dynorphin_B
Neurons in the hypothalamus central to hormonal control of reproduction
Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the hormonal control of reproduction
KNDy_neuron
Chemical compound
be implicated in pre-eclampsia during pregnancy. NKB, kisspeptin, and dynorphin together are found in the arcuate nucleus (ARC) known as the KNDy subpopulation
Neurokinin_B
Group of biological receptors
protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Even though at
Opioid_receptor
Species of plant
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Mitragyna_speciosa
Chemical compound
Zyklophin is a semisynthetic peptide derived from dynorphin A and a highly selective antagonist of the κ-opioid receptor (KOR). It is systemically-active
Zyklophin
Chemical substance with psychoactive properties
delta, and kappa (κ-opioid receptor). Endogenous opioids (enkephalins, dynorphin, endorphin) do not bind specifically to any particular opioid receptor
Narcotic
Atypical opioid drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
SR-17018
Impure form of heroin
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Black_tar_heroin
Medication
3403. PMID 9686407. Clark SD, Abi-Dargham A (October 2019). "The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia:
Naltrexone
Dried latex of the opium poppy containing narcotic compounds
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Opium
Opioid analgesic and recreational drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Heroin
Peptide hormone and neuropeptide
neurons make other peptides, including corticotropin-releasing hormone and dynorphin, for example, that act locally. The magnocellular neurons that make oxytocin
Oxytocin
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
MGM-15
Species of flowering plant in the poppy family
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Papaver_somniferum
Combination pain relief drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Hydrocodone/paracetamol
Chemical compound
Duman RS (September 2004). "Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects"
Norbinaltorphimine
Tincture of opium
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Laudanum
Combination drug formulation
high affinity and antagonizes the KOR. Through activation of the KOR, dynorphins, opioid peptides that are the endogenous ligands of the KOR and that can
Buprenorphine/samidorphan
Polypeptide hormone
gene map locus is 20pter-p12. Prodynorphin is a basic building-block of dynorphins, the chemical messengers in the brain that appear most heavily involved
Prodynorphin
Dissociative anesthetic and anti-depressant
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Ketamine
Opioid drug used in pain relief
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Hydrocodone
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Semax
Substance that causes depression
(e.g., substance P), glucocorticoids (e.g., cortisol, cortisone), and dynorphin. Anxiogenic Euphoriant Celano CM, Freudenreich O, Fernandez-Robles C,
Depressogen
Medication
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Extended-release_morphine
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
N-Phenethylnormorphine
Proposed compulsive sexual disorder
stress neurotransmitters, such as corticotropin-releasing factor and dynorphin, in the neurocircuitry of the extended amygdala. The craving and deficits
Sexual_addiction
Substance derived from opium
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Opiate
Medical condition
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Opioid_use_disorder
Chemical compound
that of EM-1 somewhat, because EM-2 additionally induces the release of dynorphin A and [Met]enkephalin in the spinal cord and brain by an unknown mechanism
Endomorphin-2
Class of opioid peptides
β-neoendorphin. Both are products of the dynorphin gene, which also expresses dynorphin A, dynorphin A1-8, and dynorphin B. These opioid neurotransmitters are
Neoendorphin
Opioid receptor antagonist
440–466. PMID 9686407. Clark SD, Abi-Dargham A (October 2019). "The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia:
Naloxone
Chemical compound
It also potentiates cognitive enhancement from memantine, decreases dynorphin release and inhibits GSK-B3. Nefiracetam Wishka DG, Walker DP, Yates KM
PHA-543,613
Semi-mythical remedy
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Mithridate
Atypical opioid analgesic compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
7-Hydroxymitragynine
Opioid analgesic compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Mitragynine
Drug mixture used mainly to treat ADHD and narcolepsy
Changes in striatal opioid peptides ↑dynorphin No change: enkephalin ↑dynorphin ↓enkephalin ↑dynorphin ↑dynorphin Mesocorticolimbic synaptic plasticity
Adderall
Pain medication of the opiate family
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Morphine
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Conolidine
Medicine used to reduce diarrhea
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Loperamide
Region of the basal forebrain
MSNs that express the D1 dopamine receptor (D1-type MSNs) and express dynorphin and substance P and those that express the D2 dopamine receptor (D2-type
Nucleus_accumbens
Opioid medication used for pain relief
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Hydromorphone
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Opioid_rotation
Investigational antidepressant compound
antagonist of the KOR, the biological target of the endogenous opioid peptide dynorphin. The medication has decent selectivity for the KOR over the μ-opioid receptor
Aticaprant
Cluster of nuclei in the brain stem
the NRM then bilaterally project efferents to the enkephalinergic and dynorphin-containing interneurons of the substantia gelatinosa of the posterior
Nucleus_raphe_magnus
Chemical compound
vasopressin in vivo. It also inhibits the degradation of met-enkephalin, dynorphin A, and other endogenous peptides. It contains the unusual amino acid Statine
Amastatin
Behavioral addiction characterized by compulsory indulgence over foods
Changes in striatal opioid peptides ↑dynorphin No change: enkephalin ↑dynorphin ↓enkephalin ↑dynorphin ↑dynorphin Mesocorticolimbic synaptic plasticity
Food_addiction
Brain region
include GABA, melanin-concentrating hormone, nociceptin, glucose, the dynorphin peptides, and the appetite-regulating peptide hormones leptin and ghrelin
Lateral_hypothalamus
Chemical compound
synthetic molecules. Endogenous opioids include endorphins, enkephalins, dynorphins, and endomorphins. Transcription and translation of opioid-encoding genes
Endomorphin
Neuropeptide chemical compound
Nociceptin is a peptide related to the kappa opioid receptor ligand dynorphin A, but it does not act at the classic opioid receptors (namely, mu, kappa
Nociceptin
Preparation of opiates
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Pantopon
Pharmaceutical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
GM-3009
Heroin-based recreational drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Cheese_(recreational_drug)
Synthetic opioid analgesic
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Carfentanil
Off-label, experimental use of the drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Low-dose_naltrexone
Pharmaceutical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
DPP-26
Opioid analgesic compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Mitragynine_pseudoindoxyl
Peptides released by neurons as intercellular messengers
several different peptides. For instance, vasopressin co-exists with dynorphin and galanin in magnocellular neurons of the supraoptic nucleus and paraventricular
Neuropeptide
Tropane alkaloid and stimulant drug
the AMPA receptor subunit GluR2 and downregulating the expression of dynorphin. Cocaine use has also been shown to increase DNA damage in the brains
Cocaine
Topics referred to by the same term
originally known as DynDNS), an Internet performance management company Dynorphin, a class of opioid peptides Nira Dyn, Israeli mathematician Dynamic apnea
Dyn
Pharmaceutical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
TRV250
Disorder resulting in compulsive behaviors
ΔFosB has been implicated in causing both increases and decreases in dynorphin expression in different studies; this table entry reflects only a decrease
Addiction
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Etomethazene
Investigational antidepressant compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Navacaprant
Opioid analgesic drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Diacetyldihydromorphine
Opioid analgesic and anesthetic veterinary drug
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Acetorphine
Opioid analgesic
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
3-Methylfentanyl
Protein
expression of AMPA receptor subunit GluR2 and also decreases expression of dynorphin, thereby enhancing sensitivity to reward. Viral overexpression of ΔFosB
FOSB
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Noroxymorphone
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Butonitazene
Opioid analgesic
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Α-Methylacetylfentanyl
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
N-Desethylprotonitazene
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine
Selank
Opiate and prodrug of morphine used to treat pain
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Codeine
Protein-coding gene in the species Homo sapiens
NOP's endogenous ligand nociceptin, which is structurally related to dynorphin A. In 1994, Mollereau et al. cloned a receptor that was highly homologous
Nociceptin_receptor
Active metabolite of codeine
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Codeine-6-glucuronide
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Cyproterone_acetate
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
IC-26
CNS stimulant and isomer of amphetamine
Changes in striatal opioid peptides ↑dynorphin No change: enkephalin ↑dynorphin ↓enkephalin ↑dynorphin ↑dynorphin Mesocorticolimbic synaptic plasticity
Dextroamphetamine
Group of subcortical nuclei involved in the motor and reward systems
and substantia nigra are primarily dopaminergic, although enkephalin, dynorphin and substance P are expressed. The striatum also contains interneurons
Basal_ganglia
Recreational drug beverage
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Lean_(drug)
Synthetic Opioid pain medication
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Tramadol
Pharmaceutical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Fluetonitazene
Semi-synthetic opioid
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Etorphine
Psychoactive chemical
peptides, produced naturally in the body, such as endorphins, enkephalins, dynorphins, and endomorphins. Endogenous opioids, non-peptide: Morphine, and some
Opioid
Form of behavioral dependence involving emotional symptoms
triggers changes in gene expression that affect proteins such as dynorphin; dynorphin peptides reduce dopamine release into the NAcc by temporarily inhibiting
Psychological_dependence
Peptide hormone in humans
leu-enkephalin are derived; and prodynorphin, which is the precursor of dynorphin and related peptides. Although they come from different precursors, opioid
Β-Endorphin
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Pholcodine
Opioid analgesic
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Valerylfentanyl
Chemical compound
Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine
Levophenacylmorphan
Chemical compound
are inhibited by opioid antagonists such as naloxone and naltrexone. Dynorphin may play a role in the inhibition of dopamine release via kappa opioid
Γ-Hydroxybutyric_acid
DYNORPHIN
DYNORPHIN
DYNORPHIN
DYNORPHIN
Female
German
Variant spelling of German Emmeline, EMMALINE means "work."
Girl/Female
Muslim
Light, Rose from heaven
Female
Native American
 Variant spelling of Native American Choctaw Tallula, TALULLAH means "leaping water." Compare with another form of Talullah.
Female
English
Feminine pet form of English unisex Lou, LOUELLA means "famous warrior."Â
Boy/Male
Tamil
Shivendra | ஷிவேநà¯à®¤à¯à®°
Lord Shiva and Lord Indra
Boy/Male
Hindu
Universe, Nature, World
Boy/Male
Greek American English
Crown; victorious.
Girl/Female
Tamil
Light
Male
Spanish
Spanish form of Middle Latin Venceslaus, VENCESLÃS means "more glory."Â
Boy/Male
Arabic, Gujarati, Hindu, Indian, Kannada, Muslim, Sindhi
Firm; Hard
DYNORPHIN
DYNORPHIN
DYNORPHIN
DYNORPHIN
DYNORPHIN