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In biochemistry, the preference of ligands to bind with one receptor over another
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. Binding selectivity describes how
Binding_selectivity
Topics referred to by the same term
Look up selectivity in Wiktionary, the free dictionary. Selectivity may refer to: Choice, making a selection among options Discrimination, the ability
Selectivity
Biochemical analysis procedure
estimate a specified model for the binding. Competition binding is used to determine the presence of selectivity for a particular ligand for receptor
Ligand_binding_assay
Substance that forms a complex with a biomolecule
advantages compared to their monovalent counterparts (such as tissue selectivity, increased binding affinity, and increased potency or efficacy), bivalents may
Ligand_(biochemistry)
Topics referred to by the same term
constant Binding domain Binding protein Binding selectivity Binding site BindingDB, an online database of measured binding affinities Binding potential
Binding
Pharmacologic characteristic
selectivity (or agonist trafficking, biased agonism, biased signaling, ligand bias, and differential engagement) is the ligand-dependent selectivity for
Functional_selectivity
Human glycoprotein that binds to androgens and estrogens
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. When produced by the
Sex_hormone–binding_globulin
Computational tools
two goals: efficiency and selectivity. Efficiency involves taking into account such factors as GC-content, efficiency of binding, complementarity, secondary
In_silico_PCR
Subdiscipline of chemistry concerned with chemical equilibrium
objective of these studies is often to find systems with a high binding selectivity of a host (receptor) for a particular target molecule or ion, the
Equilibrium_chemistry
Chaperone protein
and subtype selectivity Agents exist that have high σ1 affinity but either lack subtype selectivity or have high affinity at other binding sites, thus
Sigma-1_receptor
Set of laboratory techniques for separation of mixtures
hospitals. Affinity chromatography Aqueous normal-phase chromatography Binding selectivity Chiral analysis Chromatofocusing Chromatography in blood processing
Chromatography
Class of drug
Manning et al. presented two high-affinity MAT-ligands with good binding selectivity for SERT and DAT, namely the 4-indolyl and 1-naphthyl arylalkylamines
Serotonin–dopamine reuptake inhibitor
Serotonin–dopamine_reuptake_inhibitor
Chemical similar in structure to vitamin B12
behavior of Sinorhizobium meliloti largely correlates with the cofactor binding selectivity of its methylmalonyl-CoA mutase (MCM). Among adenyl-cobamides, paseudovitamin
Pseudovitamin_B12
Opioid analgesic of benzenoid class
such as desvenlafaxine and duloxetine. Tapentadol exhibits high binding selectivity and affinity for MOR, which is the principal target of the endogenous
Tapentadol
Drugs acting on the estrogen receptor
the binding cavity of ERβ is slightly narrower than that of ERα, however, this by itself leads to modest selectivity. To attain strong selectivity, the
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Selective relaxant binding agents (SRBAs) are a new class of drugs that selectively encapsulates and binds neuromuscular blocking agents (NMBAs). The
Selective relaxant binding agents
Selective_relaxant_binding_agents
Beta-1 selective adrenenergic blocker medication used to treat cardiovascular diseases
degree of β1-selectivity compared to atenolol, metoprolol and betaxolol. With a selectivity ranging from being 11 to 15 times more selective for β1 over
Bisoprolol
Class of drugs
conditions. Selectivity, or “binding selectivity”, describes how a ligand may bind more preferentially to one receptor than another. Selectivity can also
Adrenergic_neuron_blockers
Pharmaceutical compound
most tryptamines are highly non-selective in terms of binding to serotonin receptors, 1-propyl-5-MeO-AMT shows selectivity for the serotonin 5-HT2A receptor
1-Propyl-5-MeO-AMT
Prokaryotic potassium ion channel
channels was centered on the use of small toxin binding to reveal the location of the pore and selectivity filter among channel residues. MacKinnon's group
KcsA_potassium_channel
Unanswered question in the study of consciousness
(cognitive) binding problem is the problem of how objects, background, and abstract or emotional features are combined into a single experience. The binding problem
Binding_problem
Ability of a substance to resist changes in structure under high temperatures
evolution of a G protein-coupled receptor for expression, stability, and binding selectivity". Proceedings of the National Academy of Sciences of the United States
Thermostability
Chemical which binds to and activates a biochemical receptor
Terms that describe this phenomenon are "functional selectivity", "protean agonism", or selective receptor modulators. As mentioned above, agonists have
Agonist
Chemical compound
and 3.61 nM, respectively, demonstrating 9-fold binding selectivity and 11-fold functional selectivity for the ERβ over the ERα. An enantiomer of SERBA-2
SERBA-2
Protein molecule receiving signals for a cell
currents of different ions. This is accomplished with selectivity filters, such as the selectivity filter of the K+ ion channel Guyton, Arthur C.; Hall
Receptor_(biochemistry)
Ion channel that selectively passes K+
remove the hydration shell from the ion when it enters the selectivity filter. The selectivity filter is formed by a five residue sequence, TVGYG, termed
Potassium_channel
Chemical compound
5 μM, respectively. As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between
DCW234
Chemical compound
14-fold binding selectivity for the ERβ over the ERα (Ki = 0.19 nM versus 2.68 nM, respectively). However, it shows 32-fold functional selectivity for activation
Erteberel
Monoclonal antibody
IgG2 monoclonal antibody that inhibits interleukin-31 signaling by binding selectively to interleukin-31 receptor alpha. It is an interleukin-31 receptor
Nemolizumab
exhibits selectivity and high affinity for NET, and are therefore generally SNRIs, compounds having substituent in the 4'-position exhibits selectivity and
Development and discovery of SSRI drugs
Development_and_discovery_of_SSRI_drugs
Extremely small sensors
to their sensitivity, as well as their tunability and resulting binding selectivity, nanosensors are very effective and can be designed for a wide variety
Nanosensor
Drug discovery
RN: This group determines α- or β-receptor selectivity. The larger the substituent, the greater the selectivity for the β-receptor. If t-butyl is positioned
Discovery and development of beta2 agonists
Discovery_and_development_of_beta2_agonists
Class of proteins
Penicillin-binding proteins (PBP) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent
Penicillin-binding_proteins
Chemical compound
RTI-31 is a relatively balanced reuptake inhibitor wrt the D/N/S ratio. The binding ligand affinities for the different transporters is skewed somewhat in
RTI-31
Opioid analgesic
of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites". Life Sciences. 48 (23): PL111–PL116. doi:10
Ohmefentanyl
Half maximal inhibitory concentration
vivo. IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. pIC 50
IC50
Electrostatic phenomenon
strong affinity to the binding site. This conductivity-selectivity paradox has been explained as being a consequence of selective barrier-less conduction
Ionic_Coulomb_blockade
Chemical compound
Both compounds showed moderate binding selectivity against the 5-HT2BR and 5-HT2CR, and overall better selectivity profiles than those of classic psychedelic
(R)-70
Psychedelic drug
5-HT2A receptor, 100-fold selectivity for the serotonin 5-HT2A receptor over the serotonin 5-HT2C receptor, and 46-fold selectivity for the serotonin 5-HT2A
25CN-NBOH
Family of transport proteins
lacks the selectivity filter found in animal CNG channels as well as lacks a glycine-tyrosine-glycine-aspartate (GYGD) motif in the K+-selectivity filter
Cyclic nucleotide–gated ion channel
Cyclic_nucleotide–gated_ion_channel
Canadian geneticist
2014.05.004. PMC 4048464. PMID 24856970. Klose, Rob (2005). "DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG"
Rob_Klose
Protein
that occurs after transcription of mRNA, regulates neuroligins' binding selectivity for α- or β-neurexins as well as the function of synapses. Alternative
Neuroligin
Drug discovery
caused a loss of selectivity but not loss of the β-blockade itself. This illustrated the significance of para-substitution for β1 selectivity of β-blockers
Discovery and development of beta-blockers
Discovery_and_development_of_beta-blockers
Pharmaceutical compound
reported to be subtype-selective for 5-HT2AR, which are summarized in Table 3. [...] DOHx and DOBz also have high binding selectivity for 5-HT2AR against
2,5-Dimethoxy-4-hexylamphetamine
2,5-Dimethoxy-4-hexylamphetamine
Chemical compound
selectivity over 5-HT2B and 49-fold selectivity over 5-HT2C. It has a 5-HT2A Ki of 680 nM and an EC50 of 41 nM. (R)-69 is a biased agonist selective for
(R)-69
Drug affecting hormone receptors
relatively high binding affinity for glucocorticoid receptor compared to the progesterone receptor has sparked the demand for more selective progesterone
Selective progesterone receptor modulator
Selective_progesterone_receptor_modulator
Mammalian protein found in humans
are crucial for ligand binding and specificity. The CALCRL/RAMP complex presents a unique ligand-binding pocket, enabling selective recognition of peptide
CALCRL
ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig
PCP_site_2
German-Swiss biochemist and protein engineer
evolution of a G protein-coupled receptor for expression, stability, and binding selectivity". Proc. Natl. Acad. Sci. U. S. A. 105: 14808–14813. Schöppe, J.;
Andreas_Plückthun
Class of pharmacological agents
that affect the selectivity of the agonist. Visual inspection of selective β3-AR agonists revealed that they bind deep in the binding pocket of the receptors
Beta3-adrenergic_agonist
Chemical compound
for the ERβ was found to be 9 nM and it showed 62- and 160-fold binding selectivity for this receptor over the ARTooltip androgen receptor and the ERα
3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
make the resultant derivative display much greater efficacy, affinity, selectivity &/or strength than even the parent compound; which otherwise was compromised
List_of_cocaine_analogues
Drug class
determine the selectivity. Compounds with substituents in position 2' have selectivity for NET. Compounds with substituents in position 4' are selective serotonin
Selective norepinephrine reuptake inhibitor
Selective_norepinephrine_reuptake_inhibitor
Protein helix–loop–helix motif
This high selectivity is due to the relatively rigid coordination geometry, the presence of multiple charged amino acid side chains in the binding site, as
EF_hand
Protein that regulates the rate of DNA transcription
sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to DNA sequences
Transcription_factor
Beta blocker drug
"Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents". Japanese
Propranolol
Type of cis-regulatory element
I.; Wanke D; Birkenbihl RP; Somssich IE. (2008). "Studies on DNA-binding selectivity of WRKY transcription factors lend structural clues into WRKY-domain
W-box
Protein-coding gene in humans
first demonstration of functional selectivity with dopamine receptors. Dinapsoline – full agonist with 5-fold selectivity for D1-like receptors over D2 Dinoxyline –
Dopamine_receptor_D1
Protein-coding gene in humans
6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol: antagonist, moderate binding selectivity over D1 SCH 23390 D5 receptor has been shown to form heteromers with
Dopamine_receptor_D5
Chemical compound
and is one the most selective agonists reported to date, with high binding affinity to 5-HT2AR (Ki = 2.5 nM) and 124-fold selectivity towards the 5-HT2CR
DMBMPP
Chemical compound
receptor binding studies.89 However, it is now known that 18 also behaves as a partial agonist at human 5-HT2C receptors with low binding selectivity relative
ORG-12962
Enzyme
been developed that showed high selectivity for MMP-11. Derivatives based on phenyl rings showed the best selectivity. MMP-11 could be a useful target
Metalloprotease_inhibitor
Class of pharmaceutical drugs
degree of tissue selectivity to SARMs. Tissue selective transcription coregulator expression is another possible contributor to the selectivity of SARMs. Like
Selective androgen receptor modulator
Selective_androgen_receptor_modulator
Technique in polymer chemistry
create template-shaped cavities in polymer matrices with predetermined selectivity and high affinity. This technique is based on the system used by enzymes
Molecular_imprinting
Drug discovery
Potency and selectivity in human whole blood is used by many groups and has been accepted as a standard assessment of COX-2 potency and selectivity. One of
Discovery and development of cyclooxygenase 2 inhibitors
Discovery_and_development_of_cyclooxygenase_2_inhibitors
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
A biological membrane or biomembrane is a selectively permeable membrane that separates the interior of a cell from the external environment or creates
Biological_membrane
Protein found in humans
chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity". The Journal of Biological Chemistry. 285 (51): 39898–904
Chitinase domain-containing protein 1
Chitinase_domain-containing_protein_1
Class of antidepressant medication
for inhibition of serotonin reuptake over norepinephrine reuptake. The selectivity ratios are approximately 1:30 for venlafaxine, 1:10 for duloxetine, and
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Protein-coding gene in the species Homo sapiens
the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10
Pituitary adenylate cyclase-activating peptide
Pituitary_adenylate_cyclase-activating_peptide
Kappa opioid receptor radioligand
substantial selectivity over μ-opioid receptors (Ki = 16 ± 5 nmol/L) and δ-opioid receptors (Ki = 536 ± 234 nmol/L). It is approximately 800-fold selective for
GR-103545
Pharmaceutical compound
then attaches to active RAS. This interaction blocks downstream effector binding and inhibits oncogenic signaling. In 2026, daraxonrasib completed a phase
Daraxonrasib
Purification technique for biomolecules
acid binding interactions are frequently exploited for isolation of various biomolecules. Affinity chromatography is useful for its high selectivity and
Affinity_chromatography
Parasympathetic nervous system inhibitors
These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of
Anticholinergic
Protein-coding gene in the species Homo sapiens
(TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity".
Parathyroid hormone 2 receptor
Parathyroid_hormone_2_receptor
Regulation of enzyme activity
by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site. Due to the often high receptor selectivity and lower
Allosteric_regulation
Protein-coding gene in the species Homo sapiens
the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10
ADCYAP1R1
Chemical compound
for the nonyloxy derivative, having a 5-HT1B binding affinity of 1.0 nM, and around 300-fold selectivity over the related 5-HT1A receptor. 5-Allyloxy-AMT
5-(Nonyloxy)tryptamine
Chemical activating melatonin receptors
outside of the aromatic cycle plane increase selectivity toward the MT2 receptor, resulting in the most selective melatonin receptor ligands and simultaneously
Melatonin_receptor_agonist
Invention of new medications based on knowledge of a biological target
class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed
Drug_design
Class of chemical compounds
loss in the treatment of obesity. Compounds are known with a pronounced selectivity for each MAT – dopamine, noradrenaline and the serotonin transporter
Phenyltropane
Protein found in humans
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6, is a protein produced in the liver in animals. In humans it is encoded
Transcortin
Stage of drug discovery
in animal models of disease and also to improve selectivity against other biological targets binding that may result in undesirable side effects. On average
Hit_to_lead
Class of enzymes
in the lower binding pocket may lie too far away for interaction with the inhibitor and therefore might be irrelevant for EHNA selectivity. However the
Phosphodiesterase_2
Fungal metabolite
interactions with PKA in particular are used to illuminate the roles of selectivity and protein flexibility in the inhibition of kinases. For instance, the
Balanol
Type of receptor ligand or drug that blocks a biological response
receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist
Receptor_antagonist
Chemical compound
4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): Effects on binding affinity and selectivity for sigma receptors and monoamine transporters". Bioorganic
Cutamesine
Integral of drug concentration in blood plasma over time
action Mode of action Binding Receptor (biochemistry) Desensitization (medicine) Other effects of ligand Selectivity (Binding, Functional) Pleiotropy
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Small molecule (PROTAC)
proteasome. Because PROTACs need only to bind their targets with high selectivity (rather than inhibit the target protein's enzymatic activity), efforts
Proteolysis_targeting_chimera
Amino acid peptide
alpha-helical secondary structures, which support biological activity and binding selectivity. Multiple urocortin genes are present in vertebrate lineages as a
Urocortin_III
Pregnancy termination based on predicted sex
overwhelmingly targets female fetuses, sex-selective abortion often specifically refers to female-selective abortion. Sex-selective abortion is closely linked to female
Sex-selective_abortion
Chemical compound
different binding affinities, with the 3S,4S enantiomer having the highest overall activity. The 3R,4S enantiomer demonstrates the highest selectivity for 5-HTT
N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate
N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate
Antihistamine medication
enantiomer is the main active form. Cetirizine has 600-fold or greater selectivity for the H1 receptor over a wide variety of other sites, including muscarinic
Cetirizine
Receptor models to explain drug behavior
time, Ehrlich was trying to understand the basis of selectivity of agents. He theorized that selectivity was the basis of a preferential distribution of lead
Receptor_theory
Chemical compound
nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and
TP-13
Chemical compound
study, JDTic showed little binding selectivity over the μ-opioid receptor, but it failed to block the effects of the selective μ-opioid receptor agonist
JDTic
Chemical compound class
However, these compounds, like most peptide compounds, had problems with selectivity, potency, solubility and bioavailability. For this reason, pharmaceutical
NK1_receptor_antagonist
Drug class
agonist with approximately 4-fold greater selectivity for 5-HT2C over these related receptors, in terms of binding affinity. Vabicacserin is a full agonist
5-HT2C_receptor_agonist
Protein
This selectivity increases the separation between the desired antiinflammatory effects and undesired metabolic side effects of these selective glucocorticoids
Nuclear_receptor
Agent in biochemistry
(2018-08-06). "Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity". International Journal of Neuropsychopharmacology. 21 (10): 962–977
Inverse_agonist
Ionotropic receptor and ligand-gated ion channel
producing α2-selective agonists as anticonvulsants which lack the side effects of older drugs such as sedation and amnesia. The binding site for benzodiazepines
GABAA_receptor
BINDING SELECTIVITY
BINDING SELECTIVITY
Girl/Female
Indian
A dot on the forehead. the one which indian women who put down the same in between two eyebrows, Drop, Point
Surname or Lastname
English
English : variant of Blanton.
Surname or Lastname
English (chiefly Yorkshire)
English (chiefly Yorkshire) : unexplained; perhaps a variant of Browning. Compare Brunning.Americanized spelling of German Breuning (see Breunig).
Surname or Lastname
English
English : unexplained.German : patronymic from a personal name formed with Ban- ‘decree’, ‘command’ or Band- ‘band’, ‘tie’.
Girl/Female
Biblical
Hiding, binding.
Surname or Lastname
English and German
English and German : patronymic from Bold as a personal name.Danish : habitational name from a place so named in Jutland.
Surname or Lastname
English
English : variant of Balding.
Surname or Lastname
English and Scottish
English and Scottish : of uncertain derivation; possibly related to Bing.
Boy/Male
Muslim/Islamic
Binding Fastening
Boy/Male
Arabic, Muslim, Sindhi
Binding; Fastening
Surname or Lastname
English (now chiefly Lancashire)
English (now chiefly Lancashire) : from an unattested Old English personal name, Wilding, a derivative of Old English wilde ‘wild’, ‘savage’. It is also possible that it may be from a topographical term derived from the same vocabulary word. Compare Wild, but early forms with prepositions are not found.German : patronymic from Wilto, a short form of a Germanic personal name beginning with wild ‘wild’.
Biblical
fearful; binding
Boy/Male
Muslim
Binding, Fastening
Surname or Lastname
English
English : nickname from some fancied resemblance to the songbird (Emberiza spp.).German : patronymic from an unexplained Frisian-Lower Saxon personal name, or a derivative of Bunt- (see Bunten).Sarah Bunting (1686–1762), born in Matlock, Derbyshire, became a noted Quaker minister in Cross Wicks, NJ. It is believed but not certain that other members of her family, including her father, John Bunting, came with her to NJ sometime before 1704, when her marriage to William Murfin is recorded.
Surname or Lastname
English
English : unexplained.
Surname or Lastname
English (Hampshire and the Isle of Wight)
English (Hampshire and the Isle of Wight) : habitational name from a place on the Isle of Wight named Brading, from Old English brerd ‘hillside’ + -ingas ‘dwellers at’, i.e. ‘(settlement of) the dwellers on the hillside’.
Girl/Female
Indian
A bond, One who glues together, Is bound, Preserve
Girl/Female
Biblical
Fearful, binding.
Surname or Lastname
English
English : either from a Middle English survival of an Old English personal name, Billing, or a habitational name from a place in Northamptonshire called Billing, probably ‘(settlement of) the followers (Old English -ingas) of a man called Bill(a)’.German : from a Germanic personal name, formed with a cognate of Old Saxon bīl ‘sword’.Danish and Norwegian : from an Old Danish personal name, Billing.Swedish : shortened form of various habitational names such as Billinge, Billingsfors, etc.
Biblical
hiding, binding
BINDING SELECTIVITY
BINDING SELECTIVITY
Boy/Male
Indian, Punjabi, Sikh
World's Attraction
Boy/Male
Tamil
Fearful
Boy/Male
Tamil
Guarding, Protecting
Boy/Male
Hindu, Indian, Kannada, Marathi, Telugu, Traditional
Another Name for Lord Murugan
Boy/Male
Arabic, Muslim
Reviver of the Religion Islam
Boy/Male
Hindu
The Sun
Boy/Male
English
Brave; Manly.
Male
Hebrew
(רִמּï‹×Ÿ) Hebrew name of uncertain origin, RIMMOWN means "pomegranate." In the bible, this is the name of several places, the name of a Benjamite of Beeroth.Â
Girl/Female
American, Australian, French
Fairy Queen
Girl/Female
Hindu, Indian, Telugu
Goddess Saraswati
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
n.
The result of a judicial examination or inquiry, especially into some matter of fact; a verdict; as, the finding of a jury.
pl.
The transoms, knees, beams, keelson, and other chief timbers used for connecting and strengthening the parts of a vessel.
n.
The act or process of one who, or that which, binds.
a.
Abiding the law; waiting for the operation of law for the enforcement of rights; also, abiding by the law; obedient to the law; as, law-abiding people.
p. pr. & vb. n.
of Bind
n.
A winding or bending in and out.
a.
Making blind or as if blind; depriving of sight or of understanding; obscuring; as, blinding tears; blinding snow.
n.
The act of finding fault or blaming; -- used derogatively. Also Adj.
n.
Anything that binds; a bandage; the cover of a book, or the cover with the sewing, etc.; something that secures the edge of cloth from raveling.
v. t.
A building.
a.
Bulged; bulging; bending, or tending to bend, outward.
a.
That binds; obligatory.
a.
Wound by mechanism connected with the stem; as, a stem-winding watch.
a.
Bringing dishonor on; tending to disgrace; lessening reputation.
n.
A machine formerly used for bending a crossbow by winding it up.
n.
The beads or bead-forming quality of certain liquors; as, the beading of a brand of whisky.
n.
State of sinking or bending; sagging.
n.
A winding, bending, or twisting.
a.
Bending in and out; of a serpentine or undulating form; winding; crooked.