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In biochemistry, the preference of ligands to bind with one receptor over another
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. Binding selectivity describes how
Binding_selectivity
Topics referred to by the same term
Look up selectivity in Wiktionary, the free dictionary. Selectivity may refer to: Choice, making a selection among options Discrimination, the ability
Selectivity
Substance that forms a complex with a biomolecule
advantages compared to their monovalent counterparts (such as tissue selectivity, increased binding affinity, and increased potency or efficacy), bivalents may
Ligand_(biochemistry)
Biochemical analysis procedure
estimate a specified model for the binding. Competition binding is used to determine the presence of selectivity for a particular ligand for receptor
Ligand_binding_assay
Topics referred to by the same term
constant Binding domain Binding protein Binding selectivity Binding site BindingDB, an online database of measured binding affinities Binding potential
Binding
Computational tools
two goals: efficiency and selectivity. Efficiency involves taking into account such factors as GC-content, efficiency of binding, complementarity, secondary
In_silico_PCR
Pharmacologic characteristic
selectivity (or agonist trafficking, biased agonism, biased signaling, ligand bias, and differential engagement) is the ligand-dependent selectivity for
Functional_selectivity
Beta-1 selective adrenenergic blocker medication used to treat cardiovascular diseases
degree of β1-selectivity compared to atenolol, metoprolol and betaxolol. With a selectivity ranging from being 11 to 15 times more selective for β1 over
Bisoprolol
Ion channel that selectively passes K+
remove the hydration shell from the ion when it enters the selectivity filter. The selectivity filter is formed by a five residue sequence, TVGYG, termed
Potassium_channel
Drugs acting on the estrogen receptor
the binding cavity of ERβ is slightly narrower than that of ERα, however, this by itself leads to modest selectivity. To attain strong selectivity, the
Selective estrogen receptor modulator
Selective_estrogen_receptor_modulator
Chemical compound
5 μM, respectively. As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between
DCW234
Chaperone protein
and subtype selectivity Agents exist that have high σ1 affinity but either lack subtype selectivity or have high affinity at other binding sites, thus
Sigma-1_receptor
Subdiscipline of chemistry concerned with chemical equilibrium
objective of these studies is often to find systems with a high binding selectivity of a host (receptor) for a particular target molecule or ion, the
Equilibrium_chemistry
Selective relaxant binding agents (SRBAs) are a new class of drugs that selectively encapsulates and binds neuromuscular blocking agents (NMBAs). The
Selective relaxant binding agents
Selective_relaxant_binding_agents
Chemical similar in structure to vitamin B12
behavior of Sinorhizobium meliloti largely correlates with the cofactor binding selectivity of its methylmalonyl-CoA mutase (MCM). Among adenyl-cobamides, paseudovitamin
Pseudovitamin_B12
Opioid analgesic of benzenoid class
such as desvenlafaxine and duloxetine. Tapentadol exhibits high binding selectivity and affinity for MOR, which is the principal target of the endogenous
Tapentadol
exhibits selectivity and high affinity for NET, and are therefore generally SNRIs, compounds having substituent in the 4'-position exhibits selectivity and
Development and discovery of SSRI drugs
Development_and_discovery_of_SSRI_drugs
Set of laboratory techniques for separation of mixtures
hospitals. Affinity chromatography Aqueous normal-phase chromatography Binding selectivity Chiral analysis Chromatofocusing Chromatography in blood processing
Chromatography
Chemical compound
and 3.61 nM, respectively, demonstrating 9-fold binding selectivity and 11-fold functional selectivity for the ERβ over the ERα. An enantiomer of SERBA-2
SERBA-2
Chemical compound
for the ERβ was found to be 9 nM and it showed 62- and 160-fold binding selectivity for this receptor over the ARTooltip androgen receptor and the ERα
3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
Class of drug
Manning et al. presented two high-affinity MAT-ligands with good binding selectivity for SERT and DAT, namely the 4-indolyl and 1-naphthyl arylalkylamines
Serotonin–dopamine reuptake inhibitor
Serotonin–dopamine_reuptake_inhibitor
Human glycoprotein that binds to androgens and estrogens
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. When produced by the
Sex_hormone–binding_globulin
make the resultant derivative display much greater efficacy, affinity, selectivity &/or strength than even the parent compound; which otherwise was compromised
List_of_cocaine_analogues
Parasympathetic nervous system inhibitors
These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of
Anticholinergic
Class of drugs
conditions. Selectivity, or “binding selectivity”, describes how a ligand may bind more preferentially to one receptor than another. Selectivity can also
Adrenergic_neuron_blockers
Pharmaceutical compound
most tryptamines are highly non-selective in terms of binding to serotonin receptors, 1-propyl-5-MeO-AMT shows selectivity for the serotonin 5-HT2A receptor
1-Propyl-5-MeO-AMT
Prokaryotic potassium ion channel
channels was centered on the use of small toxin binding to reveal the location of the pore and selectivity filter among channel residues. MacKinnon's group
KcsA_potassium_channel
Chemical compound
14-fold binding selectivity for the ERβ over the ERα (Ki = 0.19 nM versus 2.68 nM, respectively). However, it shows 32-fold functional selectivity for activation
Erteberel
Unanswered question in the study of consciousness
(cognitive) binding problem is the problem of how objects, background, and abstract or emotional features are combined into a single experience. The binding problem
Binding_problem
Psychedelic drug
5-HT2A receptor, 100-fold selectivity for the serotonin 5-HT2A receptor over the serotonin 5-HT2C receptor, and 46-fold selectivity for the serotonin 5-HT2A
25CN-NBOH
Canadian geneticist
2014.05.004. PMC 4048464. PMID 24856970. Klose, Rob (2005). "DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG"
Rob_Klose
Direct vote on a specific proposal
representatives) on a proposal, law, or political issue. A referendum may be either binding, resulting in the adoption of a new policy, or consultive (or advisory)
Referendum
Protein-coding gene in humans
first demonstration of functional selectivity with dopamine receptors. Dinapsoline – full agonist with 5-fold selectivity for D1-like receptors over D2 Dinoxyline –
Dopamine_receptor_D1
Ability of a substance to resist changes in structure under high temperatures
evolution of a G protein-coupled receptor for expression, stability, and binding selectivity". Proceedings of the National Academy of Sciences of the United States
Thermostability
Invention of new medications based on knowledge of a biological target
class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed
Drug_design
Drug discovery
caused a loss of selectivity but not loss of the β-blockade itself. This illustrated the significance of para-substitution for β1 selectivity of β-blockers
Discovery and development of beta-blockers
Discovery_and_development_of_beta-blockers
Chemical which binds to and activates a biochemical receptor
Terms that describe this phenomenon are "functional selectivity", "protean agonism", or selective receptor modulators. As mentioned above, agonists have
Agonist
Monoclonal antibody
IgG2 monoclonal antibody that inhibits interleukin-31 signaling by binding selectively to interleukin-31 receptor alpha. It is an interleukin-31 receptor
Nemolizumab
Pharmaceutical compound
reported to be subtype-selective for 5-HT2AR, which are summarized in Table 3. [...] DOHx and DOBz also have high binding selectivity for 5-HT2AR against
2,5-Dimethoxy-4-hexylamphetamine
2,5-Dimethoxy-4-hexylamphetamine
Drug affecting hormone receptors
relatively high binding affinity for glucocorticoid receptor compared to the progesterone receptor has sparked the demand for more selective progesterone
Selective progesterone receptor modulator
Selective_progesterone_receptor_modulator
Drug class
determine the selectivity. Compounds with substituents in position 2' have selectivity for NET. Compounds with substituents in position 4' are selective serotonin
Selective norepinephrine reuptake inhibitor
Selective_norepinephrine_reuptake_inhibitor
Molecule-specific coordinate bonding area in biological systems
molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the
Binding_site
Protein molecule receiving signals for a cell
currents of different ions. This is accomplished with selectivity filters, such as the selectivity filter of the K+ ion channel Guyton, Arthur C.; Hall
Receptor_(biochemistry)
Drug discovery
RN: This group determines α- or β-receptor selectivity. The larger the substituent, the greater the selectivity for the β-receptor. If t-butyl is positioned
Discovery and development of beta2 agonists
Discovery_and_development_of_beta2_agonists
Protein-coding gene in the species Homo sapiens
1016/0022-2836(92)90984-R. PMID 1311770. Kirsch T, Pfäffle M (Sep 1992). "Selective binding of anchorin CII (annexin V) to type II and X collagen and to chondrocalcin
Annexin_A5
of the active site or on other proteins but the selectivity is conferred by the noncovalent binding moiety. Kinetic signatures of this type of inhibitor
Affinity_label
Mammalian protein found in Homo sapiens
EGIS-7625 – high selectivity over 5-HT2A EXT5 – highly selective EXT9 – somewhat selective LY-23,728 LY-266,097 – pKi = 9.7, 100-fold selectivity over 5-HT2A
5-HT2B_receptor
Opioid analgesic
of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites". Life Sciences. 48 (23): PL111–PL116. doi:10
Ohmefentanyl
Class of proteins
Penicillin-binding proteins (PBP) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent
Penicillin-binding_proteins
3D printing technique
in space defined by a 3D model, binding the material together to create a solid structure. It is similar to selective laser melting; the two are instantiations
Selective_laser_sintering
Protein
that occurs after transcription of mRNA, regulates neuroligins' binding selectivity for α- or β-neurexins as well as the function of synapses. Alternative
Neuroligin
ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig
PCP_site_2
Agent in biochemistry
(2018-08-06). "Making Sense of Pharmacology: Inverse Agonism and Functional Selectivity". International Journal of Neuropsychopharmacology. 21 (10): 962–977
Inverse_agonist
Class of chemical compounds
loss in the treatment of obesity. Compounds are known with a pronounced selectivity for each MAT – dopamine, noradrenaline and the serotonin transporter
Phenyltropane
single-stranded or double-stranded, which functions as a ligand by binding selectively to one or more specific target molecules, usually other nucleic acids
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Family of transport proteins
lacks the selectivity filter found in animal CNG channels as well as lacks a glycine-tyrosine-glycine-aspartate (GYGD) motif in the K+-selectivity filter
Cyclic nucleotide–gated ion channel
Cyclic_nucleotide–gated_ion_channel
Electrostatic phenomenon
strong affinity to the binding site. This conductivity-selectivity paradox has been explained as being a consequence of selective barrier-less conduction
Ionic_Coulomb_blockade
German-Swiss biochemist and protein engineer
evolution of a G protein-coupled receptor for expression, stability, and binding selectivity". Proc. Natl. Acad. Sci. U. S. A. 105: 14808–14813. Schöppe, J.;
Andreas_Plückthun
Type of catalysis involving reactants & catalysts in different phases of matter
a set of binding energies that can change the selectivity toward a specific product "scale" with each other, thus to improve the selectivity one has to
Heterogeneous_catalysis
Chemical compound
nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and
TP-13
Chemical compound
selectivity over 5-HT2B and 49-fold selectivity over 5-HT2C. It has a 5-HT2A Ki of 680 nM and an EC50 of 41 nM. (R)-69 is a biased agonist selective for
(R)-69
Chemical compound
Both compounds showed moderate binding selectivity against the 5-HT2BR and 5-HT2CR, and overall better selectivity profiles than those of classic psychedelic
(R)-70
Pharmaceutical compound
by Vernalis [64]. [...] It showed a binding affinity of 3.54 nM for A2AAR, with 54-, 431-, and 693-fold selectivity against A1AR, A2BAR, and A3AR, respectively
Ciforadenant
Kappa opioid receptor radioligand
substantial selectivity over μ-opioid receptors (Ki = 16 ± 5 nmol/L) and δ-opioid receptors (Ki = 536 ± 234 nmol/L). It is approximately 800-fold selective for
GR-103545
Receptor antagonist that acts on one or more of the opioid receptors
antagonists work the same. Some antagonists do not fully block agonists from binding to the receptor. These agonists are not necessarily considered partial
Opioid_antagonist
Type of cis-regulatory element
I.; Wanke D; Birkenbihl RP; Somssich IE. (2008). "Studies on DNA-binding selectivity of WRKY transcription factors lend structural clues into WRKY-domain
W-box
Enzyme involved in blood coagulation in humans
activated Factor X (Xa). The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. Prothrombin
Thrombin
Half maximal inhibitory concentration
vivo. IC50 can be determined with functional assays or with competition binding assays. Sometimes, IC50 values are converted to the pIC50 scale. pIC 50
IC50
Pharmaceutical compound
rigorously assessed the selectivity of these earlier compounds via employment of multiple selectivity assays. TGF-8027 was less selective for the mouse serotonin
TGF-8027
Mammalian protein found in humans
specificity, and cGMP-binding to the allosteric sites stimulates binding of PDE5 inhibitors at the catalytic site. The kinetics of inhibitor binding and inhibition
CGMP-specific phosphodiesterase type 5
CGMP-specific_phosphodiesterase_type_5
Class of enzymes
in the lower binding pocket may lie too far away for interaction with the inhibitor and therefore might be irrelevant for EHNA selectivity. However the
Phosphodiesterase_2
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
called functional selectivity (also known as agonist-directed trafficking, or conformation-specific agonism). However, the binding of any single particular
G_protein-coupled_receptor
Extremely small sensors
to their sensitivity, as well as their tunability and resulting binding selectivity, nanosensors are very effective and can be designed for a wide variety
Nanosensor
Regulation of enzyme activity
by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site. Due to the often high receptor selectivity and lower
Allosteric_regulation
Class of pharmacological agents
that affect the selectivity of the agonist. Visual inspection of selective β3-AR agonists revealed that they bind deep in the binding pocket of the receptors
Beta3-adrenergic_agonist
Technique in polymer chemistry
create template-shaped cavities in polymer matrices with predetermined selectivity and high affinity. This technique is based on the system used by enzymes
Molecular_imprinting
Class of drug
Nemeroff CB (2001). "Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine". Biol Psychiatry. 50 (5): 345–50
Serotonin_reuptake_inhibitor
Class of drug
[non-primary source needed] although not grouped as such.[citation needed] The binding profiles of SARIs and some metabolites in terms of their affinities (Ki
Serotonin antagonist and reuptake inhibitor
Serotonin_antagonist_and_reuptake_inhibitor
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
A biological membrane or biomembrane is a selectively permeable membrane that separates the interior of a cell from the external environment or creates
Biological_membrane
Protein-coding gene in humans
6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol: antagonist, moderate binding selectivity over D1 SCH 23390 D5 receptor has been shown to form heteromers with
Dopamine_receptor_D5
Mammalian protein found in humans
are crucial for ligand binding and specificity. The CALCRL/RAMP complex presents a unique ligand-binding pocket, enabling selective recognition of peptide
CALCRL
Chemical compound
2009). "On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine". Chemical Biology & Drug
Staurosporine
Class of transport proteins
Altering a serine residue at the selectivity filter, labeled Sercen, to a different amino acid alters the selectivity. Gating occurs through two mechanisms:
Chloride_channel
Chemical compound
Merck, Sharp and Dohme, which acts as a subtype-selective inverse agonist at the benzodiazepine binding site on the GABAA receptor. It binds to α1, α2
Α5IA
Gene family
The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one
ABC_transporter
Class of medications
bound in more acidic conditions, so by reversing the acidosis, protein binding increases and bioavailability thus decreases – the sodium load may also
Tricyclic_antidepressant
Protein that regulates the rate of DNA transcription
sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to DNA sequences
Transcription_factor
Pharmaceutical compound
is only 23-fold selective for 5-HT2A receptors (Ki = 2.2 nM) relative to 5-HT2C sites (Ki = 49.8 nM) [38]. Although the selectivity of 25CN-NBOH may
2,5-Dimethoxy-4-cyanoamphetamine
2,5-Dimethoxy-4-cyanoamphetamine
Protein-coding gene in the species Homo sapiens, named for ketazocine
(PET) imaging studies with the KOR-selective radioligand [11C]GR-103545 in non-human primates showed high binding potential (BPND > 1.3) in the pituitary
Κ-opioid_receptor
Enzyme
been developed that showed high selectivity for MMP-11. Derivatives based on phenyl rings showed the best selectivity. MMP-11 could be a useful target
Metalloprotease_inhibitor
Protein-coding gene in the species Homo sapiens
the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10
Pituitary adenylate cyclase-activating peptide
Pituitary_adenylate_cyclase-activating_peptide
Selective relaxant binding agent
rocuronium and vecuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA). It is marketed by Merck. The most common side effects
Sugammadex
Chemical compound
RTI-31 is a relatively balanced reuptake inhibitor wrt the D/N/S ratio. The binding ligand affinities for the different transporters is skewed somewhat in
RTI-31
Main receptor for most antipsychotic drugs
are, in general, very unselective, at best selective only for the "D2-like family" receptors and so binding to D2, D3 and D4, and often also to many other
Dopamine_receptor_D2
Chemical compound
benzodiazepine site agonist selective for certain subunits. TCS 1205 acts at the benzodiazepine binding site, it is selective for the α1 and α2 subunits
TCS-1205
Chemical compound
for the nonyloxy derivative, having a 5-HT1B binding affinity of 1.0 nM, and around 300-fold selectivity over the related 5-HT1A receptor. 5-Allyloxy-AMT
5-(Nonyloxy)tryptamine
Beta blocker drug
"Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents". Japanese
Propranolol
Chemical compound
receptor binding studies.89 However, it is now known that 18 also behaves as a partial agonist at human 5-HT2C receptors with low binding selectivity relative
ORG-12962
Medication
of an improved selectivity profile, with selectivity of S1P1 over S1P5 receptors at 27‐fold, and selectivity for S1P1 over S1P2, S1P3, and S1P4 receptors
Ozanimod
Chemical compound
and is one the most selective agonists reported to date, with high binding affinity to 5-HT2AR (Ki = 2.5 nM) and 124-fold selectivity towards the 5-HT2CR
DMBMPP
BINDING SELECTIVITY
BINDING SELECTIVITY
Surname or Lastname
English
English : variant of Balding.
Boy/Male
Muslim/Islamic
Binding Fastening
Girl/Female
Indian
A bond, One who glues together, Is bound, Preserve
Surname or Lastname
English (now chiefly Lancashire)
English (now chiefly Lancashire) : from an unattested Old English personal name, Wilding, a derivative of Old English wilde ‘wild’, ‘savage’. It is also possible that it may be from a topographical term derived from the same vocabulary word. Compare Wild, but early forms with prepositions are not found.German : patronymic from Wilto, a short form of a Germanic personal name beginning with wild ‘wild’.
Boy/Male
Muslim
Binding, Fastening
Boy/Male
Arabic, Muslim, Sindhi
Binding; Fastening
Girl/Female
Biblical
Fearful, binding.
Surname or Lastname
English
English : unexplained.German : patronymic from a personal name formed with Ban- ‘decree’, ‘command’ or Band- ‘band’, ‘tie’.
Biblical
fearful; binding
Surname or Lastname
English
English : either from a Middle English survival of an Old English personal name, Billing, or a habitational name from a place in Northamptonshire called Billing, probably ‘(settlement of) the followers (Old English -ingas) of a man called Bill(a)’.German : from a Germanic personal name, formed with a cognate of Old Saxon bīl ‘sword’.Danish and Norwegian : from an Old Danish personal name, Billing.Swedish : shortened form of various habitational names such as Billinge, Billingsfors, etc.
Girl/Female
Indian
A dot on the forehead. the one which indian women who put down the same in between two eyebrows, Drop, Point
Surname or Lastname
English and German
English and German : patronymic from Bold as a personal name.Danish : habitational name from a place so named in Jutland.
Surname or Lastname
English (chiefly Yorkshire)
English (chiefly Yorkshire) : unexplained; perhaps a variant of Browning. Compare Brunning.Americanized spelling of German Breuning (see Breunig).
Biblical
hiding, binding
Surname or Lastname
English
English : variant of Blanton.
Surname or Lastname
English
English : nickname from some fancied resemblance to the songbird (Emberiza spp.).German : patronymic from an unexplained Frisian-Lower Saxon personal name, or a derivative of Bunt- (see Bunten).Sarah Bunting (1686–1762), born in Matlock, Derbyshire, became a noted Quaker minister in Cross Wicks, NJ. It is believed but not certain that other members of her family, including her father, John Bunting, came with her to NJ sometime before 1704, when her marriage to William Murfin is recorded.
Surname or Lastname
English
English : unexplained.
Surname or Lastname
English (Hampshire and the Isle of Wight)
English (Hampshire and the Isle of Wight) : habitational name from a place on the Isle of Wight named Brading, from Old English brerd ‘hillside’ + -ingas ‘dwellers at’, i.e. ‘(settlement of) the dwellers on the hillside’.
Girl/Female
Biblical
Hiding, binding.
Surname or Lastname
English and Scottish
English and Scottish : of uncertain derivation; possibly related to Bing.
BINDING SELECTIVITY
BINDING SELECTIVITY
Girl/Female
Latin
An Amazon.
Girl/Female
Latin American English
Lily (after the flower). Pure.
Boy/Male
Anglo, Australian, British, Christian, English, German, Teutonic
Stranger; Welshman; Foreign; Celtic
Boy/Male
Arabic, Muslim
Pleasant; Happy; Jovial; Jubilant
Boy/Male
Hindu, Indian, Tamil, Telugu
Chief
Boy/Male
Indian, Sanskrit
Glory
Boy/Male
Indian
Sun
Male
English
Variant spelling of English unisex Riley, REILLY means "rye clearing.Â
Boy/Male
Anglo Saxon
Terror.
Boy/Male
Muslim
More glorious
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
BINDING SELECTIVITY
n.
State of sinking or bending; sagging.
v. t.
A building.
a.
Bringing dishonor on; tending to disgrace; lessening reputation.
a.
Abiding the law; waiting for the operation of law for the enforcement of rights; also, abiding by the law; obedient to the law; as, law-abiding people.
pl.
The transoms, knees, beams, keelson, and other chief timbers used for connecting and strengthening the parts of a vessel.
n.
The result of a judicial examination or inquiry, especially into some matter of fact; a verdict; as, the finding of a jury.
n.
A machine formerly used for bending a crossbow by winding it up.
n.
The act or process of one who, or that which, binds.
n.
The beads or bead-forming quality of certain liquors; as, the beading of a brand of whisky.
a.
Wound by mechanism connected with the stem; as, a stem-winding watch.
n.
A winding, bending, or twisting.
a.
Bending in and out; of a serpentine or undulating form; winding; crooked.
a.
Making blind or as if blind; depriving of sight or of understanding; obscuring; as, blinding tears; blinding snow.
n.
Anything that binds; a bandage; the cover of a book, or the cover with the sewing, etc.; something that secures the edge of cloth from raveling.
n.
The act of finding fault or blaming; -- used derogatively. Also Adj.
a.
That binds; obligatory.
p. pr. & vb. n.
of Bind
n.
A winding or bending in and out.
a.
Bulged; bulging; bending, or tending to bend, outward.