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PCP site 2 is a binding site that was identified as a high-affinity target for phencyclidine (PCP), an anesthetic and dissociative hallucinogen that acts
PCP_site_2
Dissociative hallucinogenic drug, mostly used recreationally
Phencyclidine or phenylcyclohexyl piperidine (PCP), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic
Phencyclidine
Glutamate receptor and ion channel protein found in nerve cells
glutamate site antagonist Phencyclidine (PCP) – dizocilpine site antagonist Phenylalanine - a naturally occurring amino acid, glycine site antagonist
NMDA_receptor
Type of drug
selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain". Synapse. 16 (1): 59–65.
Reuptake_inhibitor
Chemical compound
3-HO-PCP acts as a high-affinity uncompetitive NMDA receptor antagonist via the PCP site with a Ki of 30 nM. It has a higher affinity than PCP, which
3-HO-PCP
Pharmaceutical compound
of the NMDA receptor of about 470 μM. Ketamir-2 showed no activity at other sites besides the PCP site of the NMDA receptor when screened against a panel
Ketamir-2
British businesswoman (born 1973)
Dhabi and Qatar, and by the Qatari sovereign wealth fund. Staveley's firm, PCP Capital Partners, acted for Sheikh Mansour Bin Zayed Al Nahyan of the Abu
Amanda_Staveley
Chemical compound
3-Fluoro-PCP (3'-F-PCP, 3F-PCP) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It was first identified
3-Fluoro-PCP
Political party in Portugal
Partido Comunista Português, pronounced [pɐɾˈtiðu kumuˈniʃtɐ puɾtuˈɣeʃ], PCP) is a communist and Marxist–Leninist political party in Portugal. It is one
Portuguese_Communist_Party
Chemical compound
transporter. 3-MeO-PCP has a Ki of 20 nM for the PCP site of the NMDA receptor, which is higher than PCP or any other anisyl substition of PCP. It has secondary
3-MeO-PCP
Chemical compound
3-Methyl-PCP (3'-Methyl-PCP, meta-Methyl-PCP, 3-Me-PCP) is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative
3-Methyl-PCP
Chemical compound
a forensic laboratory in Denmark in February 2021. 3-Methyl-PCE 3-Methyl-PCP 3-Methyl-PCPy Hydroxetamine Fluorexetamine Methoxetamine Methoxieticyclidine
Deoxymethoxetamine
Chemical compound
2-FXE. Similar misidentification may have occurred in other laboratories. 2-Fluorodeschloroketamine 2F-NENDCK 3-Fluorodeschloroketamine 3-Fluoro-PCP Blixeprodil
Fluorexetamine
Class of anesthetics
2-enyl-1-phosphonic acid). Selfotel: an anxiolytic, anticonvulsant but with possible neurotoxic effects. 3-MeO-PCP: an analogue of PCP 8A-PDHQ:
NMDA_receptor_antagonist
Maoist communist party in Peru
officially the Communist Party of Peru (Partido Comunista del Perú, abbr. PCP), is a far-left political party and guerrilla group in Peru, following
Shining_Path
Chemical compound
3-Chloro-PCP (3'-Cl-PCP) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has been shown to act as an
3-Chloro-PCP
Chemical compound
Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant. First produced in the 1930s, it is marketed under many trade
Pentachlorophenol
Dissociative anesthetic and anti-depressant
"NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia"
Ketamine
Chemical compound
4-Keto-PCP is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It has potency in between that of ketamine
4-Keto-PCP
Chemical compound
Methylenedioxyphencyclidine (3,4-MD-PCP, MDPCP) is a recreational designer drug with dissociative effects. It is an arylcyclohexylamine derivative, with
MDPCP
Political party in Portugal
the Portuguese Communist Party (Portuguese: Partido Comunista Português or PCP) and the Ecologist Party "The Greens" (Portuguese: Partido Ecologista "Os
Unitary_Democratic_Coalition
Chemical compound
eticyclidine, and has been sold online as a designer drug. 3-HO-PCE 3-Chloro-PCP 4-Keto-PCP Deoxymethoxetamine MXiPr Isoethcathinone "Controlled Drugs and Substances
2-Oxo-PCE
Chemical compound
Phencyclidine (PCP) Contreras PC, DiMaggio DA, O'Donohue TL (1985). "Evidence for an endogenous peptide ligand and antagonist for PCP receptors". Prog
Α-Endopsychosin
Class of chemical compounds
(MXP), and ephenidine display high to moderate affinity for the NMDAR PCP-binding site (e.g., diphenidine Ki ≈ 18–39 nM). Additionally, some members of this
1,2-Diarylethylamine
Chemical compound
2-Bromodeschloroketamine (also known as 2-Br-2'-Oxo-PCM and bromoketamine) is a chemical compound of the arylcyclohexylamine class, which is an analog
2-Bromodeschloroketamine
Chemical compound
biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". Journal of
8A-PDHQ
Chemical compound
XW10508 PCP-related: 2-Oxo-PCE 3-Chloro-PCP 3-Fluoro-PCP 3-HO-PCP 3-HO-PCE 3-Me-PCE 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 3-Methyl-PCP 3-Methyl-PCPy 4-Keto-PCP 4-MeO-PCP
Trifluoromethyldeschloroketamine
Trifluoromethyldeschloroketamine
Pharmaceutical compound
disorders. It is taken by mouth. Blixeprodil is acts as an antagonist at the PCP site of NMDA receptors, with a Ki of 3.25 µM. The drug is orally active, in
Blixeprodil
Chemical compound
binding sites in the CNS. It is the m-isothiocyanate derivative of phencyclidine (PCP) and binds irreversibly (forming a covalent bond) to the PCP binding
Metaphit
Chemical compound
methoxetamine, but has also been sold in its own right since late 2019. 3-HO-PCP 4-Keto-PCP Desmetramadol Deoxymethoxetamine Fluorexetamine Menzies EL, Hudson SC
Hydroxetamine
Chemical compound
effects. It was made illegal in Finland in August 2019. 2-Fluorodeschloroketamine 3-Fluoro-PCP Blixeprodil Deschloroketamine Fluorexetamine Methoxmetamine
3-Fluorodeschloroketamine
Antimicrobial and antiprotozoan drug
medication used in the prevention and treatment Pneumocystis jirovecii pneumonia (PCP), and malaria (in combination with proguanil), as well as for treatment of
Atovaquone
Chemical compound
4-Methoxyphencyclidine (methoxydine, 4-MeO-PCP) is a dissociative anesthetic drug that has been sold online as a research chemical. It acts as an NMDA
4-MeO-PCP
Chemical compound
arylcyclohexylamine derivative, and a structural isomer of phencyclidine. 3-Methyl-PCP 3-HO-PCE BTCP Deoxymethoxetamine Ephenidine MDPCP Wallach J, De Paoli G,
3-Methyl-PCPy
German firearm manufacturer
pistol, PCP P34 4.5mm match pistol, PCP P40 4.5mm match pistol, PCP P44 4.5mm match pistol, PCP P8X 4.5mm match pistol, PCP C5 4.5mm, 5-shot self-indexing
Feinwerkbau
Medication
1980s and is now little known. Arylcyclohexylamine 3-MeO-PCE 3-MeO-PCP 4-MeO-PCP Phencyclidine PCPr Methoxetamine Anvisa (2023-07-24). "RDC Nº 804 -
Eticyclidine
Chemical compound
additional dissociatives 3-MeO-PCP, 4-MeO-PCP, and 3-MeO-PCE. They were shown to have significant affinity for the PCP site of the NMDA receptor. 3-MeO-PCE
3-MeO-PCE
New Psychoactive Substance Dissociative Eticyclidine Derivative
notification of its first analytical identification in March 2024. 3-Methyl-PCP 3-Methyl-PCPy Deoxymethoxetamine Wallach J, Colestock T, Cicali B, Elliott
3-Me-PCE
Chemical compound
in December 2020, and was made illegal in Hungary in April 2021. 3-Methyl-PCP Deoxymethoxetamine Fluorexetamine MDPCP Methoxpropamine O-PCE Ketamine "Analytical
Methoxisopropamine
Chemical compound
such as PCP and ketamine. Their general structure consists of a cyclohexylamine unit with an aryl group attached to the same carbon as the amine. 2-FDCK
2-Fluorodeschloroketamine
Pharmaceutical compound
with comparable effects to ketamine. A-NK acts as an antagonist at the PCP site of NMDA receptors. The effects depend on the presence of a protonable nitrogen
A-NK
Unicameral legislature of Portugal
CDS-PP IL PSN MPT PPD/PSD ASDI PRD JPP PAN PS UEDS L PCP PEV BE MDP UDP São Bento Palace ARtv (Portugal) Legislative Assembly
Assembly of the Republic (Portugal)
Assembly_of_the_Republic_(Portugal)
Chemical compound
barbiturate, but with additional PCP-like dissociative, anaesthetic and hallucinogenic effects. Due to its similarity in effects to PCP, PCPy was placed into the
Rolicyclidine
Chemical compound
doses of 2 mg per day. Deschloroketamine is likely schedule 1 in Canada as an analogue of PCP. Deschloroketamine is illegal in Latvia. Ketamine 2-Fluorodeschloroketamine
Deschloroketamine
Dissociative drug
It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics
Methoxetamine
Private university in Philadelphia, Pennsylvania, US (1821–2022)
or USciences), previously Philadelphia College of Pharmacy and Science (PCPS), was a private university in Philadelphia, Pennsylvania. On June 1, 2022
University_of_the_Sciences
Chemical compound
67 μM, with the value for PCP being 2.02 μM. Arylcyclohexylamine Ketamine 3-HO-PCE 3-MeO-PCE 3-HO-PCP 3-MeO-PCP 4-MeO-PCP Methoxyketamine Ahmadi A, Khalili
3-MeO-PCMo
Pharmaceutical compound
potent and selective noncompetitive antagonist of the NMDA receptor via PCP site, with an affinity (Ki) of 1.8 nM. It produces analgesic, anticonvulsant
CNS-5161
Chemical compound
2-MDP (U-23807A) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. The
2-MDP
Chemical compound
has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed
Dexoxadrol
official web site History section of the Party's official website Avante Festival! official website Avante! newspaper online edition PCP's short biography
Electoral history of the Portuguese Communist Party
Electoral_history_of_the_Portuguese_Communist_Party
Chemical compound
donor site and flanking phosphine donors; these compounds are referred to as PCP pincers. Although the most common class of pincer ligands features PCP donor
Transition metal pincer complex
Transition_metal_pincer_complex
Chemical compound
affinity for the sigma receptors. Because of its high affinity for the PCP site of the NMDA receptor complex, the 3H radiolabelled form of TCP is widely
Tenocyclidine
Chemical compound
there. Compared to other NMDA receptor antagonists such as dizocilpine, PCP, and ketamine, tiletamine does not significantly impact the release or metabolism
Tiletamine
Class of chemical compounds
class of pharmaceutical, designer, and experimental drugs. Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic
Arylcyclohexylamine
Pharmaceutical compound
2-FXPr (2'-fluoro-2-oxo-PCPr) is a designer drug from the arylcyclohexylamine family, which is believed to have dissociative effects. It has reportedly
2-FXPr
Central nervous system stimulant
concentrations by anatomical site. Fluid from the human colon – which contains the highest concentration of microbes of any anatomical site – contains approximately
Amphetamine
Cofactor of both fatty acid and polyketide biosynthesis
protein (ACP), aryl carrier protein (ArCP), and the peptidyl carrier protein (PCP) are a family of protein cofactors that participate in fatty acid (acyl)
Acyl_carrier_protein
Chemical compound
chemical of the arylcyclohexylamine chemical class related to phencyclidine (PCP) and eticyclidine (PCE). It acts as an NMDA receptor antagonist but has low
Dieticyclidine
Chemical compound
Vitro and Ex Vivo". Bulletin of Experimental Biology and Medicine. 164 (2): 177–180. doi:10.1007/s10517-017-3952-2. PMID 29181662. S2CID 90334012. v t e
Glufimet
observation that people with phencyclidine(PCP)-induced psychosis were lacking in glutamate transmission. (PCP is an NMDA receptor antagonist that blocks
NMDA_receptor_modulator
Discontinued computer operating system for x86 processors
related to the CP/M family through Tim Olmstead's "The Unofficial CP/M Web site" since 1997. After Olmstead's death on 12 September 2001, the free distribution
CP/M-86
Discontinued family of computer operating systems
the CP/M and MP/M families through Tim Olmstead's "The Unofficial CP/M Web site" since 1997. After Olmstead's death on 12 September 2001, the distribution
CP/M
Chemical compound
ketamine's Ki = 860 nM. Aptiganel Dizocilpine Fourphit Metaphit Selfotel [3H]N-[1-(2-thienyl)cyclohex-yl]piperidine Hays, Sheryl J.; Novak, Perry M.; Ortwine,
PD-137889
Chemical compound
cross-tolerance between PCP-like compounds and competitive NMDA antagonists". The Journal of Pharmacology and Experimental Therapeutics. 263 (2): 499–504. doi:10
Selfotel
Eco-socialist political party in Portugal
(PCP). From 1987 onwards, it entered all the legislative, and municipal elections as part of Unitary Democratic Coalition, which also includes the PCP
Ecologist_Party_"The_Greens"
Amino acid and neurotransmitter
age-related diseases of the brain. The drug phencyclidine (more commonly known as PCP or 'Angel Dust') antagonizes glutamic acid non-competitively at the NMDA
Glutamic_acid
Chemical compound
Propylphenidine Remacemide UWA-001 Morris H, Wallach J (July–August 2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs"
NPDPA
River in Pennsylvania, United States
treated water discharged from the Havertown PCP Superfund water treatment facility. The Havertown PCP Superfund site severely polluted Naylors Run. National
Naylors_Run
Chemical compound
(4): 1801–16. Bibcode:1998BpJ....75.1801D. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852. PMID 9746522. GB Patent 893920 - Polycyclic amino compounds
NEFA_(drug)
LIVRE surpassed BE and PCP by gathering 4% of the votes and six seats. The other left-wing parties, the Portuguese Communist Party (PCP) and the Left Bloc
Next Portuguese legislative election
Next_Portuguese_legislative_election
American political party
Berger, Joseph (May 22, 2011). "Workers of the World, Please See Our Web Site". New York Times. All three have greatly shrunk from their heydays. The Socialist
Communist_Party_USA
Chemical compound
Uncompetitive pore blockers (mostly dizocilpine site): 2-MDP 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 4-MeO-PCP 8A-PDHQ 18-MC α-Endopsychosin Alaproclate Alazocine
Xanthurenic_acid
Dissociative anesthetic designer drug
2023-08-27. Retrieved 2023-08-27. Morris H, Wallach J (July–August 2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs"
Diphenidine
Pharmaceutical compound
Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist. It blocks
Fourphit
Chemical compound
non-competitive NMDA receptor antagonist. It binds with high affinity to the PCP binding site on the NMDA receptor (Ki = 107 nM, determined by the displacement of
Etoxadrol
Diuretic medication
potassium, producing diuretic effects. In adults, hydrochlorothiazide acts within 2 hours, peaks at 4 hours, and lasts 6–12 hours. It is excreted primarily by
Hydrochlorothiazide
Cough suppressant and dissociative drug
retrosplenial cortices of rats administered other NMDA receptor antagonists such as PCP, but not with dextromethorphan. Dextromethorphan is considered less addictive
Dextromethorphan
Amino acid
are most important. In aqueous solution, glycine is amphoteric: below pH = 2.4, it converts to the ammonium cation called glycinium. Above about pH 9.6
Glycine
"Havertown PCP NPL site narrative". EPA. Retrieved February 25, 2010.{{cite web}}: CS1 maint: deprecated archival service (link) "LANSDOWNE RADIATION SITE LANSDOWNE
List of Superfund sites in Pennsylvania
List_of_Superfund_sites_in_Pennsylvania
Amino acid derivative
dextromethorphan (DXM), ketamine, magnesium, tiletamine, phencyclidine (PCP), riluzole, memantine, methoxetamine (MXE), methoxphenidine (MXP) and kynurenic
N-Methyl-D-aspartic_acid
Coalition (CDU) and won a combined 3.2% of the vote and elected 4 MPs to parliament. The 4 MPs elected in 2024 are all from PCP. PEV elected zero. LIVRE has no
2025 Portuguese legislative election
2025_Portuguese_legislative_election
Class of psychoactive drugs
unlike psychedelics. Despite some dissociatives, such as phencyclidine (PCP) possessing stimulating properties, most dissociatives seem to have a general
Dissociative
Pharmaceutical compound
uncompetitive NMDA receptor antagonists like ketamine and phencyclidine (PCP), L-687,414 has not been associated with the development of brain vacuoles
L-687,414
Partido Comunista Português, pronounced [pɐɾˈtiðu kumuˈniʃtɐ puɾtuˈɣeʃ], or PCP), spans a period of 104–105 years, from its foundation in 1921 as the Portuguese
History of the Portuguese Communist Party
History_of_the_Portuguese_Communist_Party
Amino acid
discovered in humans sooner, the glycine site on the NMDA receptor might instead be named the D-serine site. Outside the central nervous system, D-serine
Serine
Chemical compound
drug-appropriate responding in animals trained to discriminate phencyclidine (PCP) from saline, suggesting that the glycine receptor ligand (R)-(+)-HA-966
HA-966
Pharmaceutical compound
It is the ring-contracted cyclopentyl homologue of PCP and has around 1/10th the potency of PCP, making it a similar potency to ketamine. It has been
PCPEP
Chemical compound
Methoxpropamine (MXPr, 2-Oxo-3'-methoxy-PCPr) is a dissociative anesthetic drug of the arylcyclohexylamine class and NMDA receptor antagonist that is
Methoxpropamine
2009 American film
release that the "undead" presented are not actual zombies: "It's like a PCP zombie movie, that's my take on it 'cause they're not really dead." A plague
Dead_Air_(2009_film)
Chemical compound
non-competitive NMDA receptor antagonist. It is closely related to phencyclidine (PCP), and specifically, is a derivative of tenocyclidine (TCP). Gacyclidine exhibits
Gacyclidine
Designer drug combination mimicking MDMA
is a mixture of the entactogen 5-MAPB or MDAI, the stimulant 2-fluoromethamphetamine (2-FMA), and the serotonergic psychedelic 5-MeO-MiPT or 4-HO-MET
Borax_combo
Chemical compound
XW10508 PCP-related: 2-Oxo-PCE 3-Chloro-PCP 3-Fluoro-PCP 3-HO-PCP 3-HO-PCE 3-Me-PCE 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 3-Methyl-PCP 3-Methyl-PCPy 4-Keto-PCP 4-MeO-PCP
SN_35210
Livingston Shop Complex Superfund site progress profile". EPA. Archived from the original on June 16, 2011. Retrieved May 2, 2010. "Burlington Northern Livingston
List of Superfund sites in Montana
List_of_Superfund_sites_in_Montana
Chemical compound
glutamate binding site and thus activation of NMDAR. It has anticonvulsant effects. AP-7 functions specifically as a NMDA recognition site blocker, in contrast
AP-7_(drug)
Teledubgnosis vs. N.I.C. Agoraphobic Nosebleed – "Flesh of Jesu Mix" (2006) on PCP Torpedo/ANbRx Explosions in the Sky – "The Birth and Death of The Day (Jesu
Jesu_discography
Chemical compound
dissociative NPS makes an entrance on the drug scene". Forensic Toxicology. 36 (2): 233–242. doi:10.1007/s11419-018-0421-1. ISSN 1860-8965. Retrieved 11 April
1,2-Diphenylethylamine
Medical antimicrobial drug
infections, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function. In African trypanosomiasis it is used
Pentamidine
Chemical compound
clinical development. 1-Naphthylamine is reacted with cyanogen bromide to give 2. Treatment of this intermediate with 3-ethyl-N-methylaniline leads to addition
Aptiganel
Chemical compound
receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors. AP5 blocks NMDA receptors in micromolar concentrations
AP5
travel, tourism, insurance
PCP SITE-2
PCP SITE-2
PCP SITE-2
PCP SITE-2
PCP SITE-2
PCP SITE-2
PCP SITE-2
PCP SITE-2
PCP SITE-2
travel, tourism, insurance