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Organelle of sperm cells
The acrosome is an organelle that develops over the anterior (front) half of the head in the spermatozoa (sperm cells) of humans and many other animals
Acrosome
Sperm-meets-egg process
process known as the acrosome reaction, which is the reaction that occurs in the acrosome of the sperm as it approaches the egg. The acrosome is a membrane-bound
Acrosome_reaction
Male reproductive cell
spermatozoon approaches the ovum, it undergoes the acrosome reaction in which the membrane surrounding the acrosome fuses with the plasma membrane of the sperm's
Sperm
Union of a human egg and sperm
copulation shortly after ovulation. Upon encountering the secondary oocyte, the acrosome of the sperm produces enzymes which allow it to burrow through the outer
Human_fertilization
Glycoprotein layer surrounding the plasma membrane of mammalian oocytes
species-specific fertilization; to prevent polyspermy, and enable the acrosome reaction for the successful adhesion and penetration by the sperm cell
Zona_pellucida
Union of opposite-sex gametes in sexual reproduction to form a zygote
the ZP3 and is important for binding with the sperm and activating the acrosome reaction. ZP3 is sufficient though unnecessary for sperm/egg binding. Two
Fertilisation
Penultimate step in the activation of mammalian spermatozoa
the female reproductive tract. Sperm must undergo capacitation and the acrosome reaction to be able to penetrate through the outer layers of an oocyte
Capacitation
Cellular mantle around egg cell
fertilization to occur, sperm cells rely on hyaluronidase (an enzyme found in the acrosome of spermatozoa) to disperse the corona radiata from the zona pellucida
Corona_radiata_(embryology)
In vitro fertilization procedure
embryos that may be transferred to a maternal uterus. With this method, the acrosome reaction is skipped. There are several differences between classic IVF
Intracytoplasmic sperm injection
Intracytoplasmic_sperm_injection
Medical condition
infertility. It is characterised by round-headed spermatozoa without acrosomes, an abnormal nuclear membrane and midpiece defects. Affected males therefore
Globozoospermia
Protein-coding gene in the species Homo sapiens
the glycoprotein in the zona pellucida most important for inducting the acrosome reaction of sperm cells at the beginning of fertilization. X-ray crystallographic
ZP3
Final stage of spermatogenesis, involving spermatid maturation
one end, where the Golgi apparatus creates enzymes that will become the acrosome. At the other end, it develops a thickened midpiece, where the mitochondria
Spermiogenesis
Mammalian protein found in Homo sapiens
by the ACR gene. Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction. It aids in the penetration of the Zona
Acrosin
Type of sperm cell motility
which encloses the ovum. Hyperactivation could then be followed by the acrosome reaction where the cap-like structure on the head of the cell releases
Hyperactivation
Procreative biological processes of humanity
fertilizing it with the help of certain hydrolytic enzymes present in the acrosome. The fertilization usually occurs in the fallopian tubes, but can happen
Human_reproduction
Biological process that prevents polyspermy
This is often referred to as zona hardening. Acrosome reaction - The analogous reaction in the acrosome of the sperm Rojas, Japhet; Hinostroza, Fernando;
Cortical_reaction
Species of bird
the Passeriformes for having spermatozoa with a rounded head and a blunt acrosome. This species produces two or three broods per season, from early May to
Eurasian_bullfinch
Structure found between the acrosomal membrane and the nuclear membrane
the DNA in nuclei becomes condensed; the acrosome develops as a structure close to the nucleus. The acrosome is derived from the Golgi apparatus and contains
Acroplaxome
Union of an egg and sperm to form a zygote within the female body
fertilization for all mammals involves recognition events of the sperm and oocyte, acrosome reactions and associations, piercings of the oocyte zona pellucida by sperm
Internal_fertilization
Specialized subunit within a cell
cell components Organelle/Macromolecule Main function Structure Organisms acrosome helps spermatozoa fuse with ovum single-membrane compartment most animals
Organelle
system. However, some DFs have been identified that are located on the acrosome of sperm. Normally, capacitation is initiated through the loss of DF before
Decapacitation_factor
Protein-coding gene in the species Homo sapiens
acylglycerol catabolic process steroid hormone mediated signaling pathway acrosome reaction sperm capacitation cellular lipid metabolic process medium-chain
ABHD2
Method of testing human sperm viability
fail this test. This test evaluates the acrosome reaction of human spermatozoa. However, the incidence of acrosome reaction in freely swimming human sperm
Hamster_zona-free_ovum_test
Protein-coding gene in the species Homo sapiens
multicellular organism development cell differentiation spermatogenesis acrosome reaction penetration of zona pellucida positive regulation of protein processing
TNP2
Direct precursor of a sperm cell
thickened mid-piece where the mitochondria become localised, and form an acrosome. Spermatid DNA also undergoes packaging, becoming highly condensed. The
Spermatid
Undifferentiated male germ cell
sperm, it is an ovular shape consisting of the nucleus and the acrosome. Acrosome: The Acrosome covers two-thirds the head's outside area; it contains hydrolytic
Spermatogonium
Steroidal alkaloid found in plants of the lily family
reported to have any effect on the acrosome reaction on its own, but it is able to block the progesterone-induced acrosome reaction. Moreover, veratridine
Veratridine
Species of rodent
mobility of these mobile trains was also found to be influenced by premature acrosome reactions, altruistic acts performed by some spermatozoa for the benefit
Wood_mouse
Medical term for reduced sperm motility
fusion with the ovule. Studies in mice have shown that DHA is essential for acrosome reaction and a DHA deficiency results in abnormal sperm morphology, loss
Asthenozoospermia
Reproductive gene and associated protein
differentiation of germ cells for spermatogenesis and participates in acrosome formation for appropriate sperm-egg fusion. SPATA16 is located on chromosome
SPATA16
Development and formation of the human embryo
reaction takes place; the front part of the spermatozoan head is capped by an acrosome which contains digestive enzymes to break down the zona pellucida and allow
Human_embryonic_development
Production of sperm
The Golgi apparatus surrounds the now condensed nucleus, becoming the acrosome. Maturation then takes place under the influence of testosterone, which
Spermatogenesis
education Abstinence, be faithful, use a condom Accidental incest Acrosome Acrosome reaction Acrotomophilia Activin and inhibin Adolescent sexuality Adolescent
Index of human sexuality articles
Index_of_human_sexuality_articles
Inability to reproduce
transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process
Infertility
Protein-coding gene in the species Homo sapiens
granule membrane azurophil granule membrane Biological process regulation of acrosome reaction glycoprotein biosynthetic process epithelial cell development
B4GALT1
Protein-coding gene in the species Homo sapiens
to egg plasma membrane involved in single fertilization regulation of acrosome reaction binding of sperm to zona pellucida regulation of molecular function
CRISP1
eggs chemical influence on sperm mobility and velocity. Sperm guidance Acrosome reaction Oocyte Wessel, GM; Brooks, JM; Green, E; Haley, S; Voronina, E;
Egg_jelly
Protein-coding gene in the species Homo sapiens
of acrosome reaction negative regulation of peptidase activity negative regulation of serine-type endopeptidase activity spermatogenesis acrosome assembly
SPINK2
Species of annelid
grow to 10 mm. They have parental care.[unreliable source?] It has an acrosome shaped like a beaker. They reproduce by iteroparous.[unreliable source
Salvatoria_clavata
asymmetry of the flagella SPACA1 Sperm acrosome membrane-associated protein 1 STRING Network Aids in the acrosome expansion and establishment of normal
TMEM202
Protein-coding gene in the species Homo sapiens
Equatorin, sperm acrosome associated is a protein that in humans is encoded by the EQTN gene. GRCm38: Ensembl release 89: ENSMUSG00000028575 – Ensembl
EQTN
Biological membrane structure
together. This fusion allows the joining of two distinct structures as in the acrosome reaction during fertilization of an egg by a sperm, or the entry of a virus
Lipid_bilayer
Genus of rodents
of cases, the acrosomes of Galea sperm are smooth in outline, and only occasionally are degenerate forms present or are the acrosomes absent. In Galea
Galea_(genus)
Series of chemical reactions resulting in a cell response
ability to fertilize the female gamete, this cell suffers capacitation and acrosome reaction in female reproductive tract. The signaling pathways best described
Biochemical_cascade
Medical condition of mis-shaped sperm
(sperm with round heads), the Golgi apparatus is not transformed into the acrosome that is needed for fertilization. The presence of abnormally-shaped sperm
Teratospermia
Protein encoded in humans by c12orf71 gene
regulation; SCAN domain containing SPACA5B Sperm acrosome associated 5B; Enable lysozyme activity SPACA5 Sperm acrosome-associated protein 5; Belongs to the glycosyl
Chromosome 12 open reading frame 71
Chromosome_12_open_reading_frame_71
Protein-coding gene in the species Homo sapiens
rabbit sperm zona pellucida binding protein and localization during the acrosome reaction". Dev. Biol. 165 (2): 688–701. doi:10.1006/dbio.1994.1285. PMID 7525387
SPA17
Mammalian protein found in Homo sapiens
that of Glycodelin-A. It also binds the sperm head, thereby inhibiting acrosome reaction and sperm-egg binding. Upon de-glycosilation, glycodelin F dissociates
Glycodelin
Protein-coding gene in the species Homo sapiens
cyclase-activating G protein-coupled receptor signaling pathway single fertilization acrosome reaction olfactory learning flagellated sperm motility cellular response
ADCY3
Protein-coding gene in the species Homo sapiens
the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide
ZP2
Genus of amphibians
has triangle-shaped head and discrete acrosome vesicles, while type II sperm has elongated head and clear acrosome vesicles. Lithodytes lineatus have type
Lithodytes
Protein-coding gene in the species Homo sapiens
Mammalian testis: a comparative analysis focusing on its presence in the acrosome of spermatids". Biol. Reprod. 74 (5): 816–23. doi:10.1095/biolreprod.105
PRND
2006 compilation album by Miss Kittin
Maxximus & Something J 2:46 21. "My Red Hot Car" Thomas Jenkinson Squarepusher 1:22 22. "Perfect Girl" Alexander Chesler, Matthew Moran Acrosome 3:41
A Bugged Out Mix (Miss Kittin album)
A_Bugged_Out_Mix_(Miss_Kittin_album)
Antibodies produced against sperm antigens
transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process
Antisperm_antibodies
Protein-coding gene in the species Homo sapiens
"Human SP-10: acrosomal distribution, processing, and fate after the acrosome reaction". Biol. Reprod. 51 (6): 1222–31. doi:10.1095/biolreprod51.6.1222
ACRV1
Species of bat
unique in that the sperm head has a rounded nucleus and extremely pointed acrosome. Recent research on the bats in Costa Rica suggests that the bats exhibit
Wrinkle-faced_bat
American Biologist (1910–1978)
process of fertilization in invertebrates. Both of Jean’s Studies on the Acrosome (the second being published in 1954) pioneered the use of the electron
Jean_Clark_Dan
Greek ἄκρον (ákron), highest or farthest point acromegaly, acroosteolysis, acrosome -acusis hearing Greek ἀκουστικός (akoustikós), of or for hearing hyperacusis
List of medical roots and affixes
List_of_medical_roots_and_affixes
Protein-coding gene in the species Homo sapiens
sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells". Biology of Reproduction. 72
USP8
Breakdown of proteins into smaller polypeptides or amino acids
function in sperm adhesion to the zona pellucida during exocytosis of the acrosome". Biochemical Journal. 375 (Pt 2): 477–488. doi:10.1042/BJ20030753. ISSN 0264-6021
Proteolysis
Protein-coding gene in humans
proper shaping of sperm head and acrosome within the testis and possibly has an additional role in the sperm acrosome reaction. An understanding of the
FYN
Giant tube worm (species of annelid)
spermatozoa are thread-shaped and are composed of three distinct regions: the acrosome (6 μm), the nucleus (26 μm) and the tail (98 μm). Thus, the single spermatozoon
Riftia
Mammalian protein found in Homo sapiens
membrane Biological process lipid catabolic process positive regulation of acrosome reaction phosphatidylcholine acyl-chain remodeling retinoid metabolic process
Phospholipase_B
Human gene
Sperm acrosome developmental regulator, also known as C7orf61, is an asparagine-poor protein which in humans encoded by the SPACDR gene. The protein function
SPACDR
Protein-coding gene in the species Homo sapiens
integral component of membrane Biological process transmembrane transport acrosome assembly spermatogenesis spermatid development spermatid nucleus differentiation
Major facilitator superfamily domain containing 14A
Major_facilitator_superfamily_domain_containing_14A
Gamete-producing cell
by nuclear condensation, ejection of the cytoplasm and formation of the acrosome and flagellum.[citation needed] The developing male germ cells do not complete
Germ_cell
invertebrates, amphibians, birds, and fishes. During fertilization, the acrosome of the sperm interacts with the vitelline envelope that has species-specific
Vitellin
Cluster of cells surrounding an oocyte
layers of cumulus oophorus cells accumulate around the oocyte to aid in the acrosome reaction that enables the sperm to penetrate into the oocyte. The proximity
Cumulus_oophorus
Human chromosome
13 SNF8: encoding protein Vacuolar-sorting protein SNF8 SPACA3: Sperm acrosome membrane-associated protein 3 SPAG5: encoding protein Sperm-associated
Chromosome_17
Free-living species of nematode
spermatheca). The sperm of C. elegans is amoeboid, lacking flagella and acrosomes. When self-inseminated, the wild-type worm lays about 300 eggs. When inseminated
Caenorhabditis_elegans
spermatozoa MeSH A05.360.490.890.820 – sperm head MeSH A05.360.490.890.820.100 – acrosome MeSH A05.360.490.890.830 – sperm midpiece MeSH A05.360.490.890.840 – sperm
List_of_MeSH_codes_(A05)
Protein domain
found in the sandfly host. Identification of the outer acrosome membrane in sperm, indicating acrosome integrity. List of histologic stains that aid in diagnosis
Peanut_agglutinin
R S T U V W X Y Z See also References External links acrosomal vesicle acrosome allantois One of four extraembryonic membranes formed during the development
Glossary of developmental biology
Glossary_of_developmental_biology
Protein-coding gene in the species Homo sapiens
membrane cytoplasmic vesicle Biological process positive regulation of acrosome reaction regulation of fertilization Sources:Amigo / QuickGO Orthologs
FAM170B
Mammalian protein found in Homo sapiens
PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids". Glycobiology. 12 (11): 771–83. doi:10.1093/glycob/cwf086
POMT2
Protein-coding gene in humans
correlated with sperm motility. CIB1 has also been shown to be present in the acrosome region of the sperm, which plays a critical role in fertilization. Studies
CIB1
Protein-coding gene in the species Homo sapiens
regulation of nitric oxide mediated signal transduction regulation of acrosome reaction negative regulation of peptidase activity negative regulation
SPINK1
Argentine biologist
"Analysis of CAPZA3 localization reveals temporally discrete events during the acrosome reaction". Journal of Cellular Physiology. 224 (3): 575–580. doi:10.1002/jcp
Pablo_Visconti
Species of lizard
characterized by features such as a depression in the transverse section of the acrosome, a moderately long midpiece, columnar mitochondria, an elongated nucleus
Amphisbaena_alba
Chemical compound
(2008). "Effects of Native Human Zona Pellucida Glycoproteins 3 and 4 on Acrosome Reaction and Zona Pellucida Binding of Human Spermatozoa". Biology of Reproduction
Sialyl-Lewis_X
Protein-coding gene in the species Homo sapiens
adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism
Zonadhesin
Structure surrounding the surface of the plasma membrane of an ovum
selective nutrients between the albumen and the yolk. Teleost fish have no acrosome on their sperm cells. Their eggs coats have a small opening that lets a
Vitelline_membrane
Protein-coding gene in the species Homo sapiens
Fukuda M, Mayorga LS (July 2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Developmental Biology. 235 (2): 521–9.
SYT6
Medical condition
transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process
Male_infertility
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
COPII-coated vesicles) and secretory vesicles (including synaptosome, acrosomes, melanosomes, and chromaffin granules). Different types of biological
Biological_membrane
Protein-coding gene in humans
highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated
DPY19L2
patients with male factor infertility, labeled for normal or abnormal sperm acrosome, head, vacuole, and tail. Cropped around single sperm head. Magnification
List of datasets for machine-learning research
List_of_datasets_for_machine-learning_research
American developmental biologist (born 1937)
activation. Related work examined pH and calcium changes governing the sperm acrosome reaction and used electrically permeabilized eggs to measure changes in
David_Epel
Protein-coding gene in the species Homo sapiens
Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before
SPACA3
population. General health Semen analysis for: Sperm count Morphology Motility Acrosome activity may also be tested Screening for cytomegalovirus is not mandatory
Screening of potential sperm bank donors
Screening_of_potential_sperm_bank_donors
Peripheral membrane protein
et al. (May 2010). "Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice". The Journal of Clinical
Phospholipase_A2
Class of enzymes
[citation needed] In mammalian fertilization, hyaluronidase is released by the acrosome of the sperm cell after it has reached the oocyte, by digesting hyaluronan
Hyaluronidase
Protein-coding gene in the species Homo sapiens
"Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids". Eur. J. Biochem. 234 (1): 8–15. doi:10.1111/j.1432-1033
Centrosomal_protein_131
Chemical compound
celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction". European Journal of Pharmacology. 464 (1): 9–15. doi:10
Demethylzeylasteral
Protein-coding gene in the species Homo sapiens
reticulum membrane cytosol Biological process lipid catabolic process acrosome reaction intracellular signal transduction phosphatidylinositol metabolic
PLCD4
Protein domain
spermatozoa in the testis), the CRISP2 protein is incorporated into the acrosome where it is believed to be involved in the adhesion of germ cells with
Cysteine-rich secretory protein
Cysteine-rich_secretory_protein
Protein-coding gene in the species Homo sapiens
PMID 15489334. Cheng GY, Shi JL, Wang M, et al. (2007). "Inhibition of mouse acrosome reaction and sperm-zona pellucida binding by anti-human sperm membrane
Sperm-associated_antigen_8
Using an animal's anti-disease protections against its reproductive system
Wassarman PM (July 1990). "Identification of a ZP3-binding protein on acrosome-intact mouse sperm by photoaffinity crosslinking". Proc. Natl. Acad. Sci
Immunocontraception
Evolutionary biologist
(1988). "Fertilization in Oikopleura dioica (Tunicata, Appendicularia): Acrosome reaction, cortical reaction and sperm-egg fusion". Zoomorphology. 108 (4):
Linda_Holland
Process for assessing human fertility
content, oxidative stress, maturation assessment, DNA fragmentation and acrosome activity. Checks are also made to identify undescended testicles and retrograde
Fertility_testing
ACROSOME
ACROSOME
ACROSOME
ACROSOME
Girl/Female
Tamil
Saravati | ஸாராவதீ
A river
Boy/Male
Hindu, Indian, Punjabi, Sikh
Clean; Pure
Surname or Lastname
English (southern)
English (southern) : metonymic occupational name for a beekeeper or a gatherer or seller of honey, Middle English hony (Old English hunig), or a nickname from the same word used as a term of endearment, a sense which was common in medieval England.
Male
Egyptian
, the son of Ape.
Girl/Female
Indian, Tamil
Goddess Laxmi
Biblical
true; fearing
Boy/Male
Sikh
The one in whom peace prevades
Girl/Female
Spanish
Nice.
Boy/Male
Tamil
Sivaraman | ஸீவாரமணÂ
Surname or Lastname
Americanized spelling of Dutch Schutte ‘archer’.English
Americanized spelling of Dutch Schutte ‘archer’.English : occupational name for a scout or spy, or a nickname for someone who behaved like one, from Middle English scut ‘scout’ (Old French escoute, from escouter ‘to listen’).English : nickname for a swift runner, from Middle English scut ‘hare’.
ACROSOME
ACROSOME
ACROSOME
ACROSOME
ACROSOME