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A virtually safe dose (VSD) may be determined for those carcinogens not assumed to have a threshold. Virtually safe doses are calculated by regulatory
Virtually_safe_dose
Topics referred to by the same term
Ventricular septal defect, a defect in the ventricular septum of the heart Virtually safe dose, a concept in regulatory toxicology, applied to carcinogens with
VSD
1986 nuclear accident in the Soviet Union
ingested dose was largely from iodine and, unlike the other fission products, rapidly found its way from dairy farms to human ingestion. Similarly in dose reconstruction
Chernobyl_disaster
Vaccines to prevent rabies in humans and animals
prevent rabies. There are several rabies vaccines available that are both safe and effective. Vaccinations must be administered prior to rabies virus exposure
Rabies_vaccine
Assessment of Chernobyl's impact on Earth since 1986
evacuees, 125,000 man-Sv to the populace of Ukraine, Belarus, and Russia, and a dose to most other European countries amounting to 115,000 man-Sv. The report
Effects of the Chernobyl disaster
Effects_of_the_Chernobyl_disaster
Plant used as a dietary fiber
stools in the colon. When used to treat constipation, psyllium is taken in doses of from 3.5 grams per day to 11 grams twice daily. A 2021 review of over-the-counter
Psyllium
Medication
5 days). Based on these findings, doses of naltrexone of even less than 50 mg/day would be expected to achieve virtually complete brain MOR occupancy. Blockade
Naltrexone
Ionic compound (KI)
it must be dosed daily until a risk of significant exposure to radioiodine no longer exists. Emergency 130 milligrams potassium iodide doses provide 100 mg
Potassium_iodide
Nonsteroidal anti-inflammatory drug
heart failure. At low doses, it does not appear to increase the risk of myocardial infarction (heart attack); however, at higher doses it may. Ibuprofen can
Ibuprofen
American toxicologist
(August 1995). "Quick estimate of the regulatory virtually safe dose based on the maximum tolerated dose for rodent bioassays". Regul Toxicol Pharmacol
Michael_Dourson
Psychedelic drug
recreational doses (~50–250 μg) is considered to be very safe in terms of toxicity, with not a single toxicity-related death having been reported at such doses despite
LSD
Device which detects objects in or around a person's body
ionizing radiation. X-ray-based scanners Backscatter X-ray scanners use low dose radiation for detecting suspicious metallic and non-metallic objects hidden
Full_body_scanner
Treatment of cancer using drugs that inhibit cell division or kill cells
whether dose reduction is required. Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be
Chemotherapy
Chemical compound
product that provides 0.25 mg CPC per dose would need to take 4,000 doses at one time to reach the estimated fatal dose range. A review found that mouthwashes
Cetylpyridinium_chloride
Vitamin D3, a chemical compound
generally required before high blood calcium occurs. Normal doses, 800–2000 IU per day, are safe in pregnancy. Cholecalciferol (vitamin D3) appears to stimulate
Cholecalciferol
Opioid used to treat pain and opioid use disorder
pregnancy is safe is unclear, but use while breastfeeding is probably safe, since the dose the infant receives is 1–2% that of the maternal dose, on a weight
Buprenorphine
Substance that causes death, injury or harm to organs
severity and specific presentation of symptoms often depend on the nature and dose of the poison involved. Certain poisons, particularly caustic or irritating
Poison
Extremely venomous snake native to Australia
collected and virtually nothing was added to knowledge of its biology until the species was rediscovered in 1972. Based on the median lethal dose (LD50) of
Inland_taipan
American actor (born 1971)
place of Goodman. 5Score given by guest judge Pitbull in place of Goodman. Dose, Sarah (October 13, 2014). "Alfonso Ribeiro reveals origin of 'Carlton Dance'"
Alfonso_Ribeiro
Chemical compound found in some species of mushrooms
behavioral threshold dose. We have also shown that the drug psilocin, the active form of the prodrug psilocybin, has virtually the same potency as (R)-DOI
Psilocybin
Pain medication of the opiate family
cardiorespiratory diseases, regular, low-dose sustained-release morphine significantly reduces breathlessness safely, with its benefits maintained over time
Morphine
Vaccine used to prevent measles
all of those who do not develop immunity after a single dose develop it after a second dose. When the rate of vaccination within a population is greater
Measles_vaccine
Class of vaccines against human papillomavirus
quadrivalent and nonavalent vaccines providing virtually complete protection. The WHO recommends a one or two-dose schedule for girls aged 9–14 years, the same
HPV_vaccine
Disinfection method using ultraviolet light
2016-02-08. Mills R (September 2014). "Chip packets help make safer water in Papua New Guinea". "UV Dose & System Selection—Sizing UV Systems and Calculating the
Ultraviolet germicidal irradiation
Ultraviolet_germicidal_irradiation
Vaccines used to prevent infection by Neisseria meningitidis
conjugate vaccine, recommended as a single intramuscular dose, and is available as 1-dose and 5-dose vials. There are three quadrivalent vaccines available
Meningococcal_vaccine
Medical history of American celebrity
given Jackson 2 mg of lorazepam via IV. That dose had been followed by another dose. After the second dose, Jackson went into arrest. Murray asked doctors
Health and appearance of Michael Jackson
Health_and_appearance_of_Michael_Jackson
Chemical stimulant produced by some plants
364–374. doi:10.1093/toxsci/kfq103. PMC 2905398. PMID 20363831. there is no safe dose of nicotine during pregnancy... The general consensus among clinicians
Nicotine
Indian Government COVID-19 vaccination portal
administering 2 billion vaccinations in July, 2022 which includes, dose 1, 2 and precaution dose. As of January 2023, there are more than 1 billion registrations
CoWIN
Opioid analgesic and recreational drug
injection, so smaller doses of it are needed for the same effect on pain. Both of these factors are advantageous if giving high doses of opioids via the
Heroin
Effects of radiation released from the Fukushima nuclear accident
around the world, including in California and the Pacific Ocean. Preliminary dose-estimation reports by the World Health Organization (WHO) and the United
Radiation effects from the Fukushima nuclear accident
Radiation_effects_from_the_Fukushima_nuclear_accident
Medication used to treat hypertension and heart failure
probably represents saturable binding to ACE and is not proportional to dose. Lisinopril does not undergo metabolism and the absorbed drug is excreted
Lisinopril
Medication administered into a vein
recreational drugs. Many therapies are administered as a "bolus" or one-time dose, but they may also be administered as an extended infusion or drip. The act
Intravenous_therapy
Vaccine against COVID-19
reported deaths in the trial, it was virtually impossible to analyze efficacy against death for both the two and three dose regimens. Mexico plans to host a
Soberana_02
Wakefulness-promoting medication
and 250 mg oral tablets. A 50 mg dose of armodafinil has been said to be essentially equivalent to a 100 mg dose of modafinil in terms of drug levels
Armodafinil
Pharmaceutical compound
Pharmaceutical-grade harmine hydrochloride is safe and well-tolerated at oral doses below 2.7 mg/kg in healthy adults, with higher doses causing mild to moderate gastrointestinal
Harmine
Chemical compound
marked, and Phosote can be tolerated in larger doses and for a longer continuance than Creosote or Guaiacol. Dose of the preparation, one to two grammes three
Tricresyl_phosphate
Fluoroquinolone antibiotic
administered dose being excreted in the urine as unmetabolized drug. An additional 10% is excreted in urine as metabolites. Urinary excretion is virtually complete
Ciprofloxacin
Malignant tumor made of hormone-producing cells in the thyroid gland
administering the maximum safe dose (calculated based on a number of factors), while others favor administering smaller doses, which may still be effective
Follicular_thyroid_cancer
Combined vaccine against measles, mumps, and rubella
mumps vaccine, and rubella vaccine into a single injection. After two doses, 97% of people are protected against measles, 88% against mumps, and at
MMR_vaccine
Stomach and intestinal infection
carefully followed for maximum water depth/distance from UV source, and for dose/exposure time. Other claimed advantages include short treatment time, elimination
Travelers'_diarrhea
Class of chemical compounds
they only assess hazard, i.e. carcinogenicity at any dose. It is likely that there is a practical safe threshold for the non-genotoxic dioxins, and the present
Dioxins and dioxin-like compounds
Dioxins_and_dioxin-like_compounds
Chemicals that can interfere with endocrine or hormonal systems
safe for consumers. The Environmental Protection Agency set[when?] a reference dose for BPA at 50 μg/kg/day for mammals, although exposure to doses lower
Endocrine_disruptor
Small roll of tobacco made to be smoked
onset of using other dependence-producing substances. Strong temporal and dose-dependent associations have been reported, and a plausible biological mechanism
Cigarette
1995 film directed by Martin Scorsese
fortune has been squandered by lowlife associates, is killed with a "hot dose" in Los Angeles. That same year, Ace narrowly survives a car bomb, and suspects
Casino_(1995_film)
on ice, Kimiko's left leg grows back, and Frenchie is able to generate a dose of the virus from the leg. Kimiko and Frenchie eventually come to terms with
List_of_The_Boys_characters
Initiative on toxic substances
Proposition 65 (formally titled The Safe Drinking Water and Toxic Enforcement Act of 1986, and also referred to as Prop 65) is a California law passed
1986 California Proposition 65
1986_California_Proposition_65
Medication used to treat fungal infections
histoplasmosis, and onychomycosis. Itraconazole is over 99% protein-bound and has virtually no penetration into cerebrospinal fluid. Therefore, it should not be used
Itraconazole
American pharmaceutical company
were limited. Conclusions: Single doses of MSD-001 up to 10 mg were safe and well tolerated, with predictable PK and dose-related effects influenced by CYP2D6
Mindstate_Design_Labs
This is true for oral doses of 2 mg and 4 mg, but absorption was found to be incomplete for an oral dose of 8 mg. This dose showed 76% of the expected
Pharmacokinetics_of_estradiol
Medication
bupropion, are also considered to be safe in combination with MAOIs. However, initiation at low doses and slow upward dose titration is advisable in the case
Selegiline
Wakefulness-promoting medication
during work hours and difficulty sleeping during the day. The recommended dose for this indication is 200 mg taken approximately one hour before the start
Modafinil
Drug delivery form in which the ingredients are solidified for later consumption
are pressed or compacted into a solid dose. The main advantages of tablets are that they ensure a consistent dose of medicine that is easy to consume.
Tablet_(pharmacy)
protocols while performing sedative procedures in dentistry is crucial to ensure safe and effective sedation in dental care with minimal risks. Regulatory standards
Sedation_dentistry
Chemical compound
excretion is virtually complete. 20α-DHD is preponderantly present in the urine as a conjugate of glucuronic acid. Approximately 85% of the oral dose is successfully
Dydrogesterone
American breed of dog
This mutation causes greater sensitivity to certain drugs at normally safe doses, including ivermectin. A test is available to determine if a particular
Australian_Shepherd
Organic compound (C6H5COOH)
reaction in organic chemistry. Benzyl alcohol and benzyl chloride and virtually all benzyl derivatives are readily oxidized to benzoic acid. Benzoic acid
Benzoic_acid
Group of islands in the South Atlantic
the Falkland Islands. It successfully delivered enough Oxford-AstraZeneca doses to fully vaccinate the entire adult population within days of arrival. The
Tristan_da_Cunha
in Pro Milone as a protest against unchecked political mobs that had virtually seized control of Rome in the 60s and 50s BC. Famously quoted in the essay
List_of_Latin_phrases_(full)
American science fiction television series
positive. The website's consensus for season 1 reads: "Injecting a heavy dose of hormones and humor into the Star Trek universe, Starfleet Academy marks
Star_Trek:_Starfleet_Academy
Dean out, the djinn attack and kill his neighbors then give him a "double dose" of poison, destroying the antidote. Sam manages to bash in the head of one
List of Supernatural and The Winchesters characters
List_of_Supernatural_and_The_Winchesters_characters
Metastable nuclear isomer of technetium-99
results in radiation doses more comparable to X-ray studies like computed tomography. Technetium-99m has features that make it safer than other isotopes
Technetium-99m
Scientific discipline
practices, the usual thought is that food ought to be safe in the market and the concern is safe delivery and preparation of the food for the consumer
Food_safety
Phytocannabinoid discovered in 1940
is 56 to 61 hours after oral doses twice per day over 7 days. Based on the pharmacokinetic analysis of long-term dosing of cannabidiol in humans, the
Cannabidiol
2006 film by John Cameron Mitchell
into the characters' lives and serves the whole story up with a generous dose of sweetness and wit." The film also has a score of 64 out of 100 on Metacritic
Shortbus
Process of removing impurities from water
kill any pathogens which pass through the filters and to provide a residual dose of disinfectant to kill or inactivate potentially harmful micro-organisms
Water_purification
Need for a drug, whose discontinuation results in withdrawal symptoms
known to be a critical component and common factor in the development of virtually all forms of behavioral and drug addictions, but not dependence. The International
Substance_dependence
Systemic herbicide and crop desiccant
Agriculture Agricultural Research Service (USDA ARS) described glyphosate as a "virtually ideal" herbicide. In 2010 Powles stated: "glyphosate is a one in a 100-year
Glyphosate
Ketamine-assisted therapy telemedicine service
mental health professional is present via video conference for the first dose. In addition to the medicine, patients are shipped a sleep mask, journal
Mindbloom
American full-size pickup built by Stellantis
on June 28, 2020. O'Dell, John (February 7, 2001). "2002 Dodge Ram Gets a Dose of Steroids - lattices". LA Times. Retrieved February 25, 2016. Ehrenberg
Ram_pickup
Device to vaporize substances for inhalation
the Journal of the American Academy of Neurology, found that "there was virtually no exposure to harmful combustion products using the vaporizing device"
Vaporizer_(inhalation_device)
Love madness or intense infatuation
relationship in some cases. According to Tennov's theory and observations, small doses of attention from an LO (along with uncertainty) increase the intensity
Limerence
Infectious disease that causes a roughening of the inner surface of the eyelids
tetracycline. Azithromycin is preferred because it can be used as a single oral dose. After scarring of the eyelid has occurred, surgery may be required to correct
Trachoma
Deadly viral disease, transmitted through animals
confusion, and/or loss of consciousness. Once symptoms appear, the result is virtually always death. The time period between contracting the disease and the
Rabies
Illness from eating spoiled or contaminated food
health. Pathogens vary in minimum infectious dose; for example, Shigella sonnei has a low estimated minimum dose of < 500 colony-forming units (CFU) while
Foodborne_illness
Ion of fluorine
fluoride is also naturally present in virtually all foods and beverages at a wide range of concentrations. The maximum safe daily consumption of fluoride is
Fluoride
Milkweed butterfly in the family Nymphalidae
mouse (Peromyscus melanotis), are, like all rodents, able to tolerate large doses of cardenolides and can eat monarchs. Overwintering adults become less toxic
Monarch_butterfly
island, Ken Wheatley double-crosses the DPG and shoots Owen with a lethal dose of animal tranquilizer. Zia saves him by removing the dart. After Owen's
List of Jurassic Park (franchise) characters
List_of_Jurassic_Park_(franchise)_characters
Tropane alkaloid and stimulant drug
amount that is 40 times less than the minimum lethal dose. In contrast, addicts may tolerate doses as high as 5 grams per day. Use of cocaine causes abnormally
Cocaine
Emerging subtype of germicidal UV light
mice and humans have found no significant impact on skin health, even at doses far exceeding current guidelines. This enhanced safety is attributed to
Far-UVC
Characters from post-apocalyptic drama series
the games, which Druckmann wrote and co-directed. Casting took place virtually through Zoom due to the COVID-19 pandemic, with several high-profile guest
Characters of The Last of Us (TV series)
Characters_of_The_Last_of_Us_(TV_series)
Chemical compound
supply tends to be poor, a situation known as tumor hypoxia. Large oral doses of hydrogen peroxide at a 3% concentration may cause irritation and blistering
Hydrogen_peroxide
Cancer associated with asbestos
risk of mesothelioma. There appears to be a linear, dose–response relationship, with increasing dose producing increasing risk of disease. Nevertheless
Mesothelioma
Tropical, edible, staple fruit
occurring naturally from the potassium-40 (K-40) isotope. The banana equivalent dose of radiation was developed in 1995 as a simple teaching-tool to educate the
Banana
causes a city-wide blackout when she can no longer hold them in. A second dose of the serum makes it even worse, causing her to release a sonic blast that
List of Superman & Lois characters
List_of_Superman_&_Lois_characters
Antipsychotic medication
alcohol. In another study in which alcoholic patients were given titrated doses up to 800 mg/day, subjects showed significant improvements in ratings of
Tiapride
Plan to immunize against COVID-19
given at least one vaccine dose by end-July so that virtually all eligible Singapore residents will get at least one dose by early August. However, as
COVID-19 vaccination in Singapore
COVID-19_vaccination_in_Singapore
Chemical compound
with many combustible materials. It burns vigorously in combination with virtually any combustible material, even those normally only slightly flammable
Potassium_chlorate
cycles. As only one embryo is transferred in a natural cycle, there is virtually no risk of a multiple pregnancy. Furthermore, ovarian stimulation drugs
Natural cycle in vitro fertilization
Natural_cycle_in_vitro_fertilization
Assisted reproductive technology procedure
drugs for women aged between 40 and 42. Mild IVF is a method where a small dose of ovarian-stimulating drugs is used for a short duration during a natural
In_vitro_fertilisation
Class of drugs
performance. Health risks can be produced by long-term use or excessive doses of AAS. These effects include harmful changes in cholesterol levels (increased
Anabolic_steroid
Problematic excessive alcohol consumption
virtually all countries have penalties for drunk driving. In 2023, the World Health Organization stated that no level of alcohol consumption is safe,
Alcoholism
American nuclear air-to-air rocket
who stood there with them. Gamma and neutron doses received by observers on the ground were negligible. Doses received by aircrew were highest for the fliers
AIR-2_Genie
Burning of the skin by the sun's radiation
artificial UV exposure, including tanning beds, should be avoided as no safe dose has been established. Special protective clothing (for example, welding
Sunburn
Deliberate inhibition of nerve impulses
Advances in surgical techniques such as minimally invasive surgery have made virtually all peripheral nerves surgically accessible since the invention of open
Nerve_block
Use of immunity passports for COVID-19 vaccination
announced an update to its guidelines, requiring that the most recent vaccine dose (or proof of recovery) to have been during the past six months. This change
Vaccine passports during the COVID-19 pandemic
Vaccine_passports_during_the_COVID-19_pandemic
British physician and fraudster (1899–1983)
poisoning. He was told to give doses of 10 cc of Megimide every five minutes, and was given 100 cc to use. The recommended dose in the instructions was 100 cc
John_Bodkin_Adams
Medical condition
mucosa-associated lymphoid tissue (MALT), frequently of the stomach, but virtually any mucosal site can be affected, including breasts. It is a cancer originating
MALT_lymphoma
Alternative form of exposure therapy
Balance Scale (BBS) scores, and Timed "Up & Go" Test scores when VR was time dose matched to conventional therapy. Many studies (Cochrane Review) have shown
Virtual_reality_therapy
Coral atoll in the Marshall Islands
without telling the islanders of the danger they had been exposed to. Virtually all the inhabitants experienced severe radiation sickness, including itchiness
Rongelap_Atoll
1955 event
United States. It was the world's first successful polio vaccine, declared "safe, effective, and potent." It was possibly the most significant biomedical
Announcement of polio vaccine success
Announcement_of_polio_vaccine_success
VIRTUALLY SAFE-DOSE
VIRTUALLY SAFE-DOSE
Boy/Male
Muslim
Good habit, Plus point
Girl/Female
Arabic Muslim
Innocent.
Boy/Male
Indian
Good habit, Plus point
Boy/Male
Tamil
Feeling, Virtual
Girl/Female
Muslim
Female friend, A flower
Surname or Lastname
English
English : from Middle English sale ‘hall’, a topographic name for someone living at a hall or manor house, or a metonymic occupational name for someone employed at a hall or manor house.English : from Middle English salwe ‘sallow’ (a tree, a kind of willow), hence a topographic name for someone who lived by a sallow tree, or a habitational name from for example Sale in Greater Manchester, named from the old dative form of this word, in atte sale.French (Salé) : from Old French salé ‘salty’, hence a topographic or occupational name for someone who lived by or worked in a salt marsh, or, in a figurative sense, a nickname for an amusing or witty person.
Surname or Lastname
English
English : unexplained.
Surname or Lastname
German
German : variant spelling of Sachse.Dutch : variant of Sas 1 and 3.English : variant spelling of Sax 3.Jewish (Ashkenazic) : variant of Sachs 1.
Surname or Lastname
English
English : unexplained.Indian (Maharashtra); pronounced as two syllables : Hindu (Brahman) name found among Konkanasth Brahmans. It appears to be derived from Marathi sana ‘small’, a word of Kannada origin.African : unexplained.
Surname or Lastname
English
English : unexplained. Perhaps a variant of Sadd.French : habitational name from a place in Hérault called Saddes.French : nickname from Latin sapidus ‘prudent’, ‘wise’.
Male
English
Medieval form of English Ralph, RAFE means "wise wolf."
Surname or Lastname
English
English : variant spelling of Say 1 and 2.
Boy/Male
Muslim
Pure, Clear, Crystal
Boy/Male
Indian
Feeling, Virtual
Boy/Male
English Hebrew Spanish
Shield wolf.
Surname or Lastname
English and Welsh
English and Welsh : variant of Sayer.
Girl/Female
Latin American
Wise.
Boy/Male
Indian
Pure, Clear, Crystal
Boy/Male
English French American
Wise one.
Surname or Lastname
English and French
English and French : nickname for a wise man, from Middle English, Old French sage ‘learned’, ‘sensible’, from Latin sagus ‘prophetic’, akin to sagax ‘sharp’, ‘perceptive’.Irish : variant of Savage, via the Gaelicized form Sabhaois.German : habitational name from a place near Oldenburg, so named from an old word, sege ‘sedge’, ‘reed’.
VIRTUALLY SAFE-DOSE
VIRTUALLY SAFE-DOSE
Girl/Female
Hindu, Indian, Kannada, Marathi, Sanskrit, Sindhi, Telugu
Earth
Boy/Male
Arabic, French, Hindu, Indian, Marathi, Muslim, Sindhi
Joy; Solved; Based
Boy/Male
Arabic
Noble; Generous
Boy/Male
Indian
Unknown
Boy/Male
Indian
Singer
Surname or Lastname
English
English : variant spelling of Morrison.
Girl/Female
Bengali, Indian, Modern
A Precious Stone Called Lapis Lazuli
Girl/Female
Hebrew American English
Lily.
Boy/Male
Tamil
Girl/Female
British, Danish, English, Italian, Latin, Swedish
Blind; Sixth
VIRTUALLY SAFE-DOSE
VIRTUALLY SAFE-DOSE
VIRTUALLY SAFE-DOSE
VIRTUALLY SAFE-DOSE
VIRTUALLY SAFE-DOSE
v. t.
To render safe; to make right.
superl.
Ritually clean; fitted for holy services.
n.
A ventilated or refrigerated chest or closet for securing provisions from noxious animals or insects.
a.
Virtually involved or included; involved in substance; inferential; tacitly conceded; -- the correlative of express, or expressed. See Imply.
n.
Final cause; end; purpose of obtaining; cause; motive; reason; interest; concern; account; regard or respect; -- used chiefly in such phrases as, for the sake of, for his sake, for man's sake, for mercy's sake, and the like; as, to commit crime for the sake of gain; to go abroad for the sake of one's health.
adv.
By rites, or by a particular rite.
n.
Potentiality; efficacy; potential existence.
superl.
Conferring safety; securing from harm; not exposing to danger; confining securely; to be relied upon; not dangerous; as, a safe harbor; a safe bridge, etc.
a.
Being in essence or effect, not in fact; as, the virtual presence of a man in his agent or substitute.
n.
A suffruticose labiate plant (Salvia officinalis) with grayish green foliage, much used in flavoring meats, etc. The name is often extended to the whole genus, of which many species are cultivated for ornament, as the scarlet sage, and Mexican red and blue sage.
superl.
Free from harm, injury, or risk; untouched or unthreatened by danger or injury; unharmed; unhurt; secure; whole; as, safe from disease; safe from storms; safe from foes.
adv.
In a virtual manner; in efficacy or effect only, and not actually; to all intents and purposes; practically.
n.
A strong and fireproof receptacle (as a movable chest of steel, etc., or a closet or vault of brickwork) for containing money, valuable papers, or the like.
n.
A place for keeping things in safety.
v. t.
To conduct safely; to give safe-conduct to.
n.
That which gives a safe passage
n.
The herb sage, or salvia.
a.
To make safe; to procure the safety of; to preserve from injury, destruction, or evil of any kind; to rescue from impending danger; as, to save a house from the flames.
superl.
Incapable of doing harm; no longer dangerous; in secure care or custody; as, the prisoner is safe.
n.
The quality or state of being virtual.