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VAMP2

  • VAMP2
  • Protein-coding gene in the species Homo sapiens

    Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene. Synaptobrevins/VAMPs, syntaxins, and the 25-kD

    VAMP2

    VAMP2

    VAMP2

  • Synaptobrevin
  • Protein family

    Synaptobrevins (synaptobrevin isotypes 1-2, also called VAMP1 and VAMP2) are small integral membrane proteins of secretory vesicles with molecular weight

    Synaptobrevin

    Synaptobrevin

    Synaptobrevin

  • SNARE protein
  • Protein family

    third SNARE protein, Synaptobrevin (VAMP), is located on cell vesicles. VAMP2 is targeted and cleaved by BoNT isotypes B, D, and F in synaptic neurons

    SNARE protein

    SNARE protein

    SNARE_protein

  • Alpha-synuclein
  • Protein found in humans

    alpha-synuclein binds to VAMP2 (a synaptobrevin) and stabilizes SNARE complexes; though recent studies indicate that alpha-synuclein–VAMP2 binding is critical

    Alpha-synuclein

    Alpha-synuclein

    Alpha-synuclein

  • Exocytosis
  • Active transport and bulk transport in which a cell transports molecules out of the cell

    SNARE complex is formed by syntaxin-1 and SNAP25 at the plasma membrane and VAMP2 at the vesicle membrane. Exocytosis in neuronal chemical synapses is Ca2+

    Exocytosis

    Exocytosis

    Exocytosis

  • Active zone
  • CASK Mint Liprin-alpha-1 Docking and Priming Munc-13 Munc-18 SNAREs SNAP25 VAMP2 syntaxin Located on the synaptic membrane and binds to SNAP-25 and synaptobrevin

    Active zone

    Active zone

    Active_zone

  • SNAP23
  • Protein-coding gene in the species Homo sapiens

    KIF5B, NAPA, SNAPAP, STX11, STX1A, STX2, STX4, STX6, SYBL1, Syntaxin 3, VAMP2, VAMP3, and Vesicle-associated membrane protein 8. GRCh38: Ensembl release

    SNAP23

    SNAP23

    SNAP23

  • EGR1
  • Protein-coding gene in the species Homo sapiens

    neuronal plasticity. EGR-1 has also been found to regulate the expression of VAMP2 (a protein important for synaptic exocytosis). Beside its function in the

    EGR1

    EGR1

    EGR1

  • STX4
  • Protein-coding gene in the species Homo sapiens

    RAB4A, SNAP-25, SNAP23, STXBP1, STXBP5, Syntaxin binding protein 3, TXLNB, VAMP2, VAMP3, and Vesicle-associated membrane protein 8. GRCh38: Ensembl release

    STX4

    STX4

    STX4

  • TMEM101
  • Protein and gene in humans

    TMEM243 Transmembrane protein 243 VAMP1 Vesicle-associated membrane protein 1 VAMP2 Vesicle-associated membrane protein 2 VAPB Vesicle-associated membrane protein-associated

    TMEM101

    TMEM101

    TMEM101

  • Marco Sfogli
  • Italian guitarist (born 1980)

    Rig - Boss GT-6 - IK Multimedia Amplitube - Roland Microcube - Behringer VAmp2 - Lexicon MPXG2 Project Damage Control "Mechanism" - Mesa Boogie Studio

    Marco Sfogli

    Marco Sfogli

    Marco_Sfogli

  • RAB1A
  • Protein-coding gene in the species Homo sapiens

    (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10

    RAB1A

    RAB1A

    RAB1A

  • Vesicle-associated membrane protein
  • Protein family

    similar structure, and are mostly involved in vesicle fusion. VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents

    Vesicle-associated membrane protein

    Vesicle-associated membrane protein

    Vesicle-associated_membrane_protein

  • Soluble NSF attachment protein
  • Protein family

    vesicle trafficking proteins including synaptophysin, SNAP-25 (SNARE), VAMP2 and syntaxin-1 were also found to have various levels of increase small

    Soluble NSF attachment protein

    Soluble NSF attachment protein

    Soluble_NSF_attachment_protein

  • RABAC1
  • Protein-coding gene in the species Homo sapiens

    interact with numerous prenylated members of the Rab GTPase family and VAMP2. GRCh38: Ensembl release 89: ENSG00000105404 – Ensembl, May 2017 GRCm38:

    RABAC1

    RABAC1

    RABAC1

  • SNAP25
  • Protein-coding gene in the species Homo sapiens

    KIF5B, SNAPAP and STX11, STX1A, STX2, STX4, SYT1, Syntaxin 3, TRIM9, and VAMP2. Synaptotagmin binds SNAP-25 and syntaxins in the presence of Ca2+ (and

    SNAP25

    SNAP25

    SNAP25

  • NAPA (gene)
  • Protein-coding gene in the species Homo sapiens

    S, Leenders AG, Sheng ZH, Knepper MA, Ambudkar SV, Ambudkar IS (2004). "VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels

    NAPA (gene)

    NAPA (gene)

    NAPA_(gene)

  • RAB3A
  • Protein-coding gene in the species Homo sapiens

    JK (1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". J. Biol. Chem. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991

    RAB3A

    RAB3A

    RAB3A

  • VAPB
  • Protein-coding gene in the species Homo sapiens

    a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. Like VAPA, VAPB binds to proteins

    VAPB

    VAPB

    VAPB

  • STX1A
  • Protein-coding gene in the species Homo sapiens

    NAPA, RNF40, SCNN1G, SLC6A1, SNAP-25, SNAP23, STXBP1, STXBP5, SYT1 UNC13B, VAMP2, and VAMP8. Syntaxin GRCh38: Ensembl release 89: ENSG00000106089 – Ensembl

    STX1A

    STX1A

    STX1A

  • List of human protein-coding genes 9
  • Q9UBK9 18059 VAC14 HGNC:25507; Q08AM6 18060 VAMP1 HGNC:12642; P23763 18061 VAMP2 HGNC:12643; P63027 18062 VAMP3 HGNC:12644; Q15836 18063 VAMP4 HGNC:12645;

    List of human protein-coding genes 9

    List_of_human_protein-coding_genes_9

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