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Human gene
Tet methylcytosine dioxygenase 2 (TET2) is a human gene. It resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss
Tet methylcytosine dioxygenase 2
Tet_methylcytosine_dioxygenase_2
Chemical compound
turn reduces the levels of inflammation-promoting cytokines. Tet methylcytosine dioxygenase 2 (i.e., TET2) is an enzyme that is activated by the tricarboxylic
Itaconic_acid
Protein-coding gene in the species Homo sapiens
Tet methylcytosine dioxygenase 3 is a protein that in humans is encoded by the TET3 gene. Tet3 and its respective protein TET 3 are members of the TET
Tet methylcytosine dioxygenase 3
Tet_methylcytosine_dioxygenase_3
Mammalian protein found in Homo sapiens
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function
Tet methylcytosine dioxygenase 1
Tet_methylcytosine_dioxygenase_1
Topics referred to by the same term
Tet methylcytosine dioxygenase 1, or TET1, an enzyme Tetrachloride Tetrahedron Tetralogy of Fallot Tet (Morris Louis painting), a 1958 painting Tet, enormous
Tet
Chemical compound which is a modified DNA base
demethylation. The oxidation occurs through the TET (Ten-eleven translocation) family dioxygenases (TET enzymes) which can convert 5mC, 5hmC, and 5fC to
5-Methylcytosine
Method for analyzing DNA methylation using enzymes
input DNA: Oxidation of methylated cytosines: The enzyme TET2 (Tet Methylcytosine Dioxygenase 2) is used to oxidize 5mC and 5hmC. TET2 iteratively oxidizes
Enzymatic_methyl-seq
Laboratory technique for DNA methylation profiling
followed by PCR amplification and sequencing: TET oxidation: Double-stranded DNA is incubated with a TET dioxygenase (commonly mammalian TET2) and necessary
TET-assisted pyridine borane sequencing
TET-assisted_pyridine_borane_sequencing
Removal of a methyl group from nucleotides in DNA
are a ten-eleven translocation methylcytosine dioxygenase (TET) and thymine-DNA glycosylase (TDG). One particular TET enzyme, TET1, and TDG are present
DNA_demethylation
Family of translocation methylcytosine dioxygenases
TET enzymes are a family of ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation. 5-Methylcytosine (see
TET_enzymes
Epigenetic phenomenon
central roles of ten-eleven translocation methylcytosine dioxygenases (TETs) in the demethylation of 5-methylcytosine to form cytosine. As reviewed in 2018
Reprogramming
Chemical compound
The TET enzymes (i.e., ten-eleven translocation (TET) methylcytosine dioxygenase family of enzymes) consists of three members, TET-1, TET-2, and TET-3.
Α-Ketoglutaric_acid
Rare genetic disorder
chromosome 2 (2p13.1) encodes the tet methylcytosine dioxygenase 3 (TET3) enzyme. TET3 enzyme facilitates conversion of 5-methylcytosine (5mC) to
Beck–Fahrner_syndrome
involved predominantly in DNA repair, and the TET enzyme family, which oxidatively demethylates 5-methylcytosine, playing central roles in epigenetic regulation
DNA_oxidative_demethylase
Chemical compound
oxidation of 5-methylcytosine (5mC) via 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC), catalyzed by the TET family of dioxygenases. 5caC represents
5-Carboxylcytosine
Study of DNA modifications that do not change its sequence
caused about 80% demethylation of the 5-methylcytosines in the genome. Demethylation of CpGs in a gene promoter by TET enzyme activity increases transcription
Epigenetics
Indian-American molecular biologist
demethylation, replacement of 5-methylcytosine by cytosine. At the La Jolla Institute, her lab demonstrated the importance of TET enzymes in proper gene expression
Anjana_Rao
Chemical compound
8-Oxo-2'-deoxyguanosine (8-oxo-dG) is an oxidized derivative of deoxyguanosine. 8-Oxo-dG is one of the major products of DNA oxidation. Concentrations
8-Oxo-2'-deoxyguanosine
Heritable characteristics affecting learning
in the Figure below, titled "Demethylation of 5-Methylcytosine (5mC) in neuron DNA," especially the TET dependent pathway, have been confirmed as pathways
Epigenetics in learning and memory
Epigenetics_in_learning_and_memory
Chemical compound
cells. In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by TET enzymes. Every mammalian cell seems to contain 5-Hydroxymethylcytosine
5-Hydroxymethylcytosine
Region of often-methylated DNA with a cytosine followed by a guanine
ten-eleven translocation (TET) family of dioxygenases (TET1, TET2, TET3) to generate 5-hydroxymethylcytosine (5hmC). In successive steps TET enzymes further hydroxylate
CpG_site
Dicarboxylic acid
relate to succinate's ability to inhibit 2-oxogluterate-dependent dioxygenases. Inhibition of KDMs and TET hydroxylases results in epigenetic dysregulation
Succinic_acid
DNA repair process
deamination of guanine. (Thymidine products following deamination of 5-methylcytosine are more difficult to recognize, but can be repaired by mismatch-specific
Base_excision_repair
Species of fungus
laccase secretion. It was recently found that a TET (Ten-Eleven translocation dioxygenases) homologue, CcTET, was identified in C. cinerea, which may have
Coprinopsis_cinerea
Process of oxidative damage of deoxyribonucleic acid
where the cytosine is methylated to form 5-methylcytosine (5mC) and the guanine is oxidized to form 8-oxo-2'-deoxyguanosine (in the figure this is shown
DNA_oxidation
Protein-coding gene in the species Homo sapiens
(YSPTSPSYS) repeats. Interaction between homeobox protein NANOG and Tet methylcytosine dioxygenase 1 (TET1) has been shown to be important in establishing pluripotency
QSER1
Interconnected biochemical reactions releasing energy
demethylases (KDMs) and ten-eleven translocation (TET) enzymes; ordinarily TETs hydroxylate 5-methylcytosines to prime them for demethylation. However, in
Citric_acid_cycle
have been used for this purpose include Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), Lysine (K)-specific demethylase 1A (LSD1) and Calcium
Epigenome_editing
Study of how diet changes gene expression
translocation (TET) DNA hydroxylase family. TET enzymes play a role in DNA methylation by acting as a catalyst for the oxidization of 5-methylcytosine (5mC) into
Nutritional_epigenetics
Modified genetic code
Czodrowski P, Summerer D (April 2020). "Light-Activatable TET-Dioxygenases Reveal Dynamics of 5-Methylcytosine Oxidation and Transcriptome Reorganization". Journal
Expanded_genetic_code
Technology for examining cells
preparation step that uses the enzyme ten-eleven translocation methylcytosine dioxygenase 2 (TET2) to preserve methylated cytosines. Afterwards, they add
Spatial DNA methylation profiling
Spatial_DNA_methylation_profiling
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