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Class of drugs
Aromatase inhibitors (AIs) are a class of drugs that block the enzyme aromatase, which is responsible for converting androgens into estrogens. They are
Aromatase_inhibitor
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in
Steroidal_aromatase_inhibitor
Non-Steroidal Aromatase Inhibitors (NSAIs) are one of two categories of aromatase inhibitors (AIs). AIs are divided into two categories, steroidal aromatase
Non steroidal aromatase inhibitors
Non_steroidal_aromatase_inhibitors
Breast cancer medication
substitute estrogen with pharmaceuticals. Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery
Exemestane
Enzyme involved in estrogen production
Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens
Aromatase
Medical condition
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase
Aromatase_excess_syndrome
British pharmacologist and cancer researcher
2017) was a British biochemist who pioneered development of steroidal aromatase inhibitors in cancer research. Born in Lancashire (now Greater Manchester)
Angela_Hartley_Brodie
Chemical compound
Name) (brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage
Testolactone
Drug class
Steroidogenesis inhibitor Androgen synthesis inhibitor Progesterone synthesis inhibitor Bhatnagar, A. S.; Miller, W. R. (1999). "Pharmacology of Inhibitors of Estrogen
Estrogen_synthesis_inhibitor
Chemical compound
metandroden, as well as 1-methylandrosta-1,4-diene-3,17-dione, is a steroidal aromatase inhibitor that was studied in the treatment of cancer. It blocks the production
Atamestane
Class of drugs
term "anabolic steroid" is essentially synonymous with "steroidal androgen" or "steroidal androgen receptor agonist". Anabolic steroids have a number of
Anabolic_steroid
Immune modulating medication
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more
Janus_kinase_inhibitor
Breast cancer drug
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal
Letrozole
(2013). Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases. The Journal of Steroid Biochemistry
List of 5α-reductase inhibitors
List_of_5α-reductase_inhibitors
Antifungal chemical compound
were relatively weak inhibitors of human placental aromatase. Oral ketoconazole has been used clinically as a steroidogenesis inhibitor in men, women, and
Ketoconazole
Primary female sex hormone
are not able to synthesize C19 steroids, and therefore depend on C19 supplies from other tissues and the level of aromatase. In females, synthesis of estrogens
Estrogen
Chemical compound
sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive
Formestane
Enlargement of the human male breast
obesity. Medications such as aromatase inhibitors are effective, even in rare cases of gynecomastia from disorders such as aromatase excess syndrome or Peutz–Jeghers
Gynecomastia
Chemical compound
MDL-18962; also known as propargylestrenedione, PED) is a steroidal, irreversible aromatase inhibitor which was under development by Marion Merrell Dow/Hoechst
Plomestane
Group of stereoisomers
endogenous steroids. As such, AG is an aromatase inhibitor and adrenal steroidogenesis inhibitor, including both an androgen synthesis inhibitor and a corticosteroid
Aminoglutethimide
Androgen and anabolic steroid
fluid retention. The co-administration of an antiestrogen such as an aromatase inhibitor like anastrozole or a selective estrogen receptor modulator like
Metandienone
Class of drugs
degrader (SERD) fulvestrant, aromatase inhibitors (AIs) like anastrozole, and antigonadotropins including androgens/anabolic steroids, progestogens, and GnRH
Antiestrogen
Chemical compound
a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral
1,4,6-Androstatriene-3,17-dione
1,4,6-Androstatriene-3,17-dione
Chemical compound
Minamestane (INN (former developmental code name FCE-24,928) is a steroidal aromatase inhibitor which was under development by Farmitalia-Carlo Erba as an antineoplastic
Minamestane
Neologism from online incel communities
unauthorized use of substances (such as anabolic steroids, peptides, human growth hormone, aromatase inhibitors, weight loss medications, etc) to achieve a
Looksmaxxing
Chemical compound
2-naphthol and cinnamaldehyde. α-Naphthoflavone is a potent inhibitor of the enzyme aromatase, the enzyme that converts testosterone to estrogen. α-Naphthoflavone
Α-Naphthoflavone
Chemical compound
Use during pregnancy may harm the fetus. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the production of estrogens
Anastrozole
Type of drug
enobosarm (ostarine), LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503 Aromatase inhibitors: anastrozole, aminoglutethimide, fadrozole, finrozole, letrozole
Nonsteroidal
Chemical compound
aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. Aromatase
4-Androstene-3,6,17-trione
Drug class
A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved
Steroidogenesis_inhibitor
Chemical compound
Finrozole is an aromatase (CYP19A1) inhibitor. Finrozole was authorized for veterinary use in the European Union in April 2025. Finrozole is indicated
Finrozole
Anabolic steroid
metabolism are mixed, with some studies showing that it is metabolized by aromatase into estrogenic compounds, or by 5α-reductase into 5α-reduced androgenic
Trenbolone
Chemical compound
inactivation of aromatase in human placenta and uterine leiomyoma by 5 alpha-dihydronorethindrone, a metabolite of norethindrone, and its effect on steroid-producing
5α-Dihydronorethisterone
Chemical compound
breast cancer previously treated with an aromatase inhibitor either alone or in combination with a CDK4/6 inhibitor. Participants were excluded if they were
Imlunestrant
Enzyme that metabolizes substances by oxidation
clearance. a Moderate inhibitor causes at least a 2-fold increase in the plasma AUC values, or 50–80% decrease in clearance. a Weak inhibitor causes at least
CYP3A4
Chemical compound
progestogenic activity. It has also been found to act as an aromatase inhibitor and to inhibit the production of estrogen in breast tissue in vitro. A single
20α-Dihydroprogesterone
Chemical compound
2006). "Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5 alpha-reductase inhibitor". The Journal of Steroid Biochemistry
Testosterone_enanthate
Hormone therapy for cancer
other drugs in this class. Aminoglutethimide inhibits both aromatase and other enzymes critical for steroid hormone synthesis in the adrenal glands. It
Hormonal_therapy_(oncology)
Sex-hormonal agents may be either steroidal or nonsteroidal in chemical structure and may serve to either enhance, inhibit, or have mixed effects on the function
Sex-hormonal_agent
Chemical compound
as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen.
Danazol
Chemical compound
"IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients"
Irosustat
Chemical compound
cancer whose cancer had progressed while on or after receiving an aromatase inhibitor. The FDA granted the application for alpelisib priority review designation
Alpelisib
Human hormone
PMID 9667860. Sun J, Xiang H, Yang LL, Chen JB (2011). "A review on steroidal 5α-reductase inhibitors for treatment of benign prostatic hyperplasia". Current Medicinal
Dihydrotestosterone
Chemical compound
(HER2)-negative advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine-based therapy; or fulvestrant as initial endocrine-based
Ribociclib
Chemical compound
methodological artifact. In accordance, a 2009 study found that an aromatase inhibitor had no effect on the estrogenic potencies of tibolone or its metabolites
Tibolone
Medical drug glass
HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase Inhibitor (BELLE-2)" at ClinicalTrials.gov Di Leo A, Johnston S, Lee KS, Ciruelos
Phosphoinositide 3-kinase inhibitor
Phosphoinositide_3-kinase_inhibitor
Chemical compound
orally administered chrysin does not have clinical activity as an aromatase inhibitor. Nanoformulations of polyphenols, including chrysin, are made using
Chrysin
Medical treatment for low fertility
women with PCOS remains the anti-estrogen clomiphene citrate or the aromatase inhibitor letrozole. Treatment for oligospermia is centered around underlying
Fertility_medication
Class of pharmaceutical drugs
based on chemical structure: steroidal and nonsteroidal. Steroidal AR antagonists are structurally related to steroid hormones like testosterone and
Antiandrogen
Type of gender-affirming medical treatment
antagonists than are steroidal antiandrogens, and for this reason, in conjunction with GnRH modulators, have largely replaced steroidal antiandrogens in the
Feminizing_hormone_therapy
Chemical compound
inhibition of CYP26A1 over other steroid-metabolizing enzymes like CYP17A1 (17α-hydroxylase/17,20-lyase) and aromatase (CYP19A1). "Talarozole". AdisInsight
Talarozole
Chemical compound
the brand name Afema (by Novartis), is a selective, nonsteroidal aromatase inhibitor which is or has been used in Japan for the treatment of breast cancer
Fadrozole
Primary male sex hormone
Schlinger BA, Wingfield JC (2000). "Acute and chronic effects of an aromatase inhibitor on territorial aggression in breeding and nonbreeding male song sparrows"
Testosterone
interdependent biosynthetic pathways and hormone-receptor interactions, all aromatase inhibitors, including anastrozole, letrozole, aminoglutethimide, exemestane
List of drugs banned by the World Anti-Doping Agency
List_of_drugs_banned_by_the_World_Anti-Doping_Agency
Pharmaceutical drug classification
enclomifene) Aromatase inhibitors (e.g., anastrozole) GnRH agonists (e.g., GnRHTooltip gonadotropin-releasing hormone) Antigonadotropins Sex steroid agonists
ATC_code_L02
Progestin medication
affinity for sex steroid receptors (specifically, the PR, AR, and ER). A small amount of norethisterone is also converted by aromatase into EE. Norethisterone
Norethisterone
Medication and naturally occurring steroid hormone
combined with an aromatase inhibitor for men with secondary hypogonadism who wish to conceive children with their partners. Inhibitors and inducers of
Testosterone_(medication)
F (1988). "Effects of the aromatase inhibitor 4-hydroxyandrostenedione and the antiandrogen flutamide on growth and steroid levels in DMBA-induced rat
List_of_steroid_abbreviations
Chemical compound
effects by other means. Tropoflavin has been found to act as a weak aromatase inhibitor in vitro (Ki = 10 μM), though there is evidence to suggest that this
Tropoflavin
Type of enzyme
Steroid sulfatase – steroid synthesis, neurosteroid metabolism Others Aromatase (estrogen synthetase) – estrogen synthesis Inborn errors of steroid metabolism
Steroidogenic_enzyme
Chemical compound
Bossche HV, Moereels H, Koymans LM (1994). "Aromatase inhibitors--mechanisms for non-steroidal inhibitors". Breast Cancer Research and Treatment. 30 (1):
Rogletimide
Public medical school in Baltimore, Maryland, US
Department of Pharmacology (1979–2017), pioneered the development of steroidal aromatase inhibitors. Robert Dorsey Coale, Professor and Dean (1857–1915) at chemistry
University of Maryland School of Medicine
University_of_Maryland_School_of_Medicine
Chemical compound
inhibition of progesterone synthesis. Trilostane is not an aromatase inhibitor and hence does not inhibit the conversion of androgens like androstenedione and
Trilostane
Chemical compound
cancer. Compared to selective estrogen receptor modulators (SERMs) or aromatase inhibitors, giredestrant's degradation mechanism better addresses resistance
Giredestrant
Androgen and anabolic steroid
5α-reduced state preserves oxandrolone from being a substrate for the aromatase enzyme; therefore, oxandrolone cannot be aromatized into metabolites with
Oxandrolone
Sex change as part of the normal life cycle of a species
males of the three-spot wrasse (Halichoeres trimaculatus): Effect of aromatase inhibitor on the testis". Developmental Dynamics. 240 (1): 116–121. doi:10
Sequential_hermaphroditism
Selective estrogen receptor modulator
medications are taken for similar purposes such as clomifene and aromatase inhibitor drugs; which are used in order to try to avoid the hormone-related
Tamoxifen
Benign smooth-muscle tumors of the uterus
endometriosis indicates that aromatase inhibitors might be particularly useful in combination with a progestogenic ovulation inhibitor. Uterine artery embolization
Uterine_fibroid
Medical condition
combination of the androgen receptor antagonist bicalutamide and the aromatase inhibitor anastrozole may be used. Robert King Stone, personal physician to
Familial male-limited precocious puberty
Familial_male-limited_precocious_puberty
Prohormone of an anabolic-androgenic steroid
for a short time). The typical definition of "prohormone" includes a steroidal molecule that has the opposite molecular structure to testosterone on
Androgen_prohormone
Environmental sex determination by temperature during development
testosterone or an aromatase inhibitor is administered, indicating that the enzyme responsible for conversion of testosterone to estradiol, aromatase, plays a role
Temperature-dependent sex determination
Temperature-dependent_sex_determination
Class of compounds
(brand name Afema)—an aromatase inhibitor. Imidazo[4,5-c]pyridines: 3-Deazaneplanocin A—an S-adenosyl-L-homocysteine synthesis inhibitor and histone methyltransferase
Imidazopyridine
Chemical compound
progestogenic activity. Conversely, trenbolone acetate is not a substrate for aromatase and hence lacks estrogenic activity. The compound also has weak glucocorticoid
Trenbolone_acetate
Chemical compound
has moderate anabolic, mild androgenic, and anti-aromatase properties and is similar to the steroid clostebol (4-chlorotestosterone). 4-Androstene-3,6
4-Hydroxytestosterone
Chemical compound
involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol. Alternatively
Estradiol
Chemical compound
is devoid of other hormonal activities. Zanoterone does not inhibit 5α-reductase, aromatase, or 3α- or 3β-hydroxysteroid dehydrogenase in vitro. The drug
Zanoterone
systemic levels of estrogen, achieved by the use of drugs from the aromatase inhibitor category. These drugs target one of the enzymes that takes part in
Hormone receptor positive breast cancer
Hormone_receptor_positive_breast_cancer
Androgenic Anabolic steroid
[medical citation needed] Estrogen effects resulting from reaction with aromatase are also reduced due to lessened enzyme interaction, but effects such
Nandrolone
administration of aromatase inhibitors (AIs), which can be reversible inhibitors (non-steroidal) such as anastrozole and letrozole, or irreversible (steroidal) inhibitors
Endocrine therapy resistance in breast cancer
Endocrine_therapy_resistance_in_breast_cancer
Chemical compound
or estra-1,3,5(10)-triene-3,17α-diol) is a minor and weak endogenous steroidal estrogen that is related to 17β-estradiol (better known simply as estradiol)
17α-Estradiol
Chemical compound
aromatic A-ring products in the presence of recombinant human aromatase". The Journal of Steroid Biochemistry and Molecular Biology. 110 (3–5): 214–22. doi:10
Trestolone
Type of gender-affirming medical treatment
hormone can be administered, potentially in conjunction with an aromatase inhibitor or a GnRH analogue, to increase final height. The main effects of
Masculinizing_hormone_therapy
Chemical reaction
and gynecomastia in men. Aromatase inhibitors like exemestane (which forms a permanent and deactivating bond with the aromatase enzyme) and anastrozole
Aromatization
Androstenetrione δ4-Androstenetrione (δ4-androstene-3,6,17-trione) – an aromatase inhibitor Androstenolone Testosterone (δ4-androsten-17β-ol-3-one) – an endogenous
List_of_androstanes
Proteins activated by the hormone estrogen
aromatase inhibitors, such as anastrozole. ER status is used to determine sensitivity of breast cancer lesions to tamoxifen and aromatase inhibitors.
Estrogen_receptor
Chemical compound
aryl hydrocarbon receptor, and as an inhibitor of enzymes in the steroidogenesis pathway such as CYP17A1 and aromatase. In accordance, it has been shown
Prochloraz
Class of drugs
with other drugs such as the CDK inhibitor palbociclib (Ibrance). AZD 9496 GDC 0927 H3B 5942 GLL 398 Aromatase inhibitor Estrogen deprivation therapy Lee
Selective estrogen receptor degrader
Selective_estrogen_receptor_degrader
Chemical compound
androgenic activity. As a DHT derivative, drostanolone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites. While no data
Drostanolone_propionate
ester prodrugs of estrogens. It includes esters, as well as ethers, of steroidal estrogens like estradiol, estrone, and estriol and of nonsteroidal estrogens
List_of_estrogen_esters
January 5, 2020. "NIHF Inductee M. Judah Folkman Invented Angiogenesis Inhibitors". www.invent.org. June 5, 2024. Archived from the original on November
List of National Inventors Hall of Fame inductees
List_of_National_Inventors_Hall_of_Fame_inductees
This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list;
List_of_estrogens
British biochemist
identified was steroid sulfatase (STS) and the first potent inhibitor was designed and synthesized by the Potter research group as the steroidal sulfamate
Barry_V._L._Potter
Medication used for epilepsy, bipolar disorder and migraine
serum levels. In addition, the drug has been identified as a potent aromatase inhibitor, and suppresses estrogen concentrations. These actions are likely
Valproate
Antiandrogen medication
precocious puberty in boys at 12.5 to 100 mg/day in combination with an aromatase inhibitor like anastrozole, especially for familial male-limited precocious
Bicalutamide
ZK-190628) – steroid sulfatase inhibitor (estrogen "activation" inhibitor) for endometriosis Leflutrozole (BGS-649) – aromatase inhibitor (estrogen synthesis
List of investigational sex-hormonal agents
List_of_investigational_sex-hormonal_agents
Chemical compound
to aromatic A-ring products in the presence of recombinant human aromatase". J. Steroid Biochem. Mol. Biol. 110 (3–5): 214–22. doi:10.1016/j.jsbmb.2007
Fluoxymesterone
Chemical compound
is classified as a phytoestrogen. It has also been found to be a weak inhibitor of fatty acid amide hydrolase in vitro. The enzyme biochanin-A reductase
Biochanin_A
Mammal reproductive system cell
cells to convert androgens (coming from the thecal cells) to estradiol by aromatase during the follicular phase of the menstrual cycle. However, after ovulation
Granulosa_cell
Society guidelines). Bicalutamide is used in combination with an aromatase inhibitor such as anastrozole or letrozole in the treatment of peripheral precocious
Medical_uses_of_bicalutamide
Chemical compound
allowing it to inhibit the activity of aromatase and 3α-hydroxysteroid dehydrogenase. These enzymes are involved in the biosynthesis of steroid hormones, and
Coumestrol
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
Boy/Male
Hindu, Indian, Marathi
God; Knowledge
Girl/Female
Hindu
Fresh butter, Gentle, Soft, Always new
Boy/Male
Indian
Giver
Boy/Male
Italian American
The greatest.
Girl/Female
British, English
Town on Clay Land
Boy/Male
Arabic, Muslim
Light
Boy/Male
Indian, Traditional
Can Not Destroy; Intelligently
Boy/Male
German, Polish
Disabled
Girl/Female
Indian
Breeze, Nature, Silver, Pure
Female
Egyptian
, the goddess of the firmament.
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
STEROIDAL AROMATASE-INHIBITOR
a.
Made, or being, in the form of an orb; having a circular, or nearly circular, or a spheroidal, outline.
n.
Tissue composed of spheroidal cells.
a.
Of or pertaining to, or producing, inhibition; consisting in inhibition; tending or serving to inhibit; as, the inhibitory action of the pneumogastric on the respiratory center.
v. t.
To impregnate with aroma; to render aromatic; to give a spicy scent or taste to; to perfume.
a.
Having the form of a bunch of grapes; like a cluster of grapes, as a mineral presenting an aggregation of small spherical or spheroidal prominences.
n.
Siderite occuring in spheroidal masses.
n.
A thin spheroidal glass retort or flask, used in the sublimation of camphor.
a.
Of or pertaining to an asteroid, or to the asteroids.
n. pl.
The class Echinodermata which includes the sea urchins. They have a calcareous, usually more or less spheroidal or disk-shaped, composed of many united plates, and covered with movable spines. See Spatangoid, Clypeastroid.
n.
That which causes inhibitory action; esp., an inhibitory nerve.
a.
Causing dilation or relaxation of the blood vessels; as, the vasodilator nerves, stimulation of which causes dilation of the blood vessels to which they go. These nerves are also called vaso-inhibitory, and vasohypotonic nerves, since their stimulation causes relaxation and rest.
a.
See Vasodilator.
n.
A body, usually spheroidal, in a cell or a protozoan, distinguished from the surrounding protoplasm by a difference in refrangibility and in behavior towards chemical reagents. It is more or less protoplasmic, and consists of a clear fluid (achromatin) through which extends a network of fibers (chromatin) in which may be suspended a second rounded body, the nucleolus (see Nucleoplasm). See Cell division, under Division.
a.
See Spheroidal.
a.
A term applied to certain nerve centers which govern or restrain subsidiary centers, from which motor impressions issue.
a.
Having the form of a spheroid.
n.
A spheroidal body growing from a plant either above or below the ground (usually below), which is strictly a bud, consisting of a cluster of partially developed leaves, and producing, as it grows, a stem above, and roots below, as in the onion, tulip, etc. It differs from a corm in not being solid.
p. pr. & vb. n.
of Aromatize
n.
The quality or state of being spheroidal.
imp. & p. p.
of Aromatize