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Protein found in humans
Splicing factor 1 is a protein that in humans is encoded by the SF1 gene (previously ZNF162). This protein is involved in removing introns from pre-mRNA
Splicing_factor_1
Protein-coding gene in the species Homo sapiens
Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a
Serine/arginine-rich splicing factor 1
Serine/arginine-rich_splicing_factor_1
Proteins that aid in intron removal from messenger RNA
spliceosomes. Splicing factors regulate the binding of the snRNPs U1 and U2 to the 3' and 5' ends of the intron during splicing and can either be splicing promoters
Splicing_factor
Process in molecular biology
of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur
RNA_splicing
Topics referred to by the same term
microbial species Serine/arginine-rich splicing factor 1, a protein also known as alternative splicing factor 1 (ASF) Advanced Synchronization Facility
ASF
Process by which a gene can code for multiple proteins
Alternative splicing, alternative RNA splicing, or differential splicing is an alternative splicing process during gene expression that allows a single
Alternative_splicing
Organelle in eukaryotic cells
phosphorylation of specific proteins. The splicing speckles are also known as nuclear speckles (nuclear specks), splicing factor compartments (SF compartments),
Cell_nucleus
Topics referred to by the same term
refer to: Helicase superfamily 1, a common protein. Splicing factor 1, a protein encoded by the gene SF1 Steroidogenic factor 1, a protein encoded by the gene
SF1
Protein found in humans
Splicing factor YJU2 is a protein that in humans is encoded by the YJU2 gene (previously CCDC94). The YJU2 protein is part of the spliceosome, and is
Splicing_factor_YJU2
Protein-coding gene in the species Homo sapiens
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene. This gene belongs to the splicing factor SR family of genes
U2 small nuclear RNA auxiliary factor 1
U2_small_nuclear_RNA_auxiliary_factor_1
Protein-coding gene in the species Homo sapiens
"Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna
SLU7
Protein-coding gene in humans
Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene. SFPQ has been shown to interact with PTBP1, NONO
SFPQ
DNA sequence motif
an exonic splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous
Exonic_splicing_enhancer
Protein-coding gene in humans
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene. This gene encodes subunit 1 of the splicing factor 3b protein complex
SF3B1
block splicing of the exon. Spliceosome Exon Intron Exon Junction Complex Long JC, Caceres JF (January 2009). "The SR protein family of splicing factors: master
SR_protein
Protein found in humans
upstream of exon 1. The BDNF-AS gene generates numerous distinct non-coding RNAs through alternative splicing. This diversity of spliced isoforms is a common
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
British television series (2004–2018)
The X Factor is a British reality television music competition – that spawned the global X Factor franchise – created by Simon Cowell. Premiering on 4
The X Factor (British TV series)
The_X_Factor_(British_TV_series)
Family of proteins
pre-mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. Pre-mRNA splicing requires
DEAD_box
Protein-coding gene in humans
Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene. MDS-associated splicing factor SRSF2 affects the expression
SRSF2
Post-translational removal of peptide sequences from a protein sequence
(ATP) or guanosine triphosphate (GTP). Normally, splicing is associated only with pre-mRNA splicing. This precursor protein contains three segments—an
Protein_splicing
RNA produced by transcription
include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found
Primary_transcript
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Dierick JF, Gueydan C, Kruys V (June 2010). "The splicing factor ASF/SF2 is associated with TIA-1-related/TIA-1-containing ribonucleoproteic complexes and contributes
Stress_granule
Protein family
endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound
VEGF_receptor
American reality television music competition show
The X Factor, also known as The X Factor USA, is an American reality television music competition show created by Simon Cowell and produced by FremantleMedia
The X Factor (American TV series)
The_X_Factor_(American_TV_series)
Blood-clotting protein
Coagulation factor VIII (factor VIII, FVIII, also known as antihemophilic factor A (AHF)) is an essential blood clotting protein. In humans, it is encoded
Factor_VIII
Protein-coding gene in the species Homo sapiens
Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in
SFRS7
Protein-coding gene in humans
Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene. This gene encodes subunit 3 of the splicing factor 3a protein complex
SF3A3
Protein-coding gene in the species Homo sapiens
proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors. The TNPO3-IRF5 locus is implicated in primary
Transportin-3
Different products from the same gene
Alternative splicing generally describes a tightly regulated process in which alternative transcripts are intentionally generated by the splicing machinery
Isoform
Molecular machine that removes intron RNA from the primary transcript
sites of mRNA splicing or storage sites of mRNA splicing factors. It is now understood that nuclear speckles help concentrate splicing factors near genes
Spliceosome
Protein-coding gene in humans
Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene. In eukaryotes, the introns in the transcribed pre-mRNA first
U2AF2
Mammalian protein found in Homo sapiens
The transmembrane form of SCF is formed by alternative splicing that excludes exon 6 (Figure 1). Both forms of SCF bind to c-KIT and are biologically
Stem_cell_factor
Protein family
recognizes the H3K9me3 methylated chromatin and recruits a splicing factor to alternatively splice the mRNA, thereby excluding the EDA exon from the mature
Heterochromatin_protein_1
RNA processing within a biological cell
such mRNAs do not undergo splicing and their 3' processing is done independent of most cleavage and polyadenylation factors. Core histone mRNAs have a
Post-transcriptional modification
Post-transcriptional_modification
Protein involved in blood vessel growth
referred to as vascular permeability factor. There are multiple isoforms of VEGF-A that result from alternative splicing of mRNA from a single, 8-exon VEGFA
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Protein-coding gene in the species Homo sapiens
Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene. Pre-mRNA splicing occurs in 2 sequential transesterification
PRPF8
Gene of the species Homo sapiens
protein fox-1 homolog 3 (RBFOX3) is a protein that in humans is encoded by the RBFOX3 gene. It is related to the alternative splicing factors Rbfox1 and
RNA binding protein fox-1 homolog 3
RNA_binding_protein_fox-1_homolog_3
Protein found in humans
represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. In particular, TDP-43 is a splicing factor binding to
TAR_DNA-binding_protein_43
Protein-coding gene in the species Homo sapiens
(March 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes & Development. 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401
PTBP1
alternative splicing has a role in SZ pathology. MIAT is associated with alternative splicing through its interaction with splicing factor 1(SF1) and with
MIAT_(gene)
Protein-coding gene in humans
large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression. It is also known
SON_(gene)
Medical condition
splicing. SON also plays a key role in alternative splicing of exons. SON is required for genome stability by ensuring the efficiency of RNA splicing
ZTTK_syndrome
Protein-coding gene in the species Homo sapiens
Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative
SFRS9
instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers. In general, pre-mRNA splicing is dysregulated in a high proportion
Transcriptome_instability
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1
Fibroblast_growth_factor_1
Mammalian protein found in humans
Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by
Factor_V
Protein-coding gene in the species Homo sapiens
Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene. UCSC Genome Browser View UCSC Gene details page SFRS3
SFRS3
Protein-coding gene in the species Homo sapiens
alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They
Neuregulin_1
Family of proteins that bind to fibroblast growth factors
fibroblast growth factors, members of the largest family of growth factor ligands, comprising 22 members. The natural alternate splicing of four fibroblast
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Protein-coding gene in humans
novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing". The EMBO Journal. 21 (23):
EFTUD2
Pharmaceutical compound
2017). "Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain". Molecular Brain. 10 (1) 23. doi:10.1186/s13041-017-0304-0
Mechano_growth_factor
Protein-coding gene in humans
modified in post-transcriptional manner by alternative splicing creating different variant of mRNA. Splicing on 3´end produces transcript where 25 amino acids
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Protein-coding gene in the species Homo sapiens
involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family
SFRS6
Protein-coding gene in the species Homo sapiens
with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role
ZRSR2
Protein-coding gene in the species Homo sapiens
Splicing factor 45 is a protein that in humans is encoded by the RBM17 gene. GRCh38: Ensembl release 89: ENSG00000134453 – Ensembl, May 2017 GRCm38: Ensembl
RBM17
Protein-coding gene in the species Homo sapiens
Drosophila behaviour/human splicing (DBHS) family of proteins. Proteins in the DHBS family include mammalian SFPQ (splicing factor, proline- and glutamine-rich;
Non-POU domain-containing octamer-binding protein
Non-POU_domain-containing_octamer-binding_protein
Protein-coding gene in the species Homo sapiens
peptide. The third conserved domain of RBFOX1 is the ELAV/HuD family splicing factor. HUD is human paraneoplastic encephalomyelitis antigen D whereas ELAV
RBFOX1
Protein with antiangiogenic properties
receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood
Soluble fms-like tyrosine kinase-1
Soluble_fms-like_tyrosine_kinase-1
Gastrointestinal peptide hormone involved in glucose homeostasis
are accordingly stimulated by various nutrient, neural and endocrine factors. GLP-1 is released in a biphasic pattern with an early phase after 10–15 minutes
Glucagon-like_peptide-1
Protein-coding gene in the species Homo sapiens
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene. This gene encodes subunit 1 of the splicing factor 3a protein complex
SF3A1
InterPro Family
including von Willebrand factor. There are five named isoforms of this protein that are produced by alternative splicing. Chordin dorsalizes the developing
Chordin
Protein-coding gene in the species Homo sapiens
Moreau-Gachelin F (February 1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". The Journal of Biological Chemistry. 273
SPI1
Protein-coding gene in the species Homo sapiens
chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produce multiple
RBM10
Mammalian protein found in humans
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Mammalian protein found in Homo sapiens
acts in the nucleus to regulate splicing and transcription. TIA1 helps to recruit the splicesome to regulate RNA splicing, and it inhibits transcription
TIA1
Protein-coding gene in the species Homo sapiens
Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene
IGFBP1
Protein-coding gene in humans
contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. CDC5L has been shown to interact with:
CDC5L
Gene at the top of a regulation hierarchy
the Twist transcription factor. Other genes reported as master regulators code for SR proteins, which function as splicing factors, and some noncoding RNAs
Master_regulator_gene
Type of RNA found in cells
respectively. Furthermore, RNA editing can affect the binding of splicing factors, adding an additional layer of regulation to circRNA production. Another
Circular_RNA
Family of proteins involved in anatomical development
activation in the absence of FGFs. Alternate mRNA splicing gives rise to 'b' and 'c' variants of FGFRs 1, 2 and 3. Through this mechanism, seven different
Fibroblast_growth_factor
Region of non-coding DNA that regulates the transcription of neighboring genes
regulate gene transcription by binding to transcription factors. A single transcription factor may bind to many CREs, and hence control the expression
Cis-regulatory_element
Protein-coding gene in humans
Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene. SFRS4 has been shown to interact with Pinin. GRCh38:
SFRS4
Protein-coding gene in the species Homo sapiens
been predicted to regulate alternative splicing through its interaction with other splice factors (modulating splice site selection). In particular, it is
SREK1
Protein-coding gene in humans
POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U." Brain Res. Mol. Brain Res. 45 (1): 99–107
HNRPU
Protein-coding gene in humans
Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene. This gene encodes one of four subunits of the splicing factor 3b
SF3B4
Protein complex assembled on mRNA
joined together during RNA splicing. The EJC has major influences on translation, surveillance, localization of the spliced mRNA, and m6A methylation.
Exon_junction_complex
Largest known protein in human muscles
alternative splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect. mRNA splicing factors such as RBM20
Titin
Protein-coding gene in the species Homo sapiens
transcription factor 1: its wide distribution and production by alternative splicing". Biochemical and Biophysical Research Communications. 194 (1): 544–551
TFAM
Protein-coding gene in the species Homo sapiens
oligomerizes and carries out an unconventional RNA splicing activity, removing an intron from the X-box binding protein 1 (XBP1) mRNA, and allowing it to become translated
ERN1
Protein-coding gene in humans
Pre-mRNA-splicing factor SPF27 is a protein that in humans is encoded by the BCAS2 gene. GRCh38: Ensembl release 89: ENSG00000116752 – Ensembl, May 2017
BCAS2
Mammalian protein found in Homo sapiens
fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Glucose-6-phosphate_isomerase
Biological phenomenon
Dysregulation of components of the splicing machinery can also cause dysregulation of PE inclusion. Mutations in the splicing factor SF3B1 have been found to promote
Poison_exon
Protein-coding gene in the species Homo sapiens
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene. This gene encodes subunit 3 of the splicing factor 3b protein complex
SF3B3
Transcription factor gene involved in the urogenital system
activates WT1 the steroidogenic factor 1 There is some evidence for RNA editing of human WT1 mRNA. As with alternative splicing of the gene RNA editing increases
Wilms_tumor_protein
Protein-coding gene in the species Homo sapiens
1997). "Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing". Biochemical and Biophysical
Placental_growth_factor
Protein-coding gene in the species Homo sapiens
Splicing factor 3B subunit 5 is a protein that in humans is encoded by the SF3B5 gene. The protein is a part of splicing factor 3b. GRCh38: Ensembl release
SF3B5
(splicing) of an atypical class of introns, called U12-type, from pre-messenger RNAs in most eukaryotes. This process is called noncanonical splicing,
Minor_spliceosome
Control of gene expression at the RNA level, between transcription and translation
RNA sequence. Post-transcriptional processes consist of 5′ capping, RNA splicing, polyadenylation, subcellular localization and controlled degradation of
Post-transcriptional regulation
Post-transcriptional_regulation
Protein-coding gene in the species Homo sapiens
neuron-related-splicing factor 30 (SMNDC1) is a protein that in humans is encoded by the SMNDC1 gene. SMNDC1 is an important splicing regulator and is
Survival motor neuron domain containing 1
Survival_motor_neuron_domain_containing_1
Protein-coding gene in humans
to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity". The Journal of
NSRP1
Protein-coding gene in humans
"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Human Molecular Genetics. 9 (5): 685–94
RBMX
British and Canadian molecular biologist
evolution, regulation and function of alternative splicing, including the discovery of splicing networks that control stem cell pluripotency and neurogenesis
Benjamin_Blencowe
Class of enzymes
growth factors comprise the largest family of growth factor ligands at 23 members. The natural alternate splicing of four fibroblast growth factor receptor
Receptor_tyrosine_kinase
Cell-surface glycoprotein
Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing". Cancers. 11 (9): 1233. doi:10
CD44
ESS regions. ESSs inhibit or silence splicing of the pre-mRNA and contribute to constitutive and alternate splicing. To elicit the silencing effect, ESSs
Exonic_splicing_silencer
Conversion of a gene's sequence into a mature gene product or products
is RNA splicing. The majority of eukaryotic pre-mRNAs consist of alternating segments called exons and introns. During the process of splicing, an RNA-protein
Gene_expression
Protein-coding gene in the species Homo sapiens
Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded
HIF1A
Family of four EGF proteins
1 (NRG1), with numerous discovered isoforms stemming from alternative splicing: Type I NRG1; alternative names: Heregulin, NEU differentiation factor
Neuregulin
Non-coding RNA component of the spliceosome
molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the
U4_spliceosomal_RNA
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SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
SPLICING FACTOR-1
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