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SPLENIC MARGINAL-ZONE-LYMPHOMA

  • Marginal zone lymphoma
  • Group of lymphomas

    MALT lymphomas. Splenic marginal zone lymphomas (SMZLs) are MZLs that initially are confined to the spleen, bone marrow, and blood. Nodal marginal zone lymphomas

    Marginal zone lymphoma

    Marginal zone lymphoma

    Marginal_zone_lymphoma

  • Splenic marginal zone lymphoma
  • Medical condition

    Splenic marginal zone lymphoma (SMZL) is a type of marginal zone lymphoma, a cancer made up of B-cells that replace the normal architecture of the white

    Splenic marginal zone lymphoma

    Splenic_marginal_zone_lymphoma

  • B-cell lymphoma
  • Blood cancer that affects B-type white blood cells

    (NMZL) Splenic marginal zone lymphoma (SMZL) Intravascular lymphomas variants Intravascular large B-cell lymphoma Intravascular NK-cell lymphoma Intravascular

    B-cell lymphoma

    B-cell lymphoma

    B-cell_lymphoma

  • Indolent lymphoma
  • Medical condition

    the most common of which is follicular lymphoma. Others include cutaneous T-cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström

    Indolent lymphoma

    Indolent lymphoma

    Indolent_lymphoma

  • Splenic lymphoma with villous lymphocytes
  • identical to splenic marginal zone lymphoma, or only highly similar, is a matter of debate. Maslak, Peter (1 September 2007). "Splenic villous lymphoma—peripheral

    Splenic lymphoma with villous lymphocytes

    Splenic_lymphoma_with_villous_lymphocytes

  • Monoclonal B-cell lymphocytosis
  • Medical condition

    malignancies appear to have been primarily marginal zone B-cell lymphomas of the splenic marginal zone B-cell, splenic lymphoma/leukemia unclassifiable, hairy cell

    Monoclonal B-cell lymphocytosis

    Monoclonal_B-cell_lymphocytosis

  • Chronic lymphocytic leukemia
  • Bone marrow cancer in which lymphocytes are overproduced

    appearance include mantle cell lymphoma, marginal zone lymphoma, B-cell prolymphocytic leukemia, and lymphoplasmacytic lymphoma. B cell prolymphocytic leukemia

    Chronic lymphocytic leukemia

    Chronic lymphocytic leukemia

    Chronic_lymphocytic_leukemia

  • Nirogacestat
  • Chemical compound

    and the Cell Signaling As Novel Therapeutic Approaches for Splenic Marginal Zone Lymphoma". Blood. 128 (22): 4186. doi:10.1182/blood.v128.22.4186.4186

    Nirogacestat

    Nirogacestat

    Nirogacestat

  • Lymphoma
  • Hematologic cancer that affects lymphocytes

    prolymphocytic leukemia Lymphoplasmacytic lymphoma (such as Waldenström macroglobulinemia) Splenic marginal zone lymphoma Hairy cell leukemia Plasma cell neoplasms:

    Lymphoma

    Lymphoma

    Lymphoma

  • Non-Hodgkin lymphoma
  • Type of cancer of lymph nodes

    Hepatitis C virus: associated with splenic marginal zone lymphoma, lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma. HIV infection. Some chemicals

    Non-Hodgkin lymphoma

    Non-Hodgkin lymphoma

    Non-Hodgkin_lymphoma

  • Tumors of the hematopoietic and lymphoid tissues
  • Tumors that affect the blood, bone marrow, lymph, and lymphatic system

    marginal zone lymphoma Hairy cell leukaemia Splenic B-cell lymphoma/leukaemia, unclassifiable Splenic diffuse red pulp small B-cell lymphoma Hairy cell

    Tumors of the hematopoietic and lymphoid tissues

    Tumors of the hematopoietic and lymphoid tissues

    Tumors_of_the_hematopoietic_and_lymphoid_tissues

  • Hairy cell leukemia
  • Hematological malignancy

    the presence of HCL and to exclude other diseases, such as Splenic marginal zone lymphoma or B-cell prolymphocytic leukemia. The bone marrow in HCL may

    Hairy cell leukemia

    Hairy cell leukemia

    Hairy_cell_leukemia

  • List of cancer types
  • Primary effusion lymphoma Plasmablastic lymphoma Sézary syndrome Splenic marginal zone lymphoma T-cell prolymphocytic leukemia Basal cell carcinoma Squamous

    List of cancer types

    List of cancer types

    List_of_cancer_types

  • Splenomegaly
  • Enlargement of the spleen

    >1000 g) are chronic myelogenous leukemia myelofibrosis malaria splenic marginal zone lymphoma Splenomegaly can be classified based on its pathophysiologic

    Splenomegaly

    Splenomegaly

    Splenomegaly

  • Marginal-zone B cell
  • Type of immune cell

    insufficient antibody response to capsular polysaccharides. In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin

    Marginal-zone B cell

    Marginal-zone B cell

    Marginal-zone_B_cell

  • List of hematologic conditions
  • Florena, Ada Maria; Iannitto, Emilio (November 21, 2002). "Splenic marginal zone lymphoma". Blood. 101 (7). American Society of Hematology: 2464–2472

    List of hematologic conditions

    List_of_hematologic_conditions

  • Marginal zone
  • Part of the spleen

    Birte; Timphus, Eva Maria; Barth, Peter J. (December 2006). "The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitants"

    Marginal zone

    Marginal zone

    Marginal_zone

  • Monoclonal gammopathy of undetermined significance
  • Medical condition

    lymphocytic leukemia Non-Hodgkin lymphoma, particularly Splenic marginal zone lymphoma and Lymphoplasmocytic lymphoma Connective tissue disease such as

    Monoclonal gammopathy of undetermined significance

    Monoclonal gammopathy of undetermined significance

    Monoclonal_gammopathy_of_undetermined_significance

  • SARS-CoV-2
  • Virus that causes COVID-19

    carcinoma RNA virus HCV Hepatocellular carcinoma Splenic marginal zone lymphoma HTLV-I Adult T-cell leukemia/lymphoma Immune disorders HIV AIDS Central nervous

    SARS-CoV-2

    SARS-CoV-2

    SARS-CoV-2

  • Hematologic disease
  • Disorders of the blood and related organs

    Anaplastic large cell lymphoma Splenic marginal zone lymphoma Hepatosplenic T-cell lymphoma Angioimmunoblastic T-cell lymphoma (AILT) Myelomas Multiple myeloma

    Hematologic disease

    Hematologic_disease

  • International Classification of Diseases for Oncology
  • Diagnosis classification

    Malignant lymphoma, undifferentiated Malignant lymphoma, small noncleaved Burkitt-like lymphoma M9689/3 Splenic marginal zone lymphoma Splenic marginal zone B-cell

    International Classification of Diseases for Oncology

    International_Classification_of_Diseases_for_Oncology

  • Outline of immunology
  • Overview of and topical guide to immunology

    macrophage - Bone marrow Marginal zone macrophage - Spleen Metallophilic macrophage - Spleen Red pulp macrophage - Splenic red pulp Tingible body macrophage

    Outline of immunology

    Outline_of_immunology

  • In situ lymphoid neoplasia
  • Medical condition

    splenic marginal zone lymphoma, CLL/SLL, marginal zone lymphoma, peripheral T-cell lymphoma not otherwise specified, and classical Hodgkin lymphoma.[citation

    In situ lymphoid neoplasia

    In_situ_lymphoid_neoplasia

  • GNG11
  • Protein-coding gene in the species Homo sapiens

    processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. GRCh38: Ensembl release 89: ENSG00000127920 – Ensembl, May

    GNG11

    GNG11

    GNG11

  • Umbralisib
  • Chemical compound

    is an anti-cancer medication for the treatment of marginal zone lymphoma (MZL) and follicular lymphoma (FL). It is taken by mouth. Umbralisib is a kinase

    Umbralisib

    Umbralisib

    Umbralisib

  • Scientific Advisory Group for the Origins of Novel Pathogens
  • WHO advisory group

    carcinoma RNA virus HCV Hepatocellular carcinoma Splenic marginal zone lymphoma HTLV-I Adult T-cell leukemia/lymphoma Immune disorders HIV AIDS Central nervous

    Scientific Advisory Group for the Origins of Novel Pathogens

    Scientific Advisory Group for the Origins of Novel Pathogens

    Scientific_Advisory_Group_for_the_Origins_of_Novel_Pathogens

  • Complete Genomics
  • Chinese biotechnology company

    sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma". The Journal of Experimental Medicine. 209 (9): 1553–1565.

    Complete Genomics

    Complete_Genomics

  • Raúl Rabadán
  • Spanish-American physicist and biologist (born 1974)

    diffuse large B-cell lymphoma, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, splenic marginal zone lymphoma among others. He has

    Raúl Rabadán

    Raúl Rabadán

    Raúl_Rabadán

  • Phospholipase A2 group IVD
  • Protein-coding gene in the species Homo sapiens

    identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma". PLOS ONE. 8 (12) e83244. Bibcode:2013PLoSO...883244P. doi:10

    Phospholipase A2 group IVD

    Phospholipase A2 group IVD

    Phospholipase_A2_group_IVD

  • Copanlisib
  • Chemical compound

    granted orphan drug status for the treatment of splenic, nodal and extranodal subtypes of marginal zone lymphoma. "Aliqopa- copanlisib injection, powder, lyophilized

    Copanlisib

    Copanlisib

    Copanlisib

  • Integrin alpha E
  • Protein-coding gene in the species Homo sapiens

    cell leukemia variant, a fraction of splenic marginal zone lymphomas, and enteropathy-associated T cell lymphoma. The chief ligand for αEβ7 is E-cadherin

    Integrin alpha E

    Integrin alpha E

    Integrin_alpha_E

  • Mir-345 microRNA precursor family
  • RNA family

    (July 2012). "Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection". Leukemia

    Mir-345 microRNA precursor family

    Mir-345_microRNA_precursor_family

  • GPR183
  • Protein-coding gene in the species Homo sapiens

    bridging channels connect the marginal zone, where dendritic cells pick up plasma-soluble antigen, to the T cell zone, where they present antigen to

    GPR183

    GPR183

    GPR183

  • Gilles Salles
  • French haematologist

    several aspects of lymphoma biology (ontogeny of B- and T-cell lymphoma, biology of splenic marginal zone, prognostic factors in lymphoma). This research

    Gilles Salles

    Gilles_Salles

  • RhoH
  • Protein-coding gene in the species Homo sapiens

    of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin". Leukemia. 21

    RhoH

    RhoH

    RhoH

  • Medical terminology
  • Language used to describe the human body

    Cortez-Retamozo V, Panizzi P, et al. (July 2009). "Identification of splenic reservoir monocytes and their deployment to inflammatory sites". Science

    Medical terminology

    Medical terminology

    Medical_terminology

  • B10 cell
  • Characteristics of this phenotype are similar to immature transitional B cells, marginal zone B cells, and peritoneal B1 cells. Peritoneal B10 cells share a similar

    B10 cell

    B10_cell

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