Searches , social queries for SOMATOSTATIN
Search references for SOMATOSTATIN. Phrases containing SOMATOSTATIN
See searches and references containing SOMATOSTATIN!
Search references for SOMATOSTATIN. Phrases containing SOMATOSTATIN
See searches and references containing SOMATOSTATIN!SOMATOSTATIN
Peptide hormone that regulates the endocrine system
Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system
Somatostatin
Cell surface protein binding somatostatin and triggering intracellular changes
Somatostatin receptors are receptors for somatostatin, a small neuropeptide associated with inhibitory signaling in wide range of tissues, including the
Somatostatin_receptor
Protein-coding gene in the species Homo sapiens
Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. The SSTR2 gene is located on chromosome 17 on the long arm in position
Somatostatin_receptor_2
Class of chemical compounds
Somatostatin receptor antagonists (or somatostatin inhibitors) are a class of chemical compounds that work by imitating the structure of the neuropeptide
Somatostatin receptor antagonist
Somatostatin_receptor_antagonist
Protein-coding gene in the species Homo sapiens
Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene. Somatostatin acts at many sites to inhibit the release of many
Somatostatin_receptor_4
Protein-coding gene in the species Homo sapiens
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. Somatostatin acts at many sites to inhibit the release of many
Somatostatin_receptor_5
Mammalian protein found in Homo sapiens
by somatostatin (growth-hormone-inhibiting hormone). Somatostatin is released from neurosecretory nerve terminals of periventricular somatostatin neurons
Growth hormone–releasing hormone
Growth_hormone–releasing_hormone
Somatostatin-producing cell
Delta cells (δ-cells or D cells) are somatostatin-producing cells. They can be found in the stomach, intestine and the pancreatic islets. Delta cells comprise
Delta_cell
Protein-coding gene in the species Homo sapiens
Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene. Somatostatin acts at many sites to inhibit the release of many
Somatostatin_receptor_1
Class of pharmaceuticals
Somatostatin receptor antagonists (or somatostatin inhibitors) are a class of chemical compounds that work by imitating the structure of the neuropeptide
Somatostatin_inhibitor
Type of medical imaging
localize sarcoidosis. It is also called somatostatin receptor scintigraphy (SRS). Octreotide, a drug similar to somatostatin, is radiolabeled with indium-111
Octreotide_scan
Tumors of the endocrine and nervous systems
tumours express somatostatin receptors providing a unique target for imaging. Octreotide is a synthetic modification of somatostatin with a longer half-life
Neuroendocrine_tumor
Protein-coding gene in the species Homo sapiens
Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene. Somatostatin acts at many sites to inhibit the release of many
Somatostatin_receptor_3
Excess growth of certain parts of the body
treatment of acromegaly is to use somatostatin analogues – octreotide (Sandostatin) or lanreotide (Somatuline). Somatostatin analogues are also sometimes used
Acromegaly
Peptide hormone that stimulates growth
(GHRH or somatocrinin) and growth hormone-inhibiting hormone (GHIH or somatostatin) into the hypophyseal portal venous blood surrounding the pituitary.
Growth_hormone
Chelate of Lu-177 with dotatate, a peptide derivative bound to a DOTA molecule
used in the treatment of cancers which express somatostatin receptors. It is a radiolabeled somatostatin analog. Alternatives to 177Lu-dotatate include
Lutetium (177Lu) oxodotreotide
Lutetium_(177Lu)_oxodotreotide
Octapeptide that mimics natural somatostatin pharmacologically
name Sandostatin among others, is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone
Octreotide
Protein family
The somatostatin family is a protein family with somatostatin as titular member, a hormone which inhibits the release of the pituitary somatotropin (growth
Somatostatin_family
Medical diagnostic method
score is used to grade the uptake intensity of neuroendocrine tumors on somatostatin receptor imaging such as octreotide scan.[further explanation needed]
Krenning_score
Hormone-producing glands of a body
and release of fats. Delta cells (5%) in the islets produce regulatory somatostatin. Other glands include the thymus, the adrenal glands including the adrenal
Endocrine_system
Pharmaceutical compound
L-817818 is a chemical compound which acts as an agonist at somatostatin receptor 5. It has neuroprotective effects in animal models and modulates insulin
L-817818
Archived from the original on 2008-12-06. Retrieved 2012-09-09. Bowen R. "Somatostatin". Hypertexts for Biomedical Sciences. Colorado State University. Archived
List_of_human_hormones
Eight amino-acid long peptide covalently bonded to a DOTA chelator
a form of peptide receptor radionuclide therapy (PRRT) which targets somatostatin receptors (SSR). In that form of application it is a form of targeted
DOTA-TATE
Organ of the digestive system and endocrine system of vertebrates
regulate blood sugar levels, secreting the hormones insulin, glucagon, somatostatin and pancreatic polypeptide. As a part of the digestive system, it functions
Pancreas
Tumor of the pancreas leading to overproduction of somatostatin
delta cells of the endocrine pancreas that produces somatostatin. Increased levels of somatostatin inhibit pancreatic hormones and gastrointestinal hormones
Somatostatinoma
Pharmaceutical compound
was one of the first compounds developed that acts as an agonist at somatostatin receptor 4. It has analgesic and anti-hyperalgesic effects and is widely
J-2156
Pharmaceutical compound
L-797591 is a chemical compound which acts as an agonist at somatostatin receptor 1. It modulates insulin release and has potential applications in the
L-797591
Peptide hormone
inhibitory polypeptide Gastrin Secretion of glucagon is inhibited by: Somatostatin Amylin Insulin (via GABA) PPARγ/retinoid X receptor heterodimer. Increased
Glucagon
Group of proteins responsible for both promotion and inhibition of cellular growth
acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus. Somatomedins are a group of proteins that promote
Somatomedin
Regions of the pancreas
cells) producing pancreatic polypeptide (<5%) Delta cells producing somatostatin (<10%) Epsilon cells producing ghrelin (<1%) It has been recognized that
Pancreatic_islets
Pharmaceutical drug
hormone somatostatin, making it difficult to overdose, unlike exogenous rhGH (a synthetic version of human GH). This interaction with somatostatin prompts
Sermorelin
Experimental drug
Octreotate Octreotide Pasireotide Pentetreotide RC-160 Seglitide Somatostatin (GHIH) Somatostatin (1-28) SRIF-14 SRIF-28 TT-232 Vapreotide Veldoreotide Antagonists:
Ibutamoren
Group of biological receptors
these neurotransmitters . The opioid receptors are ~40% identical to somatostatin receptors (SSTRs). Opioid receptors are distributed widely in the brain
Opioid_receptor
Short chains of 2–50 amino acids
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Peptide
Biological signalling molecule
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Hormone
Pharmaceutical compound
NNC 26-9100 is a chemical compound which acts as an agonist at somatostatin receptor 4. It has been researched for potential applications in the treatment
NNC_26-9100
Peptide selective agonist of the ghrelin/growth hormone secretagogue receptor
Octreotate Octreotide Pasireotide Pentetreotide RC-160 Seglitide Somatostatin (GHIH) Somatostatin (1-28) SRIF-14 SRIF-28 TT-232 Vapreotide Veldoreotide Antagonists:
Ipamorelin
Digestive fluid formed in the stomach
releases gastrin releasing peptide onto G cells. Finally, it also inhibits somatostatin release from D cells. The gastric phase: About sixty percent of the total
Gastric_acid
Pharmaceutical compound
BIM-23027 is a cyclic hexapeptide which acts as a selective agonist at somatostatin receptor 2. It inhibits secretion of various hormones and increases dopamine
BIM-23027
France-based pharmaceutical group
SomaKit TOC are novel kits for radiolabeling somatostatin analogue peptides to help diagnose somatostatin receptor-positive NET lesions. Each kit has received
Advanced Accelerator Applications
Advanced_Accelerator_Applications
Isotope of indium
Octreoscan) Octreotide is an somatostatin receptor inhibitor pharmaceutical which binds with high affinity to somatostatin receptors 2 and 5, interfering
Indium-111
Tumor that often causes a syndrome of diarrhea and electrolyte imbalance
fasting VIP plasma level may confirm the diagnosis, and CT scan and somatostatin receptor scintigraphy are used to localise the tumor, which is usually
VIPoma
secretion. Low intragastric pH stimulates antral D cells to release somatostatin. Somatostatin inhibits gastrin release from G cells. Reduced gastrin secretion
Phases_of_digestion
Pharmaceutical compound
(LY3556050, CNTX-0290) is a chemical compound which acts as an agonist at somatostatin receptor 4. It has analgesic effects and has been researched for the
Mazisotine
Hormone whose molecules are peptides
Orexin/Hypocretin Oxytocin Parathyroid hormone (PTH) Prolactin Renin Somatostatin Thyroid-stimulating hormone (TSH) Thyrotropin-releasing hormone (TRH)
Peptide_hormone
Medical treatment research
of the viral approaches, neuropeptide transgenes being researched are somatostatin, galanin, and neuropeptide Y (NPY). However, adenosine and gamma-aminobutyric
Gene_therapy_for_epilepsy
production of both somatostatin and thyroid releasing hormone. The intermediate portion aids in production of thyroid releasing hormone, somatostatin, leptin, gastrin
Periventricular_nucleus
Mammalian protein found in humans
cerebral cortex, and which has a strong structural similarity to somatostatin. Unlike somatostatin, when infused into the brain, it enhances slow-wave sleep
Cortistatin_(neuropeptide)
secretion Growth hormone releasing hormone (GHRH): stimulates GH secretion Somatostatin: inhibits GH (and other hormone) secretion Gonadotropin releasing hormone
Hypothalamic–pituitary hormone
Hypothalamic–pituitary_hormone
Essential nutrient
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Vitamin_D
Dark greenish-brown fluid aiding in the digestion of fats
Gastric acid Gastric acid secretion Gastrin G cells Histamine ECL cells Somatostatin D cells Lower Endocrine/paracrine Bile and pancreatic secretion Enterogastrone
Bile
Amino acid
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Pseudoproline
Glucagon secreting cell
cytosol. This increase in calcium causes the secretion of somatostatin by the delta cells. Somatostatin inhibits glucagon secretion through the activation of
Alpha_cell
Active form of vitamin D
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Calcitriol
Pharmaceutical drug
acromegaly cannot be controlled with surgery or radiation, and the use of somatostatin analogues is unsuccessful, but is also effective as a monotherapy. It
Pegvisomant
Factor that stimulates the growth of bone tissue
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Bone_growth_factor
Pharmaceutical drug
tumors, most notably carcinoid syndrome. It is a long-acting analogue of somatostatin, like octreotide. Lanreotide (as lanreotide acetate) is manufactured
Lanreotide
Thyroid hormone
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Thyroxine
Chemical compound
Octreotate Octreotide Pasireotide Pentetreotide RC-160 Seglitide Somatostatin (GHIH) Somatostatin (1-28) SRIF-14 SRIF-28 TT-232 Vapreotide Veldoreotide Antagonists:
CJC-1295
American geneticist (1939–2022)
able to link somatostatin to a larger protein, beta-galactosidase, produce it in E. coli, isolate it, and then separate the somatostatin from the galactosidase
Arthur_Riggs_(geneticist)
US laws allowing patients access to experimental drugs and therapies
is restricted to inoperable, somatostatin receptor positive, neuroendocrine tumors, that are progressive under somatostatin analogue therapy. State legislators
Right-to-try_law
Hormone pathway
hormone (GHRH; somatocrinin), growth hormone-inhibiting hormone (GHIH; somatostatin), and ghrelin (GHS) are involved in the control of GH secretion from
Hypothalamic–pituitary–somatotropic axis
Hypothalamic–pituitary–somatotropic_axis
Class of proteins
described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos,
CREB
Agent that interferes with action at the vasopressin receptors
Nelivaptan V2 selective (V2RA) Lixivaptan Mozavaptan Satavaptan Tolvaptan Somatostatin is a competitive inhibitor. Demeclocycline, a tetracycline antibiotic
Vasopressin receptor antagonist
Vasopressin_receptor_antagonist
Genetically inherited cancer of certain nerve tissues
"Differentiated expression of somatostatin receptor subtypes in experimental models and clinical neuroblastoma: Expression of Somatostatin Receptors in Neuroblastoma"
Neuroblastoma
Type of radiotherapy
can be achieved, as in PRRT. The current generation of PRRT targets somatostatin receptors, with a range of analogue materials such as octreotide and
Peptide receptor radionuclide therapy
Peptide_receptor_radionuclide_therapy
Thyroid hormone medication
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Levothyroxine
Pharmaceutical drug
Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. The most common
Pasireotide
Gastrointestinal peptide hormone involved in glucose homeostasis
glucose-dependent. The inhibitory effect is presumably mediated indirectly through somatostatin secretion, but a direct effect cannot be completely excluded. In the
Glucagon-like_peptide-1
Pharmaceutical drug
Atesidorsen Binding proteins: GHBPTooltip Growth hormone-binding protein GHIH (somatostatin) Agonists: BIM-23052 CH-275 Cortistatin-14 Depreotide Edotreotide Ilatreotide
Tesamorelin
Amino acid-like chemical compound
Octreotate Octreotide Pasireotide Pentetreotide RC-160 Seglitide Somatostatin (GHIH) Somatostatin (1-28) SRIF-14 SRIF-28 TT-232 Vapreotide Veldoreotide Antagonists:
Modified_GRF_(1-29)
Hormone for the maternal recognition of pregnancy
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Human_chorionic_gonadotropin
American biotechnology corporation
successfully express a human gene in bacteria when they produced the hormone somatostatin in 1977. David Goeddel and Dennis Kleid were then added to the group
Genentech
Chemical compound
Palsonify, is a medication used for the treatment of acromegaly. It is a somatostatin receptor 2 agonist. It is taken by mouth. It was developed by Crinetics
Paltusotine
Cluster in the human hypothalamus
transcription of somatostatin gene coincides with the establishment of sex differences in SDN-POA. It is observed that somatostatin mRNA appears in the
Sexually_dimorphic_nucleus
American venture capitalist
funding, to jumpstart the somatostatin research. He raised approximately $850,000 by February, enough money to fund the somatostatin research projects. By
Robert_A._Swanson
Mammalian protein found in Homo sapiens
bombesin or gastrin-releasing peptide (GRP) Inhibitory factor: somatostatin - acts on somatostatin-2 receptors on G cells. in a paracrine manner via local diffusion
Gastrin
Area of the brain below the thalamus
responses and maternal behavior; the periventricular nucleus, where somatostatin neurons are located, regulating stress levels; the ventromedial hypothalamus
Hypothalamus
Branch of biology studying interactions between the nervous and endocrine systems
episodes of GHRH release and somatostatin release, which may reflect neuronal interactions between the GHRH and somatostatin cells, and negative feedback
Neuroendocrinology
Hormone released by neuroendocrine cells
hormone Corticotropin-releasing hormone Growth hormone-releasing hormone Somatostatin Gonadotropin-releasing hormone Dopamine Neurotensin Neurohypophysial
Neurohormone
Inability to properly digest food due to a lack of digestive enzymes from the pancreas
alcohol-related liver disease, Sjogren syndrome, tobacco use, and use of somatostatin analogues. EPI is caused by a progressive loss of the pancreatic cells
Exocrine pancreatic insufficiency
Exocrine_pancreatic_insufficiency
Chemical substance that enables neurotransmission
3-iodothyronamine, octopamine, tryptamine, etc. Peptides: oxytocin, somatostatin, substance P, cocaine and amphetamine regulated transcript, opioid peptides
Neurotransmitter
Medical diagnostic method
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Plasma_renin_activity
Hormones and neuropeptides
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Endorphins
Endocrine gland of the brain
growth hormone-releasing hormone (GHRH), and is inhibited by hypothalamic somatostatin. Corticotropes: Cleaved from the precursor proopiomelanocortin protein
Pituitary_gland
Gonadotropin secreted by the adenohypophysis
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Luteinizing_hormone
Tumor of the pituitary gland
treatment with somatostatin receptor ligands such as octreotide or lanreotide. In people with thyrotropinomas, treatment with somatostatin receptor ligands
Pituitary_adenoma
Cell that produces gastrointestinal hormones
single cells throughout the intestinal tract. Hormones secreted include somatostatin, motilin, cholecystokinin, neurotensin, vasoactive intestinal peptide
Enteroendocrine_cell
Family of glycoprotein hormones in vertebrata
hormone (TRH). TRH stimulates the anterior pituitary gland to produce TSH. Somatostatin is also produced by the hypothalamus, and has an opposite effect on the
Thyroid-stimulating_hormone
Hormone pathway
confirming the essential anti-proliferative role of dopaminergic signalling. Somatostatin acts as a secondary inhibitor of prolactin release, counteracting TRH-
Hypothalamic–pituitary–prolactin axis
Hypothalamic–pituitary–prolactin_axis
Protein family
Oxytocin Prokineticin 1 2 Prolactin-releasing peptide Relaxin 1 2 3 4 Somatostatin 1 2 3 4 5 Tachykinin 1 2 3 Thyrotropin Thyrotropin-releasing hormone
Alpha-2_adrenergic_receptor
Human Hormone
an alternative cleavage product of the preproprotein encoded by the somatostatin (SST) gene. Proteolytic processing of this precursor yields two distinct
Neuronostatin
the distal tuft dendrites of pyramidal cells. Martinotti cells express somatostatin and sometimes calbindin, but not parvalbumin or vasoactive intestinal
Martinotti_cell
Protein produced by the endocrine pancreas
meal, fasting, exercise, and acute hypoglycaemia, and is decreased by somatostatin and intravenous glucose. Plasma pancreatic polypeptide has been shown
Pancreatic_polypeptide
This is a list of signaling peptide/protein receptor modulators Agonists: Peptide: Adiponectin ADP-355 ADP-399; Non-peptide: AdipoRon (–)-Arctigenin Arctiin
List of signaling peptide/protein receptor modulators
List_of_signaling_peptide/protein_receptor_modulators
Hormone and medication
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Adrenaline
Protein family
respectively in humans. On the other hand, RXFP3 and RXFP4 are related to somatostatin and, in humans, are the cognate receptors for RLN3 and INSL5. There is
Relaxin family peptide hormones
Relaxin_family_peptide_hormones
Pentapeptide
activity in the hippocampus, while leu-enkephalin analogs as well as somatostatins are downregulated during stress. Stressors may impact neuropeptides
Enkephalin
Medication used to treat anxiety disorders
selective for different receptor subtypes, on oxytocin, CCK, gastrin and somatostatin plasma levels in the rat". Neuropharmacology. 35 (11): 1635–1640. doi:10
Buspirone
Class of hormones
glands Hypothalamic– pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin (GHIH) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary
Tropic_hormone
travel, tourism, insurance
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
SOMATOSTATIN
travel, tourism, insurance