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See searches and references containing RNF8!RNF8
Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. RNF8 has activity both in immune system functions and in DNA
RNF8
Complex of DNA and protein in eukaryotic cells
decondensation, but within 30 seconds of irradiation, RNF8 protein can be detected in association with γH2AX. RNF8 mediates extensive chromatin decondensation,
Chromatin
Histone protein from the H2A family
but within 30 seconds of ionizing radiation, RNF8 protein can be detected in association with γH2AX. RNF8 mediates extensive chromatin decondensation,
H2AFX
Damage in DNA which occurs naturally
decondensation, but within 30 seconds of irradiation, RNF8 protein can be detected in association with γH2AX. RNF8 mediates extensive chromatin decondensation,
DNA damage (naturally occurring)
DNA_damage_(naturally_occurring)
Genetic recombination between identical or highly similar strands of genetic material
decondensation, but within 30 seconds of irradiation, RNF8 protein can be detected in association with γH2AX. RNF8 mediates extensive chromatin decondensation,
Homologous_recombination
Mammalian protein found in Homo sapiens
the binding of RNF8, a RING finger ubiquitin ligase to the E2 ubiquitin-conjugating enzyme UBC13. This association is required for RNF8 mediated Lys-63
HERC2
Cellular mechanism
decondensation, but within 30 seconds of irradiation, RNF8 protein can be detected in association with γH2AX. RNF8 mediates extensive chromatin decondensation,
DNA_repair
Form of dynamic modification
simultaneous accumulation of RNF8 protein and the DNA repair protein NBS1 which bind to MDC1 as MDC1 attaches to γH2AX. RNF8 mediates extensive chromatin
Chromatin_remodeling
Protein-coding gene in the species Homo sapiens
the TQXF domain on MDC1 which allows it to recruit the E3 ubiquitin ligase RNF8, which will ubiquitinate the histones near the DSB which initiates further
MDC1
Gene known for its role in breast cancer
VCP is recruited to DNA lesions and cooperates with the ubiquitin ligase RNF8 to orchestrate assembly of signaling complexes for efficient DSB repair.
BRCA1
Protein family
RFPL2, RFPL3, RFPL4B, RFWD2, RFWD3, RING1, RNF2, RNF4, RNF5, RNF6, RNF7, RNF8, RNF10, RNF11, RNF12, RNF13, RNF14, RNF19A, RNF20, RNF24, RNF25, RNF26, RNF32
RING_finger_domain
Protein domain
domain solution structure of the fha domain of human ubiquitin ligase protein rnf8 Identifiers Symbol FHA Pfam PF00498 Pfam clan CL0357 InterPro IPR000253 PROSITE
Forkhead-associated_domain
genes: PCDH10, DIA1 (formerly known as C3ORF58), NHE9, CNTN3, SCN7A, and RNF8. Several of these genes appeared to be targets of MEF2, one of the transcription
Heritability_of_autism
Protein-coding gene in the species Homo sapiens
POU2F1 TBP BCL3 BRD8 ITGB3BP NCOA2 NCOA3 NCOA6 PPARGC1A TADA3L IGFBP3 NRIP1 RNF8 TRIM24 Retinoid X receptor GRCh38: Ensembl release 89: ENSG00000186350 –
Retinoid_X_receptor_alpha
Regulatory protein found in most eukaryotic tissues
"Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation". The Journal of Biological
Ubiquitin
Q99942 13848 RNF6 HGNC:10069; Q9Y252 13849 RNF7 HGNC:10070; Q9UBF6 13850 RNF8 HGNC:10071; O76064 13851 RNF10 HGNC:10055; Q8N5U6 13852 RNF11 HGNC:10056;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
scaRNAs and the enzyme telomerase. WRAP53β also targets the ubiquitin ligase RNF8 to DNA double-strand breaks(Figure 2). In addition to localizing factors
WRAP53
Protein-coding gene in the species Homo sapiens
enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x
UBE2E1
Protein-coding gene in the species Homo sapiens
ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8". Mol. Cell. Biol. 33 (4): 845–57. doi:10.1128/MCB.00990-12. PMC 3571337
DTX3L
Protein-coding gene in the species Homo sapiens
enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x
RNF14
Protein-coding gene in the species Homo sapiens
enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x
UBE2E2
Protein-coding gene in the species Homo sapiens
enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x
UBE2E3
Protein-coding gene in the species Homo sapiens
production of the heterotrimer depends on p12 degradation by the E3 ligase RNF8, a protein involved in DSBs repair and possibly homologous recombination
POLD1
RNF8
RNF8
RNF8
RNF8
Surname or Lastname
English (Devon)
English (Devon) : topographic name for someone who lived ‘at the end of the cottages’, from Middle English, Old English ende ‘end’ + cot ‘cottage’. One locality so named is Endicott in Cadbury, Devon; another is now called Youngcott, in Milton Abbot.John Endecott (1588–1665) was a prominent figure in the early history of MA, being one of the founding fathers of Salem, MA, in 1638. He served as governor of Massachusetts Bay Colony (1629–30), and worked harmoniously with his successor, John Winthrop, despite differences on points of religious doctrine. He served as governor again in 1644–45, 1649–50, 1651–54, and 1655–64, and as deputy governor in many of the intervening years. He is buried in the King’s Chapel Burying Ground in Boston.
Girl/Female
Indian
Clean, Pure
Girl/Female
Australian, Chinese, Hebrew
Thunderbolt; Form of Tama
Boy/Male
Tamil
Nandikesh | நஂதீகேஷ
Lord Shiva
Girl/Female
Hindu
Well-born, Noble
Girl/Female
Hindu
Dedication
Girl/Female
Arabic
God's Gift
Girl/Female
Indian, Punjabi, Sikh
Lion Heart
Boy/Male
Indian, Punjabi, Sikh
Self; Soul
Female
English
Variant spelling of English Bridget, BRIDGETTE means "exalted one."
RNF8
RNF8
RNF8
RNF8
RNF8