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Protein-coding gene in the species Homo sapiens
lymphocyte-specific protein encoded by the RAG2 gene on human chromosome 11. Together with the RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex
RAG2
Sequences of noncoding DNA
are conserved sequences of noncoding DNA that are recognized by the RAG1/RAG2 enzyme complex during V(D)J recombination in immature B cells and T cells
Recombination signal sequences
Recombination_signal_sequences
Protein family
receptor molecules. There are two recombination-activating genes RAG1 and RAG2, whose cellular expression is restricted to lymphocytes during their developmental
Recombination-activating_gene
Protein-coding gene in the species Homo sapiens
RAG-1 is a protein that in humans is encoded by the RAG1 gene. The RAG1 and RAG2 genes are largely conserved in humans. 55.99% and 55.98% of the encoded amino
RAG1
Autoimmune disease in which the immune system attacks healthy tissue
NEIL3, TMEM173, ADAR1, NRAS, SAMHD1, SOS1, FASLG, FAS receptor gene, RAG1, RAG2, DNASE1, SHOC2, KRAS, PTPN11, PTEN, BLK, RNASEH2A, RNASEH2B, RNASEH2C, Complement
Lupus
Order of fish
of the major groups of catfish (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE
Catfish
Medical condition
of T-cells (and B-cells) such as recombination activating genes (RAG1 and RAG2), Interleukin-7 receptor-α (IL7Rα), DCLRE1C-Artemis, RMRP-CHH, DNA-Ligase
Omenn_syndrome
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE
Aspredinidae
Adaptive immunity variety-generation process
S2CID 40771963. van Gent, Dik; Ramsden, Dale; Gellert, Martin (1996). "The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination". Cell. 85 (1):
V(D)J_recombination
White blood cells of the immune system
DN2 stage (CD44+CD25+), cells upregulate the recombination genes RAG1 and RAG2 and re-arrange the TCRβ locus, combining V-D-J recombination and constant
T_cell
Endocrine gland
process of V(D)J recombination gene rearrangement stimulated by RAG1 and RAG2 genes. This process is error-prone, and some thymocytes do not make functional
Thymus
Norman–Roberts syndrome RELN recessive Ogden syndrome X P Omenn syndrome RAG1, RAG2 recessive Osteogenesis imperfecta COL1A1, COL1A2, IFITM5 dominant 1:15,000-20
List_of_genetic_disorders
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol. Phylogenet. Evol. 41 (3): 636–62. doi:10.1016/j
Ictaluridae
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j
Ariidae
Transmembrane protein on the surface of a B cell
first in early pro-B cells in a process that is dependent on the enzymes RAG2 and RAG1. After the recombination of the D and J regions, the cell is now
B-cell_receptor
Lab mouse strain lacking immunity and fur
complete defects in the immune system have been constructed (e.g. RAG1 and RAG2 knockout mice). For these reasons, nude mice are less popular in research
Nude_mouse
Lack of or compromised immune system
genes associated with immunodeficiency diseases include CD40L, CD40, RAG1, RAG2, IL2RG, and ADA. Here is a summary of some methods utilized to identify genetic
Immunodeficiency
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j
Airbreathing_catfish
organization of the core transcriptase; TransibSU is also notable for having RAG2-like proteins. Transib is notable as the source of the two Recombination-activating
Transib
Human chromosome
6-pyruvoyltetrahydropterin synthase QSER1: glutamine serine rich protein 1 RAG1/RAG2: recombination activating genes RASSF7: encoding protein Ras association
Chromosome_11
Intravenous transference of blood products
cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout mice". Transfusion. 46 (9): 1553–60. doi:10
Blood_transfusion
American immunologist
innate immunity. In 2001, in another landmark paper, Schreiber reported that RAG2 knockout mice, which lack an adaptive immune system (T and B cells), had
Robert_D._Schreiber
Excess number of eosinophil cells in the blood
splenomegaly, and lymphadenopathy due to a causative mutation in RAG1, RAG2, or, more rarely, one of several other genes. Lymphocyte-variant hypereosinophilia
Eosinophilia
Type of transposable element in genomes
this, it has been hypothesized that these proteins, particularly Rag1 and Rag2 are derived from transposable elements. There is evidence suggesting that
DNA_transposon
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j
Pseudopimelodidae
Protein-coding gene in the species Homo sapiens
motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene
KLHDC3
Protein complex on the surface of T cells that recognizes antigens
individual somatic T cells by somatic V(D)J recombination using RAG1 and RAG2 recombinases. Unlike immunoglobulins, however, TCR genes do not undergo somatic
T-cell_receptor
Genus of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Molecular Phylogenetics and Evolution. 41 (3): 636–662
Horabagrus
Monotypic genus of fish
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE
Conorhynchos
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE
Pimelodidae
syndrome RAB27A Griscelli syndrome RAG1 Severe combined immunodeficiency RAG2 Severe combined immunodeficiency RecQL2 (WRN) DNA helicase Werner syndrome
List of genes mutated in cutaneous conditions
List_of_genes_mutated_in_cutaneous_conditions
Mouse carrying functioning human genes, cells, etc.
and IL-21. Researchers evolved this NSG model by knocking out the RAG1 and RAG2 genes (recombination activation genes), resulting into the RAGnull version
Humanized_mouse
Protein-coding gene in humans
in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review". Genet
Common_gamma_chain
Genus of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Molecular Phylogenetics and Evolution. 41 (3): 636–662
Astroblepus
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j
Anchariidae
Pathway that repairs double-strand breaks in DNA
recombination, hairpin-capped double-strand breaks are created by the RAG1/RAG2 nuclease, which cleaves the DNA at recombination signal sequences. These
Non-homologous_end_joining
Genus of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Molecular Phylogenetics and Evolution. 41 (3): 636–62
Diplomystes
Species of bat
was sanguivorous and consumed blood. Based on mitochondrial DNA and the RAG2 gene, the spectral bat is most closely related to the monotypic genus Chrotopterus
Spectral_bat
American physician-scientist and cell biologist
hematopoietic stem cell transplantation in SCID patients with IL2RG, JAK3, RAG1, or RAG2 mutations. Her group also analyzes outcomes of a gene therapy trial for X-linked
Sung-Yun_Pai
Superfamily of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j
Sisoroidea
Protein-coding gene in the species Homo sapiens
locus, controlling TCR recombination via downregulation of the Rag1 and Rag2 genes. Moreover, SATB1 represses IL-2Ralpha and IL-2 expression by recruitment
SATB1
revision is achieved via reactivation of recombination enzymes RAG1 and/or RAG2 after T cell activation in the periphery and random recombination of their
T_cell_receptor_revision
Protein-coding gene in the species Homo sapiens
ISBN 978-1-4419-0295-5. PMID 19731800. Agrawal A, Schatz DG (1997-04-04). "RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends
Artemis_(protein)
DNA sequence variations introduced in recombination
starts as the proteins, recombination activating gene-1 and -2 (RAG1 and RAG2), along with DNA repair proteins, such as Artemis, are responsible for single-stranded
Junctional_diversity
Elimination of autoreactive lymphocytes by the immune system
thymus, further proliferate and most importantly, start to express Rag1 and Rag2 (recombinases of the V(D)J recombination of T or B cell receptors). Therefore
Central_tolerance
HGNC:16798; Q5VY80 13375 RAF1 HGNC:9829; P04049 13376 RAG1 HGNC:9831; P15918 13377 RAG2 HGNC:9832; P55895 13378 RAI1 HGNC:9834; Q7Z5J4 13379 RAI2 HGNC:9835; Q9Y5P3
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
expression in adaptation to various pathogens. Specific examples include: RAG1/RAG2 TdT Cas1/Cas2 mRNA processing acts as a form of post-transcriptional regulation
Trans-regulatory_element
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–662. doi:10.1016/j
Loach_catfish
Genus of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE
Cranoglanis
Family of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE
Heptapteridae
Protein-coding gene in the species Homo sapiens
sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2". Molecular and Cellular Biology. 19 (10): 6532–42. doi:10.1128/mcb.19.10
HMGB2
High frequency of mutations within the genome of a cellular lineage
spliced together to form the final gene, which is catalyzed by RAG1 and RAG2 recombinases. Activation-Induced Cytidine Deaminase (AID) then converts cytidine
Genome_instability
with mutations in transforming growth factor-β1 gene introduced into 129/Sv Rag2 mutant mouse accelerates adenocarcinomas with strong local invasion suggesting
Mouse model of colorectal and intestinal cancer
Mouse_model_of_colorectal_and_intestinal_cancer
Genetic disorder of animals
created in 2022, one having Prkdc knocked out, the other having both Prkdc and Rag2 knocked out. Severe combined immunodeficiency, for a detailed overview of
Severe combined immunodeficiency (non-human)
Severe_combined_immunodeficiency_(non-human)
Superfamily of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j
Loricarioidei
Model of cancer
deficient (SCID) mice, NOD-SCID mice, and recombination-activating gene 2 (Rag2)-knockout mice. The mice used must be immunocompromised to prevent transplant
Patient_derived_xenograft
Medical condition
genes, i.e., NEIL3, TMEM173, ADAR1, NRAS, SAMHD1, SOS1, FASLG, FAS, RAG1, RAG2, DNASE1, SHOC2, KRAS, PTPN11, PTEN, BLK, RNASEH2A, RNASEH2B, RNASEH2C, Complement
Childhood-onset systemic lupus erythematosus
Childhood-onset_systemic_lupus_erythematosus
2020 computer chess tournament
Qd7 143. Bh4 Rxb4 144. Bg5 Ng8 145. h6 g6 146. Qh4 Ne7 147. Bf6+ Kg8 148. Rag2 Kf7 149. Bxe7 Bxe7 150. Qh5 gxh5 151. Rg7+ Ke8 152. Rxh7 Kd8 153. Rgg7 Na8
TCEC_Season_19
Overview of and topical guide to immunology
selection V(D)J recombination Artemis complex Recombination-activating gene RAG1 RAG2 Recombination signal sequences Junctional diversity Immunoglobulin class
Outline_of_immunology
Breakdown of immune system processes
increased IgE production. The syndrome is caused by mutations in the RAG1, RAG2, IL2RG, IL7RA or RMRP genes. The number of immune cells is usually normal
Immune_dysregulation
Protein found in humans
23 bp spacer, referred to as class 2. A recombinase made up of RAG1 and RAG2 subunits always cleave between these two sites. The cleavage results in two
DNA_repair_protein_XRCC4
J; Savic, S (2019). "Predicting the Occurrence of Variants in RAG1 and RAG2". Journal of Clinical Immunology. 39 (7): 688–701. doi:10.1007/s10875-019-00670-z
Predictive_genomics
RAG1 Combined cellular and humoral immune defects with granulomas; 233650; RAG2 Combined factor V and VIII deficiency; 227300; LMAN1 Combined hyperlipidemia
List_of_OMIM_disorder_codes
Superfamily of fishes
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Molecular Phylogenetics and Evolution. 41 (3): 636–662
Ictaluroidea
RAG2
RAG2
RAG2
RAG2
Girl/Female
Tamil
Victorious, Winner
Male
Hebrew
(עֻזִּיָה) Variant spelling of Hebrew Uzziya, UZIYA means "power of Jehovah." In the bible, this is the name of one of David's warriors.
Boy/Male
Indian, Kannada, Marathi, Tamil
Another Name for God Pillaiyar; Elephant-headed
Boy/Male
Indian, Sanskrit
Glorified by Fire
Boy/Male
American, British, English, Jamaican
Victorious Prince; Royal Victory
Girl/Female
Hindu, Indian, Marathi
Satisfaction
Boy/Male
Indian, Punjabi, Sikh
One who Serves God
Boy/Male
Muslim
Tent maker
Boy/Male
Celebrity, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sindhi, Tamil, Telugu, Traditional
Supreme Spirit; Lord Shiva
Girl/Female
American, Arabic, Australian, Czechoslovakian, Danish, French, German, Indian, Kannada, Muslim, Russian, Sanskrit, Sindhi, Swedish
Generosity; Dew; Giving; Hopeful; A River; A Stream; Melody
RAG2
RAG2
RAG2
RAG2
RAG2